Pongo abelii (Sumatran orangutan): 100456464 Help Entry 100456464         CDS       T01416                                  Gene name TLR2 Definition (RefSeq) toll-like receptor 2 isoform X1   KO K10159   toll-like receptor 2 Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04145   Phagosome pon04151   PI3K-Akt signaling pathway pon04613   Neutrophil extracellular trap formation pon04620   Toll-like receptor signaling pathway pon05132   Salmonella infection pon05134   Legionellosis pon05140   Leishmaniasis pon05142   Chagas disease pon05144   Malaria pon05145   Toxoplasmosis pon05146   Amoebiasis pon05152   Tuberculosis pon05161   Hepatitis B pon05162   Measles pon05168   Herpes simplex virus 1 infection pon05169   Epstein-Barr virus infection pon05170   Human immunodeficiency virus 1 infection pon05171   Coronavirus disease - COVID-19 pon05205   Proteoglycans in cancer pon05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pon05321   Inflammatory bowel disease pon05323   Rheumatoid arthritis Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04151 PI3K-Akt signaling pathway     100456464 (TLR2)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     100456464 (TLR2)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     100456464 (TLR2)    04620 Toll-like receptor signaling pathway     100456464 (TLR2)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     100456464 (TLR2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100456464 (TLR2)   09163 Immune disease    05323 Rheumatoid arthritis     100456464 (TLR2)    05321 Inflammatory bowel disease     100456464 (TLR2)   09171 Infectious disease: bacterial    05132 Salmonella infection     100456464 (TLR2)    05134 Legionellosis     100456464 (TLR2)    05152 Tuberculosis     100456464 (TLR2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     100456464 (TLR2)    05161 Hepatitis B     100456464 (TLR2)    05171 Coronavirus disease - COVID-19     100456464 (TLR2)    05162 Measles     100456464 (TLR2)    05168 Herpes simplex virus 1 infection     100456464 (TLR2)    05169 Epstein-Barr virus infection     100456464 (TLR2)   09174 Infectious disease: parasitic    05146 Amoebiasis     100456464 (TLR2)    05144 Malaria     100456464 (TLR2)    05145 Toxoplasmosis     100456464 (TLR2)    05140 Leishmaniasis     100456464 (TLR2)    05142 Chagas disease     100456464 (TLR2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pon04131]     100456464 (TLR2)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pon04147]     100456464 (TLR2)    04054 Pattern recognition receptors [BR:pon04054]     100456464 (TLR2)    04090 CD molecules [BR:pon04090]     100456464 (TLR2)    00536 Glycosaminoglycan binding proteins [BR:pon00536]     100456464 (TLR2) Membrane trafficking [BR:pon04131]  Endocytosis   Phagocytosis    Toll-like receptors     100456464 (TLR2) Exosome [BR:pon04147]  Exosomal proteins   Exosomal proteins of breast milk    100456464 (TLR2) Pattern recognition receptors [BR:pon04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    100456464 (TLR2) CD molecules [BR:pon04090]  Proteins   100456464 (TLR2) Glycosaminoglycan binding proteins [BR:pon00536]  Hyaluronan   Cell surface receptors    100456464 (TLR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 TIR LRR_4 TIR_2 LRR_9 LRR_1 LRR_5 LRRCT Motif Other DBs NCBI-GeneID:  100456464 NCBI-ProteinID:  XP_024102319 Ensembl:  ENSPPYG00000015131 LinkDB All DBs Position 4 AA seq 783 aa AA seqDB search MPHTLWMVWVLGVIISLSKEESSSQALSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSN NRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFK TLSSLTFLNLLGNPYKTLGETSLFSHLTKLRMLRVGNMDTFTKIQRKDFAGLTFLEELEI DASDLQSYEPKSLKSIQNVSHLILHMKQHTLLLEIFVDVTSSVECLELQDTDLDTFHFSE LSTGETNSLIKKFTFRNVKITDEGLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDND RVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCSLSRHLKS LEYLDLSENLMVEEYLKNSACEDAWPSLRTLILRQNHLASLEKTGETLLTLKNLTNLDIS KNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKE LYISRNKLMTLPDASLLPMLLVLKISRNTITTFSKEQLDSFHTLKTLEAGGNNFICSCEF LSFTQEQQALAKVLIDWPANYLCDSPSHVHGQRVQDVRLSVSECHRTALVSGMCCALFLL ILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRDICYDAFVSYSERDAYWVENLMVQ ELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSH FRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAA IKS NT seq 2352 nt NT seq  +upstreamnt  +downstreamnt atgccacatactttgtggatggtgtgggtcttgggggtcatcatcagcctctccaaggaa gaatcctccagtcaggctctgtcttgtgaccgcaatggtatctgcaagggcagctcagga tctttaaactccattccctcagggctcacagaagctgtaaaaagccttgacctgtccaac aacaggatcacctacattagcaacagtgacctacagaggtgtgtgaacctccaggctctg gtgctgacatccaatggaattaacacaatagaggaagattctttttcttccctgggcagt cttgaacatttagacttatcctataattacttatctaatttatcgtcttcctggttcaag accctttcttctttgacattcttaaacttactgggaaatccttacaaaaccctaggggaa acatctcttttttctcatctcacaaaattgcgaatgctgagagtaggaaatatggacacc ttcactaagattcaaagaaaagattttgctggacttaccttccttgaggaacttgagatt gatgcttcagatctacagagctatgagccaaaaagtttgaagtcaattcagaacgtaagt catctgatccttcatatgaagcagcatactttactgctggagatttttgtagatgttaca agttccgtggaatgtttggaactgcaagatactgatttggacactttccatttttcagaa ctatccactggtgaaacaaattcattgattaaaaagtttacatttagaaatgtgaaaatc accgatgaaggtttgtttcaggtcatgaaacttttgaatcagatttctggattgttagaa ttagagtttgatgactgtacccttaatggagttggtaattttagagcatctgataatgac agagttatagatccaggtaaagtggaaacgttaacaattcggaggctgcatattccaagg ttttacttattttatgatctgagcactttatattcactcacagaaagagttaaaagaatc acagtagaaaacagtaaagtttttctggttccttgttcactttcacgacatttaaaatca ttagaatacttggatctcagtgaaaatttgatggttgaagaatacttgaaaaattcagcc tgtgaggatgcctggccctctctacgaactttaattttaaggcaaaatcatttggcatca ttggaaaaaaccggagagactttgcttactctgaaaaacttgactaaccttgatatcagt aagaatagttttcattctatgcctgaaacttgtcagtggccagaaaagatgaaatatttg aacttatccagcacacgaatacacagtgtaacaggctgcattcccaagacactggaaatt ttagatgttagcaacaacaatctcaatttattttctttgaatttgccgcaactcaaagaa ctttatatttccagaaataagttgatgactctaccagatgcctccctcttacccatgtta ctagtattgaaaatcagtaggaatacaataactactttttctaaggagcaacttgactca tttcacacactgaagactttggaagctggtggcaataacttcatttgctcctgtgaattc ctctccttcactcaggagcagcaagcactggccaaagtcctgattgattggccagcaaat tacctgtgtgactctccatcccatgtgcatggccagcgggttcaggacgtccgcctctcg gtgtcggaatgtcacaggacagcactggtgtctggcatgtgctgtgctctgttcctgctg atcctgctcacgggggtcctgtgccaccgtttccatggcctgtggtacatgaaaatgatg tgggcctggctccaggccaaaaggaagcccaggaaagctcccagcagggacatctgctat gatgcatttgtttcttacagtgagcgtgatgcctactgggtggagaaccttatggtccag gagctggagaacttcaatccccccttcaagttgtgtcttcataagcgggacttcattcct ggcaagtggatcattgacaatatcattgactccattgaaaagagccacaaaactgtcttt gtgctttctgaaaactttgtgaagagtgaatggtgcaagtatgaactggacttctcccat ttccgtctttttgatgagaacaatgatgctgccattctcattcttctggagcccattgag aaaaaagccattccccagcgcttctgcaagctgcggaagataatgaacaccaagacctac ctggagtggcccatggatgaggctcagcgggaagggttttgggtaaatctgagagctgcg ataaagtcctag

Pongo abelii (Sumatran orangutan): 100457237 Help Entry 100457237         CDS       T01416                                  Gene name TLR4 Definition (RefSeq) toll-like receptor 4 isoform X1   KO K10160   toll-like receptor 4 Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04064   NF-kappa B signaling pathway pon04066   HIF-1 signaling pathway pon04145   Phagosome pon04151   PI3K-Akt signaling pathway pon04217   Necroptosis pon04613   Neutrophil extracellular trap formation pon04620   Toll-like receptor signaling pathway pon04621   NOD-like receptor signaling pathway pon05132   Salmonella infection pon05133   Pertussis pon05134   Legionellosis pon05135   Yersinia infection pon05140   Leishmaniasis pon05142   Chagas disease pon05144   Malaria pon05145   Toxoplasmosis pon05146   Amoebiasis pon05152   Tuberculosis pon05161   Hepatitis B pon05162   Measles pon05164   Influenza A pon05170   Human immunodeficiency virus 1 infection pon05171   Coronavirus disease - COVID-19 pon05205   Proteoglycans in cancer pon05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pon05321   Inflammatory bowel disease pon05323   Rheumatoid arthritis Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     100457237 (TLR4)    04066 HIF-1 signaling pathway     100457237 (TLR4)    04151 PI3K-Akt signaling pathway     100457237 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     100457237 (TLR4)   09143 Cell growth and death    04217 Necroptosis     100457237 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     100457237 (TLR4)    04620 Toll-like receptor signaling pathway     100457237 (TLR4)    04621 NOD-like receptor signaling pathway     100457237 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     100457237 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100457237 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     100457237 (TLR4)    05321 Inflammatory bowel disease     100457237 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     100457237 (TLR4)    05135 Yersinia infection     100457237 (TLR4)    05133 Pertussis     100457237 (TLR4)    05134 Legionellosis     100457237 (TLR4)    05152 Tuberculosis     100457237 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     100457237 (TLR4)    05161 Hepatitis B     100457237 (TLR4)    05171 Coronavirus disease - COVID-19     100457237 (TLR4)    05164 Influenza A     100457237 (TLR4)    05162 Measles     100457237 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     100457237 (TLR4)    05144 Malaria     100457237 (TLR4)    05145 Toxoplasmosis     100457237 (TLR4)    05140 Leishmaniasis     100457237 (TLR4)    05142 Chagas disease     100457237 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pon04131]     100457237 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:pon04054]     100457237 (TLR4)    04090 CD molecules [BR:pon04090]     100457237 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:pon00536]     100457237 (TLR4) Membrane trafficking [BR:pon04131]  Endocytosis   Phagocytosis    Toll-like receptors     100457237 (TLR4) Pattern recognition receptors [BR:pon04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    100457237 (TLR4) CD molecules [BR:pon04090]  Proteins   100457237 (TLR4) Glycosaminoglycan binding proteins [BR:pon00536]  Hyaluronan   Cell surface receptors    100457237 (TLR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 TIR LRR_4 TIR_2 LRR_9 LRR_1 LRR_6 DUF1863 Motif Other DBs NCBI-GeneID:  100457237 NCBI-ProteinID:  XP_024108556 Ensembl:  ENSPPYG00000019548 LinkDB All DBs Position 9 AA seq 830 aa AA seqDB search MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQNLALG AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL DLSSNKIQSIYCKDLQVLHQMPLLNLSLDLSLNAMNFIQPGAFKEIRLHKLTLRNSFDSL NVMKTCIQGLAGLEVHHLVLGEFRNEKNLEKFDTSALEGLCNLTIEEFRLAYLDYYLDDI IDLFNCLANVSSFSLVSVTIKSVKDFSYNFGWQHLELVNCKFGQFPTLELKSLKRLTFTA NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNDVITMGSNFLG LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLKVLKMAG NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL LVEVERMECATPSDKQGMPVLSLNITCQMNKTVIGVSVFSVLVVSVVAVLVYKFYFHLML LAGCIKYGRGENTYDAFVIYSSQDEDWVRNELVKNLEEGVPTFQLCLHYRDFIPGVAIAA NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTG NT seq 2493 nt NT seq  +upstreamnt  +downstreamnt atgatgtctgcctcgcgcctggctgggactctgatcccagccatggccttcctctcctgc gtgagaccggaaagctgggagccctgcgtagaggtggttcctaacattacttatcaatgc atggagctgaatttctacaaaatccccgacaacctccccttctcaaccaagaacctggac ctgagctttaatcccctgaggcatttaggcagctatagcttcttcagtttcccagaactg caggtgctggatttatccaggtgtgaaatccagacaattgaagatggggcatatcagagc ctaagccacctctccaccttaatattgacaggaaaccccatccagaatttagccctggga gccttttctggactgtcaagtttacagaagctggtggctgtggagacaaatctggcatct ctagagaacttccccattggacatctcaaaactttgaaagaacttaatgtggctcacaat cttatccagtctttcaaattacctgagtatttttccaatctgaccaatctagagcacttg gacctttccagcaacaagattcaaagtatttattgcaaagacttgcaggttctacatcaa atgccgctactcaatctctctttagacctgtccctgaacgctatgaactttatccaacca ggtgcatttaaagaaattaggcttcataagctgactttgagaaatagttttgatagttta aatgtaatgaaaacttgtattcaaggtctggctggtttagaagtccatcatttggttctg ggagaatttagaaatgaaaaaaacttggaaaagtttgacacatctgctctagagggcctg tgcaatttgaccattgaagaattccgattagcatacttagactactacctcgatgatatt attgacttatttaattgtttggcaaatgtttcttcattttccctggtgagtgtgactatt aaaagtgtaaaagacttttcttataatttcggatggcaacatttagaattagttaactgt aaatttggacagtttcccacattggaactcaaatctctcaaaaggcttactttcactgcc aacaaaggtgggaatgctttttcagaagttgatctaccaagccttgagtttctagatctc agtagaaatggcttgagtttcaaaggttgctgttctcaaagtgattttgggacaaccagc ctaaagtatttagatctgagcttcaatgatgttattaccatgggttcaaacttcttgggc ttagaacaactagaacatctggatttccagcattccaatttgaaacaaatgagtgagttt tcagtattcctatcactcagaaacctcatttaccttgacatttctcatactcacaccaga gttgctttcaatggcatcttcaatggcttgtccagtctcaaagtcttgaaaatggctggc aattctttccaggaaaacttccttccagatatcttcacagagctgagaaacttgaccttc ctggacctctctcagtgtcaactggagcagttgtctccaacagcatttaactcactctct agtcttcaggtactaaatatgagccacaacaacttcttttcattggatacgtttccttat aagtgtctgaactccctccaggttcttgattacagtctcaatcacataatgacttccaaa aaacaggaactacagcattttccaagtagtctagctttcttaaatcttactcagaatgac tttgcttgtacttgtgaacaccagagtttcctgcagtggatcaaggaccagaggcagctc ttggtggaagttgaacgaatggaatgtgcaacaccttcagataagcagggcatgcctgtg ctgagtttgaatatcacctgtcagatgaataagaccgtcattggtgtgtcagtcttcagt gtgcttgtagtatctgttgtagcagttctggtctataagttctattttcacctgatgctt cttgctggctgtataaagtatggtagaggtgaaaacacgtatgatgcctttgttatctac tcaagccaggatgaggactgggtaaggaatgagctagtaaagaatttagaagaaggggta cctacctttcagctctgccttcactacagagactttattcccggtgtggccattgctgcc aacatcatccatgaaggtttccataaaagccgaaaggtgattgttgtggtgtcccagcac ttcatccagagccgctggtgtatctttgaatatgagattgctcagacctggcagtttctg agcagtcgtgctggtatcatcttcattgtcctgcagaaggtggagaagaccctgctcagg cagcaggtggaactgtaccgccttctcagcaggaacacttacctggagtgggaggacagt gtcctggggcggcacatcttctggagacgactcagaaaagccctgctggatggtaaatca tggaatccagaaggaacagtgggtacaggataa

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