Pongo abelii (Sumatran orangutan): 100450941
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Entry
100450941 CDS
T01416
Gene name
PLCG1
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2
KO
K01116
phosphatidylinositol phospholipase C, gamma-1 [EC:
3.1.4.11
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon00562
Inositol phosphate metabolism
pon01100
Metabolic pathways
pon01521
EGFR tyrosine kinase inhibitor resistance
pon04012
ErbB signaling pathway
pon04014
Ras signaling pathway
pon04015
Rap1 signaling pathway
pon04020
Calcium signaling pathway
pon04062
Chemokine signaling pathway
pon04064
NF-kappa B signaling pathway
pon04066
HIF-1 signaling pathway
pon04070
Phosphatidylinositol signaling system
pon04072
Phospholipase D signaling pathway
pon04360
Axon guidance
pon04370
VEGF signaling pathway
pon04650
Natural killer cell mediated cytotoxicity
pon04658
Th1 and Th2 cell differentiation
pon04659
Th17 cell differentiation
pon04660
T cell receptor signaling pathway
pon04664
Fc epsilon RI signaling pathway
pon04666
Fc gamma R-mediated phagocytosis
pon04670
Leukocyte transendothelial migration
pon04722
Neurotrophin signaling pathway
pon04750
Inflammatory mediator regulation of TRP channels
pon04919
Thyroid hormone signaling pathway
pon04933
AGE-RAGE signaling pathway in diabetic complications
pon04935
Growth hormone synthesis, secretion and action
pon05012
Parkinson disease
pon05022
Pathways of neurodegeneration - multiple diseases
pon05135
Yersinia infection
pon05167
Kaposi sarcoma-associated herpesvirus infection
pon05170
Human immunodeficiency virus 1 infection
pon05171
Coronavirus disease - COVID-19
pon05200
Pathways in cancer
pon05205
Proteoglycans in cancer
pon05206
MicroRNAs in cancer
pon05214
Glioma
pon05223
Non-small cell lung cancer
pon05225
Hepatocellular carcinoma
pon05231
Choline metabolism in cancer
pon05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Module
pon_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100450941 (PLCG1)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
100450941 (PLCG1)
04014 Ras signaling pathway
100450941 (PLCG1)
04015 Rap1 signaling pathway
100450941 (PLCG1)
04370 VEGF signaling pathway
100450941 (PLCG1)
04064 NF-kappa B signaling pathway
100450941 (PLCG1)
04066 HIF-1 signaling pathway
100450941 (PLCG1)
04020 Calcium signaling pathway
100450941 (PLCG1)
04070 Phosphatidylinositol signaling system
100450941 (PLCG1)
04072 Phospholipase D signaling pathway
100450941 (PLCG1)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100450941 (PLCG1)
04660 T cell receptor signaling pathway
100450941 (PLCG1)
04658 Th1 and Th2 cell differentiation
100450941 (PLCG1)
04659 Th17 cell differentiation
100450941 (PLCG1)
04664 Fc epsilon RI signaling pathway
100450941 (PLCG1)
04666 Fc gamma R-mediated phagocytosis
100450941 (PLCG1)
04670 Leukocyte transendothelial migration
100450941 (PLCG1)
04062 Chemokine signaling pathway
100450941 (PLCG1)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
100450941 (PLCG1)
04919 Thyroid hormone signaling pathway
100450941 (PLCG1)
09156 Nervous system
04722 Neurotrophin signaling pathway
100450941 (PLCG1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
100450941 (PLCG1)
09158 Development and regeneration
04360 Axon guidance
100450941 (PLCG1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100450941 (PLCG1)
05206 MicroRNAs in cancer
100450941 (PLCG1)
05205 Proteoglycans in cancer
100450941 (PLCG1)
05231 Choline metabolism in cancer
100450941 (PLCG1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100450941 (PLCG1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
100450941 (PLCG1)
05214 Glioma
100450941 (PLCG1)
05223 Non-small cell lung cancer
100450941 (PLCG1)
09164 Neurodegenerative disease
05012 Parkinson disease
100450941 (PLCG1)
05022 Pathways of neurodegeneration - multiple diseases
100450941 (PLCG1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100450941 (PLCG1)
09171 Infectious disease: bacterial
05135 Yersinia infection
100450941 (PLCG1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100450941 (PLCG1)
05171 Coronavirus disease - COVID-19
100450941 (PLCG1)
05167 Kaposi sarcoma-associated herpesvirus infection
100450941 (PLCG1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100450941 (PLCG1)
Enzymes [BR:
pon01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
100450941 (PLCG1)
Membrane trafficking [BR:
pon04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
100450941 (PLCG1)
Endocytosis
Macropinocytosis
Phospholipase C
100450941 (PLCG1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
C2
SH3_1
PH
SH3_9
SH3_2
PH_12
GDPD
PH_9
Motif
Other DBs
NCBI-GeneID:
100450941
NCBI-ProteinID:
XP_009231862
Ensembl:
ENSPPYG00000011011
UniProt:
H2P1Y0
LinkDB
All DBs
Position
20
AA seq
1291 aa
AA seq
DB search
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKVKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISVEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQIINPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED
FRISQEHLTDHFDSRERRAPRRTRVNGDNRL
NT seq
3876 nt
NT seq
+upstream
nt +downstream
nt
atggcgggcgctgcgtccccttgcgccaacggctgcgggcccggcgccccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccgtggtgccgacaagatcgagggggccattgatattcgtgaaattaaggag
atccgcccagggaagacctcacgggactttgatcgctatcaagaggacccagctttccgg
ccggaccagtcacattgctttgtcattctctatggaatggaatttcgcctgaaaacgctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacaccgctgcagattgagaggtggctccggaagcag
ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac
taccagggggagctgtgggctgttgatcgcctccaggtgcaggagttcatgctcagcttc
ctccgagaccccttacgagagatcgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcacagctggatgcagtatgcccggac
accatgaacaaccctctttcccactactggatctcctcctcgcacaacacgtacctgacc
ggggaccagttctccagtgagtcctccttggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccggatgggatgccagttatttaccat
ggtcacacccttaccaccaagatcaagttctcagatgtcctgcataccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagtacttcaagaaggtgctgggggacacactcctcaccaag
cccgtggagatctccgccgatgggctcccctcacccaaccagcttaagaggaagatcctt
atcaagcacaagaagctggctgagggcagtgcctatgaggaggtgcctacatccatgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccacgaatggtatccccactactttgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgac
gggcgtcacatcgctgagcgcctgctcactgagtactgcatcgagactggagcccctgac
ggctccttcctcgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcccggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacacactaccag
caggtgcccctgcgctgtaatgagtttgagatgcgactttcagagcctgtcccacagacc
aacgcccacgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctaatgcgcgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgagggcaagatcaagcattgccgtgtccagcaagag
ggccagacagtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaaacacccactataccgcaagatgaagctgcgctatcccatcaacgaggaggca
ttggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcggtcaaagccctcttt
gactacaaggcccagagggaggacgagctgaccttcaccaagagcgccatcatccagaat
gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctgtgg
ttcccatcaaactatgtggaagagatggtcaaccccgtggccctggagccggagagggag
cacttggacgagaacagccccctaggggacttgctgcggggcgtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg
aagataatggaacggaggaagaagattgccctggagctctctgaacttgtcgtctactgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggtcaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagtcagctcgtggccctcaacttc
cagacccctgacaagcctatgcagatgaaccaggccctcttcatgacgggcaggcactgt
ggctacgtgctgcagccaagcaccatgcgggatgaggccttcgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctctgttgaggtgctgggggcccgacatctg
ccaaagaatggccgaggcattgtgtgtccttttgtggagatagaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggactcaaccctgtatgg
ccagccaagcccttccacttccagatcattaaccctgaatttgcctttctgcgcttcgtg
gtgtatgaggaagacatgtttagtgaccagaatttcttggctcaggctactttcccagta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggacctg
gagttggcctccctgctgatcaagattgacattttccctgccaagcaggagaatggtgac
ctcagtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctg
tttcacggccgagcccgggaaggctcctttgaatcccgctaccagcagccatttgaggac
ttccgcatctcccaggagcatctcacagaccattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaatggagacaaccgcctctag
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integrated database retrieval system
