KEGG   ORTHOLOGY: K04500Help
Entry
K04500                      KO                                     

Name
SMAD2
Definition
mothers against decapentaplegic homolog 2
Pathway
ko04110  Cell cycle
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05321  Inflammatory bowel disease (IBD)
Disease
H00020  Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   04390 Hippo signaling pathway
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   04371 Apelin signaling pathway
    K04500  SMAD2; mothers against decapentaplegic homolog 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09143 Cell growth and death
   04110 Cell cycle
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   04218 Cellular senescence
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04500  SMAD2; mothers against decapentaplegic homolog 2
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04500  SMAD2; mothers against decapentaplegic homolog 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   05205 Proteoglycans in cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   05212 Pancreatic cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   05225 Hepatocellular carcinoma
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   05226 Gastric cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09163 Immune disease
   05321 Inflammatory bowel disease (IBD)
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K04500  SMAD2; mothers against decapentaplegic homolog 2
BRITE hierarchy
Other DBs
GO: 0070410
Genes
HSA: 4087(SMAD2)
PTR: 455407(SMAD2)
PPS: 100980706(SMAD2)
GGO: 101154310(SMAD2)
PON: 100173357(SMAD2)
NLE: 100589735(SMAD2)
MCC: 697581(SMAD2)
MCF: 101925163(SMAD2)
CSAB: 103222457(SMAD2)
RBB: 108519603(SMAD2)
CJC: 100396826(SMAD2)
SBQ: 101040653(SMAD2)
MMU: 17126(Smad2)
MCAL: 110284497(Smad2)
MPAH: 110332834(Smad2)
RNO: 29357(Smad2)
MUN: 110550301(Smad2)
CGE: 100771578(Smad2)
NGI: 103727836(Smad2)
HGL: 101714203(Smad2)
OCU: 100359137(SMAD2)
TUP: 102499541(SMAD2)
CFA: 480144(SMAD2)
VVP: 112918856(SMAD2)
AML: 100467069(SMAD2)
UMR: 103663939(SMAD2)
UAH: 113253394(SMAD2)
ORO: 101385419(SMAD2)
FCA: 101087179(SMAD2)
PTG: 102971687(SMAD2)
PPAD: 109275745(SMAD2)
AJU: 106972947(SMAD2)
BTA: 516010(SMAD2)
BOM: 102286495(SMAD2)
BBUB: 102406564(SMAD2)
CHX: 102188455(SMAD2)
OAS: 101114231(SMAD2)
SSC: 100155304(SMAD2)
CFR: 102508588(SMAD2)
CDK: 105097587(SMAD2)
BACU: 103005078(SMAD2)
LVE: 103069124(SMAD2)
OOR: 101278299(SMAD2)
DLE: 111180276(SMAD2)
PCAD: 102978015(SMAD2)
ECB: 100033843(SMAD2)
EPZ: 103548562(SMAD2)
EAI: 106831216(SMAD2)
MYB: 102256193(SMAD2)
MYD: 102758819(SMAD2)
MNA: 107546622(SMAD2)
HAI: 109388212(SMAD2)
DRO: 112322688(SMAD2)
PALE: 102893928(SMAD2)
RAY: 107512663(SMAD2)
MJV: 108400736(SMAD2)
LAV: 100663495(SMAD2)
TMU: 101348656
MDO: 100014493(SMAD2)
SHR: 100914956(SMAD2)
PCW: 110207982(SMAD2)
GGA: 395247(SMAD2Z)
CJO: 107305704(SMAD2)
NMEL: 110389836(SMAD2)
APLA: 101805334(SMAD2)
ACYG: 106037327(SMAD2)
TGU: 100225108(SMAD2)
LSR: 110473205(SMAD2)
SCAN: 103824734
GFR: 102040865
FAB: 101818681(SMAD2)
PHI: 102100805(SMAD2)
PMAJ: 107198156(SMAD2)
CCAE: 111941053(SMAD2)
CCW: 104695695(SMAD2)
ETL: 114067837
FPG: 101918546(SMAD2)
FCH: 102059402(SMAD2)
CLV: 102085910(SMAD2)
EGZ: 104134175(SMAD2)
ACUN: 113489639(SMAD2)
PADL: 103916021(SMAD2)
AAM: 106497650(SMAD2)
ASN: 102370509(SMAD2)
AMJ: 102564903(SMAD2)
PSS: 102457921(SMAD2)
CMY: 102940642(SMAD2)
CPIC: 101939963(SMAD2)
ACS: 100554929(smad2)
PVT: 110085053(SMAD2)
PBI: 103058841
TSR: 106551732
PMUA: 114606122(SMAD2)
XLA: 399442(mad2)
XTR: 496586(smad2)
NPR: 108786433(SMAD2)
DRE: 30639(smad2)
SRX: 107743055
SANH: 107653131
SGH: 107558710(smad2)
CCAR: 109062884
IPU: 108277249(smad2)
PHYP: 113544066(smad2)
AMEX: 103025750(smad2)
EEE: 113590822(smad2)
TRU: 101072871
LCO: 104924990
NCC: 104964539
MZE: 101470473
OLA: 101159109
XMA: 102224322
XCO: 114155259
PRET: 103469777
CVG: 107098523(smad2) 107098778
NFU: 107393511
KMR: 108235010
ALIM: 106513591(smad2) 106527493
CSEM: 103397451
POV: 109626315(smad2) 109633657
LCF: 108878489
SDU: 111228088
SLAL: 111648020 111655756(smad2)
HCQ: 109525024
BPEC: 110161051
MALB: 109959661
ELS: 105014505
SFM: 108936291(smad2)
PKI: 111842093(smad2)
LCM: 102360430(SMAD2)
RTP: 109914262
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8752209
  Authors
Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L
  Title
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
  Journal
Cell 86:543-52 (1996)
DOI:10.1016/S0092-8674(00)80128-2
  Sequence
[hsa:4087]
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