Homo sapiens (human): 5211
Entry
5211 CDS
T01001
Gene name
PFKL, ATP-PFK, PFK-B, PFK-L
Definition
(RefSeq) phosphofructokinase, liver type
KO
K00850
6-phosphofructokinase 1 [EC:
2.7.1.11
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00010
Glycolysis / Gluconeogenesis
hsa00030
Pentose phosphate pathway
hsa00051
Fructose and mannose metabolism
hsa00052
Galactose metabolism
hsa01100
Metabolic pathways
hsa01200
Carbon metabolism
hsa01230
Biosynthesis of amino acids
hsa03018
RNA degradation
hsa04066
HIF-1 signaling pathway
hsa04152
AMPK signaling pathway
hsa04922
Glucagon signaling pathway
hsa05230
Central carbon metabolism in cancer
Module
hsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Network
nt06017
Glycogen metabolism
Element
N00731
Glycolysis
N00733
LDHA deficiency in glycolysis
N00735
ENO3 deficiency in glycolysis
N00737
PGAM2 deficiency in glycolysis
N00739
ALDOA deficiency in glycolysis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
5211 (PFKL)
00030 Pentose phosphate pathway
5211 (PFKL)
00051 Fructose and mannose metabolism
5211 (PFKL)
00052 Galactose metabolism
5211 (PFKL)
09120 Genetic Information Processing
09123 Folding, sorting and degradation
03018 RNA degradation
5211 (PFKL)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
5211 (PFKL)
04152 AMPK signaling pathway
5211 (PFKL)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
5211 (PFKL)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
5211 (PFKL)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
5211 (PFKL)
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:
hsa03019
]
5211 (PFKL)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.11 6-phosphofructokinase
5211 (PFKL)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein Ser/ Thr phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
5211 (PFKL)
Messenger RNA biogenesis [BR:
hsa03019
]
Prokaryotic Type
Bacterial mRNA degradation factors
RNA degradosome components
Other RNA degradosome components
5211 (PFKL)
SSDB
Motif
Pfam:
PFK
Other DBs
NCBI-GeneID:
5211
NCBI-ProteinID:
NP_002617
OMIM:
171860
HGNC:
8876
Ensembl:
ENSG00000141959
Vega:
OTTHUMG00000086910
Pharos:
P17858
(Tbio)
UniProt:
P17858
Q7L2M7
LinkDB
Position
21q22.3
AA seq
780 aa
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDG
SLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDS
ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE
NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQ
RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRS
AVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESI
VENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG
SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN
IHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFS
PVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
NT seq
2343 nt
+upstream
nt +downstream
nt
atggccgcggtggacctggagaagctgcgggcgtcgggcgcgggcaaggccatcggcgtc
ctgaccagcggcggcgacgcgcaaggcatgaacgctgctgtccgggctgtgacgcgcatg
ggcatttatgtgggtgccaaagtcttcctcatctacgagggctatgagggcctcgtggag
ggaggtgagaacatcaagcaggccaactggctgagcgtctccaacatcatccagctgggc
ggcactatcattggcagcgctcgctgcaaggcctttaccaccagggaggggcgccgggca
gcggcctacaacctggtccagcacggcatcaccaacctgtgcgtcatcggcggggatggc
agcctcacaggtgccaacatcttccgcagcgagtggggcagcctgctggaggagctggtg
gcggaaggtaagatctcagagactacagcccggacctactcgcacctgaacatcgcgggc
ctagtgggctccatcgataacgacttctgcggcaccgacatgaccatcggcacggactcg
gccctccaccgcatcatggaggtcatcgatgccatcaccaccactgcccagagccaccag
aggaccttcgtgctggaagtgatgggccggcactgcgggtacctggcgctggtatctgca
ctggcctcaggggccgactggctgttcatccccgaggctccacccgaggacggctgggag
aacttcatgtgtgagaggctgggtgagactcggagccgtgggtcccgactgaacatcatc
atcatcgctgagggtgccattgaccgcaacgggaagcccatctcgtccagctacgtgaag
gacctggtggttcagaggctgggcttcgacacccgtgtaactgtgctgggccacgtgcag
cggggagggacgccctctgccttcgaccggatcctgagcagcaagatgggcatggaggcg
gtgatggcgctgctggaagccacgcctgacacgccggcctgcgtggtcaccctctcgggg
aaccagtcagtgcggctgcccctcatggagtgcgtgcagatgaccaaggaagtgcagaaa
gccatggatgacaagaggtttgacgaggccacccagctccgtggtgggagcttcgagaac
aactggaacatttacaagctcctcgcccaccagaagccccccaaggagaagtctaacttc
tccctggccatcctgaatgtgggggccccggcggctggcatgaatgcggccgtgcgctcg
gcggtgcggaccggcatctcccatggacacacagtatacgtggtgcacgatggcttcgaa
ggcctagccaagggtcaggtgcaagaagtaggctggcacgacgtggccggctggttgggg
cgtggtggctccatgctggggaccaagaggaccctgcccaagggccagctggagtccatt
gtggagaacatccgcatctatggtattcacgccctgctggtggtcggtgggtttgaggcc
tatgaaggggtgctgcagctggtggaggctcgcgggcgctacgaggagctctgcatcgtc
atgtgtgtcatcccagccaccatcagcaacaacgtccctggcaccgacttcagcctgggc
tccgacactgctgtaaatgccgccatggagagctgtgaccgcatcaaacagtctgcctcg
gggaccaagcgccgtgtgttcatcgtggagaccatggggggttactgtggctacctggcc
accgtgactggcattgctgtgggggccgacgccgcctacgtcttcgaggaccctttcaac
atccacgacttaaaggtcaacgtggagcacatgacggagaagatgaagacagacattcag
aggggcctggtgctgcggaacgagaagtgccatgactactacaccacggagttcctgtac
aacctgtactcatcagagggcaagggcgtcttcgactgcaggaccaatgtcctgggccac
ctgcagcagggtggcgctccaaccccctttgaccggaactatgggaccaagctgggggtg
aaggccatgctgtggttgtcggagaagctgcgcgaggtttaccgcaagggacgggtgttc
gccaatgccccagactcggcctgcgtgatcggcctgaagaagaaggcggtggccttcagc
cccgtcactgagctcaagaaagacactgatttcgagcaccgcatgccacgggagcagtgg
tggctgagcctgcggctcatgctgaagatgctggcacaataccgcatcagtatggccgcc
tacgtgtcaggggagctggagcacgtgacccgccgcaccctgagcatggacaagggcttc
tga
DBGET
integrated database retrieval system
