KEGG   NETWORK: N00425Help
Entry
N00425                      Network                                

Name
HCMV UL36 to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
hcmvUL36 -| CASP8 -> BID -> (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
K22788 -| 841 -> 637 -> (581,578) -> 54205 -- 317 -> 842 -> 836
Class
nt06131 Apoptosis (viruses and bacteria)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
841  CASP8; caspase 8
637  BID; BH3 interacting domain death agonist
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K22788  UL36; viral inhibitor of caspase-8-induced apoptosis
Reference
  Authors
Brune W
  Title
Inhibition of programmed cell death by cytomegaloviruses.
  Journal
Virus Res 157:144-50 (2011)
DOI:10.1016/j.virusres.2010.10.012
Reference
  Authors
Michaelis M, Kotchetkov R, Vogel JU, Doerr HW, Cinatl J Jr
  Title
Cytomegalovirus infection blocks apoptosis in cancer cells.
  Journal
Cell Mol Life Sci 61:1307-16 (2004)
DOI:10.1007/s00018-004-3417-4
Reference
  Authors
Brune W, Andoniou CE
  Title
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
  Journal
Viruses 9:E249 (2017)
DOI:10.3390/v9090249
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