Entry
Symbol
PIK3R1_2_3
Name
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Pathway
map01521 EGFR tyrosine kinase inhibitor resistance
map04070 Phosphatidylinositol signaling system
map04072 Phospholipase D signaling pathway
map04213 Longevity regulating pathway - multiple species
map04550 Signaling pathways regulating pluripotency of stem cells
map04613 Neutrophil extracellular trap formation
map04620 Toll-like receptor signaling pathway
map04625 C-type lectin receptor signaling pathway
map04650 Natural killer cell mediated cytotoxicity
map04660 T cell receptor signaling pathway
map04662 B cell receptor signaling pathway
map04664 Fc epsilon RI signaling pathway
map04666 Fc gamma R-mediated phagocytosis
map04670 Leukocyte transendothelial migration
map04750 Inflammatory mediator regulation of TRP channels
map04810 Regulation of actin cytoskeleton
map04914 Progesterone-mediated oocyte maturation
map04919 Thyroid hormone signaling pathway
map04923 Regulation of lipolysis in adipocytes
map04932 Non-alcoholic fatty liver disease
map04933 AGE-RAGE signaling pathway in diabetic complications
map04935 Growth hormone synthesis, secretion and action
map04960 Aldosterone-regulated sodium reabsorption
map04973 Carbohydrate digestion and absorption
map05100 Bacterial invasion of epithelial cells
map05163 Human cytomegalovirus infection
map05166 Human T-cell leukemia virus 1 infection
map05167 Kaposi sarcoma-associated herpesvirus infection
map05168 Herpes simplex virus 1 infection
map05170 Human immunodeficiency virus 1 infection
map05207 Chemical carcinogenesis - receptor activation
map05208 Chemical carcinogenesis - reactive oxygen species
map05230 Central carbon metabolism in cancer
map05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
map05418 Fluid shear stress and atherosclerosis
Reaction
R03362 ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
R04545 ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
R05795 ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase
Disease
H01387 Activated PI3K-delta syndrome
H01885 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04014 Ras signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04015 Rap1 signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04370 VEGF signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04630 JAK-STAT signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04668 TNF signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04066 HIF-1 signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04068 FoxO signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04070 Phosphatidylinositol signaling system
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04072 Phospholipase D signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04071 Sphingolipid signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04024 cAMP signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04151 PI3K-Akt signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04152 AMPK signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04150 mTOR signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09133 Signaling molecules and interaction
04081 Hormone signaling
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09143 Cell growth and death
04210 Apoptosis
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04218 Cellular senescence
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09144 Cellular community - eukaryotes
04510 Focal adhesion
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04550 Signaling pathways regulating pluripotency of stem cells
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09142 Cell motility
04810 Regulation of actin cytoskeleton
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04613 Neutrophil extracellular trap formation
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04620 Toll-like receptor signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04625 C-type lectin receptor signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04650 Natural killer cell mediated cytotoxicity
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04660 T cell receptor signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04662 B cell receptor signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04664 Fc epsilon RI signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04666 Fc gamma R-mediated phagocytosis
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04670 Leukocyte transendothelial migration
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04062 Chemokine signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09152 Endocrine system
04910 Insulin signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04923 Regulation of lipolysis in adipocytes
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04929 GnRH secretion
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04915 Estrogen signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04914 Progesterone-mediated oocyte maturation
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04917 Prolactin signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04926 Relaxin signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04935 Growth hormone synthesis, secretion and action
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04919 Thyroid hormone signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09154 Digestive system
04973 Carbohydrate digestion and absorption
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09156 Nervous system
04725 Cholinergic synapse
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04722 Neurotrophin signaling pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09158 Development and regeneration
04360 Axon guidance
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04380 Osteoclast differentiation
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09149 Aging
04211 Longevity regulating pathway
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04213 Longevity regulating pathway - multiple species
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05206 MicroRNAs in cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05205 Proteoglycans in cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05207 Chemical carcinogenesis - receptor activation
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05208 Chemical carcinogenesis - reactive oxygen species
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05203 Viral carcinogenesis
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05230 Central carbon metabolism in cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05231 Choline metabolism in cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09162 Cancer: specific types
05210 Colorectal cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05212 Pancreatic cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05225 Hepatocellular carcinoma
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05226 Gastric cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05214 Glioma
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05221 Acute myeloid leukemia
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05220 Chronic myeloid leukemia
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05218 Melanoma
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05211 Renal cell carcinoma
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05215 Prostate cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05213 Endometrial cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05224 Breast cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05222 Small cell lung cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05223 Non-small cell lung cancer
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05170 Human immunodeficiency virus 1 infection
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05161 Hepatitis B
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05160 Hepatitis C
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05171 Coronavirus disease - COVID-19
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05164 Influenza A
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05162 Measles
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05168 Herpes simplex virus 1 infection
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05163 Human cytomegalovirus infection
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05167 Kaposi sarcoma-associated herpesvirus infection
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05169 Epstein-Barr virus infection
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05165 Human papillomavirus infection
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09171 Infectious disease: bacterial
05131 Shigellosis
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05135 Yersinia infection
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05100 Bacterial invasion of epithelial cells
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09174 Infectious disease: parasitic
05146 Amoebiasis
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05142 Chagas disease
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09164 Neurodegenerative disease
05010 Alzheimer disease
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05017 Spinocerebellar ataxia
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05020 Prion disease
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05418 Fluid shear stress and atherosclerosis
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
05415 Diabetic cardiomyopathy
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04932 Non-alcoholic fatty liver disease
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04931 Insulin resistance
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
04933 AGE-RAGE signaling pathway in diabetic complications
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
01524 Platinum drug resistance
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
01522 Endocrine resistance
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Membrane trafficking [BR:ko04131 ]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
BRITE hierarchy
Genes
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Taxonomy UniProt
Reference
Authors
Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J
Title
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
Journal
Sequence
Reference
Authors
Janssen JW, Schleithoff L, Bartram CR, Schulz AS
Title
An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.
Journal
Sequence
Reference
Authors
Dey BR, Furlanetto RW, Nissley SP
Title
Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.
Journal
Sequence
LinkDB
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