KEGG   NETWORK: N00724Help
Entry
N00724                      Network                                

Name
IAV NS1 to oligoadenylate synthetase (OAS)/RNase L pathway
Definition
iavNS1 -| OAS -> 2-5A -> RNASEL
  Expanded
K19396 -| (4938,4939,4940) -> C20935 -> 6041
Class
nt06137 OAS/RNase L pathway (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
6041  RNASEL; ribonuclease L
Perturbant
K19396  NS1; non-structural protein 1
Metabolite
C20935  2-5A
Reference
  Authors
Osterlund P, Strengell M, Sarin LP, Poranen MM, Fagerlund R, Melen K, Julkunen I
  Title
Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry.
  Journal
J Virol 86:11183-93 (2012)
DOI:10.1128/JVI.01050-12
Reference
  Authors
Hale BG, Randall RE, Ortin J, Jackson D
  Title
The multifunctional NS1 protein of influenza A viruses.
  Journal
J Gen Virol 89:2359-76 (2008)
DOI:10.1099/vir.0.2008/004606-0
Reference
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
LinkDB All DBs

DBGET integrated database retrieval system