KEGG   ORTHOLOGY: K01116
Entry
K01116                      KO                                     
Symbol
PLCG1
Name
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Pathway
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map01521  EGFR tyrosine kinase inhibitor resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04070  Phosphatidylinositol signaling system
map04072  Phospholipase D signaling pathway
map04360  Axon guidance
map04370  VEGF signaling pathway
map04613  Neutrophil extracellular trap formation
map04650  Natural killer cell mediated cytotoxicity
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04670  Leukocyte transendothelial migration
map04722  Neurotrophin signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map04919  Thyroid hormone signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map04935  Growth hormone synthesis, secretion and action
map05012  Parkinson disease
map05022  Pathways of neurodegeneration - multiple diseases
map05110  Vibrio cholerae infection
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05131  Shigellosis
map05135  Yersinia infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05223  Non-small cell lung cancer
map05225  Hepatocellular carcinoma
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04014 Ras signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04015 Rap1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04370 VEGF signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04064 NF-kappa B signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04066 HIF-1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04020 Calcium signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04070 Phosphatidylinositol signaling system
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04072 Phospholipase D signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04650 Natural killer cell mediated cytotoxicity
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04660 T cell receptor signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04658 Th1 and Th2 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04659 Th17 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04664 Fc epsilon RI signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04666 Fc gamma R-mediated phagocytosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04670 Leukocyte transendothelial migration
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04062 Chemokine signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04919 Thyroid hormone signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09158 Development and regeneration
   04360 Axon guidance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05206 MicroRNAs in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05205 Proteoglycans in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05231 Choline metabolism in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05214 Glioma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05223 Non-small cell lung cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05171 Coronavirus disease - COVID-19
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05131 Shigellosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05135 Yersinia infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05022 Pathways of neurodegeneration - multiple diseases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 5335(PLCG1)
PTR: 458253(PLCG1)
PPS: 100995010(PLCG1)
GGO: 101135199(PLCG1)
PON: 100450941(PLCG1)
NLE: 100591458(PLCG1)
MCC: 697069(PLCG1)
MCF: 102138726(PLCG1)
CSAB: 103245987(PLCG1)
CATY: 105588401(PLCG1)
PANU: 101012165(PLCG1)
TGE: 112632711(PLCG1)
RRO: 104672220(PLCG1)
RBB: 108519825(PLCG1)
TFN: 117068778(PLCG1)
PTEH: 111553217(PLCG1)
CJC: 100397497(PLCG1)
SBQ: 101046976(PLCG1)
CSYR: 103262907(PLCG1)
MMUR: 105865830(PLCG1)
OGA: 100948398(PLCG1)
MMU: 18803(Plcg1)
MCAL: 110290454(Plcg1)
MPAH: 110319649(Plcg1)
RNO: 25738(Plcg1)
MCOC: 116091317(Plcg1)
MUN: 110552794(Plcg1)
CGE: 100769697(Plcg1)
PLEU: 114692579(Plcg1)
NGI: 103747244(Plcg1)
HGL: 101705192(Plcg1)
CPOC: 100716986(Plcg1)
CCAN: 109683399(Plcg1)
DORD: 105981663(Plcg1)
DSP: 122120202(Plcg1)
NCAR: 124977089
OCU: 100349958(PLCG1)
OPI: 101520175(PLCG1)
TUP: 102469651(PLCG1)
CFA: 485874(PLCG1)
VVP: 112928123(PLCG1)
VLG: 121477887(PLCG1)
AML: 100480586(PLCG1)
UMR: 103669754(PLCG1)
UAH: 113258609(PLCG1)
UAR: 123796994(PLCG1)
ELK: 111141423
LLV: 125109927
MPUF: 101685356(PLCG1)
ORO: 101380728(PLCG1)
EJU: 114223136(PLCG1)
ZCA: 113938304(PLCG1)
MLX: 118011488(PLCG1)
FCA: 101092925(PLCG1)
PYU: 121012188(PLCG1)
PBG: 122496268(PLCG1)
PTG: 102952137(PLCG1)
PPAD: 109272437(PLCG1)
AJU: 106974495(PLCG1)
HHV: 120228585(PLCG1)
BTA: 281987(PLCG1)
BOM: 102265099(PLCG1)
BIU: 109567698(PLCG1)
BBUB: 102400354(PLCG1)
CHX: 102181878(PLCG1)
OAS: 101103341(PLCG1)
ODA: 120869330(PLCG1)
CCAD: 122448704(PLCG1)
SSC: 100152497(PLCG1)
CFR: 102524452(PLCG1)
CBAI: 105071939(PLCG1)
CDK: 105085024(PLCG1)
VPC: 102542680(PLCG1)
BACU: 103016663(PLCG1)
LVE: 103068930(PLCG1)
OOR: 101281412(PLCG1)
DLE: 111184170(PLCG1)
PCAD: 102992700(PLCG1)
PSIU: 116740089(PLCG1)
ECB: 100070545(PLCG1)
EPZ: 103562208(PLCG1)
EAI: 106834358(PLCG1)
MYB: 102248243(PLCG1)
MYD: 102756475(PLCG1)
MMYO: 118662889(PLCG1)
MLF: 102421330(PLCG1)
MNA: 107542131(PLCG1)
PKL: 118708113(PLCG1)
HAI: 109379925(PLCG1)
DRO: 112303845(PLCG1)
SHON: 118985484(PLCG1)
AJM: 119063199(PLCG1)
PDIC: 114506303(PLCG1)
PHAS: 123814793(PLCG1)
MMF: 118618299(PLCG1)
RFQ: 117015909(PLCG1)
PALE: 102896228(PLCG1)
PGIG: 120603668(PLCG1)
PVP: 105296521(PLCG1)
RAY: 107506741(PLCG1)
MJV: 108407248(PLCG1)
TOD: 119235450(PLCG1)
SARA: 101545860(PLCG1)
LAV: 100677739(PLCG1)
TMU: 101359597
DNM: 101411498(PLCG1)
MDO: 100032696(PLCG1)
GAS: 123237416(PLCG1)
SHR: 100923119(PLCG1)
PCW: 110216705(PLCG1)
OAA: 100078757(PLCG1)
GGA: 419175(PLCG1) 776273
PCOC: 116227799 116235162(PLCG1)
MGP: 100542272 100548670(PLCG1)
CJO: 107310620 107322901(PLCG1)
NMEL: 110393955 110408143(PLCG1)
APLA: 101792010 101798692(PLCG1)
ACYG: 106042207 106043486(PLCG1)
AFUL: 116486200 116495680(PLCG1)
TGU: 100220070(PLCG1) 115494036
LSR: 110469274(PLCG1) 110475168
SCAN: 103818789(PLCG1) 103826392
PMOA: 120504669 120511282(PLCG1)
OTC: 121333386 121343724(PLCG1)
PRUF: 121349284 121359593(PLCG1)
GFR: 102032882(PLCG1) 102038983
FAB: 101806517(PLCG1) 101820005
PHI: 102100949 102114427(PLCG1)
PMAJ: 107200506 107213300(PLCG1)
CCAE: 111925206 111938259(PLCG1)
CCW: 104687887(PLCG1) 104692596
ZAB: 102063253(PLCG1) 102070810
FPG: 101912447(PLCG1) 101918282
FCH: 102046961 102057302(PLCG1)
CLV: 102098341(PLCG1) 102098590
EGZ: 104128859 104132170(PLCG1)
NNI: 104009589(PLCG1) 104020599
ACUN: 113477170 113487655(PLCG1)
PADL: 103912439(PLCG1) 103925979
ACHC: 115339114(PLCG1) 115340577
AAM: 106488145(PLCG1) 106494802
AROW: 112967901 112971424(PLCG1)
NPD: 112949622(PLCG1) 112954009
DNE: 112979055(PLCG1) 112991307
ASN: 102368895 102369875(PLCG1)
AMJ: 102563626(PLCG1) 102574067
CPOO: 109313182(PLCG1) 109322589
GGN: 109292397(PLCG1) 109305247
PSS: 102459944(PLCG1) 102461099
CMY: 102944142(PLCG1) 102946940
CPIC: 101930905 101935550(PLCG1)
TST: 117873861 117885831(PLCG1)
CABI: 116815149 116817342(PLCG1)
ACS: 100559347(plcg1) 100566976
PVT: 110070157 110076765(PLCG1)
SUND: 121929364(PLCG1) 121929490
PBI: 103062888 103064933(PLCG1)
PMUR: 107287257(PLCG1) 107298984
TSR: 106549424(PLCG1)
PGUT: 117663635(PLCG1) 117666979
VKO: 123028453(PLCG1) 123035300
PMUA: 114599554(PLCG1) 114600186
ZVI: 118088856(PLCG1) 118089856
GJA: 107109685(PLCG1) 107121439
XLA: 108702812 108719445 398359(plcg1.L) 398360(plcg1.S)
XTR: 100496658 100496674(plcg1)
NPR: 108786812(PLCG1) 108789042
RTEM: 120918704(PLCG1) 120939772
BBUF: 121000970 121003186(PLCG1)
BGAR: 122940991(PLCG1)
DRE: 373867(plcg1)
SANH: 107663201(plcg1) 107703619
CCAR: 109066470 109071906(plcg1)
CAUA: 113040970(plcg1) 113068656
PPRM: 120491887
IPU: 108275796(plcg1)
PHYP: 113545570(plcg1)
SMEO: 124399277(plcg1)
TFD: 113651828(plcg1)
AMEX: 103023099(plcg1)
EEE: 113588884(plcg1)
TRU: 101065481 101069039(plcg1)
LCO: 104925092(plcg1) 104927718
NCC: 104954784 104964925(plcg1)
CGOB: 115006734 115011301(plcg1)
ELY: 117253479 117258827(plcg1)
PLEP: 121946685(plcg1) 121963117
SLUC: 116038103 116062265(plcg1)
ECRA: 117947430(plcg1) 117949908
PFLV: 114558144(plcg1) 114561436
GAT: 120823912(plcg1)
PPUG: 119216496 119223301(plcg1)
MSAM: 119900255 119905411(plcg1)
CUD: 121511686 121517235(plcg1)
MZE: 101470576(plcg1) 101473405
ONL: 100704581(plcg1) 100711065
OAU: 116332045 116334564(plcg1)
OLA: 101163005(plcg1) 101167946
OML: 112150370 112158781(plcg1)
XMA: 102217766(plcg1) 102229810
XCO: 114146805(plcg1) 114151085
XHE: 116725415 116728103(plcg1)
PRET: 103463411 103467475(plcg1)
PFOR: 103129695 103141866(plcg1)
PLAI: 106937578 106940345(plcg1)
PMEI: 106909447(plcg1) 106919104
GAF: 122828386(plcg1) 122838256
CVG: 107083024 107087598(plcg1)
CTUL: 119774047(plcg1) 119787619
GMU: 124869858(plcg1) 124873539
NFU: 107391021(plcg1) 107393039
KMR: 108235263(plcg1) 108248356
ALIM: 106523657(plcg1) 106526007
NWH: 119417581(plcg1) 119430403
AOCE: 111576272(plcg1) 111582127
CSEM: 103385539(plcg1) 103399890
SSEN: 122777504(plcg1) 122781292
HHIP: 117759796 117764528(plcg1)
LCF: 108877896(plcg1) 108879537
SDU: 111219324(plcg1) 111227542
SLAL: 111668916(plcg1) 111671648
XGL: 120790483 120803745(plcg1)
HCQ: 109514977(plcg1) 109524567
BPEC: 110164633(plcg1) 110172233
MALB: 109961232 109964670(plcg1)
SASA: 106560399 106566556(plcg1)
OTW: 112222319(plcg1) 112251330
OMY: 110492526(plcg1) 110523019
OGO: 123996699 124045594(plcg1)
ONE: 115101998(plcg1) 115108766
SALP: 111975516 111976591(plcg1)
SNH: 120054971 120061431(plcg1)
ELS: 105011953 105013964(plcg1)
AANG: 118208555(plcg1) 118225935
LOC: 102684678(plcg1) 102696192
LCM: 102352804 102362442(PLCG1)
CMK: 103186275(plcg1)
RTP: 109912305 109939029(plcg1)
BFO: 118417806
BBEL: 109473767
CIN: 100178711
APLC: 110980002
SKO: 100377901
DME: Dmel_CG4200(sl)
DER: 6550553
DSE: 116801966
DSI: Dsimw501_GD17281(Dsim_GD17281)
DAN: 6501908
DSR: 110181712
DPO: Dpse_GA18024(Dpse_small-wing)
DPE: 6599358
DMN: 108156056
DWI: 6648777
DGR: 6564826
DAZ: 108617824
DNV: 108655465
DHE: 111594077
DVI: 6631556
CCAT: 101461358
BOD: 106621926
MDE: 101900328
SCAC: 106084315
LCQ: 111684567
ACOZ: 120956548
AARA: 120899719
AAG: 5564766
CPII: 120423157
AME: 551709
ACER: 108004149
ALAB: 122711003
BIM: 100748682
BBIF: 117208499
BVK: 117242996
BVAN: 117164972
BTER: 100647687
BPYO: 122574589
CCAL: 108629199
OBB: 114871263
MGEN: 117219131
NMEA: 116428997
CGIG: 122397090
SOC: 105196430
MPHA: 105833149
AEC: 105144421
ACEP: 105624086
PBAR: 105431231
VEM: 105560673
HST: 105188458
DQU: 106743174
CFO: 105257806
FEX: 115235984
LHU: 105673001
PGC: 109852947
OBO: 105286217
PCF: 106786441
PFUC: 122519752
VPS: 122630398
NVI: 100123217
CSOL: 105368048
TPRE: 106659590
MDL: 103577678
CGLO: 123270370
FAS: 105272066
DAM: 107038623
CCIN: 107265921
TCA: 660210
DPA: 109537047
SOY: 115878143
ATD: 109597552
CSET: 123307246
LDC: 111503416
NVL: 108561344
APLN: 108742977
PPYR: 116173773
OTU: 111426782
BMOR: 100329155(PLCg)
BMAN: 114250026
MSEX: 115455765
BANY: 112048663
PMAC: 106717301
PPOT: 106104480
PXU: 106126231
PRAP: 110998146
ZCE: 119835662
HAW: 110374501
TNL: 113505041
SLIU: 111360524
OFU: 114359335
PXY: 105381166
API: 100166969
DNX: 107163682
AGS: 114120080
RMD: 113553363
BTAB: 109035929
DCI: 103520225
CLEC: 106662403
HHAL: 106680176
NLU: 111051096
FOC: 113206987
ZNE: 110834677
CSEC: 111866231
FCD: 110851828
PVM: 113828575
PJA: 122251600
PCHN: 125045593
HAME: 121879670
PCLA: 123755966
PTRU: 123498080
HAZT: 108675741
EAF: 111694868
DSV: 119466610
RSAN: 119376389
RMP: 119176473
VDE: 111246565
VJA: 111264790
TUT: 107359684
CSCU: 111628132
PTEP: 107452539
SDM: 118198563
CEL: CELE_T01E8.3(plc-3)
CBR: CBG_18715(Cbr-plc-3)
TSP: Tsp_10563
BGT: 106062205
CRG: 105340725
MYI: 110450840
PMAX: 117337032
MMER: 123550511
OBI: 106874041
OSN: 115220856
LAK: 106152397
EPA: 110244579
ATEN: 116296605
ADF: 107357605
AMIL: 114966528
PDAM: 113679030
SPIS: 111332971
HMG: 100212273
AQU: 100633163
 » show all
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
Reference
  Authors
Carpenter G, Ji Q
  Title
Phospholipase C-gamma as a signal-transducing element.
  Journal
Exp Cell Res 253:15-24 (1999)
DOI:10.1006/excr.1999.4671
Reference
PMID:2167438
  Authors
Burgess WH, Dionne CA, Kaplow J, Mudd R, Friesel R, Zilberstein A, Schlessinger J, Jaye M
  Title
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
  Journal
Mol Cell Biol 10:4770-7 (1990)
DOI:10.1128/MCB.10.9.4770
  Sequence
[hsa:5335]
LinkDB

DBGET integrated database retrieval system