KEGG   ORTHOLOGY: K07293
Entry
K07293                      KO                                     
Symbol
PTPN11
Name
tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Pathway
map04013  MAPK signaling pathway - fly
map04014  Ras signaling pathway
map04072  Phospholipase D signaling pathway
map04360  Axon guidance
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04670  Leukocyte transendothelial migration
map04722  Neurotrophin signaling pathway
map04920  Adipocytokine signaling pathway
map04931  Insulin resistance
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05168  Herpes simplex virus 1 infection
map05205  Proteoglycans in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05211  Renal cell carcinoma
map05220  Chronic myeloid leukemia
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00523  Noonan syndrome and related disorders
H01018  Metachondromatosis
H01738  Noonan syndrome
H01984  Leopard syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02541  Jvenile myelomonocytic leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04014 Ras signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04630 JAK-STAT signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04072 Phospholipase D signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04650 Natural killer cell mediated cytotoxicity
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04670 Leukocyte transendothelial migration
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09158 Development and regeneration
   04360 Axon guidance
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05208 Chemical carcinogenesis - reactive oxygen species
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05211 Renal cell carcinoma
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05130 Pathogenic Escherichia coli infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
Protein phosphatases and associated proteins [BR:ko01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
Other DBs
GO: 0004726
Genes
HSA: 5781(PTPN11)
PTR: 748225(PTPN11)
PPS: 100967833 100970556(PTPN11)
GGO: 101133729(PTPN11)
PON: 100440983(PTPN11)
NLE: 100602671(PTPN11) 100605369
MCC: 712044(PTPN11)
MCF: 102129572(PTPN11)
CSAB: 103239151(PTPN11)
CATY: 105573167(PTPN11)
PANU: 101008549(PTPN11)
TGE: 112635452(PTPN11)
RRO: 104674419(PTPN11)
RBB: 108540455(PTPN11)
TFN: 117089376(PTPN11)
PTEH: 111537181(PTPN11)
CJC: 100414905(PTPN11)
SBQ: 101031381(PTPN11) 101033019
CSYR: 103276181(PTPN11)
MMUR: 105878675(PTPN11)
OGA: 100955860(PTPN11)
MMU: 19247(Ptpn11)
MCAL: 110294055(Ptpn11)
MPAH: 110339175(Ptpn11)
RNO: 25622(Ptpn11)
MCOC: 116068338(Ptpn11)
MUN: 110546380(Ptpn11)
CGE: 100771077(Ptpn11)
PLEU: 114681906(Ptpn11)
NGI: 103745559(Ptpn11)
HGL: 101701336(Ptpn11)
CPOC: 100732797(Ptpn11)
CCAN: 109696291(Ptpn11)
DORD: 105990684(Ptpn11)
DSP: 122098592(Ptpn11)
NCAR: 124990645
OCU: 100339517(PTPN11)
OPI: 101529639(PTPN11)
TUP: 102485136(PTPN11) 102498455
CFA: 477488(PTPN11)
VVP: 112926139 112935165(PTPN11)
VLG: 121475547(PTPN11)
AML: 100468867(PTPN11) 100471152
UMR: 103661289(PTPN11)
UAH: 113266983(PTPN11) 113270688
UAR: 123778834(PTPN11)
LLV: 125081916
MPUF: 101678858(PTPN11) 101688002
ORO: 101368461(PTPN11) 101374328
EJU: 114213370 114219111(PTPN11)
ZCA: 113912429(PTPN11)
MLX: 118018488(PTPN11)
FCA: 101085500(PTPN11)
PYU: 121010320(PTPN11)
PBG: 122470240(PTPN11)
PTG: 102951653(PTPN11) 102954137
PPAD: 109273906 109277629(PTPN11)
AJU: 106982085(PTPN11) 106988776
HHV: 120236974(PTPN11) 120242567
BTA: 533590(PTPN11)
BOM: 102276389(PTPN11)
BIU: 109570168 109570927(PTPN11)
BBUB: 102401129 102405817(PTPN11)
CHX: 102177271(PTPN11)
OAS: 101114308(PTPN11)
ODA: 120871132(PTPN11) 120880615
CCAD: 122422795(PTPN11)
SSC: 100170851(PTPN11) 100620540
CFR: 102523889(PTPN11)
CBAI: 105080590(PTPN11)
CDK: 105102551(PTPN11) 105105612
VPC: 102529754(PTPN11)
BACU: 103004467(PTPN11)
LVE: 103088783(PTPN11)
OOR: 101275685 101288182(PTPN11)
DLE: 111187198 111188123(PTPN11)
PCAD: 102979922(PTPN11) 102987506
PSIU: 116765123(PTPN11)
ECB: 100056857(PTPN11) 100146191
EPZ: 103557133(PTPN11) 103558567
EAI: 106842252(PTPN11) 106845198
MYB: 102251345(PTPN11)
MYD: 102755861(PTPN11)
MMYO: 118678341(PTPN11)
MLF: 102420806(PTPN11)
MNA: 107529574(PTPN11)
PKL: 118725234(PTPN11)
HAI: 109382264(PTPN11) 109391216
DRO: 112310448(PTPN11)
SHON: 118991117(PTPN11)
AJM: 119040448(PTPN11)
PDIC: 114509670(PTPN11)
PHAS: 123820995(PTPN11)
MMF: 118639877(PTPN11)
RFQ: 117017450(PTPN11)
PALE: 102889219(PTPN11)
PGIG: 120606707(PTPN11) 120614076
PVP: 105289236(PTPN11)
RAY: 107510717 107513271(PTPN11)
MJV: 108405695
TOD: 119244965(PTPN11)
SARA: 101552022(PTPN11) 101556236
LAV: 100674758(PTPN11)
TMU: 101348102
DNM: 101435063(PTPN11)
MDO: 100023824 100028991(PTPN11)
GAS: 123243044 123256872(PTPN11)
SHR: 100930062(PTPN11)
PCW: 110201173 110203391(PTPN11)
OAA: 100086381 100089978(PTPN11)
GGA: 395815(PTPN11) 419429
PCOC: 116228565(PTPN11) 116242713
MGP: 100541480 100550508(PTPN11)
CJO: 107321154(PTPN11) 107323557
NMEL: 110406211(PTPN11) 110408529
APLA: 101789439
ACYG: 106031098(PTPN11) 106044308
AFUL: 116496024(PTPN11) 116497573
TGU: 100218949(PTPN11)
LSR: 110478178(PTPN11)
SCAN: 103818137(PTPN11)
PMOA: 120509573(PTPN11)
OTC: 121338859(PTPN11)
PRUF: 121364826(PTPN11)
GFR: 102033785(PTPN11)
FAB: 101811730(PTPN11)
PHI: 102103197(PTPN11)
PMAJ: 107211728(PTPN11)
CCAE: 111936431(PTPN11)
CCW: 104688668(PTPN11) 104693326
ETL: 114062648(PTPN11) 114071019
ZAB: 102066384(PTPN11)
FPG: 101914986(PTPN11) 101915334
FCH: 102054041 102058357(PTPN11)
CLV: 102084071(PTPN11) 102097440
EGZ: 104123916(PTPN11) 104133393
NNI: 104009062 104020567(PTPN11)
ACUN: 113485966(PTPN11) 113487880
TALA: 104359108(PTPN11) 104368318
PADL: 103917957 103925702(PTPN11)
ACHC: 115343160 115345970(PTPN11)
AAM: 106492969(PTPN11) 106495554
AROW: 112963349(PTPN11) 112970089
NPD: 112945166(PTPN11) 112957413
DNE: 112983482 112991774(PTPN11)
ASN: 102371778(PTPN11) 102386995
AMJ: 102562607 102570430(PTPN11)
CPOO: 109312671(PTPN11) 109314434
GGN: 109290555(PTPN11) 109293724
PSS: 102443910 102453333(PTPN11)
CMY: 102934329(PTPN11) 102934807
CPIC: 101941295 101949667(PTPN11)
TST: 117867923 117887968(PTPN11)
CABI: 116824594 116836789(PTPN11)
MRV: 120386082(PTPN11) 120387948
ACS: 100559345(ptpn11) 100564881
PVT: 110073274 110083443(PTPN11)
SUND: 121916573(PTPN11) 121937372
PBI: 103048752 103055536(PTPN11)
PMUR: 107286989(PTPN11) 107297989
TSR: 106539364(PTPN11) 106556002
PGUT: 117658751 117672263(PTPN11)
VKO: 123028618(PTPN11) 123031028
PMUA: 114602500 114602756(PTPN11)
ZVI: 118086429 118086624(PTPN11)
GJA: 107110836 107112180(PTPN11)
STOW: 125442510(PTPN11) 125445552
XLA: 108697240(ptpn11b.S) 108716965 399291(ptpn11.S) 444193(ptpn11b.L)
XTR: 548434(ptpn11b) 549586(ptpn11)
NPR: 108790634 108798021(PTPN11)
RTEM: 120915454 120933130(PTPN11)
BBUF: 120988535(PTPN11) 120997090
BGAR: 122924570(PTPN11) 122928690
DRE: 333979(ptpn11a) 393426(ptpn11b)
PPRM: 120463116(ptpn11b) 120482018(ptpn11a)
MAMB: 125259936(ptpn11b) 125262517(ptpn11a)
IPU: 108276278(ptpn11b) 108277290(ptpn11a)
PHYP: 113530358 113544720(ptpn11)
SMEO: 124393652(ptpn11a)
TFD: 113638452(ptpn11a) 113658113(ptpn11b)
AMEX: 103022363(ptpn11) 103032744
EEE: 113580163 113591662(ptpn11)
TRU: 101068465(ptpn11) 101076633
LCO: 104919515 104934925(ptpn11)
NCC: 104956326 104967981(ptpn11)
CGOB: 115010746 115016662(ptpn11)
ELY: 117258419(ptpn11b) 117269642(ptpn11a)
PLEP: 121946887(ptpn11b) 121959592(ptpn11a)
SLUC: 116040746(ptpn11b) 116051029(ptpn11a)
ECRA: 117947049 117959143(ptpn11a)
PFLV: 114559065 114570677(ptpn11)
GAT: 120829464(ptpn11b) 120831714(ptpn11a)
PPUG: 119221895(ptpn11b) 119226376(ptpn11a)
MSAM: 119905928(ptpn11b) 119915161(ptpn11a)
CUD: 121518221(ptpn11b) 121524755(ptpn11a)
MZE: 101469361 101475609(ptpn11)
ONL: 100697902(ptpn11) 100700918
OAU: 116313166(ptpn11a) 116317376(ptpn11b)
OLA: 101156835(ptpn11) 101172160
OML: 112159720(ptpn11b) 112162955(ptpn11a)
XMA: 102223330 102232688(ptpn11)
XCO: 114147980 114149733(ptpn11)
XHE: 116720017 116724114(ptpn11)
PRET: 103467098 103473239(ptpn11)
PFOR: 103153507 103155575(ptpn11)
PLAI: 106938905 106947468(ptpn11)
PMEI: 106908907(ptpn11) 106932994
GAF: 122819708(ptpn11a) 122831403(ptpn11b)
CVG: 107086071(ptpn11) 107086704
CTUL: 119784762(ptpn11a) 119786496(ptpn11b)
GMU: 124866921(ptpn11b) 124872082(ptpn11a)
NFU: 107396142(ptpn11) 107397076
KMR: 108233149(ptpn11b) 108247149(ptpn11a)
ALIM: 106518899 106527575(ptpn11)
NWH: 119417149(ptpn11b) 119424655(ptpn11a)
AOCE: 111567360 111572898(ptpn11)
CSEM: 103384897 103389968(ptpn11)
POV: 109626354(ptpn11) 109630583
SSEN: 122758347(ptpn11a) 122776904(ptpn11b)
HHIP: 117765296(ptpn11b) 117771786(ptpn11a)
LCF: 108882629 108897434(ptpn11)
SDU: 111217827(ptpn11) 111227612
SLAL: 111656118 111666017(ptpn11)
XGL: 120804218(ptpn11b) 120806522(ptpn11a)
HCQ: 109507188(ptpn11) 109511800
BPEC: 110157366(ptpn11) 110157943
MALB: 109952842(ptpn11) 109967179
ELS: 105007638(ptpn11) 105013921
AANG: 118208610(ptpn11b) 118211692 118213242(ptpn11a)
LOC: 102682867(ptpn11) 102697778
LCM: 102352712 102357168(PTPN11)
CMK: 103184045(ptpn11a) 103187442(ptpn11b)
RTP: 109926577 109932773(ptpn11)
BFO: 118430024
BBEL: 109480021
CIN: 100184658
SCLV: 120327787
APLC: 110984574
SKO: 102803939
DME: Dmel_CG3954(csw)
DER: 6555622
DSE: 6616088
DSI: Dsimw501_GD24731(Dsim_GD24731)
DAN: 6504142
DSR: 110180159
DPE: 6600767
DMN: 108162535
DWI: 6648549
DGR: 6566332
DAZ: 108619678
DNV: 108656917
DVI: 6633324
CCAT: 101459152
BOD: 106621284
MDE: 101887567
SCAC: 106087566
LCQ: 111685385
ACOZ: 120950021
AARA: 120895943
AAG: 5570773
CNS: 116340555
AME: 412529
ACER: 108000417
ALAB: 122711751
BIM: 100746379
BBIF: 117211138
BVK: 117238523
BVAN: 117160382
BTER: 100644829
BPYO: 122577206
CCAL: 108623268
OBB: 114875774
MGEN: 117227483
NMEA: 116424621
CGIG: 122395630
SOC: 105194971
MPHA: 105836746
AEC: 105154855
ACEP: 105620789
PBAR: 105429975
VEM: 105561475
HST: 105186698
DQU: 106749128
CFO: 105254344
FEX: 115236536
LHU: 105677799
PGC: 109861190
OBO: 105283745
PCF: 106786660
PFUC: 122515473
VPS: 122635689
NVI: 100115335
CSOL: 105359860
TPRE: 106648937
MDL: 103573389
CGLO: 123260596
FAS: 105269908
DAM: 107045737
AGIF: 122852167
CCIN: 107271573
TCA: 660085
DPA: 109536044
SOY: 115881513
ATD: 109594310
AGB: 108915940
LDC: 111507908
NVL: 108560697
APLN: 108732945
PPYR: 116172192
PXY: 105384127
API: 100163524
DNX: 107163725
AGS: 114125542
RMD: 113550141
BTAB: 109040742
DCI: 103514734
CLEC: 106671929
HHAL: 106683221
FOC: 113206955
ZNE: 110838312
CSEC: 111867734
FCD: 110853883
PVM: 113817688
PJA: 122257958
PCHN: 125041856
HAME: 121880031
PCLA: 123757839
PTRU: 123520207
HAZT: 108679181
EAF: 111714672
LSM: 121114975
DSV: 119446843
RSAN: 119389320
RMP: 119184305
VDE: 111252760
VJA: 111271398
TUT: 107367026
DPTE: 113794101
DFR: 124490135
PTEP: 107456622
SDM: 118205460
CEL: CELE_F59G1.5(ptp-2)
CBR: CBG_02539(Cbr-ptp-2)
BMY: BM_BM4610(Bma-ptp-2)
TSP: Tsp_10590
PCAN: 112556534
BGT: 106072917
GAE: 121390611
HRF: 124144404
HRJ: 124257158
MYI: 110455301
PMAX: 117345286
MMER: 123527830
OBI: 106868673
OSN: 115224801
NVE: 116617638
EPA: 110237259
ATEN: 116294928
ADF: 107346465
AMIL: 114975988
PDAM: 113672176
SPIS: 111329394
DGT: 114518227
XEN: 124444400
 » show all
Reference
  Authors
Jakob S, Schroeder P, Lukosz M, Buchner N, Spyridopoulos I, Altschmied J, Haendeler J
  Title
Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.
  Journal
J Biol Chem 283:33155-61 (2008)
DOI:10.1074/jbc.M805138200
Reference
  Authors
Lee HH, Chang ZF
  Title
Regulation of RhoA-dependent ROCKII activation by Shp2.
  Journal
J Cell Biol 181:999-1012 (2008)
DOI:10.1083/jcb.200710187
Reference
PMID:1281790
  Authors
Adachi M, Sekiya M, Miyachi T, Matsuno K, Hinoda Y, Imai K, Yachi A
  Title
Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.
  Journal
FEBS Lett 314:335-9 (1992)
DOI:10.1016/0014-5793(92)81500-L
  Sequence
[hsa:5781]
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