KEGG   NETWORK: N00187
Entry
N00187                      Network                                

Name
KSHV Kaposin B to p38 signaling pathway
Definition
MAPK14 -> (MK2+K12) -| TTP
  Expanded
1432 -> (9261+K21656) -| 7538
Class
nt06211 Other MAPK signaling
nt06110 MAPK signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
1432  MAPK14; mitogen-activated protein kinase 14
9261  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
7538  ZFP36; ZFP36 ring finger protein
Perturbant
K21656 (K12)  K12; KSHV protein K12
Reference
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
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