KEGG ORTHOLOGY: K04428

ORTHOLOGY: K04428

Entry

K04428                      KO

Symbol

MAP3K4, MEKK4

Name

mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04624

Toll and Imd signaling pathway

map04912

GnRH signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4

Other DBs

GO:

0004709

Genes

HSA:	4216(MAP3K4)

PTR:	463119(MAP3K4)

PPS:	100981441(MAP3K4)

GGO:	101152649(MAP3K4)

PON:	100442172(MAP3K4)

NLE:	100602313(MAP3K4)

HMH:	116473620(MAP3K4)

MCC:	710360(MAP3K4)

MCF:	101865276(MAP3K4)

MTHB:

126952364

MNI:	105487510(MAP3K4)

CSAB:

103240840(MAP3K4)

CATY:

105594238(MAP3K4)

PANU:

101009746(MAP3K4)

TGE:	112623312(MAP3K4)

MLEU:

105536526(MAP3K4)

RRO:	104669999(MAP3K4)

RBB:	108527990(MAP3K4)

TFN:	117096914(MAP3K4)

PTEH:

111550306(MAP3K4)

CANG:

105506725(MAP3K4)

CJC:	100413660(MAP3K4)

SBQ:	101042401(MAP3K4)

CIMI:

108310811(MAP3K4)

CSYR:

103262504(MAP3K4)

MMUR:

105868604(MAP3K4)

LCAT:

123633438(MAP3K4)

PCOQ:

105812407(MAP3K4)

OGA:	100949460(MAP3K4)

MMU:	26407(Map3k4)

MCAL:

110312545(Map3k4)

MPAH:

110338018(Map3k4)

RNO:	308106(Map3k4)

MCOC:

116079226(Map3k4)

ANU:	117700162(Map3k4)

MUN:	110554862(Map3k4)

CGE:	100764060(Map3k4)

MAUA:

101825628(Map3k4)

PROB:

127237739(Map3k4)

PLEU:

114691364(Map3k4)

MORG:

121466395(Map3k4)

MFOT:

126497713

AAMP:

119820823(Map3k4)

NGI:	103737023(Map3k4)

HGL:	101701961(Map3k4)

CPOC:

100724828(Map3k4)

CCAN:

109700149(Map3k4)

DORD:

105991838(Map3k4)

DSP:	122116096(Map3k4)

PLOP:

125357471(Map3k4)

NCAR:

124988149

MMMA:

107153105(Map3k4)

OCU:

100358104

OPI:	101517932(MAP3K4)

TUP:	102479582(MAP3K4)

GVR:	103592019(MAP3K4)

CFA:	476262(MAP3K4)

CLUD:

112643465(MAP3K4)

VVP:	112932971(MAP3K4)

VLG:	121484094(MAP3K4)

NPO:	129500244(MAP3K4)

AML:	100465667(MAP3K4)

UMR:	103660898(MAP3K4)

UAH:	113259629(MAP3K4)

UAR:	123797538(MAP3K4)

ELK:

111158665

LLV:

125102269

MPUF:

101689879(MAP3K4)

MNP:	132018446(MAP3K4)

MLK:	131833393(MAP3K4)

NVS:	122902766(MAP3K4)

ORO:	101379514(MAP3K4)

EJU:	114203524 114203526 114209226(MAP3K4)

ZCA:	113926391(MAP3K4)

MLX:	118001818 118001935

NSU:	110583163(MAP3K4)

LWW:	102743912(MAP3K4)

FCA:	101097977(MAP3K4)

PYU:	121013213(MAP3K4)

PCOO:

112862214(MAP3K4)

PBG:	122490157(MAP3K4)

PVIV:

125165221(MAP3K4)

LRUF:

124528221

PTG:	102952700(MAP3K4)

PPAD:

109245401(MAP3K4)

PUC:

125939033

AJU:

106985032

HHV:	120224269(MAP3K4)

BTA:	511779(MAP3K4)

BOM:	102283969(MAP3K4)

BIU:	109563601(MAP3K4)

BBUB:

102412509(MAP3K4)

BBIS:

104989266(MAP3K4)

CHX:	102172543(MAP3K4)

OAS:	101113246(MAP3K4)

BTAX:

128053073(MAP3K4)

ODA:	120862825(MAP3K4)

CCAD:

122434125(MAP3K4)

MBEZ:

129561294(MAP3K4)

SSC:	100154202(MAP3K4)

CFR:	102509815(MAP3K4)

CBAI:

105077460(MAP3K4)

CDK:	105086293(MAP3K4)

VPC:	102524979(MAP3K4)

BACU:

103006512(MAP3K4)

BMUS:

118905198(MAP3K4)

LVE:	103075844(MAP3K4)

OOR:	101277039(MAP3K4)

DLE:	111168464(MAP3K4)

PCAD:

102977794(MAP3K4)

PSIU:

116763745(MAP3K4)

NASI:

112401608(MAP3K4)

ECB:	100058153(MAP3K4)

EPZ:	103556184(MAP3K4)

EAI:	106842047(MAP3K4)

MYB:	102262729(MAP3K4)

MYD:	102757393(MAP3K4)

MMYO:

118659761(MAP3K4)

MLF:	102426152(MAP3K4)

PKL:	118708850(MAP3K4)

EFUS:

103299827(MAP3K4)

MNA:	107535728(MAP3K4)

DRO:	112297294(MAP3K4)

SHON:

118995987(MAP3K4)

AJM:	119034988(MAP3K4)

PDIC:

114490085(MAP3K4)

PHAS:

123821571(MAP3K4)

MMF:	118621085(MAP3K4)

PPAM:

129088232(MAP3K4)

HAI:	109394013(MAP3K4)

RFQ:	117018595(MAP3K4)

PALE:

102888506(MAP3K4)

PGIG:

120618266(MAP3K4)

PVP:	105305679(MAP3K4)

RAY:	107514741(MAP3K4)

MJV:	108403112(MAP3K4)

TOD:	119251557(MAP3K4)

SARA:

101557576(MAP3K4)

SETR:

125996544(MAP3K4)

LAV:	100664871(MAP3K4)

TMU:

101342450

ETF:	101639947(MAP3K4)

DNM:	101435792(MAP3K4)

MDO:	100032495(MAP3K4)

GAS:	123243748(MAP3K4)

SHR:	100928208(MAP3K4)

AFZ:

127562393

PCW:	110208619(MAP3K4)

OAA:	100081562(MAP3K4)

GGA:	421579(MAP3K4)

PCOC:

116242061(MAP3K4)

MGP:	100548383(MAP3K4)

CJO:	107311515(MAP3K4)

TPAI:

128080898(MAP3K4)

LMUT:

125688781(MAP3K4)

NMEL:

110395417(MAP3K4)

APLA:

101795899(MAP3K4)

ACYG:

106039514(MAP3K4)

CATA:

118243843(MAP3K4)

AFUL:

116487327(MAP3K4)

TGU:	100229845(MAP3K4)

LSR:	110477918(MAP3K4)

SCAN:

103821627(MAP3K4)

PMOA:

120506844(MAP3K4)

OTC:	121335758(MAP3K4)

PRUF:

121358675(MAP3K4)

GFR:	102043718(MAP3K4)

FAB:	101814940(MAP3K4)

OMA:	130250964(MAP3K4)

PHI:	102101107(MAP3K4)

PMAJ:

107201928(MAP3K4)

CCAE:

111926951(MAP3K4)

CCW:	104684463(MAP3K4)

CBRC:

103624194(MAP3K4)

ETL:	114055651(MAP3K4)

ZAB:	102074889(MAP3K4)

ACHL:

103812175(MAP3K4)

SVG:	106852970(MAP3K4)

MMEA:

130576007(MAP3K4)

HRT:	120750188(MAP3K4)

FPG:	101918017(MAP3K4)

FCH:	102048037(MAP3K4)

CLV:	102086486(MAP3K4)

EGZ:	104124823(MAP3K4)

NNI:	104018435(MAP3K4)

PCRI:

104030508(MAP3K4)

PLET:

104614048(MAP3K4)

EHS:	104511286(MAP3K4)

PCAO:

104052344(MAP3K4)

ACUN:

113477881(MAP3K4)

TALA:

104362499(MAP3K4)

PADL:

103914152(MAP3K4)

AFOR:

103907865(MAP3K4)

ACHC:

115344333(MAP3K4)

HALD:

104316804(MAP3K4)

HLE:	104842256(MAP3K4)

AGEN:

126039044

GCL:

127014121

CCRI:

104168452(MAP3K4)

CSTI:

104560034(MAP3K4)

CMAC:

104479593(MAP3K4)

MUI:	104540800(MAP3K4)

BREG:

104636503(MAP3K4)

GSTE:

104260740

LDI:	104346909(MAP3K4)

MNB:	103779507(MAP3K4)

OHA:	104334710(MAP3K4)

NNT:	104412008(MAP3K4)

SHAB:

115613582(MAP3K4)

DPUB:

104307727(MAP3K4)

ACAR:

104525390(MAP3K4)

CPEA:

104390820(MAP3K4)

AVIT:

104271444(MAP3K4)

CVF:	104295752(MAP3K4)

RTD:	128906529(MAP3K4)

CUCA:

104056487(MAP3K4)

TEO:	104375638(MAP3K4)

BRHI:

104496961(MAP3K4)

AAM:	106486799(MAP3K4)

AROW:

112966410(MAP3K4)

NPD:	112951950(MAP3K4)

TGT:	104573398(MAP3K4)

DNE:	112988961(MAP3K4)

SCAM:

104152832(MAP3K4)

ASN:	102382136(MAP3K4)

AMJ:	102573918(MAP3K4)

CPOO:

109320062(MAP3K4)

GGN:	109304413(MAP3K4)

PSS:	102446659(MAP3K4)

CMY:	102936228(MAP3K4)

CCAY:

125633990(MAP3K4)

DCC:	119853138(MAP3K4)

CPIC:

101946795(MAP3K4)

TST:	117874783(MAP3K4)

CABI:

116832461(MAP3K4)

MRV:	120400708(MAP3K4)

ACS:	100560027(map3k4)

ASAO:

132761109(MAP3K4)

PVT:	110087352(MAP3K4)

SUND:

121929432(MAP3K4)

PBI:	103059578(MAP3K4)

PMUR:

107292071(MAP3K4)

CTIG:

120314787(MAP3K4)

TSR:	106549188(MAP3K4)

PGUT:

117672073(MAP3K4)

APRI:

131190807(MAP3K4)

PTEX:

113439289(MAP3K4)

NSS:	113417052(MAP3K4)

VKO:	123019057(MAP3K4)

PMUA:

114594310(MAP3K4)

PRAF:

128410722(MAP3K4)

ZVI:	118081954(MAP3K4)

HCG:	128344573(MAP3K4)

GJA:	107113333(MAP3K4)

STOW:

125428087(MAP3K4)

EMC:	129331745(MAP3K4)

XLA:	100126613(map3k4.S)

XTR:	100497217(map3k4)

NPR:	108795048(MAP3K4)

RTEM:

120937407(MAP3K4)

BBUF:

120998572(MAP3K4)

BGAR:

122936143(MAP3K4)

MUO:	115466686(MAP3K4)

GSH:	117357331(MAP3K4)

DRE:	325488(map3k4)

SRX:	107705416 107739870

SANH:

107654971 107679660

SGH:	107553172 107602945(map3k4)

CCAR:

109052888 109096081

CAUA:

113056767 113112502

CGIB:

127970638 128026046

PTET:

122356415 122356416(map3k4)

LROH:

127174736(map3k4)

OMC:	131551844(map3k4)

PPRM:

120467764(map3k4)

RKG:	130088279(map3k4)

MAMB:

125277165(map3k4)

CIDE:

127525563

MASI:

127412023 127413879

TROS:

130558827(map3k4)

TDW:	130431293(map3k4)

MANU:

129415527(map3k4)

IPU:

108260840

IFU:	128604520(map3k4)

PHYP:

113544293(map3k4)

SMEO:

124381434(map3k4)

TFD:	113660711(map3k4)

TVC:	132841855(map3k4)

AMEX:

103046281(map3k4)

CMAO:

118816782(map3k4)

EEE:	113581424(map3k4)

CHAR:

105890949(map3k4)

TRU:	101076799 115246474

TFS:	130533310(map3k4)

TNG:	GSTEN00030726G001

LCO:	104940016(map3k4)

NCC:	104953033(map3k4)

TBEN:

117499637(map3k4)

CGOB:

115019839(map3k4)

PGEO:

117459814(map3k4)

GACU:

117536847(map3k4)

EMAC:

134859124(map3k4)

ELY:	117248444(map3k4)

EFO:	125903596(map3k4)

PLEP:

121954529(map3k4)

SLUC:

116052359(map3k4)

ECRA:

117960393(map3k4)

ESP:	116704886(map3k4)

PFLV:

114572027(map3k4)

GAT:	120820425(map3k4)

PPUG:

119214154(map3k4)

AFB:	129092174(map3k4)

CLUM:

117744339(map3k4)

PSWI:

130206842(map3k4)

MSAM:

119917295(map3k4)

SCHU:

122884672(map3k4)

CUD:	121511085(map3k4)

ALAT:

119033400(map3k4)

MZE:	101485830(map3k4)

ONL:	100701169(map3k4)

OAU:	116322740(map3k4)

OLA:	101174856(map3k4)

OML:	112161704(map3k4)

CSAI:

133463327(map3k4)

XMA:	102230475(map3k4)

XCO:	114137786(map3k4)

XHE:	116713097(map3k4)

PRET:

103477032(map3k4)

PFOR:

103134094(map3k4)

PLAI:

106951872(map3k4)

PMEI:

106915515(map3k4)

GAF:	122842183(map3k4)

PPRL:

129359801(map3k4)

CVG:	107103016(map3k4)

CTUL:

119790714(map3k4)

GMU:	124859256(map3k4)

NFU:	107373664(map3k4)

KMR:	108234108(map3k4)

ALIM:

106518124(map3k4)

NWH:	119417946(map3k4)

AOCE:

111562975(map3k4)

MCEP:

125019058(map3k4)

CSEM:

103387276(map3k4)

POV:	109634498(map3k4)

SSEN:

122781920(map3k4)

HHIP:

117775425(map3k4)

HSP:	118119073(map3k4)

SMAU:

118283612(map3k4)

LCF:

108894538

SDU:	111234458(map3k4)

SLAL:

111658959(map3k4)

XGL:	120796389(map3k4)

HCQ:	109516250(map3k4)

SSCV:

125978745

SBIA:

133509601(map3k4)

PEE:	133409822(map3k4)

PTAO:

133485895(map3k4)

BPEC:

110157029(map3k4)

MALB:

109961895(map3k4)

BSPL:

114870830(map3k4)

SJO:	128372778(map3k4)

SASA:

106589750 106611248

STRU:

115152798(map3k4) 115200875

OTW:	112224608 112236421

OMY:	110499330 110503014

OGO:	124038652 124040324

ONE:	115118837 115144388

OKI:	109870569 109882110

OKE:	118396657 118402794

SALP:

111968073 112070316

SNH:	120029587(map3k4) 120041312

CCLU:

121540796 121554627

ELS:	105008100(map3k4)

SFM:	108942741(map3k4)

PKI:	111853413(map3k4)

AANG:

118217895(map3k4)

LOC:	102685764(map3k4)

PSPA:

121316302(map3k4) 121316717

ARUT:

117402821(map3k4) 117411192

PSEX:

120516902(map3k4)

LCM:	102366133(MAP3K4)

CMK:	103175928(map3k4)

RTP:	109926885(map3k4)

CPLA:

122552974(map3k4)

HOC:	132819825(map3k4)

LERI:

129699539(map3k4)

PMRN:

116955477

LRJ:	133356999(MAP3K4)

CIN:

SCLV:

SPU:

APLC:

DME:	Dmel_CG7717(Mekk1)

DER:

6553864

DSE:

6613723

DSI:	Dsimw501_GD20154(Dsim_GD20154)

DYA:	Dyak_GE25175

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21956

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ001610

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_213875

BANY:

PXU:

PRAP:

ZCE:

AAGE:

HZE:

TNL:

SLIU:

OFU:

PXY:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_233822

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:	135205419 135205420

HAZT:

EAF:

LSM:

TCF:

PPOI:

PMEO:

CEL:	CELE_B0414.7(mtk-1)

CBR:	CBG_04061(Cbr-mtk-1)

CRQ:	GCK72_001010

BMY:	BM_BM6488(Bma-mtk-1)

LOA:	LOAG_05861

LGI:	LOTGIDRAFT_168212

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105334041 105339386 117691552 117692324

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:	5501414 5508320

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

AQU:

Reference

PMID:9079650

Authors

Gerwins P, Blank JL, Johnson GL

Title

Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.

Journal

J Biol Chem 272:8288-95 (1997)
DOI:10.1074/jbc.272.13.8288

Sequence

[mmu:26407]

LinkDB

DBGET integrated database retrieval system