KEGG   Pan paniscus (bonobo): 100969981
Entry
100969981         CDS       T02283                                 

Gene name
PIK3R2
Definition
(RefSeq) phosphoinositide-3-kinase regulatory subunit 2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease - COVID-19
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100969981 (PIK3R2)
   04014 Ras signaling pathway
    100969981 (PIK3R2)
   04015 Rap1 signaling pathway
    100969981 (PIK3R2)
   04370 VEGF signaling pathway
    100969981 (PIK3R2)
   04630 JAK-STAT signaling pathway
    100969981 (PIK3R2)
   04668 TNF signaling pathway
    100969981 (PIK3R2)
   04066 HIF-1 signaling pathway
    100969981 (PIK3R2)
   04068 FoxO signaling pathway
    100969981 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    100969981 (PIK3R2)
   04072 Phospholipase D signaling pathway
    100969981 (PIK3R2)
   04071 Sphingolipid signaling pathway
    100969981 (PIK3R2)
   04024 cAMP signaling pathway
    100969981 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    100969981 (PIK3R2)
   04152 AMPK signaling pathway
    100969981 (PIK3R2)
   04150 mTOR signaling pathway
    100969981 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100969981 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    100969981 (PIK3R2)
   04218 Cellular senescence
    100969981 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100969981 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100969981 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100969981 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100969981 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    100969981 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    100969981 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    100969981 (PIK3R2)
   04660 T cell receptor signaling pathway
    100969981 (PIK3R2)
   04662 B cell receptor signaling pathway
    100969981 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    100969981 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    100969981 (PIK3R2)
   04670 Leukocyte transendothelial migration
    100969981 (PIK3R2)
   04062 Chemokine signaling pathway
    100969981 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100969981 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    100969981 (PIK3R2)
   04929 GnRH secretion
    100969981 (PIK3R2)
   04915 Estrogen signaling pathway
    100969981 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    100969981 (PIK3R2)
   04917 Prolactin signaling pathway
    100969981 (PIK3R2)
   04926 Relaxin signaling pathway
    100969981 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    100969981 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    100969981 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100969981 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100969981 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    100969981 (PIK3R2)
   04722 Neurotrophin signaling pathway
    100969981 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100969981 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    100969981 (PIK3R2)
   04380 Osteoclast differentiation
    100969981 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    100969981 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    100969981 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100969981 (PIK3R2)
   05206 MicroRNAs in cancer
    100969981 (PIK3R2)
   05205 Proteoglycans in cancer
    100969981 (PIK3R2)
   05203 Viral carcinogenesis
    100969981 (PIK3R2)
   05230 Central carbon metabolism in cancer
    100969981 (PIK3R2)
   05231 Choline metabolism in cancer
    100969981 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100969981 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100969981 (PIK3R2)
   05212 Pancreatic cancer
    100969981 (PIK3R2)
   05225 Hepatocellular carcinoma
    100969981 (PIK3R2)
   05226 Gastric cancer
    100969981 (PIK3R2)
   05214 Glioma
    100969981 (PIK3R2)
   05221 Acute myeloid leukemia
    100969981 (PIK3R2)
   05220 Chronic myeloid leukemia
    100969981 (PIK3R2)
   05218 Melanoma
    100969981 (PIK3R2)
   05211 Renal cell carcinoma
    100969981 (PIK3R2)
   05215 Prostate cancer
    100969981 (PIK3R2)
   05213 Endometrial cancer
    100969981 (PIK3R2)
   05224 Breast cancer
    100969981 (PIK3R2)
   05222 Small cell lung cancer
    100969981 (PIK3R2)
   05223 Non-small cell lung cancer
    100969981 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100969981 (PIK3R2)
   05017 Spinocerebellar ataxia
    100969981 (PIK3R2)
   05020 Prion disease
    100969981 (PIK3R2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100969981 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100969981 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    100969981 (PIK3R2)
   04931 Insulin resistance
    100969981 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100969981 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100969981 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    100969981 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100969981 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    100969981 (PIK3R2)
   05161 Hepatitis B
    100969981 (PIK3R2)
   05160 Hepatitis C
    100969981 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    100969981 (PIK3R2)
   05164 Influenza A
    100969981 (PIK3R2)
   05162 Measles
    100969981 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    100969981 (PIK3R2)
   05163 Human cytomegalovirus infection
    100969981 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100969981 (PIK3R2)
   05169 Epstein-Barr virus infection
    100969981 (PIK3R2)
   05165 Human papillomavirus infection
    100969981 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100969981 (PIK3R2)
   05142 Chagas disease
    100969981 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100969981 (PIK3R2)
   01524 Platinum drug resistance
    100969981 (PIK3R2)
   01522 Endocrine resistance
    100969981 (PIK3R2)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100969981 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_9 ATG11 Ribosomal_L22e SH3_2 Tai4
Other DBs
NCBI-GeneID: 100969981
NCBI-ProteinID: XP_008969294
LinkDB
Position
19
AA seq 661 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALRGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPP
KAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTL
TLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSK
YQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNET
IKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLR
AQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYAL
MEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKH
CVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAA
R
NT seq 1986 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgctctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtagtgagccgggcggccttgcaggcg
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aacgagcgcacacggcagcgaggtgacttccctggcacctatgtggagttcctggggccc
gtggccctggcccggcccggccctcgcccacggggcccccgcccactgcccgccaggccc
cgtgatggggcccctgagccaggcctcacactccccgacttgcccgagcagttctcccca
cctgatgtggctccccctcttctggtgaagcttgtggaggccattgaaaggacagggctg
gacagcgaatctcactaccgcccggagctgcccgcaccgcgtacagactggtccctgagc
gacgtggatcagtgggacacggcagccctggctgacggcattaagagcttcctgctggca
ctgcccgcgccgctcgtgacccccgaggcctcggccgaggcgcgccgggccctgcggggg
ggcgctcccgacgggagtgagcccagccctgacttcccggcgctgctggtggagaagctg
cttcaggaacacttggaagagcaggaggttgcgcccccagcgctgccgcctaaacccccc
aaggcaaagccggcccccacagtcctggccaatggagggagcccaccctccctgcaggat
gctgagtggtactggggggacatttcaagggaggaggtgaacgagaaactccgggacact
cccgatggcaccttcctagtccgagatgcttctagcaagatccagggcgagtacacgctg
accctcaggaaaggcgggaacaataagctgatcaaggtcttccaccgagatgggcactat
ggcttctcagagccactcaccttctgctccgttgtggacctcatcaatcactaccgccac
gagtctctggcccagtacaacgccaagctggacacacggctcctctaccctgtgtccaaa
taccagcaggaccagattgtcaaggaggacagtgtggaggcagtgggcgcccagcttaag
gtctatcaccagcagtaccaggacaagagccgcgagtatgaccagctttatgaagagtac
acacggacctcccaggagctgcagatgaagcgtactgcaattgaggccttcaatgagact
atcaagatctttgaagagcagggccagactcaagagaaatgcagcaaggaatacctggag
cgcttccggcgtgagggcaacgagaaagagatgcaaaggatcctgctgaactccgagcgg
ctcaagtcccgcattgccgagatccatgagagccgcacgaagctggagcagcagctgcgg
gcccaggcctcggacaacagagagatcgacaagcgcatgaacagcctcaagccggacctc
atgcagctgcgcaagatccgagaccagtacctcgtgtggctcacccagaaaggcgcccgg
cagaagaaaatcaacgagtggctggggattaaaaatgagactgaggaccagtacgcactc
atggaggacgaggacgatctcccgcaccacgaggaacgcacttggtacgtgggcaagatc
aaccgcacgcaggcagaggagatgttgagcggcaagcgggatggcaccttcctcatccgc
gagagcagccagcggggctgctacgcctgctccgtggtagtggacggcgacaccaagcac
tgcgtcatctaccgcacggccaccggcttcggcttcgcggagccctacaacctgtacggg
tcgctgaaggagctggtgctgcactaccagcacgcctcgctggtgcagcacaacgacgcg
ctcaccgtcaccctggcgcacccagtgcgcgccccgggccccggcccgccgcctgccgcc
cgctga

KEGG   Pan paniscus (bonobo): 100986080
Entry
100986080         CDS       T02283                                 

Gene name
PIK3R3
Definition
(RefSeq) phosphoinositide-3-kinase regulatory subunit 3
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease - COVID-19
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100986080 (PIK3R3)
   04014 Ras signaling pathway
    100986080 (PIK3R3)
   04015 Rap1 signaling pathway
    100986080 (PIK3R3)
   04370 VEGF signaling pathway
    100986080 (PIK3R3)
   04630 JAK-STAT signaling pathway
    100986080 (PIK3R3)
   04668 TNF signaling pathway
    100986080 (PIK3R3)
   04066 HIF-1 signaling pathway
    100986080 (PIK3R3)
   04068 FoxO signaling pathway
    100986080 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    100986080 (PIK3R3)
   04072 Phospholipase D signaling pathway
    100986080 (PIK3R3)
   04071 Sphingolipid signaling pathway
    100986080 (PIK3R3)
   04024 cAMP signaling pathway
    100986080 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    100986080 (PIK3R3)
   04152 AMPK signaling pathway
    100986080 (PIK3R3)
   04150 mTOR signaling pathway
    100986080 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100986080 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    100986080 (PIK3R3)
   04218 Cellular senescence
    100986080 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100986080 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    100986080 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100986080 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100986080 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    100986080 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    100986080 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    100986080 (PIK3R3)
   04660 T cell receptor signaling pathway
    100986080 (PIK3R3)
   04662 B cell receptor signaling pathway
    100986080 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    100986080 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    100986080 (PIK3R3)
   04670 Leukocyte transendothelial migration
    100986080 (PIK3R3)
   04062 Chemokine signaling pathway
    100986080 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100986080 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    100986080 (PIK3R3)
   04929 GnRH secretion
    100986080 (PIK3R3)
   04915 Estrogen signaling pathway
    100986080 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    100986080 (PIK3R3)
   04917 Prolactin signaling pathway
    100986080 (PIK3R3)
   04926 Relaxin signaling pathway
    100986080 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    100986080 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    100986080 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100986080 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100986080 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    100986080 (PIK3R3)
   04722 Neurotrophin signaling pathway
    100986080 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100986080 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    100986080 (PIK3R3)
   04380 Osteoclast differentiation
    100986080 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    100986080 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    100986080 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100986080 (PIK3R3)
   05206 MicroRNAs in cancer
    100986080 (PIK3R3)
   05205 Proteoglycans in cancer
    100986080 (PIK3R3)
   05203 Viral carcinogenesis
    100986080 (PIK3R3)
   05230 Central carbon metabolism in cancer
    100986080 (PIK3R3)
   05231 Choline metabolism in cancer
    100986080 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100986080 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100986080 (PIK3R3)
   05212 Pancreatic cancer
    100986080 (PIK3R3)
   05225 Hepatocellular carcinoma
    100986080 (PIK3R3)
   05226 Gastric cancer
    100986080 (PIK3R3)
   05214 Glioma
    100986080 (PIK3R3)
   05221 Acute myeloid leukemia
    100986080 (PIK3R3)
   05220 Chronic myeloid leukemia
    100986080 (PIK3R3)
   05218 Melanoma
    100986080 (PIK3R3)
   05211 Renal cell carcinoma
    100986080 (PIK3R3)
   05215 Prostate cancer
    100986080 (PIK3R3)
   05213 Endometrial cancer
    100986080 (PIK3R3)
   05224 Breast cancer
    100986080 (PIK3R3)
   05222 Small cell lung cancer
    100986080 (PIK3R3)
   05223 Non-small cell lung cancer
    100986080 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100986080 (PIK3R3)
   05017 Spinocerebellar ataxia
    100986080 (PIK3R3)
   05020 Prion disease
    100986080 (PIK3R3)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100986080 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100986080 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    100986080 (PIK3R3)
   04931 Insulin resistance
    100986080 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100986080 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100986080 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    100986080 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100986080 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    100986080 (PIK3R3)
   05161 Hepatitis B
    100986080 (PIK3R3)
   05160 Hepatitis C
    100986080 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    100986080 (PIK3R3)
   05164 Influenza A
    100986080 (PIK3R3)
   05162 Measles
    100986080 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    100986080 (PIK3R3)
   05163 Human cytomegalovirus infection
    100986080 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100986080 (PIK3R3)
   05169 Epstein-Barr virus infection
    100986080 (PIK3R3)
   05165 Human papillomavirus infection
    100986080 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100986080 (PIK3R3)
   05142 Chagas disease
    100986080 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100986080 (PIK3R3)
   01524 Platinum drug resistance
    100986080 (PIK3R3)
   01522 Endocrine resistance
    100986080 (PIK3R3)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100986080 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 Transcrip_act Cupin_8 Fez1 DUF5638
Other DBs
NCBI-GeneID: 100986080
NCBI-ProteinID: XP_003812802
UniProt: A0A2R8ZHQ7
LinkDB
Position
1
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagcagttccaaatggaatgaaggacagttctgtttctctt
caggatgcagaatggtactggggggatatttcaagggaggaggtaaatgacaaattgcgg
gatatgccagatgggaccttcttggtccgagatgcctcaacaaaaatgcagggagattat
actttgactttgcggaagggaggcaataataagttaataaagatctatcaccgggatggt
aaatatggcttttctgatcctctgacatttaattccgtggtggagctcattaaccactat
caccatgaatctcttgctcagtacaatcccaaacttgatgtgaagctgatgtacccagtg
tccagataccaacaggatcagttggtaaaagaagataatattgatgcagtaggtaaaaaa
ctgcaagaataccactctcagtatcaggagaagagtaaagagtatgataggctgtatgaa
gaatatactagaacatcccaggaaatacagatgaagaggactgcaatagaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcacacacaagaacaacatagcaaagaatat
attgagcgatttcgcagagaggggaatgaaaaggagattgaacgaattatgatgaattat
gataaattgaaatcacgtctgggagagattcatgatagcaaaatgcgtctagagcaggat
ttgaagaaacaagctttggacaaccgagaaatagataaaaaaatgaatagtatcaaacct
gacctgatccagctgcgaaagatccgagatcaacaccttgtatggctcaatcacaaagga
gtgagacagaaacgcctgaatgtctggctgggaattaagaatgaggatgctgatgagaac
tattttatcaatgaggaagatgaaaacctgccccattatgatgagaaaacctggtttgtt
gaggatatcaatcgagtacaagcagaggacttgctttatgggaaacctgatggtgcattc
ttaattcgtgagagtagcaagaaaggatgctatgcttgctctgtggtggccgatggggaa
gtgaagcactgtgtgatctacagcactgctcggggctatggctttgcagagccctacaac
ctgtacagctctctgaaggagctagtgctccattaccagcagacatccttggttcagcac
aacgactccctcaacgtcaggcttgcctaccctgttcatgcacagatgccctcgctttgc
agataa

KEGG   Pan paniscus (bonobo): 100989732
Entry
100989732         CDS       T02283                                 

Gene name
PIK3CD
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00562  Inositol phosphate metabolism
pps01100  Metabolic pathways
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05132  Salmonella infection
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease - COVID-19
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100989732 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100989732 (PIK3CD)
   04014 Ras signaling pathway
    100989732 (PIK3CD)
   04015 Rap1 signaling pathway
    100989732 (PIK3CD)
   04370 VEGF signaling pathway
    100989732 (PIK3CD)
   04630 JAK-STAT signaling pathway
    100989732 (PIK3CD)
   04668 TNF signaling pathway
    100989732 (PIK3CD)
   04066 HIF-1 signaling pathway
    100989732 (PIK3CD)
   04068 FoxO signaling pathway
    100989732 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    100989732 (PIK3CD)
   04072 Phospholipase D signaling pathway
    100989732 (PIK3CD)
   04071 Sphingolipid signaling pathway
    100989732 (PIK3CD)
   04024 cAMP signaling pathway
    100989732 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    100989732 (PIK3CD)
   04152 AMPK signaling pathway
    100989732 (PIK3CD)
   04150 mTOR signaling pathway
    100989732 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100989732 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    100989732 (PIK3CD)
   04218 Cellular senescence
    100989732 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100989732 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    100989732 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100989732 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100989732 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    100989732 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    100989732 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    100989732 (PIK3CD)
   04660 T cell receptor signaling pathway
    100989732 (PIK3CD)
   04662 B cell receptor signaling pathway
    100989732 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    100989732 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    100989732 (PIK3CD)
   04670 Leukocyte transendothelial migration
    100989732 (PIK3CD)
   04062 Chemokine signaling pathway
    100989732 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100989732 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    100989732 (PIK3CD)
   04929 GnRH secretion
    100989732 (PIK3CD)
   04915 Estrogen signaling pathway
    100989732 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    100989732 (PIK3CD)
   04917 Prolactin signaling pathway
    100989732 (PIK3CD)
   04926 Relaxin signaling pathway
    100989732 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    100989732 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    100989732 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100989732 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100989732 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    100989732 (PIK3CD)
   04722 Neurotrophin signaling pathway
    100989732 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100989732 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    100989732 (PIK3CD)
   04380 Osteoclast differentiation
    100989732 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    100989732 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    100989732 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100989732 (PIK3CD)
   05206 MicroRNAs in cancer
    100989732 (PIK3CD)
   05205 Proteoglycans in cancer
    100989732 (PIK3CD)
   05203 Viral carcinogenesis
    100989732 (PIK3CD)
   05230 Central carbon metabolism in cancer
    100989732 (PIK3CD)
   05231 Choline metabolism in cancer
    100989732 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100989732 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100989732 (PIK3CD)
   05212 Pancreatic cancer
    100989732 (PIK3CD)
   05225 Hepatocellular carcinoma
    100989732 (PIK3CD)
   05226 Gastric cancer
    100989732 (PIK3CD)
   05214 Glioma
    100989732 (PIK3CD)
   05221 Acute myeloid leukemia
    100989732 (PIK3CD)
   05220 Chronic myeloid leukemia
    100989732 (PIK3CD)
   05218 Melanoma
    100989732 (PIK3CD)
   05211 Renal cell carcinoma
    100989732 (PIK3CD)
   05215 Prostate cancer
    100989732 (PIK3CD)
   05213 Endometrial cancer
    100989732 (PIK3CD)
   05224 Breast cancer
    100989732 (PIK3CD)
   05222 Small cell lung cancer
    100989732 (PIK3CD)
   05223 Non-small cell lung cancer
    100989732 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100989732 (PIK3CD)
   05017 Spinocerebellar ataxia
    100989732 (PIK3CD)
   05020 Prion disease
    100989732 (PIK3CD)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100989732 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100989732 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    100989732 (PIK3CD)
   04931 Insulin resistance
    100989732 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100989732 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100989732 (PIK3CD)
   05135 Yersinia infection
    100989732 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    100989732 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100989732 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    100989732 (PIK3CD)
   05161 Hepatitis B
    100989732 (PIK3CD)
   05160 Hepatitis C
    100989732 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    100989732 (PIK3CD)
   05164 Influenza A
    100989732 (PIK3CD)
   05162 Measles
    100989732 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    100989732 (PIK3CD)
   05163 Human cytomegalovirus infection
    100989732 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100989732 (PIK3CD)
   05169 Epstein-Barr virus infection
    100989732 (PIK3CD)
   05165 Human papillomavirus infection
    100989732 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100989732 (PIK3CD)
   05142 Chagas disease
    100989732 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100989732 (PIK3CD)
   01524 Platinum drug resistance
    100989732 (PIK3CD)
   01522 Endocrine resistance
    100989732 (PIK3CD)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100989732 (PIK3CD)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100989732 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 100989732
NCBI-ProteinID: XP_008973885
UniProt: A0A2R9B610
LinkDB
Position
1
AA seq 1044 aa
MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH
MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSARTWGP
GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
AKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP
HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEIQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR
QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgccccctggggtggactgccccatggaattctggaccaaggaggagaatcagagcgtc
gtggttgacttcctgctgcccacaggggtctacctgaacttccctgtgtcccgcaatgcc
aacctcagcaccatcaagcagctgctgtggcaccgcgcccagtatgagccgctcttccac
atgctcagtggccccgaggcctatgtgttcacctgcatcaaccagacagcggagcagcaa
gagctggaggacgagcaacggcgtctgtgtgacgtgcagcccttcctgcccgtcctgcgc
ctggtggcccgtgagggcgaccgcgtgaagaagctcatcaactcacagatcagcctcctc
atcggcaaaggcctccacgagtttgactccttgtgcgacccagaagtgaacgactttcgc
gccaagatgtgccaattctgcgaggaggcggccgcccgccggcagcagctgggctgggag
gcctggctgcagtacagtttccccctgcagctggagccctcggctcgaacctgggggcct
ggcaccctgcggctcccaaaccgggcccttctggtcaacgttaagtttgagggcagcgag
gagagcttcaccttccaggtgtccaccaaggacgtgccgctggcgctgatggcctgtgcc
ctgcggaagaaggccacggtgttccggcagccgctggtggagcagccggaagactacacg
ctgcaggtgaacggcaggcatgagtacctgtatggcagctacccgctctgccagttccag
tacatctgcagctgcctgcacagtgggttgacccctcacctgaccatggtccattcctcc
tccatcctcgccatgcgggatgagcagagcaaccctgccccccaggtccagaaaccgcgt
gccaaaccacctcccattcctgcgaagaagccttcctctgtgtccctgtggtccctggag
cagccgttccgcatcgagctcatccagggcagcaaagtgaacgccgacgagcggatgaag
ctggtggtgcaggccgggcttttccacggcaacgagatgctgtgcaagacggtgtccagc
tcggaggtgagcgtgtgctcggagcccgtgtggaagcagcggctggagttcgacatcaac
atctgtgacctgccccgcatggcccgtctctgctttgcgctgtacgccgtgatcgagaaa
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccattgcctgg
gccaacctcatgctgtttgactacaaggaccagcttaagaccggggaacgctgcctctat
atgtggccctccgtcccagatgagaagggcgagctgctgaaccccacgggcactgtgcgc
agtaaccccaacacggatagcgccgccgccctgctcatctgcctgcccgaggtggccccg
caccccgtgtactaccctgccctggagaagatcttggagctggggcgacacagcgagtgt
gtgcatgtcactgaggaggagcagctgcagctgcgggaaatcctggagcggcgggggtct
ggggagttgtatgagcacgagaaggacctggtgtggaagctgcggcatgaaatccaggag
cacttcccggaggcgctagcccggctgctgctggtcaccaagtggaacaagcatgaggat
gtggcccagatgctctacctgctgtgctcctggccggagctgcccgtcctgagcgccctg
gagctgctagacttcagcttccccgattgccacgtaggctccttcgccatcaagtcgctg
aggaaactgacggacgatgagctgttccagtacctgctgcagctggtgcaggtgctcaag
tacgagtcctacctggactgcgagctgaccaaattcctgctggaccgggccctggccaac
cgcaagatcggccacttccttttctggcacctccgctccgagatgcacgtgccgtcggtg
gccctgcgcttcggcctcatcctggaggcctactgcaggggcagcacccaccacatgaag
gtgctgatgaagcagggggaagcactgagcaaactgaaggccctgaatgacttcgtcaag
ctgagctctcagaagacccccaagccccagaccaaggagctgatgcacttgtgcatgcgg
caggaggcctacctagaggccctctcccacctgcagtccccactcgaccccagcaccctg
ctggctgaagtctgcgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg
atcatgtacagcaacgaggaggcaggcagtggcggcagcgtgggcatcatctttaagaac
ggggatgacctccggcaggacatgctgaccctgcagatgatccagctcatggacgtcctg
tggaagcaggaggggctggacctgaggatgaccccctacggctgcctccccaccggggac
cgcacaggcctcattgaggtggtactccgttcagacaccatcgccaacatccaactcaac
aagagcaacatggcagccacagccgccttcaacaaggacgccctgctcaactggctgaag
tccaagaacccgggggaggccctggatcgagccattgaggagttcaccctctcctgtgct
ggctattgtgtggccacatatgtgctgggcatcggcgatcggcacagcgacaacatcatg
atccgagagagtgggcagctgttccacattgattttggccactttctggggaatttcaag
accaagtttggaatcaaccgcgagcgtgtcccattcatcctcacctatgactttgtccat
gtgattcagcaggggaagactaataatagtgagaaatttgaacggttccggggctactgt
gaaagggcctacaccatcctgcggcgccacgggcttctcttcctccacctctttgccctg
atgcgggcggcaggcctgcctgagctcagctgctccaaagacatccagtatctcaaggac
tccctggcactggggaaaacagaggaggaggcactgaagcacttccgagtgaagtttaac
gaagccctccgtgagagctggaaaaccaaagtgaactggctggcccataacgtgtccaaa
gacaacaggcagtag

KEGG   Pan paniscus (bonobo): 100990108
Entry
100990108         CDS       T02283                                 

Gene name
PIK3CB
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00562  Inositol phosphate metabolism
pps01100  Metabolic pathways
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05132  Salmonella infection
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease - COVID-19
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100990108 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100990108 (PIK3CB)
   04014 Ras signaling pathway
    100990108 (PIK3CB)
   04015 Rap1 signaling pathway
    100990108 (PIK3CB)
   04370 VEGF signaling pathway
    100990108 (PIK3CB)
   04630 JAK-STAT signaling pathway
    100990108 (PIK3CB)
   04668 TNF signaling pathway
    100990108 (PIK3CB)
   04066 HIF-1 signaling pathway
    100990108 (PIK3CB)
   04068 FoxO signaling pathway
    100990108 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100990108 (PIK3CB)
   04072 Phospholipase D signaling pathway
    100990108 (PIK3CB)
   04071 Sphingolipid signaling pathway
    100990108 (PIK3CB)
   04024 cAMP signaling pathway
    100990108 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100990108 (PIK3CB)
   04152 AMPK signaling pathway
    100990108 (PIK3CB)
   04150 mTOR signaling pathway
    100990108 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100990108 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    100990108 (PIK3CB)
   04218 Cellular senescence
    100990108 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100990108 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    100990108 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100990108 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100990108 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100990108 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    100990108 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100990108 (PIK3CB)
   04660 T cell receptor signaling pathway
    100990108 (PIK3CB)
   04662 B cell receptor signaling pathway
    100990108 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100990108 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100990108 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100990108 (PIK3CB)
   04062 Chemokine signaling pathway
    100990108 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100990108 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    100990108 (PIK3CB)
   04929 GnRH secretion
    100990108 (PIK3CB)
   04915 Estrogen signaling pathway
    100990108 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100990108 (PIK3CB)
   04917 Prolactin signaling pathway
    100990108 (PIK3CB)
   04926 Relaxin signaling pathway
    100990108 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    100990108 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100990108 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100990108 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100990108 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    100990108 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100990108 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100990108 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    100990108 (PIK3CB)
   04380 Osteoclast differentiation
    100990108 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    100990108 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    100990108 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100990108 (PIK3CB)
   05206 MicroRNAs in cancer
    100990108 (PIK3CB)
   05205 Proteoglycans in cancer
    100990108 (PIK3CB)
   05203 Viral carcinogenesis
    100990108 (PIK3CB)
   05230 Central carbon metabolism in cancer
    100990108 (PIK3CB)
   05231 Choline metabolism in cancer
    100990108 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100990108 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100990108 (PIK3CB)
   05212 Pancreatic cancer
    100990108 (PIK3CB)
   05225 Hepatocellular carcinoma
    100990108 (PIK3CB)
   05226 Gastric cancer
    100990108 (PIK3CB)
   05214 Glioma
    100990108 (PIK3CB)
   05221 Acute myeloid leukemia
    100990108 (PIK3CB)
   05220 Chronic myeloid leukemia
    100990108 (PIK3CB)
   05218 Melanoma
    100990108 (PIK3CB)
   05211 Renal cell carcinoma
    100990108 (PIK3CB)
   05215 Prostate cancer
    100990108 (PIK3CB)
   05213 Endometrial cancer
    100990108 (PIK3CB)
   05224 Breast cancer
    100990108 (PIK3CB)
   05222 Small cell lung cancer
    100990108 (PIK3CB)
   05223 Non-small cell lung cancer
    100990108 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100990108 (PIK3CB)
   05017 Spinocerebellar ataxia
    100990108 (PIK3CB)
   05020 Prion disease
    100990108 (PIK3CB)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100990108 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100990108 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    100990108 (PIK3CB)
   04931 Insulin resistance
    100990108 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100990108 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100990108 (PIK3CB)
   05135 Yersinia infection
    100990108 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    100990108 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100990108 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    100990108 (PIK3CB)
   05161 Hepatitis B
    100990108 (PIK3CB)
   05160 Hepatitis C
    100990108 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    100990108 (PIK3CB)
   05164 Influenza A
    100990108 (PIK3CB)
   05162 Measles
    100990108 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    100990108 (PIK3CB)
   05163 Human cytomegalovirus infection
    100990108 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100990108 (PIK3CB)
   05169 Epstein-Barr virus infection
    100990108 (PIK3CB)
   05165 Human papillomavirus infection
    100990108 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100990108 (PIK3CB)
   05142 Chagas disease
    100990108 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100990108 (PIK3CB)
   01524 Platinum drug resistance
    100990108 (PIK3CB)
   01522 Endocrine resistance
    100990108 (PIK3CB)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100990108 (PIK3CB)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100990108 (PIK3CB)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C
Other DBs
NCBI-GeneID: 100990108
NCBI-ProteinID: XP_003826592
UniProt: A0A2R9AJY1
LinkDB
Position
3
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaaaatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcatcgtagct
gttcattttgaaaactgccaggacgtgtttagctttcaagtgtctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagcgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtgatgaacagggccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatctaatcttcctcttccattaccaccaaagaaaaca
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaacgaaaactatt
aatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatgttaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcaatatctttta
caactggtgcaagtgttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgccgtgaagttaaacagagccaaagggaaggag
gccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgacggcacgggaatctcttc
atcactctctttgcgctgatgttgactgcagggcttcctgaactcacatcagtcaaagat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

KEGG   Pan paniscus (bonobo): 100990828
Entry
100990828         CDS       T02283                                 

Gene name
PIK3CA
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00562  Inositol phosphate metabolism
pps01100  Metabolic pathways
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05132  Salmonella infection
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease - COVID-19
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100990828 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100990828 (PIK3CA)
   04014 Ras signaling pathway
    100990828 (PIK3CA)
   04015 Rap1 signaling pathway
    100990828 (PIK3CA)
   04370 VEGF signaling pathway
    100990828 (PIK3CA)
   04630 JAK-STAT signaling pathway
    100990828 (PIK3CA)
   04668 TNF signaling pathway
    100990828 (PIK3CA)
   04066 HIF-1 signaling pathway
    100990828 (PIK3CA)
   04068 FoxO signaling pathway
    100990828 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100990828 (PIK3CA)
   04072 Phospholipase D signaling pathway
    100990828 (PIK3CA)
   04071 Sphingolipid signaling pathway
    100990828 (PIK3CA)
   04024 cAMP signaling pathway
    100990828 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100990828 (PIK3CA)
   04152 AMPK signaling pathway
    100990828 (PIK3CA)
   04150 mTOR signaling pathway
    100990828 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100990828 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    100990828 (PIK3CA)
   04218 Cellular senescence
    100990828 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100990828 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    100990828 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100990828 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100990828 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100990828 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    100990828 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100990828 (PIK3CA)
   04660 T cell receptor signaling pathway
    100990828 (PIK3CA)
   04662 B cell receptor signaling pathway
    100990828 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100990828 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100990828 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100990828 (PIK3CA)
   04062 Chemokine signaling pathway
    100990828 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100990828 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    100990828 (PIK3CA)
   04929 GnRH secretion
    100990828 (PIK3CA)
   04915 Estrogen signaling pathway
    100990828 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100990828 (PIK3CA)
   04917 Prolactin signaling pathway
    100990828 (PIK3CA)
   04926 Relaxin signaling pathway
    100990828 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    100990828 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100990828 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100990828 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100990828 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    100990828 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100990828 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100990828 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    100990828 (PIK3CA)
   04380 Osteoclast differentiation
    100990828 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    100990828 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    100990828 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100990828 (PIK3CA)
   05206 MicroRNAs in cancer
    100990828 (PIK3CA)
   05205 Proteoglycans in cancer
    100990828 (PIK3CA)
   05203 Viral carcinogenesis
    100990828 (PIK3CA)
   05230 Central carbon metabolism in cancer
    100990828 (PIK3CA)
   05231 Choline metabolism in cancer
    100990828 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100990828 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100990828 (PIK3CA)
   05212 Pancreatic cancer
    100990828 (PIK3CA)
   05225 Hepatocellular carcinoma
    100990828 (PIK3CA)
   05226 Gastric cancer
    100990828 (PIK3CA)
   05214 Glioma
    100990828 (PIK3CA)
   05221 Acute myeloid leukemia
    100990828 (PIK3CA)
   05220 Chronic myeloid leukemia
    100990828 (PIK3CA)
   05218 Melanoma
    100990828 (PIK3CA)
   05211 Renal cell carcinoma
    100990828 (PIK3CA)
   05215 Prostate cancer
    100990828 (PIK3CA)
   05213 Endometrial cancer
    100990828 (PIK3CA)
   05224 Breast cancer
    100990828 (PIK3CA)
   05222 Small cell lung cancer
    100990828 (PIK3CA)
   05223 Non-small cell lung cancer
    100990828 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100990828 (PIK3CA)
   05017 Spinocerebellar ataxia
    100990828 (PIK3CA)
   05020 Prion disease
    100990828 (PIK3CA)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100990828 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100990828 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    100990828 (PIK3CA)
   04931 Insulin resistance
    100990828 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100990828 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100990828 (PIK3CA)
   05135 Yersinia infection
    100990828 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    100990828 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100990828 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    100990828 (PIK3CA)
   05161 Hepatitis B
    100990828 (PIK3CA)
   05160 Hepatitis C
    100990828 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    100990828 (PIK3CA)
   05164 Influenza A
    100990828 (PIK3CA)
   05162 Measles
    100990828 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    100990828 (PIK3CA)
   05163 Human cytomegalovirus infection
    100990828 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100990828 (PIK3CA)
   05169 Epstein-Barr virus infection
    100990828 (PIK3CA)
   05165 Human papillomavirus infection
    100990828 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100990828 (PIK3CA)
   05142 Chagas disease
    100990828 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100990828 (PIK3CA)
   01524 Platinum drug resistance
    100990828 (PIK3CA)
   01522 Endocrine resistance
    100990828 (PIK3CA)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100990828 (PIK3CA)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100990828 (PIK3CA)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_C2 PI3K_p85B DUF2321 ASC Ribosomal_S15
Other DBs
NCBI-GeneID: 100990828
NCBI-ProteinID: XP_014199940
LinkDB
Position
3
AA seq 1061 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKNSSKAISTRDPL
SEITEQEKDFLWSHRWLIHNYLSPLNMIYCLSHTQMYCLVKDWPPIKPEQAMELLDCNYP
DPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFF
FWHLKSEMHNKTVSQRFGLLLESYCRACGVYLKHLNRQVEAMEKLINLTDILKQEKKDET
QKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPD
IMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGL
IEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRPCAGYCVA
TFISGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKG
AQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLA
LDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3186 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaagaacagctcaaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagccacagatggctcattcacaac
tatctttcccctttaaatatgatttattgtctttctcatacacagatgtattgcttggta
aaagattggcctccaatcaaacctgaacaggctatggaacttctggactgtaattaccca
gatcctatggttcgaggttttgctgttcggtgcttggaaaaatatttaacagatgacaaa
ctttctcagtatttaattcagctagtacaggtcctaaaatatgaacaatatttggataac
ttgcttgtgagatttttactgaagaaagcattgactaatcaaaggattgggcactttttc
ttttggcatttaaaatctgagatgcacaataaaacagttagccagaggtttggcctgctt
ttggagtcctattgtcgtgcatgtggggtgtatttgaagcacctgaataggcaagtcgag
gcaatggaaaagctcattaacttaactgacattctcaaacaggagaagaaggatgaaaca
caaaaggtacagatgaagtttttagttgagcaaatgaggcgaccagatttcatggatgct
ctacagggctttctgtctcctctaaaccctgctcatcaactaggaaacctcaggcttgaa
gagtgtcgaattatgtcctctgcaaaaaggccactgtggttgaattgggagaacccagac
atcatgtcagagttactgtttcagaacaatgagatcatctttaaaaatggggatgattta
cggcaagatatgctaacacttcaaattattcgtattatggaaaatatctggcaaaatcaa
ggtcttgatcttcgaatgttaccttatggttgtctgtcaatcggtgactgtgtgggactt
attgaggtggtgcgaaattctcacactattatgcaaattcagtgcaaaggcggcttgaaa
ggtgcactgcagttcaacagccacacactacatcagtggctcaaagacaagaacaaagga
gaaatatatgatgcagccattgacctgtttacacgtccatgtgctggatactgtgtagct
accttcatttcgggaattggagatcgtcacaatagtaacatcatggtgaaagacgatgga
caactgtttcatatagattttggacactttttggatcacaagaagaaaaaatttggttat
aaacgagaacgtgtgccatttgttttgacacaggatttcttaatagtgattagtaaagga
gcccaagaatgcacaaagacaagagaatttgagaggtttcaggagatgtgttacaaggct
tatctagctattcgacagcatgccaatctcttcataaatcttttctcaatgatgcttggc
tctggaatgccagaactacaatcttttgatgacattgcatacattcgaaagaccctagcc
ttagataaaactgagcaagaggctttggagtatttcatgaaacaaatgaatgatgcacat
catggtggctggacaacaaaaatggattggatcttccacacaattaaacagcatgcattg
aactga

KEGG   Pan paniscus (bonobo): 100994315
Entry
100994315         CDS       T02283                                 

Gene name
PIK3R1
Definition
(RefSeq) phosphoinositide-3-kinase regulatory subunit 1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease - COVID-19
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100994315 (PIK3R1)
   04014 Ras signaling pathway
    100994315 (PIK3R1)
   04015 Rap1 signaling pathway
    100994315 (PIK3R1)
   04370 VEGF signaling pathway
    100994315 (PIK3R1)
   04630 JAK-STAT signaling pathway
    100994315 (PIK3R1)
   04668 TNF signaling pathway
    100994315 (PIK3R1)
   04066 HIF-1 signaling pathway
    100994315 (PIK3R1)
   04068 FoxO signaling pathway
    100994315 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    100994315 (PIK3R1)
   04072 Phospholipase D signaling pathway
    100994315 (PIK3R1)
   04071 Sphingolipid signaling pathway
    100994315 (PIK3R1)
   04024 cAMP signaling pathway
    100994315 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    100994315 (PIK3R1)
   04152 AMPK signaling pathway
    100994315 (PIK3R1)
   04150 mTOR signaling pathway
    100994315 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100994315 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    100994315 (PIK3R1)
   04218 Cellular senescence
    100994315 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100994315 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100994315 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100994315 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100994315 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    100994315 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    100994315 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    100994315 (PIK3R1)
   04660 T cell receptor signaling pathway
    100994315 (PIK3R1)
   04662 B cell receptor signaling pathway
    100994315 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    100994315 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    100994315 (PIK3R1)
   04670 Leukocyte transendothelial migration
    100994315 (PIK3R1)
   04062 Chemokine signaling pathway
    100994315 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100994315 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    100994315 (PIK3R1)
   04929 GnRH secretion
    100994315 (PIK3R1)
   04915 Estrogen signaling pathway
    100994315 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    100994315 (PIK3R1)
   04917 Prolactin signaling pathway
    100994315 (PIK3R1)
   04926 Relaxin signaling pathway
    100994315 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    100994315 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    100994315 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100994315 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100994315 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    100994315 (PIK3R1)
   04722 Neurotrophin signaling pathway
    100994315 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100994315 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    100994315 (PIK3R1)
   04380 Osteoclast differentiation
    100994315 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    100994315 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    100994315 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100994315 (PIK3R1)
   05206 MicroRNAs in cancer
    100994315 (PIK3R1)
   05205 Proteoglycans in cancer
    100994315 (PIK3R1)
   05203 Viral carcinogenesis
    100994315 (PIK3R1)
   05230 Central carbon metabolism in cancer
    100994315 (PIK3R1)
   05231 Choline metabolism in cancer
    100994315 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100994315 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100994315 (PIK3R1)
   05212 Pancreatic cancer
    100994315 (PIK3R1)
   05225 Hepatocellular carcinoma
    100994315 (PIK3R1)
   05226 Gastric cancer
    100994315 (PIK3R1)
   05214 Glioma
    100994315 (PIK3R1)
   05221 Acute myeloid leukemia
    100994315 (PIK3R1)
   05220 Chronic myeloid leukemia
    100994315 (PIK3R1)
   05218 Melanoma
    100994315 (PIK3R1)
   05211 Renal cell carcinoma
    100994315 (PIK3R1)
   05215 Prostate cancer
    100994315 (PIK3R1)
   05213 Endometrial cancer
    100994315 (PIK3R1)
   05224 Breast cancer
    100994315 (PIK3R1)
   05222 Small cell lung cancer
    100994315 (PIK3R1)
   05223 Non-small cell lung cancer
    100994315 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100994315 (PIK3R1)
   05017 Spinocerebellar ataxia
    100994315 (PIK3R1)
   05020 Prion disease
    100994315 (PIK3R1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100994315 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100994315 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    100994315 (PIK3R1)
   04931 Insulin resistance
    100994315 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100994315 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100994315 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    100994315 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100994315 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    100994315 (PIK3R1)
   05161 Hepatitis B
    100994315 (PIK3R1)
   05160 Hepatitis C
    100994315 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    100994315 (PIK3R1)
   05164 Influenza A
    100994315 (PIK3R1)
   05162 Measles
    100994315 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    100994315 (PIK3R1)
   05163 Human cytomegalovirus infection
    100994315 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100994315 (PIK3R1)
   05169 Epstein-Barr virus infection
    100994315 (PIK3R1)
   05165 Human papillomavirus infection
    100994315 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100994315 (PIK3R1)
   05142 Chagas disease
    100994315 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100994315 (PIK3R1)
   01524 Platinum drug resistance
    100994315 (PIK3R1)
   01522 Endocrine resistance
    100994315 (PIK3R1)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100994315 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_9 SH3_2 Laminin_I Lant_dehydr_C PI_PP_I FANCI_S2 Mod_r Bap31_Bap29_C
Other DBs
NCBI-GeneID: 100994315
NCBI-ProteinID: XP_003806841
UniProt: A0A2R9CKR4
LinkDB
Position
5
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccggccacctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagtttgcccctcctgacattgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcagaa
ttacgacagcttcttgattgtgatacaccctccgtggacttggaaatgatcgatgtgcac
gttttggccgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctccagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagacgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaaattg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
cgagaatatgatagattatatgaagaatatacccgcacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caagagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcactggtggaagatgatgaagatttgccccatcatgat
gagaagacatggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcaactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

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