Homo sapiens (human): 7390 Help Entry 7390              CDS       T01001                                  Gene name UROS, UROIIIS Definition (RefSeq) uroporphyrinogen III synthase   KO K01719   uroporphyrinogen-III synthase [EC:4.2.1.75] Organism hsa  Homo sapiens (human) Pathway hsa00860   Porphyrin and chlorophyll metabolism hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors Module hsa_M00868   Heme biosynthesis, animals and fungi, glycine => heme Network nt06011  Heme biosynthesis   Element N00601   Heme biosynthesis N00602   FECH deficiency in heme biosynthesis N00603   PPOX deficiency in heme biosynthesis N00604   CPOX deficiency in heme biosynthesis N00605   UROD deficiency in heme biosynthesis N00606   UROS deficiency in heme biosynthesis Disease H00201   Erythropoietic porphyria H01763   Porphyria Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09108 Metabolism of cofactors and vitamins    00860 Porphyrin and chlorophyll metabolism     7390 (UROS) Enzymes [BR:hsa01000]  4. Lyases   4.2  Carbon-oxygen lyases    4.2.1  Hydro-lyases     4.2.1.75  uroporphyrinogen-III synthase      7390 (UROS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  HEM4 Motif Other DBs NCBI-GeneID:  7390 NCBI-ProteinID:  NP_000366 OMIM:  606938 HGNC:  12592 Ensembl:  ENSG00000188690 Vega:  OTTHUMG00000019236 Pharos:  P10746(Tbio) UniProt:  P10746 A0A0S2Z4T8 LinkDB All DBs Structure PDB:  1JR2 Thumbnails Position 10q26.2 AA seq 265 aa AA seqDB search MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS CTAESPTPQALATGIRKALQPHGCC NT seq 798 nt NT seq  +upstreamnt  +downstreamnt atgaaggttcttttactgaaggatgcgaaggaagatgactgtggccaggatccgtatatc agggaattaggattatatggacttgaagccactttgatccctgttttatcgtttgagttt ttgtctcttcccagtttctctgagaagctttctcatcctgaagattacgggggactcatt tttaccagccccagagcagtggaagcagcagagttatgtttggagcaaaacaataaaact gaagtctgggaaaggtctctgaaagaaaaatggaatgccaagtcagtgtatgtggttgga aatgctactgcttctctagtgagtaaaattggcctggatacagaaggagaaacctgtgga aatgcagaaaagcttgcagaatatatttgttccagggagtcctcagcactgcctcttcta tttccctgtggaaacctcaaaagagaaatcctgccaaaagcgctcaaggacaaagggatt gccatggaaagcataactgtgtatcagacagttgcacacccaggaatccaagggaacctg aacagctactattcccagcagggggttccagccagcatcacattttttagtccctctggc ctcacatacagtctcaagcacattcaggagttatctggtgacaatatcgatcaaattaag tttgcagccatcggccccactacggctcgcgcgctggccgcccagggccttcctgtaagc tgcactgcagagagccccacgccacaagccctggccactggcatcaggaaggctctccag ccccatggctgctgctga

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