KEGG ORTHOLOGY: K10159

ORTHOLOGY: K10159

Entry

K10159                      KO

Symbol

TLR2, CD282

Name

toll-like receptor 2

Pathway

map04145

Phagosome

map04151

PI3K-Akt signaling pathway

map04613

Neutrophil extracellular trap formation

map04620

Toll-like receptor signaling pathway

map05132

Salmonella infection

map05134

Legionellosis

map05140

Leishmaniasis

map05142

Chagas disease

map05144

Malaria

map05145

Toxoplasmosis

map05146

Amoebiasis

map05152

Tuberculosis

map05161

Hepatitis B

map05162

Measles

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05205

Proteoglycans in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05417

Lipid and atherosclerosis

Disease

H00342

Tuberculosis

H00344

Leprosy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K10159  TLR2, CD282; toll-like receptor 2
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K10159  TLR2, CD282; toll-like receptor 2
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K10159  TLR2, CD282; toll-like receptor 2
   04620 Toll-like receptor signaling pathway
    K10159  TLR2, CD282; toll-like receptor 2
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K10159  TLR2, CD282; toll-like receptor 2
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K10159  TLR2, CD282; toll-like receptor 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K10159  TLR2, CD282; toll-like receptor 2
   05161 Hepatitis B
    K10159  TLR2, CD282; toll-like receptor 2
   05171 Coronavirus disease - COVID-19
    K10159  TLR2, CD282; toll-like receptor 2
   05162 Measles
    K10159  TLR2, CD282; toll-like receptor 2
   05168 Herpes simplex virus 1 infection
    K10159  TLR2, CD282; toll-like receptor 2
   05169 Epstein-Barr virus infection
    K10159  TLR2, CD282; toll-like receptor 2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K10159  TLR2, CD282; toll-like receptor 2
   05134 Legionellosis
    K10159  TLR2, CD282; toll-like receptor 2
   05152 Tuberculosis
    K10159  TLR2, CD282; toll-like receptor 2
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K10159  TLR2, CD282; toll-like receptor 2
   05144 Malaria
    K10159  TLR2, CD282; toll-like receptor 2
   05145 Toxoplasmosis
    K10159  TLR2, CD282; toll-like receptor 2
   05140 Leishmaniasis
    K10159  TLR2, CD282; toll-like receptor 2
   05142 Chagas disease
    K10159  TLR2, CD282; toll-like receptor 2
  09163 Immune disease
   05323 Rheumatoid arthritis
    K10159  TLR2, CD282; toll-like receptor 2
   05321 Inflammatory bowel disease
    K10159  TLR2, CD282; toll-like receptor 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K10159  TLR2, CD282; toll-like receptor 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K10159  TLR2, CD282; toll-like receptor 2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K10159  TLR2, CD282; toll-like receptor 2
   04054 Pattern recognition receptors
    K10159  TLR2, CD282; toll-like receptor 2
   04090 CD molecules
    K10159  TLR2, CD282; toll-like receptor 2
   00536 Glycosaminoglycan binding proteins
    K10159  TLR2, CD282; toll-like receptor 2
Membrane trafficking [BR:ko04131]
Endocytosis
  Phagocytosis
   Toll-like receptors
    K10159  TLR2, CD282; toll-like receptor 2
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of breast milk
   K10159  TLR2, CD282; toll-like receptor 2
Pattern recognition receptors [BR:ko04054]
Membrane-bound pattern recognition receptors
  Toll-like receptors
   K10159  TLR2, CD282; toll-like receptor 2
CD molecules [BR:ko04090]
Proteins
  K10159  CD282, TLR2; toll-like receptor 2
Glycosaminoglycan binding proteins [BR:ko00536]
Hyaluronan
  Cell surface receptors
   K10159  TLR2, CD282; toll-like receptor 2

Genes

HSA:	7097(TLR2)

PTR:	471325(TLR2)

PPS:	100994768(TLR2)

GGO:	101128447(TLR2)

PON:	100456464(TLR2)

PPYG:

129035412(TLR2)

NLE:	100604724(TLR2)

HMH:	116465400(TLR2)

SSYN:

129481156(TLR2)

MCC:	574290(TLR2)

MCF:	102146068(TLR2)

MTHB:

126955690

MNI:	105463507(TLR2)

CSAB:

103236415

CATY:

105580685(TLR2)

PANU:

103884712(TLR2)

TGE:	112624698(TLR2)

MLEU:

105531455(TLR2)

RRO:	104677747(TLR2)

RBB:	108529041(TLR2)

TFN:

117086043

PTEH:

111553190(TLR2)

CANG:

105524473

CJC:	100404611(TLR2)

SBQ:	101045472(TLR2)

CIMI:

108282777

ANAN:

105714556(TLR2)

CSYR:

103274468(TLR2)

MMUR:

105881794(TLR2)

LCAT:

123638501(TLR2)

PCOQ:

105811134(TLR2)

OGA:	100964048(TLR2)

MMU:	24088(Tlr2)

MCAL:

110291353(Tlr2)

MPAH:

110320724(Tlr2)

RNO:	310553(Tlr2)

MCOC:

116093042(Tlr2)

ANU:	117707783(Tlr2)

MUN:	110541773(Tlr2)

CGE:	100771475(Tlr2)

MAUA:

101838156(Tlr2)

PROB:

127232768(Tlr2)

PLEU:

114710188(Tlr2)

MORG:

121452676(Tlr2)

MFOT:

126511616

AAMP:

119826466(Tlr2)

NGI:	103750991(Tlr2)

HGL:	101724657(Tlr2)

CPOC:

100717682(Tlr2)

CCAN:

109701180(Tlr2)

DORD:

105995883(Tlr2)

DSP:	122127146(Tlr2)

PLOP:

125341577(Tlr2)

NCAR:

124994917

MMMA:

107141269

OCU:	100009578(TLR2)

OPI:	101523730(TLR2)

TUP:	102482498(TLR2)

CFA:	448807(TLR2)

CLUD:

112654591(TLR2)

VVP:	112933419(TLR2)

VLG:	121480909(TLR2)

NPO:	129516767(TLR2)

AML:	100465129(TLR2)

UMR:

103658031

UAH:	113255769(TLR2)

UAR:	123793207(TLR2)

ELK:

111154734

LLV:

125093126

MPUF:

101681595(TLR2)

MNP:	132000985(TLR2)

MLK:	131831467(TLR2)

NVS:	122889469(TLR2)

ORO:	101363280(TLR2) 101367407

EJU:	114210089(TLR2)

ZCA:	113925471(TLR2)

MLX:	118022230(TLR2) 118022538

NSU:	110588386 110588474(TLR2)

LWW:	102737828(TLR2)

FCA:	493797(TLR2)

PYU:	121026443 121026463

PCOO:

112858853

PBG:	122475284(TLR2)

PVIV:

125163954(TLR2)

LRUF:

124520186

PTG:	102962241 102964242

PPAD:

109262509(TLR2)

PUC:

125923764

AJU:

106982476

HHV:	120233209(TLR2)

BTA:	281534(TLR2)

BOM:	102268835(TLR2)

BIU:	109571498(TLR2)

BBUB:

102397791(TLR2)

BBIS:

104989153(TLR2)

CHX:	100860747(TLR2)

OAS:	554262(TLR2)

BTAX:

128062410(TLR2)

CSUM:

138093606(TLR2)

ODA:	120871484(TLR2)

CCAD:

122451361(TLR2)

MREE:

136145957(TLR2)

MBEZ:

129542442(TLR2)

SSC:	396623(TLR2)

CFR:	102523960(TLR2)

CBAI:

105079727(TLR2)

CDK:	105099662(TLR2)

VPC:	102525227(TLR2)

BACU:

102998386(TLR2)

BMUS:

118896009(TLR2)

LVE:

103090179

OOR:	101276053(TLR2)

DLE:	111187714(TLR2)

PCAD:

102976342(TLR2)

PSIU:

116754202(TLR2)

NASI:

112407985(TLR2)

ECB:	100009701(TLR2)

EPZ:	103553736(TLR2)

EAI:	106821799(TLR2)

MYB:	102256005(TLR2)

MYD:	102761137(TLR2)

MMYO:

118658736(TLR2)

MLF:	102424442(TLR2)

MDT:	132235454(TLR2)

PKL:	118711134(TLR2)

EFUS:

103288450(TLR2)

MNA:	107525584(TLR2)

DRO:	112312607(TLR2)

SHON:

118995387(TLR2)

AJM:	119065905(TLR2)

PDIC:

114503036(TLR2)

PHAS:

123813727(TLR2)

MMF:	118616119(TLR2)

PPAM:

129061625(TLR2)

HAI:	109382017(TLR2)

RFQ:	117037546(TLR2)

PALE:

102893057(TLR2)

PGIG:

120613273(TLR2)

PVP:	105291526(TLR2)

RAY:	107510758(TLR2)

MJV:	108390634(TLR2)

TOD:	119233466(TLR2)

SARA:

101542483(TLR2)

SETR:

126003414(TLR2)

LAV:	100654442(TLR2)

TMU:

101342847

ETF:	101643417(TLR2)

DNM:	101421345(TLR2)

MDO:	100024558(TLR2)

GAS:	123251496(TLR2)

SHR:	100932981(TLR2)

AFZ:

127540467

PCW:	110213633(TLR2)

TVP:	118854154(TLR2)

PBRV:

138175169(TLR2)

OAA:	100081248(TLR2)

GGA:	374141(TLR2A) 769014(TLR2B)

MGP:	104910743 109363679 109363685

CJO:	107313061 107313069

TPAI:

128084363(TLR2) 128084365

LMUT:

125691799 125691800(TLR2)

NMEL:

110398324(TLR2)

APLA:

101791786(TLR2) 110351185

ACYG:

106032265 106032266

CATA:

118249208 118249271(TLR2)

AFUL:

116488900 116488978(TLR2)

TGU:	100219691(TLR2)

SCAN:

103826229(TLR2)

PMOA:

120497936 120497937

OTC:	121331387 121331388

PRUF:

121360328 121360373

GFR:	102036739 102045171

FAB:	101811742 101811943(TLR2)

OMA:	130252788 130252789(TLR2)

PHI:	102104379 102104560(TLR2)

PMAJ:

107202976(TLR2)

CCAE:

111927833 111927834

CCW:	104697168(TLR2) 120409612

CBRC:

103617360 103617361

ACOE:

138109016 138109687

ETL:	114066323(TLR2)

ZAB:	102063127(TLR2)

ZLE:	135446672 135447324(TLR2)

ACHL:

103806228 103811860

SVG:	106861726(TLR2)

MMEA:

130579325(TLR2)

HRT:	120752902 120753504

SATI:

136360438(TLR2) 136360439

FPG:	101923386(TLR2) 101923563

FCH:	102051584(TLR2)

NNT:	104401150(TLR2)

SHAB:

115610854(TLR2) 115610981

ACUN:

113479805 113479806(TLR2)

TALA:

116965176(TLR2)

ACHC:

115339865 115339882(TLR2)

HLE:	104827771 104843273

AGEN:

126044629 126044630

HHAR:

128137044 128137061

GCL:	127015580 127015793

CSTI:

104562380

LDI:

104345532

MNB:	103768149 103772535

DPUB:

104298307(TLR2) 104298317

PPUS:

135178432 135178434

AVIT:

104275874 104280221(TLR2)

BRHI:

104495472

EGZ:	104126737 104126791(TLR2)

NNI:	104008501 104021229(TLR2) 104021230

PCRI:

PCAO:

PADL:

AFOR:

FGA:	104069477 104077048

CLV:	102084454 102084767(TLR2)

MUI:	104536714 104542596

EHS:	104502684(TLR2)

CMAC:

104473065(TLR2)

CUCA:

104054217(TLR2)

TEO:	104376160 104379432(TLR2)

BREG:

OHA:

ACAR:

CPEA:

CVF:	104293775 104294126 104294127

RTD:	128910481 128910566(TLR2)

AAM:	106491872 106491913

AROW:

112967647 112976729 112976730

NPD:	112949303(TLR2)

TGT:	104566013(TLR2)

DNE:	112985951 112985953(TLR2)

SCAM:

104145540 104145542

ASN:	102368109(TLR2) 102368346 102383734 102384063

AMJ:	102571171(CD14) 102572093(TLR2) 106740518(TLR2)

CPOO:

109309593(TLR2) 109309681

GGN:	109300368 109300828(TLR2)

PSS:	102445063 102457158(TLR2) 102457570 102458059

CMY:	102934124 102943966 102944187

CCAY:

125625972 125635718 125635747

DCC:	119847754 119855141 119855269

CPIC:

101932351(TLR2) 101932616 101937770 101939272

TST:	117869678 117878440 117878538

CABI:

116824075 116824076(TLR2) 116831845

MRV:	120390761 120406276(TLR2) 120407011

ACS:	100564001(tlr2) 100564196 100564690 103278612 103278613(cd14)

ASAO:

132776793 132776794 132776795

PVT:	110069865 110072767(TLR2) 110082123

SUND:

121930303 121931996

PBI:	103049109 103064827(TLR2)

PMUR:

107283615(CD14) 107288063 107289574(TLR2)

CTIG:

120309597(TLR2) 120314888

TSR:	106544777(TLR2) 106553961

PGUT:

117662113(TLR2) 117671348

APRI:

131203177(TLR2)

PTEX:

113435841(TLR2)

NSS:	113417952(TLR2)

VKO:	123023851(TLR2)

PMUA:

114586776 114601154(CD14)

PRAF:

128421069(TLR2)

ZVI:	118076498 118079342(CD14) 118084395(TLR2)

HCG:	128328284(TLR2)

GJA:	107107978 107108593(TLR2) 107119739

STOW:

125439146 125439571(TLR2)

EMC:	129337116(TLR2)

XLA:	108699311 108699322 108699606 108700404 108706656 108710847

XTR:	100485512 100485771(tlr2) 100485927 100487973 116409470

NPR:	108788197(TLR2) 108791424 108795015

RTEM:

120920062(TLR2) 120932459(CD14)

BBUF:

120990049(TLR2) 121008994

BGAR:

122926450 122942595(TLR2)

MUO:

115476667

GSH:	117351709 117358950(TLR2)

DRE:	403125(tlr2) 403133(tlr18)

SRX:	107717772 107722930

SANH:

107663243 107689857 107702532(tlr2)

SGH:	107590711 107597981

CCAR:

109060541 109073772 109074587

CAUA:

113059585 113093059 113116771

CGIB:

127948925 127974955 127985733 128030704

PTET:

122346867(tlr2) 122360297(tlr18)

LROH:

127151788(tlr2) 127178597(tlr18)

OMC:	131521342(tlr18) 131549258(tlr2)

PPRM:

120463819(tlr2) 120484621(tlr18)

RKG:	130069309(tlr18) 130096862(tlr2)

MAMB:

125243183(tlr18) 125272716(tlr2)

CIDE:

127496769 127525683

CERY:

137032534(tlr2) 137034439(tlr18)

MASI:

127443498 127445422 127453406

TROS:

130552481(tlr2) 130557525(tlr18)

TDW:	130410141(tlr2) 130432366(tlr18)

MANU:

129444970(tlr2) 129448122(tlr18)

IPU:	108258959 108272691(tlr18)

IFU:	128601965(tlr2) 128610284(tlr18)

PHYP:

113533829 113535686(tlr2)

SMEO:

124378063(tlr2) 124384137(tlr18)

TFD:	113640381(tlr2) 113644773(tlr18)

TVC:	132839182(tlr2) 132845889(tlr18)

TRN:	134310788(tlr18) 134328550(tlr2)

AMEX:

103042489(tlr18) 103044794(tlr2) 103045101

CMAO:

118802154 118802155(tlr2) 118813108(tlr18)

EEE:	113583650 113589619

CHAR:

105891725(tlr18) 105903891(tlr2)

TRU:	101068527 101068557(tlr2)

TFS:	130522399(tlr2) 130532143(tlr18)

TNG:	GSTEN00004567G001

LCO:	104923941 104934739 104938453

NCC:

104943968

TBEN:

117469881 117481585 117494857(tlr18)

CGOB:

115009776(tlr2) 115014553 115020848

PGEO:

117447943 117460761 117463567

GACU:

117553624 117556193 117563201(tlr18)

EMAC:

134861669(tlr18) 134864416 134876155

ELY:	117246200 117254631 117265722(tlr18)

EFO:	125883414 125886267 125892600(tlr18)

PLEP:

121940407 121941713 121946307(tlr18) 121962081

SLUC:

116049085(tlr18) 116051764 116052112

ECRA:

117945977(tlr18) 117962114

ESP:	116690715 116690724(tlr2)

PFLV:

114545526 114556771 114562422 114562886(tlr2)

GAT:	120811005(tlr18) 120822770(tlr2)

PPUG:

119197595(tlr18) 119222892(tlr2)

AFB:	129093095 129095397 129109086(tlr18)

CLUM:

117745125(tlr18) 117746792 117747505

PSWI:

130187916(tlr18)

CANA:

137780989(tlr18) 137781868 137792981

CVE:	137874446 137885410 137887166(tlr18)

MSAM:

119898091(tlr18) 119898773 119913078

SCHU:

122870109 122874079 122880368 122881275(tlr18)

CUD:	121504107 121504364 121504365 121504758 121504890 121507773 121507774 121507775 121507776 121507777 121507831 121513395(tlr18) 121515920

ALAT:

119005747(tlr18) 119007510 119020799 119027456

ASTR:

137600993(tlr18)

MZE:	101463793 101470585 101484533 106675443 106675704

ONL:	100694547(tlr2) 100705953 102076284 102076916(tlr2) 102077009 109202487

OAU:	116312407 116312408 116317422 116333491(tlr18)

OLA:	101155381 101162959 101173259

OML:	112136553(tlr18) 112155905 112156495

CSAI:

133420343 133420381 133420940 133420954 133440663(tlr18)

XMA:	102226787 102227045 102230797

XCO:	114140250 114157991 114158033

XHE:	116717639 116732043 116732869

PRET:

103460805(tlr2) 103477637 103480941

PFOR:

103149044(tlr2) 103155238

PLAI:

106947305 106947306 106959996

PMEI:

106920377 106924268(tlr2)

GAF:	122820936 122820938 122830836(tlr18)

PPRL:

129351429 129370861(tlr18) 129376764

CVG:	107082271(tlr2) 107082292 107084756

CTUL:

119781865(tlr18) 119797978 119797979

GMU:	124865385(tlr18) 124880508 124880509 124880848

NFU:	107379226 107395103

KMR:	108239773 108243184(tlr18) 108248293(tlr2)

ALIM:

106526902 106529226

NWH:	119409653(tlr18) 119417310(tlr2)

AOCE:

111571645 111586854(tlr2)

EJA:	138213779(tlr18) 138214185(tlr2)

MCEP:

125003751 125008678(tlr2) 125017001(tlr18) 125023802

CSEM:

103388693

POV:	109633418 109646959(tlr2)

SSEN:

122766853(tlr2) 122774672(tlr18)

HHIP:

117770129 117776644(tlr18) 117779093

HSP:	118102678(tlr2) 118114297(tlr18)

PPLT:

128430232 128436925 128449156(tlr18)

SMAU:

118283876(tlr2) 118285011(tlr18) 118312269

LCF:	108883170(tlr18) 108885865 108901668 108902352

SDU:	111216599(tlr2) 111222405 111236680 111240019

SLAL:

111668167 111669232

XGL:	120784198(tlr18) 120797238(tlr2)

HCQ:

109512204

SSCV:

125975209(tlr18)

SBIA:

133500323(tlr18)

PEE:	133401555(tlr18)

PTAO:

133479423(tlr18)

BPEC:

110160272 110170449

MALB:

109968926

BSPL:

114843048(tlr18) 114851239(tlr2)

SJO:	128366894(tlr18) 128379964 128384059

SASA:

106580799 106605325 106608430

STRU:

115176782 115178865 115198035

OTW:	112229323(tlr18) 112237807(tlr2)

OMY:	100750259(tlr2) 110487251(tlr18) 110514733

OGO:	123997036 124005693 124013924(tlr2)

ONE:	115103983 115141066

OKI:	109882984 109901726 109903645

OKE:	118364051 118367486(tlr18) 118377787(tlr2)

SALP:

111965103 112076105

SNH:	120031357 120041431 120048414

CCLU:

121543120 121571065

ELS:	105028681 105030906(tlr2)

SFM:

108926796

PKI:

111838449

AANG:

118229631(tlr18) 118231932 118231933

LOC:	102687114 107077084(tlr2)

PSPA:

121309885(tlr18) 121327847(tlr2) 121331267

ARUT:

117395620 117408874 117413139 117416631 117965134

PSEX:

120527440(tlr18)

LCM:	102350366 102355189 102367073(TLR2)

CMK:	103185476 103185499

RTP:	109912800 109928617

CPLA:

122554467 122554772(tlr2)

HOC:	132818507 132819313 132819394

LERI:

129701139(prg4b) 129702580(tlr2)

PMRN:

116938861 116938862 116957696

LRJ:	133345800 133345801 133345803

HAME:

PPOI:

DSV:

CSCU:

CVS:

PVUL:

126823654 126823656 126825506

HRF:	124110340 124111012 124111015 124126792 124132656 124134791 124151809 124151813 124152451

HRJ:	124269430 124269469 124269852 124286645 124289089

HASI:

137272304 137274459 137283752 137287532 137287630 137294963 137295217

CRG:

117692251

CANU:

128164706 128173514 128177291 128182770 128182789 128183906 128183995 128184388 128184588 128184918 128185946

CVN:	111102496 111104187 111104188 111108808 111112133 111112140 111112158 111114417 111114419

OED:	125664252 125664253 130046322 130047628 130047630

PMAX:

117320158 117320159 117322517 117322518 117325711 117330866 117340547 117343932 117343980 117344055

AIRR:

138329470

MMER:

123556839 123563464

RPHI:

132714864 132720377 132744805

DPOL:

127845372 127859167

MAEA:

128234139 128234764 128240582 128240583

LJP:	135479508 135479758

AMIL:

114952281

PDAM:

113685912

» show all

Reference

PMID:9596645

Authors

Chaudhary PM, Ferguson C, Nguyen V, Nguyen O, Massa HF, Eby M, Jasmin A, Trask BJ, Hood L, Nelson PS

Title

Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.

Journal

Blood 91:4020-7 (1998)

Sequence

[hsa:7097]

Reference

PMID:19931471

Authors

Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, Han SH, Lee H, Paik SG, Lee JO

Title

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.

Journal

Immunity 31:873-84 (2009)
DOI:10.1016/j.immuni.2009.09.018

Sequence

[mmu:24088]

LinkDB

DBGET integrated database retrieval system