KEGG   ORTHOLOGY: K06704
Entry
K06704                      KO                                     
Symbol
ADAM10, CD156c
Name
disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81]
Pathway
map04361  Axon regeneration
map05010  Alzheimer disease
map05120  Epithelial cell signaling in Helicobacter pylori infection
Disease
H00056  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.81  ADAM10 endopeptidase
     K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10
CD molecules [BR:ko04090]
 Proteins
  K06704  CD156c, ADAM10; a disintegrin and metalloproteinase domain 10
Genes
HSA: 102(ADAM10)
PTR: 746942(ADAM10)
PPS: 100979438(ADAM10)
GGO: 101142970(ADAM10)
PON: 100169741(ADAM10)
NLE: 100606667(ADAM10)
MCC: 701355(ADAM10)
MCF: 101925715(ADAM10)
CSAB: 103245557(ADAM10)
CATY: 105601091(ADAM10)
PANU: 101023521 116275816(ADAM10)
TGE: 112627561(ADAM10)
RRO: 104670896(ADAM10)
RBB: 108544959(ADAM10)
TFN: 117070589(ADAM10)
PTEH: 111553697(ADAM10)
CJC: 100415138(ADAM10)
SBQ: 101041855(ADAM10)
CSYR: 103249370(ADAM10)
MMUR: 105881392(ADAM10)
LCAT: 123623265(ADAM10)
OGA: 100962332(ADAM10)
MMU: 11487(Adam10)
MCAL: 110302364(Adam10)
MPAH: 110327224(Adam10)
RNO: 29650(Adam10)
MCOC: 116073842(Adam10)
CGE: 100772891(Adam10)
MAUA: 101831586(Adam10)
PLEU: 114690776(Adam10)
MORG: 121466052(Adam10)
AAMP: 119809064(Adam10)
NGI: 103737147(Adam10)
HGL: 101698280(Adam10)
CPOC: 100718999(Adam10)
CCAN: 109689747
DORD: 105980955(Adam10)
DSP: 122114386(Adam10)
NCAR: 124976191
OCU: 100101614(ADAM10)
OPI: 101527689(ADAM10)
TUP: 102467957(ADAM10)
CFA: 478321(ADAM10)
VVP: 112920741(ADAM10)
VLG: 121484395(ADAM10)
AML: 100476350(ADAM10)
UMR: 103676794(ADAM10)
UAH: 113269679(ADAM10)
UAR: 123785029(ADAM10)
ELK: 111153288
LLV: 125103845
MPUF: 101673179(ADAM10)
ORO: 101380324(ADAM10)
EJU: 114206362(ADAM10)
ZCA: 113909095(ADAM10)
MLX: 118003444(ADAM10)
FCA: 101087998(ADAM10)
PYU: 121041772(ADAM10)
PBG: 122468583(ADAM10)
PTG: 102950285(ADAM10)
PPAD: 109262917(ADAM10)
AJU: 106973789(ADAM10)
HHV: 120230860(ADAM10)
BTA: 282132(ADAM10)
BOM: 102285401(ADAM10)
BIU: 109564357(ADAM10)
BBUB: 102390753(ADAM10)
CHX: 102172903(ADAM10)
OAS: 101116733(ADAM10)
ODA: 120853042(ADAM10)
CCAD: 122443550(ADAM10)
SSC: 397345(ADAM10)
CFR: 102518129(ADAM10)
CBAI: 105080513(ADAM10)
CDK: 105088967(ADAM10)
VPC: 102527501(ADAM10)
BACU: 103011557(ADAM10)
LVE: 103071850(ADAM10)
OOR: 101275940(ADAM10)
DLE: 111177664(ADAM10)
PCAD: 102975188(ADAM10)
PSIU: 116748974(ADAM10)
ECB: 100068314(ADAM10)
EPZ: 103552041(ADAM10)
EAI: 106830043(ADAM10)
MYB: 102260183(ADAM10)
MYD: 102754258(ADAM10)
MMYO: 118652779(ADAM10)
MLF: 102442016(ADAM10)
MNA: 107533751(ADAM10)
PKL: 118720561(ADAM10)
HAI: 109390694(ADAM10)
DRO: 112311976(ADAM10)
SHON: 118992259(ADAM10)
AJM: 119053476(ADAM10)
PDIC: 114493218(ADAM10)
PHAS: 123808151(ADAM10)
MMF: 118636203(ADAM10)
RFQ: 117023543(ADAM10)
PALE: 102895434(ADAM10)
PGIG: 120604587(ADAM10)
PVP: 105294280(ADAM10)
RAY: 107518608(ADAM10)
MJV: 108393396(ADAM10)
TOD: 119238671(ADAM10)
SARA: 101538322(ADAM10)
LAV: 100659084(ADAM10)
TMU: 101350043
DNM: 101417950(ADAM10)
MDO: 100024929 100027329(ADAM10)
GAS: 123232128 123238019(ADAM10)
SHR: 100913194(ADAM10) 100925760
PCW: 110197392 110205292(ADAM10)
OAA: 100074755(ADAM10) 114806495
GGA: 374113(ADAM10)
PCOC: 116244652(ADAM10)
MGP: 100545069
CJO: 107318510(ADAM10)
NMEL: 110403587(ADAM10)
APLA: 101794215(ADAM10)
ACYG: 106033621(ADAM10)
AFUL: 116493283(ADAM10)
TGU: 100219653(ADAM10)
LSR: 110471419(ADAM10)
SCAN: 103816174(ADAM10)
PMOA: 120509226(ADAM10)
OTC: 121343422(ADAM10)
PRUF: 121354390(ADAM10)
GFR: 102043060(ADAM10)
FAB: 101811782(ADAM10)
PHI: 102110765(ADAM10)
PMAJ: 107209233(ADAM10)
CCAE: 111933890(ADAM10)
CCW: 104684038(ADAM10)
ETL: 114056365(ADAM10)
ZAB: 102073584(ADAM10)
FPG: 101910860(ADAM10)
FCH: 102050786(ADAM10)
CLV: 102083444(ADAM10)
EGZ: 104130770(ADAM10)
NNI: 104016847(ADAM10)
PLET: 104621900(ADAM10)
ACUN: 113483904(ADAM10)
TALA: 104367477(ADAM10)
PADL: 103914880(ADAM10)
ACHC: 115341169(ADAM10)
AAM: 106496382(ADAM10)
AROW: 112974729(ADAM10)
NPD: 112952770(ADAM10)
DNE: 112991137(ADAM10)
AMJ: 102562482 102563250(ADAM10)
CPOO: 109308972(ADAM10) 109320461
GGN: 109288646(ADAM10) 109294893
PSS: 102444574(ADAM10) 102461827
CMY: 102936468 102944138(ADAM10)
TST: 117868878 117883650(ADAM10)
CABI: 116821168(ADAM10) 116838433
MRV: 120373604(ADAM10) 120391577
ACS: 100553674(adam10)
PVT: 110074537(ADAM10) 110079237
SUND: 121932590(ADAM10) 121936559
PBI: 103053091 103062263(ADAM10)
PMUR: 107283154(ADAM10)
TSR: 106542883(ADAM10)
PGUT: 117660950(ADAM10) 117668650
VKO: 123027648(ADAM10)
PMUA: 114583918(ADAM10) 114588574
ZVI: 118086073 118093232(ADAM10)
GJA: 107107516(ADAM10)
STOW: 125424460(ADAM10)
XLA: 108706832 108711361 399187(adam10.S)
XTR: 100491788 733451(adam10)
NPR: 108789826(ADAM10) 108796952
RTEM: 120924706 120931382(ADAM10)
BBUF: 120985758(ADAM10) 120989514
BGAR: 122919690 122927656(ADAM10)
DRE: 393392(adam10b) 560975(si:ch1073-396h14.1) 566044(adam10a)
PPRM: 120474036 120486226(si:ch1073-396h14.1) 120491441(adam10a)
MAMB: 125246761 125251118(si:ch1073-396h14.1) 125261896(adam10b) 125264716(adam10a)
IPU: 108259300(adam10a) 108271130(si:ch1073-396h14.1) 108275251
SMEO: 124379666(adam10a) 124391425(si:ch1073-396h14.1) 124392002
TFD: 113636788(adam10a) 113639154 113644300(si:ch1073-396h14.1)
NCC: 104960057(adam10) 104960084
ELY: 117252642(adam10a) 117253616(si:ch1073-396h14.1) 117262371
PLEP: 121937813(si:ch1073-396h14.1) 121947514(adam10a) 121950293
SLUC: 116038274 116055227(si:ch1073-396h14.1) 116060685(adam10a)
ECRA: 117949631 117951000(si:ch1073-396h14.1) 117958595(adam10a)
GAT: 120809559 120812703 120824183(si:ch1073-396h14.1) 120831617(adam10a)
PPUG: 119195954 119216355(si:ch1073-396h14.1) 119228370(adam10a)
MSAM: 119890154(adam10a) 119893471 119900750(si:ch1073-396h14.1)
CUD: 121508420(adam10a) 121512543(si:ch1073-396h14.1) 121514982
ALAT: 119017915(adam10a) 119023933 119028768(si:ch1073-396h14.1)
OAU: 116309232(si:ch1073-396h14.1) 116326736 116334631(adam10a)
OML: 112150653(si:ch1073-396h14.1) 112152362 112160714(adam10a)
GAF: 122835335 122838502(si:ch1073-396h14.1) 122843708(adam10a)
CTUL: 119775039 119780852(si:ch1073-396h14.1) 119795460(adam10a)
GMU: 124866912(adam10a) 124873924(si:ch1073-396h14.1) 124880736
KMR: 108230196 108230826(si:ch1073-396h14.1) 108251752(adam10a)
NWH: 119407429(si:ch1073-396h14.1) 119416346 119422316(adam10a)
SSEN: 122760920 122761376 122780907(si:ch1073-396h14.1)
HHIP: 117756608(adam10a) 117760656(si:ch1073-396h14.1) 117763808
HSP: 118106022(adam10a) 118109680 118121612(si:ch1073-396h14.1)
XGL: 120789059(adam10a) 120790937(si:ch1073-396h14.1) 120793207
BSPL: 114852731(adam10a) 114853516(si:ch1073-396h14.1) 114857455
OTW: 112219062 112249184 112252197(si:ch1073-396h14.1) 112263716(adam10a) 112265333
OMY: 110501717(si:ch1073-396h14.1) 110502564 110521213 110526414(adam10a) 118944511
OGO: 123998865(si:ch1073-396h14.1) 124031711 124033743 124035726 124037494
AANG: 118215630 118225832(si:ch1073-396h14.1) 118227666
LOC: 102689715(adam10) 102693175
PSPA: 121294484 121299163 121300696(si:ch1073-396h14.1)
LCM: 102349523 102351415(ADAM10)
CMK: 103183500(si:ch1073-396h14.1) 103189371(adam10a)
RTP: 109936297(adam10)
CIN: 100184040
SCLV: 120336775
DME: Dmel_CG1964(Kul) Dmel_CG7147(kuz)
DSI: Dsimw501_GD15481(Dsim_GD15481) Dsimw501_GD21457(Dsim_GD21457)
CCAT: 101455868
BOD: 106622771
LSQ: 119609134
ASTE: 118511695
CEL: CELE_DY3.7(sup-17)
CBR: CBG_12369(Cbr-sup-17)
BMY: BM_BM3076(Bma-sup-17)
TSP: Tsp_11370
OBI: 106879111
OSN: 115219650
 » show all
Reference
PMID:9305925
  Authors
Rosendahl MS, Ko SC, Long DL, Brewer MT, Rosenzweig B, Hedl E, Anderson L, Pyle SM, Moreland J, Meyers MA, Kohno T, Lyons D, Lichenstein HS
  Title
Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.
  Journal
J Biol Chem 272:24588-93 (1997)
DOI:10.1074/jbc.272.39.24588
  Sequence
[hsa:102]
Reference
  Authors
Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, De Strooper B, Grassi J, Lopez-Perez E, Checler F
  Title
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
  Journal
J Biol Chem 276:37743-6 (2001)
DOI:10.1074/jbc.M105677200
  Sequence
[hsa:102]
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