KEGG T01001: 6874

Homo sapiens (human): 6874

Entry

6874 CDS T01001

Gene name

TAF4, TAF(II)130, TAF(II)135, TAF2C, TAF2C1, TAF4A, TAFII-130, TAFII-135, TAFII130, TAFII135

Definition

(RefSeq) TATA-box binding protein associated factor 4

K03129

transcription initiation factor TFIID subunit 4

Organism

hsa Homo sapiens (human)

Pathway

hsa03022

Basal transcription factors

hsa05016

Huntington disease

Network

nt06440 Transcription
nt06461 Huntington disease

Element

N00981

Mutation-caused aberrant Htt to CREB-mediated transcription

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09121 Transcription
   03022 Basal transcription factors
    6874 (TAF4)
09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    6874 (TAF4)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    6874 (TAF4)
   03036 Chromosome and associated proteins [BR:hsa03036]
    6874 (TAF4)
Transcription machinery [BR:hsa03021]
Eukaryotic type
  RNA polymerase II system
   Basal transcription factors
    TFIID
     6874 (TAF4)
   Coactivators
    SAGA/TFTC/STAGA complex
     6874 (TAF4)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Histone modification proteins
   HAT complexes
    TFTC complex
     6874 (TAF4)

SSDB

Motif

Pfam:

TAF4 TAFH tRNA-synt_1c

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

O00268(Tbio)

UniProt:

O00268

LinkDB

Structure

PDB:

2P6V 1H3O 6MZC 6MZM 6MZD 6MZL

Position

20q13.33

AA seq 1085 aa
MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGN
HVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPA
PPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGP
GPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQT
PPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPP
AAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQT
LAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATT
SGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQA
HAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATL
QRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVPGATTTSSAATETMENVKKCKNFL
STLIKLASSGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRS
LPALRQLTPDSAAFIQQSQQQPPPPTSQATTALTAVVLSSSVQRTAGKTAATVTSALQPP
VLSLTQPTQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTP
QQIQLNPLQPVPVVKPAVLPGTKALSAVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASM
AGVNLSEESARILATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVS
YVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDE
QEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKV
DCPGPGSGAEGSGPGSVVPGSSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLY
KAFLK

NT seq 3258 nt +upstreamnt +downstreamnt
atggcggcgggctcggatctgctggacgaggtcttcttcaacagcgaggtggacgagaaa
gtggtgagcgacctggtgggctcgctggagtcgcagctggcggccagcgcggcccaccac
caccacctcgcgccgcgcacgcccgaggtgcgggccgcggccgccggcgcgctcgggaac
catgttgtgagcggcagcccggccggagccgcgggcgcagggccggccgcccccgccgag
ggcgcgcccggagcggcgccggagccgccccccgcaggtagagcgcggccggggggcggg
gggccgcagcgcccgggccccccctcaccgcgccgcccccttgtccccgcagggcccgcg
ccgcccgccgcgaagctgaggccgccgcccgagggcagcgcggggtcctgcgccccggtg
cccgccgccgccgccgtcgccgcggggcccgagcccgcccccgccggccccgccaagccc
gccggccccgccgcgctggccgcccgcgccggccccggccccgggcccggccccggcccc
ggccccggccctggccctggcaagcccgccggccccggcgccgcgcaaactttgaatggg
agcgccgcgctgctgaactcgcaccacgccgccgcacctgctgtcagcctggtcaacaac
gggcccgccgcgctgctgccgctgcccaagcccgccgcccccggcactgtcatccagacg
ccccccttcgtgggcgccgccgcgccccccgcgcccgccgcgccctcgccccccgccgcc
cccgcgcccgccgcccccgccgccgccccgcccccgccaccccccgcgcccgccactctg
gcccggccgcccggccaccccgccggacccccgaccgccgcgcccgccgtgccgcccccc
gccgccgcccagaacgggggcagcgccggggcagcccccgcccccgccccggccgccggg
ggccccgcgggggtcagcggccaacccgggcccggcgcggcggctgcggcgccggcgccg
ggggtcaaggccgagtcgcccaagagggtggtgcaggcggcgcccccggcggcgcagacc
ctggcggccagcggcccggccagcacggcggccagcatggtcatcgggccaactatgcaa
ggggcgctgcccagcccggccgccgtcccgccgcccgcccccgggacccccaccgggctg
cccaaaggcgcggccggcgcagtgacccagagcctgtcccggacgcccacggccaccacc
agcgggattcgggccaccctgacgcccaccgtgctggccccccgcttgccgcagccgcct
cagaacccgaccaacatccagaacttccagctgcccccaggaatggtcctcgtccgaagt
gagaatgggcagttgttaatgattcctcagcaggccttggcccagatgcaggcgcaggcc
catgcccagcctcagaccaccatggcgcctcgccctgccacccccacaagtgcccctccc
gtccagatctccaccgtacaggcacctggaacacctatcattgcacggcaggtgacccca
actaccataattaagcaagtgtctcaggcccagacaacggtgcagcccagtgcaaccctg
cagcgctcgcccggcgtccagcctcagctcgttctgggtggcgctgcccagacggcttca
cttgggacggcgacggctgttcagacggggactcctcagcgcacggtaccaggggcgacc
accacttcctcagctgccacggaaactatggaaaacgtgaagaaatgtaaaaatttccta
tctacgttaataaaactggcttcatctggcaagcagtctacagagacagcagctaatgtg
aaagagctcgtgcagaatttactggatggaaaaatagaagcagaagatttcacaagcagg
ttataccgagaacttaattcttcacctcaaccttaccttgtgcctttcctgaagaggagc
ttacccgccttgagacagctgacccccgactccgcggccttcatccagcagagccagcag
cagccgccaccgcccacctcgcaggccaccactgcgctcacggccgtggtgctgagtagc
tcggtccagcgcacggccgggaagacggcggccaccgtgaccagtgccctccagccccct
gtgctcagcctcacgcagcccacgcaggtcggcgtcggcaagcaggggcaacccacaccg
ctggtcatccagcagcctccgaagccaggagccctgatccggcccccgcaggtgacgttg
acgcagacacccatggtcgccctgcggcagcctcacaaccggatcatgctcaccacgcct
cagcagatccagctgaacccactgcagccagtccctgtggtgaaacccgccgtgttacct
ggaaccaaagccctttctgctgtctcggcacaagcagctgctgcacagaaaaataaactc
aaggagcctgggggaggttcgtttcgggacgatgatgacattaatgatgttgcatcgatg
gctggagtaaacttgtcagaagaaagtgcaagaatattagccacgaactctgaattggtg
ggcacgctaacgcggtcctgtaaagatgaaaccttcctcctccaagcgcctttgcagaga
agaatattagaaataggtaaaaaacatggtataacggaattacatccagatgtagtaagt
tatgtatcacatgccacgcaacaaaggctacagaatcttgtagagaaaatatcagaaaca
gctcagcagaagaacttttcttacaaggatgacgacagatatgagcaggcgagtgacgtc
cgggcacagctcaagttttttgaacagcttgatcaaatcgaaaagcagaggaaggatgag
caggagcgggagatcctgatgagggcagcaaagtctcggtcaagacaagaagatccagaa
cagttaaggctgaaacagaaggcaaaggagatgcagcaacaggaactggcacaaatgaga
cagcgggacgccaacctcacagcactagcagcgatcgggcccaggaaaaagaggaaagtg
gactgtccggggccgggctcaggagcagaggggtcgggccccggctcagtggtcccaggc
agctcgggtgtcggaacccccagacagttcacgcgacaaagaatcacgcgggtcaacctc
agggacctcatattttgtttagaaaatgaacgtgagacaagccattcactgctgctctac
aaagcattccttaagtga

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