KEGG ORTHOLOGY: K06704

ORTHOLOGY: K06704

Entry

K06704                      KO

Symbol

ADAM10, CD156c

Name

disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81]

Pathway

map04361

Axon regeneration

map05010

Alzheimer disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

Disease

H00056

Alzheimer disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
09160 Human Diseases
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.81  ADAM10 endopeptidase
     K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M12: astacin/adamalysin family
   K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
CD molecules [BR:ko04090]
Proteins
  K06704  CD156c, ADAM10; a disintegrin and metalloproteinase domain 10

Genes

HSA:	102(ADAM10)

PTR:	746942(ADAM10)

PPS:	100979438(ADAM10)

GGO:	101142970(ADAM10)

PON:	100169741(ADAM10)

NLE:	100606667(ADAM10)

MCC:	701355(ADAM10)

MCF:	101925715(ADAM10)

CSAB:

103245557(ADAM10)

CATY:

105601091(ADAM10)

PANU:

101023521 116275816(ADAM10)

TGE:	112627561(ADAM10)

RRO:	104670896(ADAM10)

RBB:	108544959(ADAM10)

TFN:	117070589(ADAM10)

PTEH:

111553697(ADAM10)

CJC:	100415138(ADAM10)

SBQ:	101041855(ADAM10)

CSYR:

103249370(ADAM10)

MMUR:

105881392(ADAM10)

LCAT:

123623265(ADAM10)

OGA:	100962332(ADAM10)

MMU:	11487(Adam10)

MCAL:

110302364(Adam10)

MPAH:

110327224(Adam10)

RNO:	29650(Adam10)

MCOC:

116073842(Adam10)

MUN:	110561143 110561144

CGE:	100772891(Adam10)

MAUA:

101831586(Adam10)

PLEU:

114690776(Adam10)

MORG:

121466052(Adam10)

AAMP:

119809064(Adam10)

NGI:	103737147(Adam10)

HGL:	101698280(Adam10)

CPOC:

100718999(Adam10)

CCAN:

109689747

DORD:

105980955(Adam10)

DSP:	122114386(Adam10)

NCAR:

124976191

OCU:	100101614(ADAM10)

OPI:	101527689(ADAM10)

TUP:	102467957(ADAM10)

CFA:	478321(ADAM10)

VVP:	112920741(ADAM10)

VLG:	121484395(ADAM10)

AML:	100476350(ADAM10)

UMR:	103676794(ADAM10)

UAH:	113269679(ADAM10)

UAR:	123785029(ADAM10)

ELK:

111153288

LLV:

125103845

MPUF:

101673179(ADAM10)

ORO:	101380324(ADAM10)

EJU:	114206362(ADAM10)

ZCA:	113909095(ADAM10)

MLX:	118003444(ADAM10)

FCA:	101087998(ADAM10)

PYU:	121041772(ADAM10)

PBG:	122468583(ADAM10)

PTG:	102950285(ADAM10)

PPAD:

109262917(ADAM10)

AJU:	106973789(ADAM10)

HHV:	120230860(ADAM10)

BTA:	282132(ADAM10)

BOM:	102285401(ADAM10)

BIU:	109564357(ADAM10)

BBUB:

102390753(ADAM10)

CHX:	102172903(ADAM10)

OAS:	101116733(ADAM10)

ODA:	120853042(ADAM10)

CCAD:

122443550(ADAM10)

SSC:	397345(ADAM10)

CFR:	102518129(ADAM10)

CBAI:

105080513(ADAM10)

CDK:	105088967(ADAM10)

VPC:	102527501(ADAM10)

BACU:

103011557(ADAM10)

LVE:	103071850(ADAM10)

OOR:	101275940(ADAM10)

DLE:	111177664(ADAM10)

PCAD:

102975188(ADAM10)

PSIU:

116748974(ADAM10)

ECB:	100068314(ADAM10)

EPZ:	103552041(ADAM10)

EAI:	106830043(ADAM10)

MYB:	102260183(ADAM10)

MYD:	102754258(ADAM10)

MMYO:

118652779(ADAM10)

MLF:	102442016(ADAM10)

MNA:	107533751(ADAM10)

PKL:	118720561(ADAM10)

HAI:	109390694(ADAM10)

DRO:	112311976(ADAM10)

SHON:

118992259(ADAM10)

AJM:	119053476(ADAM10)

PDIC:

114493218(ADAM10)

PHAS:

123808151(ADAM10)

MMF:	118636203(ADAM10)

RFQ:	117023543(ADAM10)

PALE:

102895434(ADAM10)

PGIG:

120604587(ADAM10)

PVP:	105294280(ADAM10)

RAY:	107518608(ADAM10)

MJV:	108393396(ADAM10)

TOD:	119238671(ADAM10)

SARA:

101538322(ADAM10)

LAV:	100659084(ADAM10)

TMU:

101350043

DNM:	101417950(ADAM10)

MDO:	100024929 100027329(ADAM10)

GAS:	123232128 123238019(ADAM10)

SHR:	100913194(ADAM10) 100925760

PCW:	110197392 110205292(ADAM10)

OAA:	100074755(ADAM10) 114806495

GGA:	374113(ADAM10)

PCOC:

116244652(ADAM10)

MGP:

100545069

CJO:	107318510(ADAM10)

NMEL:

110403587(ADAM10)

APLA:

101794215(ADAM10)

ACYG:

106033621(ADAM10)

AFUL:

116493283(ADAM10)

TGU:	100219653(ADAM10)

LSR:	110471419(ADAM10)

SCAN:

103816174(ADAM10)

PMOA:

120509226(ADAM10)

OTC:	121343422(ADAM10)

PRUF:

121354390(ADAM10)

GFR:	102043060(ADAM10)

FAB:	101811782(ADAM10)

PHI:	102110765(ADAM10)

PMAJ:

107209233(ADAM10)

CCAE:

111933890(ADAM10)

CCW:	104684038(ADAM10)

ETL:	114056365(ADAM10)

ZAB:	102073584(ADAM10)

FPG:	101910860(ADAM10)

FCH:	102050786(ADAM10)

CLV:	102083444(ADAM10)

EGZ:	104130770(ADAM10)

NNI:	104016847(ADAM10)

PLET:

104621900(ADAM10)

ACUN:

113483904(ADAM10)

TALA:

104367477(ADAM10)

PADL:

103914880(ADAM10)

ACHC:

115341169(ADAM10)

AAM:	106496382(ADAM10)

AROW:

112974729(ADAM10)

NPD:	112952770(ADAM10)

DNE:	112991137(ADAM10)

ASN:	102371205 102371793

AMJ:	102562482 102563250(ADAM10)

CPOO:

109308972(ADAM10) 109320461

GGN:	109288646(ADAM10) 109294893

PSS:	102444574(ADAM10) 102461827

CMY:	102936468 102944138(ADAM10)

CPIC:

101948731 101953463

TST:	117868878 117883650(ADAM10)

CABI:

116821168(ADAM10) 116838433

MRV:	120373604(ADAM10) 120391577

ACS:	100553674(adam10)

PVT:	110074537(ADAM10) 110079237

SUND:

121932590(ADAM10) 121936559

PBI:	103053091 103062263(ADAM10)

PMUR:

107283154(ADAM10)

TSR:	106542883(ADAM10)

PGUT:

117660950(ADAM10) 117668650

VKO:	123027648(ADAM10)

PMUA:

114583918(ADAM10) 114588574

ZVI:	118086073 118093232(ADAM10)

GJA:	107107516(ADAM10)

STOW:

125424460(ADAM10)

XLA:	108706832 108711361 399187(adam10.S)

XTR:	100491788 733451(adam10)

NPR:	108789826(ADAM10) 108796952

RTEM:

120924706 120931382(ADAM10)

BBUF:

120985758(ADAM10) 120989514

BGAR:

122919690 122927656(ADAM10)

DRE:	393392(adam10b) 560975(si:ch1073-396h14.1) 566044(adam10a)

SRX:	107706850 107715085 107741424 107750500

SANH:

107653620 107670741 107687609 107700430 107704208

SGH:	107552424 107561888 107574154 107585986 107588113 107595097

CCAR:

109050964 109062319 109087040 109087041 109109603 109113683

CAUA:

113040149 113040165 113042957 113042958 113051523 113051912 113067144 113105935

PPRM:

120474036 120486226(si:ch1073-396h14.1) 120491441(adam10a)

MAMB:

125246761 125251118(si:ch1073-396h14.1) 125261896(adam10b) 125264716(adam10a)

IPU:	108259300(adam10a) 108271130(si:ch1073-396h14.1) 108275251

PHYP:

113530072 113536691 113540838(adam10)

SMEO:

124379666(adam10a) 124391425(si:ch1073-396h14.1) 124392002

TFD:	113636788(adam10a) 113639154 113644300(si:ch1073-396h14.1)

AMEX:

103027184 103041829 103043423

EEE:	113571849 113574487 113575694(adam10)

TRU:	101068415 101072781 101078173(adam10)

TNG:	GSTEN00017721G001 GSTEN00025611G001 GSTEN00028800G001

LCO:	104924306(adam10) 104931412 109138148

NCC:	104960057(adam10) 104960084

CGOB:

115007325 115009702 115025305(adam10)

ELY:	117252642(adam10a) 117253616(si:ch1073-396h14.1) 117262371

PLEP:

121937813(si:ch1073-396h14.1) 121947514(adam10a) 121950293

SLUC:

116038274 116055227(si:ch1073-396h14.1) 116060685(adam10a)

ECRA:

117949631 117951000(si:ch1073-396h14.1) 117958595(adam10a)

PFLV:

114560197 114561555 114571794(adam10)

GAT:	120809559 120812703 120824183(si:ch1073-396h14.1) 120831617(adam10a)

PPUG:

119195954 119216355(si:ch1073-396h14.1) 119228370(adam10a)

MSAM:

119890154(adam10a) 119893471 119900750(si:ch1073-396h14.1)

CUD:	121508420(adam10a) 121512543(si:ch1073-396h14.1) 121514982

ALAT:

119017915(adam10a) 119023933 119028768(si:ch1073-396h14.1)

MZE:	101468342(adam10) 101469610 101471777

ONL:	100695735 100707598 100710655(adam10)

OAU:	116309232(si:ch1073-396h14.1) 116326736 116334631(adam10a)

OLA:	101155340(adam10) 101159183 101172489

OML:	112150653(si:ch1073-396h14.1) 112152362 112160714(adam10a)

XMA:	102230569(adam10) 102232731 102235509

XCO:	114142909(adam10) 114150800 114160272

XHE:	116718526(adam10) 116725567 116735620

PRET:

103462514(adam10) 103463533 103466445

PFOR:

103129915 103155695 103156888

PLAI:

106955286 106958140 106958532

PMEI:

106907089 106919346 106928916

GAF:	122835335 122838502(si:ch1073-396h14.1) 122843708(adam10a)

CVG:	107087405 107095645(adam10) 107097307

CTUL:

119775039 119780852(si:ch1073-396h14.1) 119795460(adam10a)

GMU:	124866912(adam10a) 124873924(si:ch1073-396h14.1) 124880736

NFU:	107381374(adam10) 107388626 107393171

KMR:	108230196 108230826(si:ch1073-396h14.1) 108251752(adam10a)

ALIM:

106521566 106526819 106531660(adam10)

NWH:	119407429(si:ch1073-396h14.1) 119416346 119422316(adam10a)

AOCE:

111577572(adam10) 111577716 111578412 111586567

CSEM:

103378728(adam10) 103380473 103397216

POV:	109624447 109625416 109636872(adam10)

SSEN:

122760920 122761376 122780907(si:ch1073-396h14.1)

HHIP:

117756608(adam10a) 117760656(si:ch1073-396h14.1) 117763808

HSP:	118106022(adam10a) 118109680 118121612(si:ch1073-396h14.1)

LCF:	108876711 108881395 108887706(adam10)

SDU:	111221439(adam10) 111229691 111232234

SLAL:

111654257 111655135(adam10) 111666982

XGL:	120789059(adam10a) 120790937(si:ch1073-396h14.1) 120793207

HCQ:	109507576 109525931(adam10) 109532053

BPEC:

110160182 110169553 110175225(adam10)

MALB:

109963286(adam10) 109967440 109973882

BSPL:

114852731(adam10a) 114853516(si:ch1073-396h14.1) 114857455

SASA:

106561772 106561774 106562201(adam10) 106573543 106584732 106587342

OTW:	112219062 112249184 112252197(si:ch1073-396h14.1) 112263716(adam10a) 112265333

OMY:	110501717(si:ch1073-396h14.1) 110502564 110521213 110526414(adam10a) 118944511

OGO:	123998865(si:ch1073-396h14.1) 124031711 124033743 124035726 124037494

ONE:	115109210 115112270 115113653 115124074 115144664

SALP:

111952855 111969384 111973806 112068468

SNH:	120025369 120036120 120047253 120052330 120053169(si:ch1073-396h14.1) 120066766

ELS:	105011472 105016508(adam10) 105018354

SFM:	108919823 108926731(adam10) 108931162

PKI:	111845001 111846754 111860388

AANG:

118215630 118225832(si:ch1073-396h14.1) 118227666

LOC:	102689715(adam10) 102693175

PSPA:

121294484 121299163 121300696(si:ch1073-396h14.1)

ARUT:

117401274 117429900 117963203(adam10a) 117966367

LCM:	102349523 102351415(ADAM10)

CMK:	103183500(si:ch1073-396h14.1) 103189371(adam10a)

RTP:	109936297(adam10)

BFO:	118411340 118411919 118412071 118412678

BBEL:

109468335 109468471 109468715 109468796

CIN:

100184040

SCLV:

120336775

SPU:	115918272 115919534 581388 755122

APLC:

110979325 110989644 110989645

SKO:	100313545(Adam10) 100366937 100367090 100367238 102807735

DME:	Dmel_CG1964(Kul) Dmel_CG7147(kuz)

DER:	6540795 6554538

DSE:	6612731 6617895

DSI:	Dsimw501_GD15481(Dsim_GD15481) Dsimw501_GD21457(Dsim_GD21457)

DYA:	Dyak_GE18670 Dyak_GE23876

DAN:	6505589 6506009

DSR:	110185137 110189010

DPO:	Dpse_GA15157 Dpse_GA20137

DPE:	6593486 6595137

DMN:	108156102 108162207

DWI:	6644248 6647620

DGR:	6567184 6569582

DMO:	Dmoj_GI10418 Dmoj_GI17667

DAZ:	108611405 108616110

DNV:	108659131 115563697

DHE:	111592702 111600434

DVI:	6632222 6634065

CCAT:

101455868

BOD:

106622771

MDE:	101888784 101900641

SCAC:

106082815 106089926

LCQ:	111687946 111690479

LSQ:

119609134

HIS:	119650694 119650921

AGA:	AgaP_AGAP003070 AgaP_AGAP008790

ACOZ:

120948706 120955312 120960899

AARA:

120898114 120899748

ASTE:

118511695

AAG:	5565610 5575585

AALB:

109410817 109621728 115256260

CQU:	CpipJ_CPIJ016694 CpipJ_CPIJ017248

CPII:

120421296 120424630

CNS:	116341542 116345620

BCOO:

119070042 119071547

AME:	409611 409692 410609

ACER:

107994235 108000950 108001185

ALAB:

122712815 122712908 122719607

BIM:	100743906 100745330 100746737

BBIF:

117208929 117209893 117216802

BVK:	117230491 117230827 117235321

BVAN:

117160523 117164369 117166445

BTER:

100649309 100650342 100651761

BPYO:

122570335 122575365 122575766

CCAL:

108626630 108628261 108630835

OBB:	114874433 114876424 114883107

MGEN:

117222094 117223028 117225172

NMEA:

116429251 116429544 116431352

CGIG:

122396188 122401744 122405321

SOC:	105193142 105201458

MPHA:

105833729 105837793

AEC:	105153222 105154964

ACEP:

105622013 105626161

PBAR:

105429073 105430103

VEM:	105559899 105565273

HST:	105184009 105191448

DQU:	106741621 106751921

CFO:	105248456 105253828

FEX:	115234608 115237314

LHU:	105671140 105675974

PGC:	109855381 109863846

OBO:	105281663 105284419

PCF:	106784078 106784802 106790186

PFUC:

122513965 122521467 122523545

VPS:	122627349 122629531 122633897

NVI:	100117425 100120688

CSOL:

105365278 105367405

TPRE:

106651781 106657105

MDL:	103571724 103580624 103581013

CGLO:

123262848 123264729 123271459

FAS:	105267024 105267045 105273108

DAM:	107035459 107038309 107040618

AGIF:

122850084 122854975 122858939

CCIN:

107263166 107264542 107268185

TCA:	659820 661872

DPA:	109536145 109543348 109546236

SOY:	115874612 115874613 115882775 115884798 115887382 115887387

ATD:	109594866 109608669

CSET:

123308802 123315573

AGB:	108903817 108906840

LDC:	111505843 111507221 111507902

NVL:	108562925 108565817

APLN:

108734318 108734964

PPYR:

116164872 116167113 116167115

OTU:	111413356 111420464 111424671

BMOR:

101745975 101747087 110385458

BMAN:

114239703 114242067 114245089

MSEX:

115447604 115448198 115452805

DPL:	KGM_204534 KGM_208907 KGM_208923

BANY:

112043461 112053037 112054680

PMAC:

106720588 106720604

PPOT:

106103498 106111711

PXU:	106115840 106115996

PRAP:

110995185 110995601 111002035

ZCE:	119837157 119840388 119840581

HAW:	110383922 110383939

TNL:	113494213 113500625 113500765 113500808

SLIU:

111351070 111355438 111355647

OFU:	114353679 114361841 114366719

PXY:	105382897 105393130 105396406

API:	100163716 100166223

DNX:	107165629 107172187

AGS:	114130150 114132195

RMD:	113549234 113551419

BTAB:

109032598 109034688

DCI:	103513829 103518111

CLEC:

106663669 106669688

HHAL:

106683289 106686740

NLU:	111044216 111054136

PHU:	Phum_PHUM259590 Phum_PHUM259860

FOC:	113201936 113205559

TPAL:

117649610 117649987

ZNE:	110830086 110832133

CSEC:

111862333 111867292

FCD:	110848219 110858640

DPX:	DAPPUDRAFT_310789 DAPPUDRAFT_99915

DMK:	116916909 116932428

PVM:	113803072 113807613

PJA:	122248958 122266244

PCHN:

125033622 125040023

HAME:

121853479 121863996 121879430

PCLA:

123766772 123773138

PTRU:

123502954 123510302

HAZT:

108671972 108679974

EAF:	111698034 111704670 111709038 111712714 111713433

LSM:	121113583 121121325 121122187 121131774 121131882

PPOI:

119089849 119111239 119111240 119111242 119111857

ISC:	IscW_ISCW001038 IscW_ISCW002405 IscW_ISCW003792 IscW_ISCW014660

DSV:	119432845 119448863 119455611 119455860 119456432 119456691 119456715 119456719 119456827 119456995 119457091 119457614 119462221 119462270 119462273

RSAN:

119375037 119381865 119393090 119393092 119393264 119394647 119394802 119394815 119394848 119394854 119394903 119394905 119394920 119397371

RMP:	119168276 119169701 119171595 119171598 119171781 119172289 119172596 119172734 119172754 119172892 119173739 119184081 119184932 119185859 119187018

VDE:	111245256 111245594 111253857

VJA:	111261476 111262792

TUT:	107362658 107369529

DPTE:

113798778 113799663

DFR:	124498357 124500201

PTEP:

107437723 107445643 107448159 107455245

SDM:	118185997 118186283 118186863 118188832 118200803 118203260

CEL:	CELE_DY3.7(sup-17)

CBR:	CBG_12369(Cbr-sup-17)

BMY:	BM_BM3076(Bma-sup-17)

LOA:	LOAG_00135

NAI:	NECAME_03812

TSP:

Tsp_11370

HRO:	HELRODRAFT_113770 HELRODRAFT_191436

LGI:	LOTGIDRAFT_138941 LOTGIDRAFT_235956 LOTGIDRAFT_54048

PCAN:

112555188 112566009 112570800 112577167 112577169

BGT:	106051225 106055443 106059943

GAE:	121369787 121370310 121370363 121370365 121372011 121372012 121373320 121373354

HRF:	124115045 124125978

HRJ:	124253926 124268832 124269537

CRG:	105317458 105323098 105346452 105347325 109620949 117687376 117687384

MYI:	110450489 110457318 110465949 110466983

PMAX:

117314957 117315663 117322949 117339763

MMER:

123542283 123542541 123544997 123545470 123559793 123560941

OBI:

106879111

OSN:

115219650

LAK:	106151004 106168401 106177601 106177612 106180087

SMM:	Smp_197390

NVE:	5501630 5513665 5517822

EPA:	110237622 110248525 110254921

ATEN:

116290581 116291980 116308772

ADF:	107344794 107356551

AMIL:

114949978 114958833 114961861

PDAM:

113670791 113672703 113683701

SPIS:

111334955 111336097 111340547

DGT:	114519082 114522772 114530322 114530383 114536582

XEN:	124439126 124439129 124439431 124447186 124451092 124452214

HMG:	100208233 100215515

TAD:	TRIADDRAFT_19172 TRIADDRAFT_19354 TRIADDRAFT_51548 TRIADDRAFT_51549 TRIADDRAFT_52298 TRIADDRAFT_56535 TRIADDRAFT_60597 TRIADDRAFT_62134 TRIADDRAFT_62135

AQU:	100632085 105314001 109584186

MBR:	MONBRDRAFT_29860 MONBRDRAFT_31368

SRE:	PTSG_01510 PTSG_07825 PTSG_10317

» show all

Reference

PMID:9305925

Authors

Rosendahl MS, Ko SC, Long DL, Brewer MT, Rosenzweig B, Hedl E, Anderson L, Pyle SM, Moreland J, Meyers MA, Kohno T, Lyons D, Lichenstein HS

Title

Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.

Journal

J Biol Chem 272:24588-93 (1997)
DOI:10.1074/jbc.272.39.24588

Sequence

[hsa:102]

Reference

PMID:11477090

Authors

Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, De Strooper B, Grassi J, Lopez-Perez E, Checler F

Title

The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.

Journal

J Biol Chem 276:37743-6 (2001)
DOI:10.1074/jbc.M105677200

Sequence

[hsa:102]

LinkDB

DBGET integrated database retrieval system