Entry
Symbol
metH, MTR
Name
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13 ]
Pathway
map00270 Cysteine and methionine metabolism
map01110 Biosynthesis of secondary metabolites
map04980 Cobalamin transport and metabolism
Module
M00017 Methionine biosynthesis, aspartate => homoserine => methionine
Reaction
R00946 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
R09365 5-methyltetrahydropteroyltri-L-glutamate:L-selenohomocysteine Se-methyltransferase
Disease
H00262 Neural tube defects, folate-sensitive
H01285 Methylcobalamin deficiency type G
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
K00548 metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
K00548 metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
K00548 metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase
09150 Organismal Systems
09154 Digestive system
04980 Cobalamin transport and metabolism
K00548 metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase
Enzymes [BR:ko01000 ]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
K00548 metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase
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Genes
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Taxonomy UniProt
Reference
Authors
Banerjee RV, Johnston NL, Sobeski JK, Datta P, Matthews RG
Title
Cloning and sequence analysis of the Escherichia coli metH gene encoding cobalamin-dependent methionine synthase and isolation of a tryptic fragment containing the cobalamin-binding domain.
Journal
J Biol Chem 264:13888-95 (1989)
Sequence
LinkDB
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