KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100588468
Entry
100588468         CDS       T03265                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521  EGFR tyrosine kinase inhibitor resistance
nle01522  Endocrine resistance
nle04010  MAPK signaling pathway
nle04012  ErbB signaling pathway
nle04014  Ras signaling pathway
nle04062  Chemokine signaling pathway
nle04068  FoxO signaling pathway
nle04072  Phospholipase D signaling pathway
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04380  Osteoclast differentiation
nle04510  Focal adhesion
nle04540  Gap junction
nle04550  Signaling pathways regulating pluripotency of stem cells
nle04630  JAK-STAT signaling pathway
nle04650  Natural killer cell mediated cytotoxicity
nle04660  T cell receptor signaling pathway
nle04662  B cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04714  Thermogenesis
nle04722  Neurotrophin signaling pathway
nle04910  Insulin signaling pathway
nle04912  GnRH signaling pathway
nle04915  Estrogen signaling pathway
nle04917  Prolactin signaling pathway
nle04926  Relaxin signaling pathway
nle04935  Growth hormone synthesis, secretion and action
nle05034  Alcoholism
nle05160  Hepatitis C
nle05161  Hepatitis B
nle05163  Human cytomegalovirus infection
nle05165  Human papillomavirus infection
nle05200  Pathways in cancer
nle05203  Viral carcinogenesis
nle05205  Proteoglycans in cancer
nle05206  MicroRNAs in cancer
nle05210  Colorectal cancer
nle05211  Renal cell carcinoma
nle05213  Endometrial cancer
nle05214  Glioma
nle05215  Prostate cancer
nle05220  Chronic myeloid leukemia
nle05221  Acute myeloid leukemia
nle05223  Non-small cell lung cancer
nle05224  Breast cancer
nle05225  Hepatocellular carcinoma
nle05226  Gastric cancer
nle05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100588468 (GRB2)
   04012 ErbB signaling pathway
    100588468 (GRB2)
   04014 Ras signaling pathway
    100588468 (GRB2)
   04630 JAK-STAT signaling pathway
    100588468 (GRB2)
   04068 FoxO signaling pathway
    100588468 (GRB2)
   04072 Phospholipase D signaling pathway
    100588468 (GRB2)
   04151 PI3K-Akt signaling pathway
    100588468 (GRB2)
   04150 mTOR signaling pathway
    100588468 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100588468 (GRB2)
   04540 Gap junction
    100588468 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100588468 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100588468 (GRB2)
   04660 T cell receptor signaling pathway
    100588468 (GRB2)
   04662 B cell receptor signaling pathway
    100588468 (GRB2)
   04664 Fc epsilon RI signaling pathway
    100588468 (GRB2)
   04062 Chemokine signaling pathway
    100588468 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100588468 (GRB2)
   04912 GnRH signaling pathway
    100588468 (GRB2)
   04915 Estrogen signaling pathway
    100588468 (GRB2)
   04917 Prolactin signaling pathway
    100588468 (GRB2)
   04926 Relaxin signaling pathway
    100588468 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    100588468 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100588468 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100588468 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    100588468 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100588468 (GRB2)
   05206 MicroRNAs in cancer
    100588468 (GRB2)
   05205 Proteoglycans in cancer
    100588468 (GRB2)
   05203 Viral carcinogenesis
    100588468 (GRB2)
   05231 Choline metabolism in cancer
    100588468 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100588468 (GRB2)
   05225 Hepatocellular carcinoma
    100588468 (GRB2)
   05226 Gastric cancer
    100588468 (GRB2)
   05214 Glioma
    100588468 (GRB2)
   05221 Acute myeloid leukemia
    100588468 (GRB2)
   05220 Chronic myeloid leukemia
    100588468 (GRB2)
   05211 Renal cell carcinoma
    100588468 (GRB2)
   05215 Prostate cancer
    100588468 (GRB2)
   05213 Endometrial cancer
    100588468 (GRB2)
   05224 Breast cancer
    100588468 (GRB2)
   05223 Non-small cell lung cancer
    100588468 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    100588468 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100588468 (GRB2)
   05160 Hepatitis C
    100588468 (GRB2)
   05163 Human cytomegalovirus infection
    100588468 (GRB2)
   05165 Human papillomavirus infection
    100588468 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100588468 (GRB2)
   01522 Endocrine resistance
    100588468 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nle04131]
    100588468 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:nle04990]
    100588468 (GRB2)
Membrane trafficking [BR:nle04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    100588468 (GRB2)
Domain-containing proteins not elsewhere classified [BR:nle04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   100588468 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 100588468
NCBI-ProteinID: XP_003279121
Ensembl: ENSNLEG00000000865
UniProt: A0A2I3HAR1
LinkDB
Position
14
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaacgaagaatgtgatcagaactggtacaaggcagag
cttaatggaaaagacggcttcattcccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagtgagagcgctcctggggacttctccctctctgtcaag
tttggaaacgatgtgcagcacttcaaggtgctccgagatggagccggaaagtacttcctc
tgggtggtgaagttcaattctttgaatgagctggtggattatcacagatctacatctgtc
tccagaaaccagcagatattcctgcgggacatagaacaggtgccacagcagccgacatac
gtccaggccctctttgactttgatccccaggaggatggagagctgggcttccgccgggga
gattttatccatgtcatggataactcagaccccaactggtggaaaggagcttgccacggg
cagaccggcatgtttccccgcaattatgtcacccctgtgaaccggaacgtctaa

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