Homo sapiens (human): 102
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Entry
102 CDS
T01001
Symbol
ADAM10, AD10, AD18, CD156c, CDw156, HsT18717, MADM, RAK, kuz
Name
(RefSeq) disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein
KO
K06704
disintegrin and metalloproteinase domain-containing protein 10 [EC:
3.4.24.81
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04148
Efferocytosis
hsa04519
Cadherin signaling
hsa05010
Alzheimer disease
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
Network
nt06535
Efferocytosis
Element
N01749
Find-me signal (CX3CL1)
Disease
H00056
Alzheimer disease
H02665
Reticulate acropigmentation of Kitamura
Drug target
Aderbasib:
D09320
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04519 Cadherin signaling
102 (ADAM10)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
102 (ADAM10)
09160 Human Diseases
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
102 (ADAM10)
09164 Neurodegenerative disease
05010 Alzheimer disease
102 (ADAM10)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
102 (ADAM10)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
hsa04090
]
102 (ADAM10)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.81 ADAM10 endopeptidase
102 (ADAM10)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M12: astacin/adamalysin family
102 (ADAM10)
CD molecules [BR:
hsa04090
]
Proteins
102 (ADAM10)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Reprolysin_2
Reprolysin_5
Reprolysin_3
ADAM10_Cys-rich
Reprolysin_4
Disintegrin
Pep_M12B_propep
Reprolysin
Peptidase_M66
Motif
Other DBs
NCBI-GeneID:
102
NCBI-ProteinID:
NP_001101
OMIM:
602192
HGNC:
188
Ensembl:
ENSP00000260408.3
UniProt:
O14672
Structure
PDB
PDBj
LinkDB
All DBs
Position
15:complement(58588809..58749707)
Genome browser
AA seq
748 aa
AA seq
DB search
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
NT seq
2247 nt
NT seq
+upstream
nt +downstream
nt
atggtgttgctgagagtgttaattctgctcctctcctgggcggcggggatgggaggtcag
tatgggaatcctttaaataaatatatcagacattatgaaggattatcttacaatgtggat
tcattacaccaaaaacaccagcgtgccaaaagagcagtctcacatgaagaccaattttta
cgtctagatttccatgcccatggaagacatttcaacctacgaatgaagagggacacttcc
cttttcagtgatgaatttaaagtagaaacatcaaataaagtacttgattatgatacctct
catatttacactggacatatttatggtgaagaaggaagttttagccatgggtctgttatt
gatggaagatttgaaggattcatccagactcgtggtggcacattttatgttgagccagca
gagagatatattaaagaccgaactctgccatttcactctgtcatttatcatgaagatgat
attaactatccccataaatacggtcctcaggggggctgtgcagatcattcagtatttgaa
agaatgaggaaataccagatgactggtgtagaggaagtaacacagatacctcaagaagaa
catgctgctaatggtccagaacttctgaggaaaaaacgtacaacttcagctgaaaaaaat
acttgtcagctttatattcagactgatcatttgttctttaaatattacggaacacgagaa
gctgtgattgcccagatatccagtcatgttaaagcgattgatacaatttaccagaccaca
gacttctccggaatccgtaacatcagtttcatggtgaaacgcataagaatcaatacaact
gctgatgagaaggaccctacaaatcctttccgtttcccaaatattggtgtggagaagttt
ctggaattgaattctgagcagaatcatgatgactactgtttggcctatgtcttcacagac
cgagattttgatgatggcgtacttggtctggcttgggttggagcaccttcaggaagctct
ggaggaatatgtgaaaaaagtaaactctattcagatggtaagaagaagtccttaaacact
ggaattattactgttcagaactatgggtctcatgtacctcccaaagtctctcacattact
tttgctcacgaagttggacataactttggatccccacatgattctggaacagagtgcaca
ccaggagaatctaagaatttgggtcaaaaagaaaatggcaattacatcatgtatgcaaga
gcaacatctggggacaaacttaacaacaataaattctcactctgtagtattagaaatata
agccaagttcttgagaagaagagaaacaactgttttgttgaatctggccaacctatttgt
ggaaatggaatggtagaacaaggtgaagaatgtgattgtggctatagtgaccagtgtaaa
gatgaatgctgcttcgatgcaaatcaaccagagggaagaaaatgcaaactgaaacctggg
aaacagtgcagtccaagtcaaggtccttgttgtacagcacagtgtgcattcaagtcaaag
tctgagaagtgtcgggatgattcagactgtgcaagggaaggaatatgtaatggcttcaca
gctctctgcccagcatctgaccctaaaccaaacttcacagactgtaataggcatacacaa
gtgtgcattaatgggcaatgtgcaggttctatctgtgagaaatatggcttagaggagtgt
acgtgtgccagttctgatggcaaagatgataaagaattatgccatgtatgctgtatgaag
aaaatggacccatcaacttgtgccagtacagggtctgtgcagtggagtaggcacttcagt
ggtcgaaccatcaccctgcaacctggatccccttgcaacgattttagaggttactgtgat
gttttcatgcggtgcagattagtagatgctgatggtcctctagctaggcttaaaaaagca
atttttagtccagagctctatgaaaacattgctgaatggattgtggctcattggtgggca
gtattacttatgggaattgctctgatcatgctaatggctggatttattaagatatgcagt
gttcatactccaagtagtaatccaaagttgcctcctcctaaaccacttccaggcacttta
aagaggaggagacctccacagcccattcagcaaccccagcgtcagcggccccgagagagt
tatcaaatgggacacatgagacgctaa
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