Methylobacterium sp. 4-46: M446_1239
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Entry
M446_1239 CDS
T00679
Name
(GenBank) 2-oxo-acid dehydrogenase E1 subunit, homodimeric type
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
met
Methylobacterium sp. 4-46
Pathway
met00010
Glycolysis / Gluconeogenesis
met00020
Citrate cycle (TCA cycle)
met00620
Pyruvate metabolism
met00785
Lipoic acid metabolism
met01100
Metabolic pathways
met01110
Biosynthesis of secondary metabolites
met01120
Microbial metabolism in diverse environments
met01200
Carbon metabolism
met01210
2-Oxocarboxylic acid metabolism
Module
met_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
met00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
M446_1239
00020 Citrate cycle (TCA cycle)
M446_1239
00620 Pyruvate metabolism
M446_1239
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
M446_1239
Enzymes [BR:
met01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
M446_1239
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Gene cluster
GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_N
Transketolase_C
Motif
Other DBs
NCBI-ProteinID:
ACA15763
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Position
1359166..1361820
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AA seq
884 aa
AA seq
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MDSTRDPDPIETREWLDSLDGVLEVEGPDRAHFLIEQVIEEARKKGAPVPYSANTAYLNT
IPLEAQAKHPGDRAIEHRIRSAIRWNAIAIILRNNKDSSELGGHIASFQSAATLYDTGFM
HFWRGASDGHGGDLIYVQGHCSPGIYARAFLEGRITEEQLLSFRQEVSGKGLSSYPHPWL
MPDFWQFPTVSMGLGPLMAIYQARYLRYLHHRGLADTDRRKVWAFMGDGEMDEPESLGAI
SLAAREKLDNLVFVINCNLQRLDGPVRGNGKIVQELEANFRGAGWNVIKVLWGSGWDALL
ARDTSGMLARLMTECVDGEYQDFKSKNGAYIREHFFGRYPETKALVADWSDDDIWRLTRG
GHDPSKVYAAYHAAVNHKGQPTVILAKTVKGYGMGEAGEAQNITHQQKKMGEAVLRQFRD
RFQIDLTDDKLTEIPFIRFPDGSPEHRYLMARRQALGGPLPARRQKSQSLEVPPLSAFSA
QLKETAGREISTTMAFVRVLNTLLRDKEIGKRIVPIVPDESRTFGMEGMFRQFGIFSQVG
QLYRPEDANQLMYYKEDKNGQMLQEGINEAGAMSSWIAAATSYSHSNAPTIPFYIYYSMF
GFQRVGDLAWAAGDLRARGFLIGGTAGRTTLNGEGLQHEDGHSHLFSATIPNCVSYDPTF
SYEVAVIVQDGLRRMYGEQEDVFYYITVMNENYEHPGMPDGAQEGIIKGMYLFREGKGKG
PRVQLLGSGTILREVIAGAELLEKDFGIVADIWSCPSFTELARDAMAVERWNMLHPTETP
RKSYVETCLSGRSGPVIAASDYMRLFADQIRPFVPARYKVLGTDGFGRSDYRVRLRDFFE
VDRRWVAVAALKSLAEDKRVPTAKVVEAIAKYGIDPGKPAPWTV
NT seq
2655 nt
NT seq
+upstream
nt +downstream
nt
ttggattccacacgcgatcccgatccgatcgaaacccgcgaatggctcgactccctggat
ggcgtcctggaggtcgagggtcctgaccgggcgcacttcctgatcgagcaggtgatcgag
gaggcccgcaagaagggcgctcccgtcccctactccgccaacaccgcctacctgaacacg
attcccctcgaggcgcaggccaagcacccgggcgaccgcgccatcgagcaccgcatccgc
tcggcgatccgctggaacgccatcgcgatcatcctgcgcaacaacaaggattcctcggag
ctgggcggccacatcgcgagcttccagtccgccgcgacgctctacgacaccggcttcatg
catttctggcgcggggcgagcgacggccacggcggcgacctgatctacgtccagggtcat
tgctcgccgggcatctacgcccgcgccttcctggagggccggatcacggaggagcagttg
ctctccttccgccaggaggtctccggcaagggcctgtcctcctatccgcatccctggctg
atgccggatttctggcaattcccgaccgtctcgatgggcctcgggccgctgatggcgatc
taccaggcgcggtatctccgctacctgcaccatcgcggcctcgccgacaccgaccgtcgc
aaggtctgggccttcatgggcgacggcgagatggacgagcccgagtccctcggcgcgatc
tccctcgccgcgcgggagaaactcgacaacctcgtcttcgtgatcaactgcaacctgcag
cgcctcgacgggccggtgcgcggcaacggcaagatcgtccaggagctggaggccaatttc
cgcggcgcgggctggaacgtcatcaaggtgctgtggggctcagggtgggacgcgctgctc
gcccgcgacacatcgggcatgctggcccgcctgatgaccgagtgcgtcgacggcgagtac
caggacttcaagtcgaagaacggcgcctacatccgcgagcacttcttcggccgctatccg
gagaccaaggcgctggtcgccgactggagcgacgacgacatctggcggctgacccgcggc
ggccacgaccccagcaaggtctacgcggcctaccacgccgcggtgaaccacaagggccag
cccaccgtcatcctcgccaagaccgtcaagggctacggcatgggcgaggccggcgaggcc
cagaacatcacccaccagcagaagaagatgggcgaggcggtcctccggcagttccgcgac
cgcttccagatcgacctcaccgacgacaagctcaccgagatcccgttcatccgcttcccc
gacgggagccccgagcaccgctacctgatggcgcggcgccaagccctcggcgggccgctg
ccggcgcggcggcagaagtcgcagagcctggaggtgcctccgctctcggccttctcggcc
cagctcaaggagacggcgggccgggagatctccaccaccatggccttcgtgcgggtgctc
aacacgctcctgcgcgacaaggagatcggcaagcgcatcgtgccgatcgtgcccgacgag
agccgcaccttcggcatggagggcatgttccgccagttcggcatcttcagccaggtcggc
cagctctaccggcccgaggatgccaaccagctgatgtactacaaggaggacaagaacggg
cagatgctgcaggagggcatcaacgaggccggggcgatgtcgtcctggatcgcggcggcg
acctcctactcgcactcgaacgcgccgacgatcccgttctacatctactactcgatgttc
ggcttccagcgggtcggcgacctggcctgggcggcgggcgacctgcgggcgcgcggcttc
ctgatcggcggcacggccgggcgcaccacgctcaacggcgaggggctgcagcacgaggac
ggccacagccacctgttctcggccacgatcccgaactgcgtctcctacgacccgaccttc
tcgtacgaggtggcggtgatcgtgcaggacggtctgcgccggatgtacggcgagcaggag
gacgtcttctactacatcaccgtgatgaacgagaactacgagcatccgggcatgccggac
ggagcgcaggagggcatcatcaaggggatgtacctgttccgcgagggcaaggggaagggc
ccgcgggtgcagctcctgggctcgggcacgatcctgcgcgaggtcatcgccggggccgaa
ctcctggagaaggatttcggcatcgtggccgacatctggtcctgcccgagcttcacggag
ctggcgcgcgacgccatggcggtggagcgctggaacatgctccacccgaccgagaccccg
cgcaaatcctacgtcgagacctgcctgtcgggccgctccggcccggtgatcgcggcgagc
gactacatgcggctgttcgccgaccagatccgccccttcgtgcccgcccgctacaaggtg
ctcggcacggacgggttcgggcgctcggactaccgggtacgcctgcgcgacttcttcgag
gtcgaccggcgctgggtcgccgtggcggcgctcaagagcctcgcggaggacaaacgggtc
ccgaccgcgaaggtggtggaggccatcgccaagtacggcatcgaccccggcaagcccgcg
ccctggacggtctag
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