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Description |
Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.
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Class |
Cellular Processes; Cell growth and death
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Pathway map |

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Disease |
H02312 | Glutathione synthetase deficiency |
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Other DBs |
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Reference |
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Authors |
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR |
Title |
Regulated necrosis: disease relevance and therapeutic opportunities. |
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Reference |
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Authors |
Yang WS, Stockwell BR |
Title |
Ferroptosis: Death by Lipid Peroxidation. |
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Reference |
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Authors |
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H |
Title |
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. |
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Reference |
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Authors |
D'Herde K, Krysko DV |
Title |
Ferroptosis: Oxidized PEs trigger death. |
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Reference |
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Authors |
Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S |
Title |
Ferroptosis and cell death mechanisms in Parkinson's disease. |
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Reference |
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Authors |
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y |
Title |
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. |
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Reference |
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Authors |
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D |
Title |
Ferroptosis: process and function. |
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Reference |
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Authors |
Murphy ME |
Title |
Ironing out how p53 regulates ferroptosis. |
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Reference |
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Authors |
Muckenthaler MU, Rivella S, Hentze MW, Galy B |
Title |
A Red Carpet for Iron Metabolism. |
Journal |
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Reference |
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Authors |
Yu H, Guo P, Xie X, Wang Y, Chen G |
Title |
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. |
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Reference |
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Authors |
Wang SJ, Ou Y, Jiang L, Gu W |
Title |
Ferroptosis: A missing puzzle piece in the p53 blueprint? |
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Reference |
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Authors |
Cao JY, Dixon SJ |
Title |
Mechanisms of ferroptosis. |
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Reference |
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Authors |
Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW |
Title |
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. |
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Reference |
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Authors |
Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ |
Title |
The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis. |
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Reference |
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Authors |
Kwon MY, Park E, Lee SJ, Chung SW |
Title |
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death. |
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Reference |
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Authors |
Reed JC, Pellecchia M |
Title |
Ironing out cell death mechanisms. |
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Related pathway |
map00900 | Terpenoid backbone biosynthesis |
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KO pathway |
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LinkDB |
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