Homo sapiens (human): 6768
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Entry
6768 CDS
T01001
Symbol
ST14, ARCI11, CAP3, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
Name
(RefSeq) ST14 transmembrane serine protease matriptase
KO
K08670
suppressor of tumorigenicity protein 14 [EC:
3.4.21.109
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04382
Cornified envelope formation
hsa05206
MicroRNAs in cancer
Network
nt06545
Cornified envelope formation
Element
N01930
Processing of profilaggrin to filaggrin and binding to keratin filaments
Disease
H00734
Autosomal recessive congenital ichthyosis
H00739
Ichthyosis with hypotrichosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09158 Development and regeneration
04382 Cornified envelope formation
6768 (ST14)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
6768 (ST14)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
6768 (ST14)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.109 matriptase
6768 (ST14)
Peptidases and inhibitors [BR:
hsa01002
]
Serine peptidases
Family S1: chymotrypsin family
6768 (ST14)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Trypsin
CUB
Ldl_recept_a
SEA
CUB_2
DUF1986
CDCP1_CUB_6
Motif
Other DBs
NCBI-GeneID:
6768
NCBI-ProteinID:
NP_068813
OMIM:
606797
HGNC:
11344
Ensembl:
ENSG00000149418
UniProt:
Q9Y5Y6
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:130159782..130210362
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AA seq
855 aa
AA seq
DB search
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
NT seq
2568 nt
NT seq
+upstream
nt +downstream
nt
atggggagcgatcgggcccgcaagggcggagggggcccgaaggacttcggcgcgggactc
aagtacaactcccggcacgagaaagtgaatggcttggaggaaggcgtggagttcctgcca
gtcaacaacgtcaagaaggtggaaaagcatggcccggggcgctgggtggtgctggcagcc
gtgctgatcggcctcctcttggtcttgctggggatcggcttcctggtgtggcatttgcag
taccgggacgtgcgtgtccagaaggtcttcaatggctacatgaggatcacaaatgagaat
tttgtggatgcctacgagaactccaactccactgagtttgtaagcctggccagcaaggtg
aaggacgcgctgaagctgctgtacagcggagtcccattcctgggcccctaccacaaggag
tcggctgtgacggccttcagcgagggcagcgtcatcgcctactactggtctgagttcagc
atcccgcagcacctggtggaggaggccgagcgcgtcatggccgaggagcgcgtagtcatg
ctgcccccgcgggcgcgctccctgaagtcctttgtggtcacctcagtggtggctttcccc
acggactccaaaacagtacagaggacccaggacaacagctgcagctttggcctgcacgcc
cgcggtgtggagctgatgcgcttcaccacgcccggcttccctgacagcccctaccccgct
catgcccgctgccagtgggccctgcggggggacgccgactcagtgctgagcctcaccttc
cgcagctttgaccttgcgtcctgcgacgagcgcggcagcgacctggtgacggtgtacaac
accctgagccccatggagccccacgccctggtgcagttgtgtggcacctaccctccctcc
tacaacctgaccttccactcctcccagaacgtcctgctcatcacactgataaccaacact
gagcggcggcatcccggctttgaggccaccttcttccagctgcctaggatgagcagctgt
ggaggccgcttacgtaaagcccaggggacattcaacagcccctactacccaggccactac
ccacccaacattgactgcacatggaacattgaggtgcccaacaaccagcatgtgaaggtg
cgcttcaaattcttctacctgctggagcccggcgtgcctgcgggcacctgccccaaggac
tacgtggagatcaacggggagaaatactgcggagagaggtcccagttcgtcgtcaccagc
aacagcaacaagatcacagttcgcttccactcagatcagtcctacaccgacaccggcttc
ttagctgaatacctctcctacgactccagtgacccatgcccggggcagttcacgtgccgc
acggggcggtgtatccggaaggagctgcgctgtgatggctgggccgactgcaccgaccac
agcgatgagctcaactgcagttgcgacgccggccaccagttcacgtgcaagaacaagttc
tgcaagcccctcttctgggtctgcgacagtgtgaacgactgcggagacaacagcgacgag
caggggtgcagttgtccggcccagaccttcaggtgttccaatgggaagtgcctctcgaaa
agccagcagtgcaatgggaaggacgactgtggggacgggtccgacgaggcctcctgcccc
aaggtgaacgtcgtcacttgtaccaaacacacctaccgctgcctcaatgggctctgcttg
agcaagggcaaccctgagtgtgacgggaaggaggactgtagcgacggctcagatgagaag
gactgcgactgtgggctgcggtcattcacgagacaggctcgtgttgttgggggcacggat
gcggatgagggcgagtggccctggcaggtaagcctgcatgctctgggccagggccacatc
tgcggtgcttccctcatctctcccaactggctggtctctgccgcacactgctacatcgat
gacagaggattcaggtactcagaccccacgcagtggacggccttcctgggcttgcacgac
cagagccagcgcagcgcccctggggtgcaggagcgcaggctcaagcgcatcatctcccac
cccttcttcaatgacttcaccttcgactatgacatcgcgctgctggagctggagaaaccg
gcagagtacagctccatggtgcggcccatctgcctgccggacgcctcccatgtcttccct
gccggcaaggccatctgggtcacgggctggggacacacccagtatggaggcactggcgcg
ctgatcctgcaaaagggtgagatccgcgtcatcaaccagaccacctgcgagaacctcctg
ccgcagcagatcacgccgcgcatgatgtgcgtgggcttcctcagcggcggcgtggactcc
tgccagggtgattccgggggacccctgtccagcgtggaggcggatgggcggatcttccag
gccggtgtggtgagctggggagacggctgcgctcagaggaacaagccaggcgtgtacaca
aggctccctctgtttcgggactggatcaaagagaacactggggtatag
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