KEGG   DISEASE: Kaposi sarcoma
H00041                      Disease                                
Kaposi sarcoma
Solid tumor [DS:H02421]
Soft tissue sarcomas [DS:H02427]
Kaposi sarcoma (KS) is an angioproliferative disease classified into classic KS, endemic KS, iatrogenic KS, and HIV-associated KS (HIV-KS), however, they share the same histological traits and are all associated with infection by the human herpesvirus 8 (HHV8; also known as KSHV). Evidence indicates that KS progression occurs upon the deregulated expression of anti-apoptotic genes (Bcl-2), oncogenes (c-myc, c-int, ras) and oncosuppressor genes (TP53), and is associated with the long-lasting expression of HHV8 latency genes (LANA, v-cyc D, v-FLIP, Kaposin). All these genes are, in fact, expressed or altered in most KS spindle cells in the nodular-late stage of KS. Bcl-2 acts as a major KS progression factor, and TP53 and c-myc may also have a role in disease progression. HHV8 latency gene products may be involved in KS progression due to their capability of promoting cell growth by direct effects or antiapoptotic effects.
Cancer; Viral infectious disease
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant mesenchymal neoplasms
     2B57  Kaposi sarcoma, primary site
      H00041  Kaposi sarcoma
Pathway-based classification of diseases [BR:br08402]
 Signal transduction
  nt06505  WNT signaling
   H00041  Kaposi sarcoma
  nt06518  JAK-STAT signaling
   H00041  Kaposi sarcoma
  nt06516  TNF signaling
   H00041  Kaposi sarcoma
 Cellular process
  nt06532  Autophagy
   H00041  Kaposi sarcoma
  nt06524  Apoptosis
   H00041  Kaposi sarcoma
 Immune system
  nt06513  Complement cascade
   H00041  Kaposi sarcoma
  nt06517  TLR signaling
   H00041  Kaposi sarcoma
  nt06533  Chemokine signaling
   H00041  Kaposi sarcoma
Genome-based classification of infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H00041  Kaposi sarcoma
hsa05167  Kaposi sarcoma-associated herpesvirus infection
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06505 WNT signaling
nt06513 Complement cascade
nt06516 TNF signaling
nt06517 TLR signaling
nt06518 JAK-STAT signaling
nt06524 Apoptosis
nt06532 Autophagy
nt06533 Chemokine signaling
BCL2 (overexpression) [HSA:596] [KO:K02161]
MYC (overexpression) [HSA:4609] [KO:K04377]
FGF3 (overexpression, mutation) [HSA:2248] [KO:K04358]
KRAS (overexpression, mutation) [HSA:3845] [KO:K07827]
TP53 [HSA:7157] [KO:K04451]
Human herpesvirus 8 (KSHV) [GN:T40081]
Human immunodeficiency virus 1 [GN:T40001]
Alitretinoin [DR:D02815]
Vinblastine sulfate [DR:D01068]
Paclitaxel [DR:D00491]
Doxorubicin hydrochloride [DR:D01275]
Interferon alfa-2b [DR:D02745]
Other DBs
ICD-11: 2B57
ICD-10: C46
MeSH: D012514
PMID:11423257 (GENE)
Ensoli B, Sgadari C, Barillari G, Sirianni MC, Sturzl M, Monini P
Biology of Kaposi's sarcoma.
Eur J Cancer 37:1251-69 (2001)
Schwartz RA.
Kaposi's sarcoma: an update.
J Surg Oncol 87:146-51 (2004)

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