Rattus norvegicus (rat): 25614
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Entry
25614 CDS
T01003
Gene name
Ptk2, FAK, FRNK, p125FAK
Definition
(RefSeq) protein tyrosine kinase 2
KO
K05725
focal adhesion kinase 1 [EC:
2.7.10.2
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno01522
Endocrine resistance
rno04012
ErbB signaling pathway
rno04062
Chemokine signaling pathway
rno04151
PI3K-Akt signaling pathway
rno04360
Axon guidance
rno04370
VEGF signaling pathway
rno04510
Focal adhesion
rno04670
Leukocyte transendothelial migration
rno04810
Regulation of actin cytoskeleton
rno04935
Growth hormone synthesis, secretion and action
rno05100
Bacterial invasion of epithelial cells
rno05135
Yersinia infection
rno05146
Amoebiasis
rno05163
Human cytomegalovirus infection
rno05165
Human papillomavirus infection
rno05170
Human immunodeficiency virus 1 infection
rno05200
Pathways in cancer
rno05202
Transcriptional misregulation in cancer
rno05205
Proteoglycans in cancer
rno05222
Small cell lung cancer
rno05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
25614 (Ptk2)
04370 VEGF signaling pathway
25614 (Ptk2)
04151 PI3K-Akt signaling pathway
25614 (Ptk2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
25614 (Ptk2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
25614 (Ptk2)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
25614 (Ptk2)
04062 Chemokine signaling pathway
25614 (Ptk2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
25614 (Ptk2)
09158 Development and regeneration
04360 Axon guidance
25614 (Ptk2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
25614 (Ptk2)
05202 Transcriptional misregulation in cancer
25614 (Ptk2)
05205 Proteoglycans in cancer
25614 (Ptk2)
09162 Cancer: specific types
05222 Small cell lung cancer
25614 (Ptk2)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
25614 (Ptk2)
09171 Infectious disease: bacterial
05135 Yersinia infection
25614 (Ptk2)
05100 Bacterial invasion of epithelial cells
25614 (Ptk2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
25614 (Ptk2)
05163 Human cytomegalovirus infection
25614 (Ptk2)
05165 Human papillomavirus infection
25614 (Ptk2)
09174 Infectious disease: parasitic
05146 Amoebiasis
25614 (Ptk2)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
25614 (Ptk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rno01001
]
25614 (Ptk2)
01009 Protein phosphatases and associated proteins [BR:
rno01009
]
25614 (Ptk2)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
25614 (Ptk2)
Protein kinases [BR:
rno01001
]
Non-receptor tyrosine kinases
FAK family
25614 (Ptk2)
Protein phosphatases and associated proteins [BR:
rno01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
25614 (Ptk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Focal_AT
Pkinase
FERM_N_2
FERM_M
Kinase-like
FERM_F2
Motif
Other DBs
NCBI-GeneID:
25614
NCBI-ProteinID:
NP_037213
RGD:
3443
Ensembl:
ENSRNOG00000007916
UniProt:
O35346
LinkDB
All DBs
Position
7q34
AA seq
1055 aa
AA seq
DB search
MAAAYLDPNLNHTPSSSTKTHLGTGTERSPGAMERVLKVFHYFESSNEPTTWASIIRHGD
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQDIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI
LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQ
TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFII
RPQKEGERALPSIPKLANNEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE
RIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH
PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT
SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA
YDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQISGYPGSHGIPAMAGSIYPGQASLLDQTELWNHRPQE
MSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS
RGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPAESYNE
GVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEV
GLALRTLLATVDETIPILPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYK
KQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
NT seq
3168 nt
NT seq
+upstream
nt +downstream
nt
atggcagctgcttatcttgacccaaacttgaatcacacaccaagttcgagtactaagact
cacctgggtactggcacggaacggtcccctggtgcaatggaacgagtattaaaggtcttt
cattattttgaaagcagtaatgagccaaccacctgggccagtattatcaggcatggagac
gctactgacgtcaggggaatcattcagaagatagtggacagtcacaaagtaaagcacgtg
gcctgctatggatttcgcctcagtcacctgcgatcggaggaggtgcactggctgcatgtg
gacatgggtgtctccagtgtgagggagaaatacgaactcgcccacccaccagaggagtgg
aaatatgagttgagaattcgttatttgccaaaaggatttctaaaccagtttactgaagat
aagccaacattgaatttcttctatcaacaggtgaagagtgactacatgctagaaatagct
gatcaagtagaccaagacatagctttgaagttgggttgtttggaaattaggcgatcctac
tgggagatgaggggcaacgccctagagaagaagtccaactatgaagtgttagagaaagat
gttggtttaaagcgattttttcccaagagtttactggattccgtcaaggccaaaacacta
agaaagctgatccagcaaacattcaggcagtttgccaaccttaatagagaagaaagcatc
ctgaaattctttgagattctctctccagtgtacagatttgacaaagagtgcttcaagtgt
gcccttgggtcaagttggattatttctgtggaactggcgatcggcccagaagaagggatc
agttacctgacagacaagggctgcaatcccacacacctagcggacttcaaccaagtgcag
actatccagtactcaaacagtgaagacaaagacaggaaaggaatgctacaactcaaaatc
gctggtgctcctgagcctctgacagtgacggccccatccctaaccattgcagagaacatg
gctgacctgatcgatggatactgccggctggtgaacggagccacgcagtccttcatcatc
agaccccagaaagaaggtgaacgggcattgccatcaataccaaagttggccaacaatgaa
aagcaaggcatgcggacacatgcagtctctgtgtcagagacagatgactatgccgagatc
atcgatgaggaagacacatacaccatgccctcaaccagggattatgagattcagagagaa
agaatagaacttggacgctgtattggagaaggccagtttggagatgtacatcaaggcgtg
tacctgagcccagagaatccagctttggctgttgcaatcaaaacatgtaaaaactgtact
tcggacagcgtgagagagaagttccttcaagaagccttaacaatgcgccagtttgaccat
cctcacatcgtgaagctgattggagtcattacagagaacccagtttggataatcatggag
ttgtgcacacttggagagctgaggtcatttttgcaagtaaggaaatacagcttggatcta
gcatctttgatcttatatgcctatcagcttagtacagcactcgcgtatctggagagcaaa
agatttgttcacagggacattgctgcacggaatgttctggtgtcttcaaatgattgtgta
aaattaggagactttggattatctcgatatatggaagacagtacttactataaagcttcc
aaaggaaaattacctattaaatggatggctccagagtcaatcaattttcgacgttttacc
tcagctagtgacgtgtggatgtttggtgtgtgtatgtgggagatactgatgcatggcgtg
aagccttttcaaggagtgaagaacaatgatgtgatcggtcgaattgaaaatggggaaaga
ttaccaatgcctccaaattgtcctcccaccctctacagccttatgacgaaatgttgggcc
tatgaccccagcagacggcccaggtttactgaactaaaagctcagctcagcacaatcctg
gaggaagagaaggtgcagcaagaagaacggatgaggatggaatccagaagacaggcaaca
gtgtcctgggactctggagggtctgatgaagcaccacccaagcccagcagacctggttat
cctagcccgaggtccagtgaaggattttatcccagcccacagcacatggtccagaccaat
cactatcagatctctggctacccaggttcccatggaatcccagccatggctggcagcatt
tacccaggtcaggcatctcttctggaccagacagaattgtggaatcacagacctcaggag
atgtccatgtggcagcccagtgtggaggactcagcagctttagatcttcgagggatggga
caggtgcttcctcctcacctgatggaagagcggctaatccgacagcagcaggaaatggag
gaagaccagcgctggctggaaaaggaagagcgattcctgaaacctgatgtgaggctctct
cgaggcagcatcgacagggaggacgggagttttcagggtccgactggaaaccaacacatc
tatcagcctgtgggaaaaccagatcctgcagctccaccaaagaaaccacctcgccctgga
gcacctggccacctaagcaacttgtccagcatcagcagccctgcagaaagctacaatgag
ggtgtcaagccgtggaggcttcagccccaggaaatcagcccccctcccactgccaacctt
gaccgatccaatgacaaggtatatgaaaatgtgacgggcctagtgaaggctgtcattgag
atgtccagcaaaatccaaccagctcctccagaagagtacgtccctatggtgaaggaagtt
ggcctggccctgcggaccttactggccactgtggatgagaccattcccatccttccagcc
agcacccatcgagagatcgagatggcacagaagctgctgaactccgacttgggtgagctc
atcagcaagatgaagctggcgcagcagtatgtcatgaccagccttcagcaggagtacaag
aagcagatgctgacagctgctcacgccctggctgtggatgccaagaatctacttgatgtt
attgatcaagcgagactgaaaatgctagggcagacacggccacactga
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integrated database retrieval system
