Homo sapiens (human): 5211 Help Entry 5211              CDS       T01001                                  Gene name PFKL, ATP-PFK, PFK-B, PFK-L Definition (RefSeq) phosphofructokinase, liver type   KO K00850   6-phosphofructokinase 1 [EC:2.7.1.11] Organism hsa  Homo sapiens (human) Pathway hsa00010   Glycolysis / Gluconeogenesis hsa00030   Pentose phosphate pathway hsa00051   Fructose and mannose metabolism hsa00052   Galactose metabolism hsa01100   Metabolic pathways hsa01200   Carbon metabolism hsa01230   Biosynthesis of amino acids hsa03018   RNA degradation hsa04066   HIF-1 signaling pathway hsa04152   AMPK signaling pathway hsa04919   Thyroid hormone signaling pathway hsa04922   Glucagon signaling pathway hsa05230   Central carbon metabolism in cancer Module hsa_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate Network nt06017  Glycogen metabolism   Element N00731   Glycolysis N00733   LDHA deficiency in glycolysis N00735   ENO3 deficiency in glycolysis N00737   PGAM2 deficiency in glycolysis N00739   ALDOA deficiency in glycolysis Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     5211 (PFKL)    00030 Pentose phosphate pathway     5211 (PFKL)    00051 Fructose and mannose metabolism     5211 (PFKL)    00052 Galactose metabolism     5211 (PFKL)  09120 Genetic Information Processing   09123 Folding, sorting and degradation    03018 RNA degradation     5211 (PFKL)  09130 Environmental Information Processing   09132 Signal transduction    04066 HIF-1 signaling pathway     5211 (PFKL)    04152 AMPK signaling pathway     5211 (PFKL)  09150 Organismal Systems   09152 Endocrine system    04922 Glucagon signaling pathway     5211 (PFKL)    04919 Thyroid hormone signaling pathway     5211 (PFKL)  09160 Human Diseases   09161 Cancer: overview    05230 Central carbon metabolism in cancer     5211 (PFKL)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:hsa01009]     5211 (PFKL)   09182 Protein families: genetic information processing    03019 Messenger RNA biogenesis [BR:hsa03019]     5211 (PFKL) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.11  6-phosphofructokinase      5211 (PFKL) Protein phosphatases and associated proteins [BR:hsa01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      5211 (PFKL) Messenger RNA biogenesis [BR:hsa03019]  Prokaryotic type   Bacterial mRNA degradation factors    RNA degradosome components     Other RNA degradosome components      5211 (PFKL) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PFK Motif Other DBs NCBI-GeneID:  5211 NCBI-ProteinID:  NP_002617 OMIM:  171860 HGNC:  8876 Ensembl:  ENSG00000141959 Vega:  OTTHUMG00000086910 Pharos:  P17858(Tbio) UniProt:  P17858 Q7L2M7 LinkDB All DBs Position 21q22.3 AA seq 780 aa AA seqDB search MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDG SLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDS ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQ RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRS AVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESI VENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN IHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFS PVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF NT seq 2343 nt NT seq  +upstreamnt  +downstreamnt atggccgcggtggacctggagaagctgcgggcgtcgggcgcgggcaaggccatcggcgtc ctgaccagcggcggcgacgcgcaaggcatgaacgctgctgtccgggctgtgacgcgcatg ggcatttatgtgggtgccaaagtcttcctcatctacgagggctatgagggcctcgtggag ggaggtgagaacatcaagcaggccaactggctgagcgtctccaacatcatccagctgggc ggcactatcattggcagcgctcgctgcaaggcctttaccaccagggaggggcgccgggca gcggcctacaacctggtccagcacggcatcaccaacctgtgcgtcatcggcggggatggc agcctcacaggtgccaacatcttccgcagcgagtggggcagcctgctggaggagctggtg gcggaaggtaagatctcagagactacagcccggacctactcgcacctgaacatcgcgggc ctagtgggctccatcgataacgacttctgcggcaccgacatgaccatcggcacggactcg gccctccaccgcatcatggaggtcatcgatgccatcaccaccactgcccagagccaccag aggaccttcgtgctggaagtgatgggccggcactgcgggtacctggcgctggtatctgca ctggcctcaggggccgactggctgttcatccccgaggctccacccgaggacggctgggag aacttcatgtgtgagaggctgggtgagactcggagccgtgggtcccgactgaacatcatc atcatcgctgagggtgccattgaccgcaacgggaagcccatctcgtccagctacgtgaag gacctggtggttcagaggctgggcttcgacacccgtgtaactgtgctgggccacgtgcag cggggagggacgccctctgccttcgaccggatcctgagcagcaagatgggcatggaggcg gtgatggcgctgctggaagccacgcctgacacgccggcctgcgtggtcaccctctcgggg aaccagtcagtgcggctgcccctcatggagtgcgtgcagatgaccaaggaagtgcagaaa gccatggatgacaagaggtttgacgaggccacccagctccgtggtgggagcttcgagaac aactggaacatttacaagctcctcgcccaccagaagccccccaaggagaagtctaacttc tccctggccatcctgaatgtgggggccccggcggctggcatgaatgcggccgtgcgctcg gcggtgcggaccggcatctcccatggacacacagtatacgtggtgcacgatggcttcgaa ggcctagccaagggtcaggtgcaagaagtaggctggcacgacgtggccggctggttgggg cgtggtggctccatgctggggaccaagaggaccctgcccaagggccagctggagtccatt gtggagaacatccgcatctatggtattcacgccctgctggtggtcggtgggtttgaggcc tatgaaggggtgctgcagctggtggaggctcgcgggcgctacgaggagctctgcatcgtc atgtgtgtcatcccagccaccatcagcaacaacgtccctggcaccgacttcagcctgggc tccgacactgctgtaaatgccgccatggagagctgtgaccgcatcaaacagtctgcctcg gggaccaagcgccgtgtgttcatcgtggagaccatggggggttactgtggctacctggcc accgtgactggcattgctgtgggggccgacgccgcctacgtcttcgaggaccctttcaac atccacgacttaaaggtcaacgtggagcacatgacggagaagatgaagacagacattcag aggggcctggtgctgcggaacgagaagtgccatgactactacaccacggagttcctgtac aacctgtactcatcagagggcaagggcgtcttcgactgcaggaccaatgtcctgggccac ctgcagcagggtggcgctccaaccccctttgaccggaactatgggaccaagctgggggtg aaggccatgctgtggttgtcggagaagctgcgcgaggtttaccgcaagggacgggtgttc gccaatgccccagactcggcctgcgtgatcggcctgaagaagaaggcggtggccttcagc cccgtcactgagctcaagaaagacactgatttcgagcaccgcatgccacgggagcagtgg tggctgagcctgcggctcatgctgaagatgctggcacaataccgcatcagtatggccgcc tacgtgtcaggggagctggagcacgtgacccgccgcaccctgagcatggacaagggcttc tga

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