Homo sapiens (human): 5581 Entry 5581              CDS       T01001                                  Gene name PRKCE, PKCE, nPKC-epsilon Definition (RefSeq) protein kinase C epsilon   KO K18050   novel protein kinase C epsilon type [EC:2.7.11.13] Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04071   Sphingolipid signaling pathway hsa04270   Vascular smooth muscle contraction hsa04371   Apelin signaling pathway hsa04530   Tight junction hsa04666   Fc gamma R-mediated phagocytosis hsa04750   Inflammatory mediator regulation of TRP channels hsa04925   Aldosterone synthesis and secretion hsa04930   Type II diabetes mellitus hsa04931   Insulin resistance hsa04933   AGE-RAGE signaling pathway in diabetic complications hsa05131   Shigellosis hsa05206   MicroRNAs in cancer Drug target Safingol:  D05784 Safingol hydrochloride:  D05785 Sotrastaurin (DG01406):  D09671 D09718 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     5581 (PRKCE)    04071 Sphingolipid signaling pathway     5581 (PRKCE)    04022 cGMP-PKG signaling pathway     5581 (PRKCE)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04530 Tight junction     5581 (PRKCE)  09150 Organismal Systems   09151 Immune system    04666 Fc gamma R-mediated phagocytosis     5581 (PRKCE)   09152 Endocrine system    04925 Aldosterone synthesis and secretion     5581 (PRKCE)   09153 Circulatory system    04270 Vascular smooth muscle contraction     5581 (PRKCE)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     5581 (PRKCE)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     5581 (PRKCE)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     5581 (PRKCE)    04931 Insulin resistance     5581 (PRKCE)    04933 AGE-RAGE signaling pathway in diabetic complications     5581 (PRKCE)   09171 Infectious disease: bacterial    05131 Shigellosis     5581 (PRKCE)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     5581 (PRKCE) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      5581 (PRKCE) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   PKC family [OT]    5581 (PRKCE) SSDB Motif Pfam:  Pkinase Pkinase_Tyr C1_1 C2 Pkinase_C FTA2 Kinase-like Kdo Haspin_kinase APH Other DBs NCBI-GeneID:  5581 NCBI-ProteinID:  NP_005391 OMIM:  176975 HGNC:  9401 Ensembl:  ENSG00000171132 Vega:  OTTHUMG00000128817 Pharos:  Q02156(Tchem) UniProt:  Q02156 L7RTI5 LinkDB Structure PDB:  2WH0 Position 2p21 AA seq 737 aa MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI NQEEFKGFSYFGEDLMP NT seq 2214 nt   +upstreamnt  +downstreamnt atggtagtgttcaatggccttcttaagatcaaaatctgcgaggccgtgagcttgaagccc acagcctggtcgctgcgccatgcggtgggaccccggccgcagactttccttctcgacccc tacattgccctcaatgtggacgactcgcgcatcggccaaacggccaccaagcagaagacc aacagcccggcctggcacgacgagttcgtcaccgatgtgtgcaacggacgcaagatcgag ctggctgtctttcacgatgcccccataggctacgacgacttcgtggccaactgcaccatc cagtttgaggagctgctgcagaacgggagccgccacttcgaggactggattgatctggag ccagaaggaagagtgtatgtgatcatcgatctctcagggtcgtcgggtgaagcccctaaa gacaatgaagagcgtgtgttcagggaacgcatgcggccgaggaagcggcagggggccgtc aggcgcagggtccatcaggtcaacggccacaagttcatggccacctatcttcggcagccc acctactgctcccattgcagagacttcatctggggtgtcataggaaagcagggataccag tgtcaagtctgcacctgcgtggtccacaagcggtgccacgagctcataatcacaaagtgt gctgggttaaagaagcaggagacccccgaccaggtgggctcccagcggttcagcgtcaac atgccccacaagttcggtatccacaactacaaggtccctaccttctgcgatcactgtggg tccctgctctggggactcttgcggcagggtttgcagtgtaaagtctgcaaaatgaatgtt caccgtcgatgtgagaccaacgtggctcccaactgtggagtggatgccagaggaatcgcc aaagtactggccgacctgggcgttaccccagacaaaatcaccaacagcggccagagaagg aaaaagctcattgctggtgccgagtccccgcagcctgcttctggaagctcaccatctgag gaagatcgatccaagtcagcacccacctccccttgtgaccaggaaataaaagaacttgag aacaacattcggaaagccttgtcatttgacaaccgaggagaggagcaccgggcagcatcg tctcctgatggccagctgatgagccccggtgagaatggcgaagtccggcaaggccaggcc aagcgcctgggcctggatgagttcaacttcatcaaggtgttgggcaaaggcagctttggc aaggtcatgttggcagaactcaagggcaaagatgaagtatatgctgtgaaggtcttaaag aaggacgtcatccttcaggatgatgacgtggactgcacaatgacagagaagaggattttg gctctggcacggaaacacccgtaccttacccaactctactgctgcttccagaccaaggac cgcctctttttcgtcatggaatatgtaaatggtggagacctcatgtttcagattcagcgc tcccgaaaattcgacgagcctcgttcacggttctatgctgcagaggtcacatcggccctc atgttcctccaccagcatggagtcatctacagggatttgaaactggacaacatccttctg gatgcagaaggtcactgcaagctggctgacttcgggatgtgcaaggaagggattctgaat ggtgtgacgaccaccacgttctgtgggactcctgactacatagctcctgagatcctgcag gagttggagtatggcccctccgtggactggtgggccctgggggtgctgatgtacgagatg atggctggacagcctccctttgaggccgacaatgaggacgacctatttgagtccatcctc catgacgacgtgctgtacccagtctggctcagcaaggaggctgtcagcatcttgaaagct ttcatgacgaagaatccccacaagcgcctgggctgtgtggcatcgcagaatggcgaggac gccatcaagcagcacccattcttcaaagagattgactgggtgctcctggagcagaagaag atcaagccacccttcaaaccacgcattaaaaccaaaagagacgtcaataattttgaccaa gactttacccgggaagagccggtactcacccttgtggacgaagcaattgtaaagcagatc aaccaggaggaattcaaaggtttctcctactttggtgaagacctgatgccctga

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