Homo sapiens (human): 2956
Help
Entry
2956 CDS
T01001
Symbol
MSH6, GTBP, GTMBP, HNPCC5, HSAP, LYNCH5, MMRCS3, MSH-6, p160
Name
(RefSeq) mutS homolog 6
KO
K08737
DNA mismatch repair protein MSH6
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa03430
Mismatch repair
hsa05200
Pathways in cancer
hsa05210
Colorectal cancer
Network
nt06503
Mismatch repair
Element
N01432
Mismatch repair
Disease
H00020
Colorectal cancer
H00876
Mismatch repair deficiency
H02565
Hereditary nonpolyposis colorectal cancer
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03430 Mismatch repair
2956 (MSH6)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2956 (MSH6)
09162 Cancer: specific types
05210 Colorectal cancer
2956 (MSH6)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
2956 (MSH6)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:
hsa03400
]
2956 (MSH6)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
SSBR (single strand breaks repair)
MMR (mismatch excision repair)
Mismatch and loop recognition factors
2956 (MSH6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MutS_V
MutS_III
MutS_I
PWWP
MutS_IV
MutS_II
HORMA
MUM1-like_PWWP
UPF0524
Motif
Other DBs
NCBI-GeneID:
2956
NCBI-ProteinID:
NP_000170
OMIM:
600678
HGNC:
7329
Ensembl:
ENSG00000116062
UniProt:
P52701
Q3SWU9
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:47783145..47810101
Genome browser
AA seq
1360 aa
AA seq
DB search
MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPL
ARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFI
REKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRAD
EALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRR
SSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKR
KRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSS
RPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQN
FDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKV
ARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLL
SLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGN
LSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLK
GMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTT
RSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCA
PLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDS
RAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEG
RFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN
RIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLIN
AEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVIL
LPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGK
STLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASI
LMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNV
AVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKA
REFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL
NT seq
4083 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcgacagagcaccctgtacagcttcttccccaagtctccggcgctgagtgatgcc
aacaaggcctcggccagggcctcacgcgaaggcggccgtgccgccgctgcccccggggcc
tctccttccccaggcggggatgcggcctggagcgaggctgggcctgggcccaggcccttg
gcgcgctccgcgtcaccgcccaaggcgaagaacctcaacggagggctgcggagatcggta
gcgcctgctgcccccaccagttgtgacttctcaccaggagatttggtttgggccaagatg
gagggttacccctggtggccttgtctggtttacaaccacccctttgatggaacattcatc
cgcgagaaagggaaatcagtccgtgttcatgtacagttttttgatgacagcccaacaagg
ggctgggttagcaaaaggcttttaaagccatatacaggttcaaaatcaaaggaagcccag
aagggaggtcatttttacagtgcaaagcctgaaatactgagagcaatgcaacgtgcagat
gaagccttaaataaagacaagattaagaggcttgaattggcagtttgtgatgagccctca
gagccagaagaggaagaagagatggaggtaggcacaacttacgtaacagataagagtgaa
gaagataatgaaattgagagtgaagaggaagtacagcctaagacacaaggatctaggcga
agtagccgccaaataaaaaaacgaagggtcatatcagattctgagagtgacattggtggc
tctgatgtggaatttaagccagacactaaggaggaaggaagcagtgatgaaataagcagt
ggagtgggggatagtgagagtgaaggcctgaacagccctgtcaaagttgctcgaaagcgg
aagagaatggtgactggaaatggctctcttaaaaggaaaagctctaggaaggaaacgccc
tcagccaccaaacaagcaactagcatttcatcagaaaccaagaatactttgagagctttc
tctgcccctcaaaattctgaatcccaagcccacgttagtggaggtggtgatgacagtagt
cgccctactgtttggtatcatgaaactttagaatggcttaaggaggaaaagagaagagat
gagcacaggaggaggcctgatcaccccgattttgatgcatctacactctatgtgcctgag
gatttcctcaattcttgtactcctgggatgaggaagtggtggcagattaagtctcagaac
tttgatcttgtcatctgttacaaggtggggaaattttatgagctgtaccacatggatgct
cttattggagtcagtgaactggggctggtattcatgaaaggcaactgggcccattctggc
tttcctgaaattgcatttggccgttattcagattccctggtgcagaagggctataaagta
gcacgagtggaacagactgagactccagaaatgatggaggcacgatgtagaaagatggca
catatatccaagtatgatagagtggtgaggagggagatctgtaggatcattaccaagggt
acacagacttacagtgtgctggaaggtgatccctctgagaactacagtaagtatcttctt
agcctcaaagaaaaagaggaagattcttctggccatactcgtgcatatggtgtgtgcttt
gttgatacttcactgggaaagtttttcataggtcagttttcagatgatcgccattgttcg
agatttaggactctagtggcacactatcccccagtacaagttttatttgaaaaaggaaat
ctctcaaaggaaactaaaacaattctaaagagttcattgtcctgttctcttcaggaaggt
ctgatacccggctcccagttttgggatgcatccaaaactttgagaactctccttgaggaa
gaatattttagggaaaagctaagtgatggcattggggtgatgttaccccaggtgcttaaa
ggtatgacttcagagtctgattccattgggttgacaccaggagagaaaagtgaattggcc
ctctctgctctaggtggttgtgtcttctacctcaaaaaatgccttattgatcaggagctt
ttatcaatggctaattttgaagaatatattcccttggattctgacacagtcagcactaca
agatctggtgctatcttcaccaaagcctatcaacgaatggtgctagatgcagtgacatta
aacaacttggagatttttctgaatggaacaaatggttctactgaaggaaccctactagag
agggttgatacttgccatactccttttggtaagcggctcctaaagcaatggctttgtgcc
ccactctgtaaccattatgctattaatgatcgtctagatgccatagaagacctcatggtt
gtgcctgacaaaatctccgaagttgtagagcttctaaagaagcttccagatcttgagagg
ctactcagtaaaattcataatgttgggtctcccctgaagagtcagaaccacccagacagc
agggctataatgtatgaagaaactacatacagcaagaagaagattattgattttctttct
gctctggaaggattcaaagtaatgtgtaaaattatagggatcatggaagaagttgctgat
ggttttaagtctaaaatccttaagcaggtcatctctctgcagacaaaaaatcctgaaggt
cgttttcctgatttgactgtagaattgaaccgatgggatacagcctttgaccatgaaaag
gctcgaaagactggacttattactcccaaagcaggctttgactctgattatgaccaagct
cttgctgacataagagaaaatgaacagagcctcctggaatacctagagaaacagcgcaac
agaattggctgtaggaccatagtctattgggggattggtaggaaccgttaccagctggaa
attcctgagaatttcaccactcgcaatttgccagaagaatacgagttgaaatctaccaag
aagggctgtaaacgatactggaccaaaactattgaaaagaagttggctaatctcataaat
gctgaagaacggagggatgtatcattgaaggactgcatgcggcgactgttctataacttt
gataaaaattacaaggactggcagtctgctgtagagtgtatcgcagtgttggatgtttta
ctgtgcctggctaactatagtcgagggggtgatggtcctatgtgtcgcccagtaattctg
ttgccggaagataccccccccttcttagagcttaaaggatcacgccatccttgcattacg
aagactttttttggagatgattttattcctaatgacattctaataggctgtgaggaagag
gagcaggaaaatggcaaagcctattgtgtgcttgttactggaccaaatatggggggcaag
tctacgcttatgagacaggctggcttattagctgtaatggcccagatgggttgttacgtc
cctgctgaagtgtgcaggctcacaccaattgatagagtgtttactagacttggtgcctca
gacagaataatgtcaggtgaaagtacattttttgttgaattaagtgaaactgccagcata
ctcatgcatgcaacagcacattctctggtgcttgtggatgaattaggaagaggtactgca
acatttgatgggacggcaatagcaaatgcagttgttaaagaacttgctgagactataaaa
tgtcgtacattattttcaactcactaccattcattagtagaagattattctcaaaatgtt
gctgtgcgcctaggacatatggcatgcatggtagaaaatgaatgtgaagaccccagccag
gagactattacgttcctctataaattcattaagggagcttgtcctaaaagctatggcttt
aatgcagcaaggcttgctaatctcccagaggaagttattcaaaagggacatagaaaagca
agagaatttgagaagatgaatcagtcactacgattatttcgggaagtttgcctggctagt
gaaaggtcaactgtagatgctgaagctgtccataaattgctgactttgattaaggaatta
tag
Homo sapiens (human): 4437
Help
Entry
4437 CDS
T01001
Symbol
MSH3, DUP, FAP4, MRP1
Name
(RefSeq) mutS homolog 3
KO
K08736
DNA mismatch repair protein MSH3
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa03430
Mismatch repair
hsa05200
Pathways in cancer
hsa05210
Colorectal cancer
Network
nt06503
Mismatch repair
Element
N01432
Mismatch repair
Disease
H00020
Colorectal cancer
H00026
Endometrial cancer
H01025
Familial adenomatous polyposis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03430 Mismatch repair
4437 (MSH3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4437 (MSH3)
09162 Cancer: specific types
05210 Colorectal cancer
4437 (MSH3)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
4437 (MSH3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:
hsa03400
]
4437 (MSH3)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
SSBR (single strand breaks repair)
MMR (mismatch excision repair)
Mismatch and loop recognition factors
4437 (MSH3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MutS_V
MutS_III
MutS_I
MutS_II
Spectrin_Dys-1
MutS_IV
Motif
Other DBs
NCBI-GeneID:
4437
NCBI-ProteinID:
NP_002430
OMIM:
600887
HGNC:
7326
Ensembl:
ENSG00000113318
UniProt:
P20585
Structure
PDB
PDBj
LinkDB
All DBs
Position
5:80654652..80876815
Genome browser
AA seq
1137 aa
AA seq
DB search
MSRRKPASGGLAASSSAPARQAVLSRFFQSTGSLKSTSSSTGAADQVDPGAAAAAAAAAA
AAPPAPPAPAFPPQLPPHIATEIDRRKKRPLENDGPVKKKVKKVQQKEGGSDLGMSGNSE
PKKCLRTRNVSKSLEKLKEFCCDSALPQSRVQTESLQERFAVLPKCTDFDDISLLHAKNA
VSSEDSKRQINQKDTTLFDLSQFGSSNTSHENLQKTASKSANKRSKSIYTPLELQYIEMK
QQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAK
GYKVGVVKQTETAALKAIGDNRSSLFSRKLTALYTKSTLIGEDVNPLIKLDDAVNVDEIM
TDTSTSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSELETRMSS
LQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKDT
VDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGT
TLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEV
LHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVN
SHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQ
GVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRF
HSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKV
AKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMG
GKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTA
EIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKN
YSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPG
EILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWTEEFNMEETQTSLLH
NT seq
3414 nt
NT seq
+upstream
nt +downstream
nt
atgtctcgccggaagcctgcgtcgggcggcctcgctgcctccagctcagcccctgcgagg
caagcggttttgagccgattcttccagtctacgggaagcctgaaatccacctcctcctcc
acaggtgcagccgaccaggtggaccctggcgctgcagcggctgcagcggccgcagcggcc
gcagcgcccccagcgcccccagctcccgccttcccgccccagctgccgccgcacatagct
acagaaattgacagaagaaagaagagaccattggaaaatgatgggcctgttaaaaagaaa
gtaaagaaagtccaacaaaaggaaggaggaagtgatctgggaatgtctggcaactctgag
ccaaagaaatgtctgaggaccaggaatgtttcaaagtctctggaaaaattgaaagaattc
tgctgcgattctgcccttcctcaaagtagagtccagacagaatctctgcaggagagattt
gcagttctgccaaaatgtactgattttgatgatatcagtcttctacacgcaaagaatgca
gtttcttctgaagattcgaaacgtcaaattaatcaaaaggacacaacactttttgatctc
agtcagtttggatcatcaaatacaagtcatgaaaatttacagaaaactgcttccaaatca
gctaacaaacggtccaaaagcatctatacgccgctagaattacaatacatagaaatgaag
cagcagcacaaagatgcagttttgtgtgtggaatgtggatataagtatagattctttggg
gaagatgcagagattgcagcccgagagctcaatatttattgccatttagatcacaacttt
atgacagcaagtatacctactcacagactgtttgttcatgtacgccgcctggtggcaaaa
ggatataaggtgggagttgtgaagcaaactgaaactgcagcattaaaggccattggagac
aacagaagttcactcttttcccggaaattgactgccctttatacaaaatctacacttatt
ggagaagatgtgaatcccctaatcaagctggatgatgctgtaaatgttgatgagataatg
actgatacttctaccagctatcttctgtgcatctctgaaaataaggaaaatgttagggac
aaaaaaaagggcaacatttttattggcattgtgggagtgcagcctgccacaggcgaggtt
gtgtttgatagtttccaggactctgcttctcgttcagagctagaaacccggatgtcaagc
ctgcagccagtagagctgctgcttccttcggccttgtccgagcaaacagaggcgctcatc
cacagagccacatctgttagtgtgcaggatgacagaattcgagtcgaaaggatggataac
atttattttgaatacagccatgctttccaggcagttacagagttttatgcaaaagataca
gttgacatcaaaggttctcaaattatttctggcattgttaacttagagaagcctgtgatt
tgctctttggctgccatcataaaatacctcaaagaattcaacttggaaaagatgctctcc
aaacctgagaattttaaacagctatcaagtaaaatggaatttatgacaattaatggaaca
acattaaggaatctggaaatcctacagaatcagactgatatgaaaaccaaaggaagtttg
ctgtgggttttagaccacactaaaacttcatttgggagacggaagttaaagaagtgggtg
acccagccactccttaaattaagggaaataaatgcccggcttgatgctgtatcggaagtt
ctccattcagaatctagtgtgtttggtcagatagaaaatcatctacgtaaattgcccgac
atagagaggggactctgtagcatttatcacaaaaaatgttctacccaagagttcttcttg
attgtcaaaactttatatcacctaaagtcagaatttcaagcaataatacctgctgttaat
tcccacattcagtcagacttgctccggaccgttattttagaaattcctgaactcctcagt
ccagtggagcattacttaaagatactcaatgaacaagctgccaaagttggggataaaact
gaattatttaaagacctttctgacttccctttaataaaaaagaggaaggatgaaattcaa
ggtgttattgacgagatccgaatgcatttgcaagaaatacgaaaaatactaaaaaatcct
tctgcacaatatgtgacagtatcaggacaggagtttatgatagaaataaagaactctgct
gtatcttgtataccaactgattgggtaaaggttggaagcacaaaagctgtgagccgcttt
cactctccttttattgtagaaaattacagacatctgaatcagctccgggagcagctagtc
cttgactgcagtgctgaatggcttgattttctagagaaattcagtgaacattatcactcc
ttgtgtaaagcagtgcatcacctagcaactgttgactgcattttctccctggccaaggtc
gctaagcaaggagattactgcagaccaactgtacaagaagaaagaaaaattgtaataaaa
aatggaaggcaccctgtgattgatgtgttgctgggagaacaggatcaatatgtcccaaat
aatacagatttatcagaggactcagagagagtaatgataattaccggaccaaacatgggt
ggaaagagctcctacataaaacaagttgcattgattaccatcatggctcagattggctcc
tatgttcctgcagaagaagcgacaattgggattgtggatggcattttcacaaggatgggt
gctgcagacaatatatataaaggacagagtacatttatggaagaactgactgacacagca
gaaataatcagaaaagcaacatcacagtccttggttatcttggatgaactaggaagaggg
acgagcactcatgatggaattgccattgcctatgctacacttgagtatttcatcagagat
gtgaaatccttaaccctgtttgtcacccattatccgccagtttgtgaactagaaaaaaat
tactcacaccaggtggggaattaccacatgggattcttggtcagtgaggatgaaagcaaa
ctggatccaggcgcagcagaacaagtccctgattttgtcaccttcctttaccaaataact
agaggaattgcagcaaggagttatggattaaatgtggctaaactagcagatgttcctgga
gaaattttgaagaaagcagctcacaagtcaaaagagctggaaggattaataaatacgaaa
agaaagagactcaagtattttgcaaagttatggacgatgcataatgcacaagacctgcag
aagtggacagaggagttcaacatggaagaaacacagacttctcttcttcattaa
DBGET
integrated database retrieval system
