KEGG   Loxodonta africana (African savanna elephant): 100674758
Entry
100674758         CDS       T04351                                 

Gene name
PTPN11
Definition
(RefSeq) tyrosine-protein phosphatase non-receptor type 11 isoform X1
  KO
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav04014  Ras signaling pathway
lav04072  Phospholipase D signaling pathway
lav04360  Axon guidance
lav04625  C-type lectin receptor signaling pathway
lav04630  JAK-STAT signaling pathway
lav04650  Natural killer cell mediated cytotoxicity
lav04670  Leukocyte transendothelial migration
lav04722  Neurotrophin signaling pathway
lav04920  Adipocytokine signaling pathway
lav04931  Insulin resistance
lav05168  Herpes simplex virus 1 infection
lav05205  Proteoglycans in cancer
lav05211  Renal cell carcinoma
lav05220  Chronic myeloid leukemia
lav05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100674758 (PTPN11)
   04630 JAK-STAT signaling pathway
    100674758 (PTPN11)
   04072 Phospholipase D signaling pathway
    100674758 (PTPN11)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100674758 (PTPN11)
   04650 Natural killer cell mediated cytotoxicity
    100674758 (PTPN11)
   04670 Leukocyte transendothelial migration
    100674758 (PTPN11)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    100674758 (PTPN11)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100674758 (PTPN11)
  09158 Development and regeneration
   04360 Axon guidance
    100674758 (PTPN11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    100674758 (PTPN11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100674758 (PTPN11)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    100674758 (PTPN11)
   05211 Renal cell carcinoma
    100674758 (PTPN11)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    100674758 (PTPN11)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    100674758 (PTPN11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:lav01009]
    100674758 (PTPN11)
Enzymes [BR:lav01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     100674758 (PTPN11)
Protein phosphatases and associated proteins [BR:lav01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    100674758 (PTPN11)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 100674758
NCBI-ProteinID: XP_023395098
LinkDB
Position
Unknown
AA seq 597 aa
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFRENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQVLLQGNTERTVW
QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILI
DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSK
RKGHEYTNIKYSLADQTSGDQSPLPPCTPTPSCTEMREDNARVYENVGLMQQQKSFR
NT seq 1794 nt   +upstreamnt  +downstreamnt
atgacatcgcgaagatggtttcacccaaatatcactggcgtggaggcagaaaacctactg
ttgacaagaggagttgatggcagttttttggcaagacccagtaaaagtaaccctggagac
ttcacactttccgttagaagaaatggagctgtcacccacatcaagattcagaacactggt
gattactatgacctgtacggaggggagaagtttgccactttggctgagctggtccagtat
tacatggaacatcacgggcaattgaaagagaagaatggagacgttattgagctcaaatat
cctctgaactgtgcagaccctacctctgaaaggtggtttcatggacacctgtctgggaaa
gaagccgagaaattactgacagagaaaggaaaacacggcagctttcttgtgcgcgagagc
cagagccaccctggagattttgttctctctgtccgcactggagatgacaaaggggagagc
aatgatggcaagtctaaagtgacccacgtcatgattcgctgtcaggaactgaaatatgat
gtcggtggaggagagcggtttgattctttgacagatctcgtggagcattacaagaagaac
cctatggtagaaacattgggcaccgttctacaactcaagcagcccctcaatacaactcgt
atcaatgctgctgagatagaaagccgtgttcgagaactaagcaaattagctgagaccaca
gataaagtcaaacaaggcttttgggaagaatttgagactctgcaacaacaggagtgcaaa
cttctctacagccgcaaagagggccaaaggcaagaaaataaaaacaaaaatagatataaa
aacatcctgccttttgatcacaccagggttgtcctacacgatggcgatcccaacgagcct
gtttcagattatatcaatgcaaatattataatgcctgaatttgaaaccaagtgcaacaat
tcaaaacccaagaagagttacattgccacccaaggctgcctgcaaaacacggtgaacgac
ttctggcggatggtgttccgggagaactcccgagtgattgtcatgacaacgaaagaagtg
gagagaggaaagagtaaatgtgtcaaatactggcctgatgagtatgccctcaaagaatat
ggggtcatgcgtgttaggaacgtcaaagaaagtgccgctcatgactataccttaagagaa
cttaaactttcgaaggttgggcaagttctactccagggcaatacggagagaaccgtctgg
caataccactttcggacctggccggaccatggcgtgcccagtgaccccgggggtgtgctg
gacttcttggaggaggtgcaccacaagcaggagagcatcatggatgcggggcctgtggtg
gttcactgcagtgctggaattggccgaacagggacattcattgtgattgatatcctcatt
gacatcatcagagagaaaggcgtcgactgtgacatcgatgttcccaaaaccatccagatg
gtgcggtctcagaggtcagggatggtccagacagaagcacaataccggttcatctatatg
gctgtccagcactatattgaaacactacagcgcaggatcgaagaagaacagaaaagcaag
aggaaagggcatgaatatacaaatattaagtattccctagcggaccagaccagtggagat
cagagtccccttccaccttgtaccccaacaccatcctgtacagaaatgagagaagataat
gccagagtctatgaaaacgtgggtctgatgcagcagcagaaaagtttcagatga

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