Entry
Name
Ferroptosis
Description
Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Orthology
K06519 solute carrier family 3, member 2
K13869 solute carrier family 7 (L-type amino acid transporter), member 11
K11205 glutamate--cysteine ligase regulatory subunit
K10142 metalloreductase STEAP3 [EC:1.16.1.-]
K21398 natural resistance-associated macrophage protein 2
K14714 solute carrier family 39 (zinc transporter), member 8
K14720 solute carrier family 39 (zinc transporter), member 14
K13162 poly(rC)-binding protein 2
K14685 solute carrier family 40 (iron-regulated transporter), member 1
K12889 poly(rC)-binding protein 1
K10435 microtubule-associated protein 1 light chain
K08339 autophagy-related protein 5
K08337 ubiquitin-like modifier-activating enzyme ATG7
K09289 nuclear receptor coactivator 4
K15040 voltage-dependent anion channel protein 2
K15041 voltage-dependent anion channel protein 3
K21421 NADPH oxidase 2 [EC:1.-.-.-]
Compound
C00129 Isopentenyl diphosphate
C00356 (S)-3-Hydroxy-3-methylglutaryl-CoA
C00669 gamma-L-Glutamyl-L-cysteine
C16170 (7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA
C21480 1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21481 1-Octadecanoyl-2-(7Z,10Z,13Z,16Z-docosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21482 1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21483 1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21484 1-Octadecanoyl-sn-glycero-3-phosphoethanolamine
D00448 Sulfasalazine (USP/INN)
Reference
Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
Title
Regulated necrosis: disease relevance and therapeutic opportunities.
Journal
Reference
Authors
Yang WS, Stockwell BR
Title
Ferroptosis: Death by Lipid Peroxidation.
Journal
Reference
Authors
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H
Title
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
Journal
Reference
Authors
D'Herde K, Krysko DV
Title
Ferroptosis: Oxidized PEs trigger death.
Journal
Reference
Authors
Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S
Title
Ferroptosis and cell death mechanisms in Parkinson's disease.
Journal
Reference
Authors
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
Title
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Journal
Reference
Authors
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D
Title
Ferroptosis: process and function.
Journal
Reference
Authors
Murphy ME
Title
Ironing out how p53 regulates ferroptosis.
Journal
Reference
Authors
Muckenthaler MU, Rivella S, Hentze MW, Galy B
Title
A Red Carpet for Iron Metabolism.
Journal
Reference
Authors
Yu H, Guo P, Xie X, Wang Y, Chen G
Title
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.
Journal
Reference
Authors
Wang SJ, Ou Y, Jiang L, Gu W
Title
Ferroptosis: A missing puzzle piece in the p53 blueprint?
Journal
Reference
Authors
Cao JY, Dixon SJ
Title
Mechanisms of ferroptosis.
Journal
Reference
Authors
Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW
Title
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
Journal
Reference
Authors
Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ
Title
The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.
Journal
Reference
Authors
Kwon MY, Park E, Lee SJ, Chung SW
Title
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.
Journal
Reference
Authors
Reed JC, Pellecchia M
Title
Ironing out cell death mechanisms.
Journal
Related pathway
ko00900 Terpenoid backbone biosynthesis
LinkDB
All DBs