Entry Name Kedarcidin 2-hydroxynaphthoate moiety biosynthesis, malonyl-CoA => 3,6,8-trihydroxy-2-naphthoate => 3-hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA
Definition K21221 K21222 K21223 K21224 K21225
Diagram Orthology kedU38; iterative type I polyketide synthase KedU38
kedN3; cytochrome P450 monooxygenase [EC:1.14.-.-] [RN:
R11387 ]
kedN1; O-methyltransferase [EC:2.1.1.-] [RN:
R11388 ]
kedN5; radical SAM C-methyltransferase [RN:
R11389 ]
kedN2; acyl-CoA synthetase [RN:
R11390 ]
Ortholog table Taxonomy Module table Class Pathway modules; Biosynthesis of terpenoids and polyketides; Enediyne biosynthesisBRITE hierarchy
Pathway map01059 Biosynthesis of enediyne antibiotics
map01110 Biosynthesis of secondary metabolites
Reaction Compound C21320 3,6,8-Trihydroxy-2-naphthoate
C21321 3,6,7,8-Tetrahydroxy-2-naphthoate
C21322 3-Hydroxy-6,7,8-trimethoxy-2-naphthoate
C21323 3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoate
C21324 3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA
Reference Authors Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
Title Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
Journal LinkDB All DBs
