KEGG   ORTHOLOGY: K05725
Entry
K05725                      KO                                     

Symbol
PTK2, FAK
Name
focal adhesion kinase 1 [EC:2.7.10.2]
Pathway
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04062  Chemokine signaling pathway
map04151  PI3K-Akt signaling pathway
map04360  Axon guidance
map04370  VEGF signaling pathway
map04510  Focal adhesion
map04670  Leukocyte transendothelial migration
map04810  Regulation of actin cytoskeleton
map04935  Growth hormone synthesis, secretion and action
map05100  Bacterial invasion of epithelial cells
map05131  Shigellosis
map05135  Yersinia infection
map05146  Amoebiasis
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05205  Proteoglycans in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05222  Small cell lung cancer
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
   04370 VEGF signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
   04151 PI3K-Akt signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05725  PTK2, FAK; focal adhesion kinase 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05725  PTK2, FAK; focal adhesion kinase 1
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K05725  PTK2, FAK; focal adhesion kinase 1
   04062 Chemokine signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05725  PTK2, FAK; focal adhesion kinase 1
  09158 Development and regeneration
   04360 Axon guidance
    K05725  PTK2, FAK; focal adhesion kinase 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
   05202 Transcriptional misregulation in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
   05205 Proteoglycans in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
   05208 Chemical carcinogenesis - reactive oxygen species
    K05725  PTK2, FAK; focal adhesion kinase 1
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05163 Human cytomegalovirus infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05165 Human papillomavirus infection
    K05725  PTK2, FAK; focal adhesion kinase 1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05725  PTK2, FAK; focal adhesion kinase 1
   05135 Yersinia infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05100 Bacterial invasion of epithelial cells
    K05725  PTK2, FAK; focal adhesion kinase 1
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05725  PTK2, FAK; focal adhesion kinase 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05725  PTK2, FAK; focal adhesion kinase 1
   05418 Fluid shear stress and atherosclerosis
    K05725  PTK2, FAK; focal adhesion kinase 1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K05725  PTK2, FAK; focal adhesion kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05725  PTK2, FAK; focal adhesion kinase 1
   01009 Protein phosphatases and associated proteins
    K05725  PTK2, FAK; focal adhesion kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05725  PTK2, FAK; focal adhesion kinase 1
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  FAK family
   K05725  PTK2, FAK; focal adhesion kinase 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K05725  PTK2, FAK; focal adhesion kinase 1
Other DBs
GO: 0004715
Genes
HSA: 5747(PTK2)
PTR: 464422(PTK2)
PPS: 100989953(PTK2)
GGO: 101128620(PTK2)
PON: 100447959(PTK2)
MCC: 700634(PTK2)
MCF: 101925550(PTK2)
CSAB: 103237724(PTK2)
CATY: 105581292(PTK2)
PANU: 101022936(PTK2)
RRO: 104679749(PTK2)
RBB: 108544148(PTK2)
TFN: 117079459(PTK2)
PTEH: 111553372(PTK2)
CJC: 100395283(PTK2)
SBQ: 101052217(PTK2)
MMUR: 105855154(PTK2)
MMU: 14083(Ptk2)
MCAL: 110310271(Ptk2)
MPAH: 110334478(Ptk2)
RNO: 25614(Ptk2)
MCOC: 116073569(Ptk2)
MUN: 110542391(Ptk2)
CGE: 100759464(Ptk2)
PLEU: 114704659(Ptk2)
NGI: 103748419(Ptk2)
HGL: 101711587(Ptk2)
CCAN: 109681968(Ptk2)
OCU: 100347455(PTK2)
TUP: 102483369(PTK2)
CFA: 475108(PTK2)
VVP: 112909230(PTK2)
VLG: 121498821(PTK2)
AML: 100464496(PTK2)
UMR: 103670589(PTK2)
UAH: 113248466(PTK2)
ORO: 101371010(PTK2)
ELK: 111146744
MPUF: 101681759(PTK2)
EJU: 114211152(PTK2)
MLX: 118015244(PTK2)
FCA: 101095952(PTK2)
PYU: 121043038(PTK2)
PTG: 102953254(PTK2)
PPAD: 109273067(PTK2)
AJU: 106984404(PTK2)
HHV: 120232325(PTK2)
BTA: 506270(PTK2)
BOM: 102280095(PTK2)
BIU: 109568429(PTK2)
BBUB: 102389136(PTK2)
CHX: 102177814(PTK2)
OAS: 101120842(PTK2)
ODA: 120878853(PTK2)
CCAD: 122451056(PTK2)
SSC: 102167153(PTK2)
CBAI: 105074777
CDK: 105095121(PTK2)
BACU: 103013388(PTK2)
LVE: 103082438(PTK2)
OOR: 101275490(PTK2)
DLE: 111165046(PTK2)
PCAD: 102982229(PTK2)
ECB: 100058245(PTK2)
EPZ: 103561848(PTK2)
EAI: 106846305(PTK2)
MYB: 102245460(PTK2)
MYD: 102754742(PTK2)
MMYO: 118670566(PTK2)
MNA: 107533206(PTK2)
HAI: 109390857(PTK2)
SHON: 118988708(PTK2)
AJM: 119064798(PTK2)
MMF: 118631501(PTK2)
PALE: 102898998(PTK2)
PGIG: 120588751(PTK2)
RAY: 107504408(PTK2)
TOD: 119235583(PTK2)
LAV: 100668436(PTK2)
TMU: 101351714
MDO: 100027188(PTK2)
SHR: 100933019(PTK2)
PCW: 110194600(PTK2)
OAA: 100076789(PTK2)
GGA: 396416(PTK2)
PCOC: 116227775(PTK2)
CJO: 107310587(PTK2)
NMEL: 110393818(PTK2)
APLA: 101796890(PTK2)
ACYG: 106043708(PTK2)
TGU: 100221659(PTK2)
LSR: 110471669(PTK2)
SCAN: 103814761(PTK2)
PMOA: 120512796(PTK2)
GFR: 102043366(PTK2)
FAB: 101814936(PTK2)
PHI: 102104319(PTK2)
PMAJ: 107199979(PTK2)
CCAE: 111925177(PTK2)
CCW: 104692616(PTK2)
ETL: 114061597(PTK2)
FPG: 101922646(PTK2)
FCH: 102059158(PTK2)
CLV: 102093049(PTK2)
EGZ: 104135598(PTK2)
NNI: 104020584(PTK2)
PADL: 103920642(PTK2)
AAM: 106482268
NPD: 112953989(PTK2)
ASN: 102375664(PTK2)
AMJ: 106736955(PTK2)
CPOO: 109322207(PTK2)
GGN: 109305225(PTK2)
PSS: 102453077(PTK2)
CPIC: 101943190(PTK2)
TST: 117873845(PTK2)
CABI: 116838184(PTK2)
ACS: 100554871(ptk2)
PVT: 110084855(PTK2)
PBI: 103060776(PTK2)
PGUT: 117676523(PTK2)
PMUA: 114600216(PTK2)
ZVI: 118090037(PTK2)
XLA: 399286(ptk2.L) 432072(ptk2.S)
XTR: 733890(ptk2)
NPR: 108792768(PTK2)
DRE: 142986(ptk2ab) 386705(ptk2aa)
SRX: 107741772
CCAR: 109092941
IPU: 108256909(ptk2) 108267913
PHYP: 113533847 113536245(ptk2)
AMEX: 103033402 103041623(ptk2)
EEE: 113571245 113590645(ptk2)
LCO: 104938545
CGOB: 115015974 115021192(ptk2)
PLEP: 121945745
ECRA: 117945717(ptk2ab) 117957177(ptk2aa)
GAT: 120810078
MSAM: 119897851
CUD: 121514041
OLA: 101155713(ptk2)
XMA: 102223109
XCO: 114142248
XHE: 116717721
PRET: 103478404(ptk2)
CTUL: 119779657(ptk2aa) 119791340
NFU: 107396176(ptk2)
KMR: 108232279
SLAL: 111657213
SFM: 108922037(ptk2) 108940645
PKI: 111843830(ptk2) 111844688
LCM: 102356941(PTK2)
CMK: 103181063(ptk2)
BFO: 118409818
BBEL: 109480936
CIN: 100176095
SCLV: 120345501
SPU: 105436929
DME: Dmel_CG10023(Fak)
DER: 6547429
DSE: 6609940
DSI: Dsimw501_GD25321(Dsim_GD25321)
DAN: 6495456
DSR: 110176395
DPO: Dpse_GA10015(Dpse_fak)
DPE: 6590135
DMN: 108160000
DWI: 6640912
DGR: 6560353
DAZ: 108615172
DNV: 115563874
DHE: 111600150
DVI: 6626795
CCAT: 101457238
MDE: 101887255
LCQ: 111677048
ACOZ: 120954970
AAG: 5565233
AALB: 109401644
AME: 724973
ACER: 108000830
BIM: 100742416
BBIF: 117212322
BTER: 100651181
CCAL: 108623737
OBB: 114877622
MGEN: 117220828
NMEA: 116425549
CGIG: 122395820
SOC: 105205797
MPHA: 105833444
AEC: 105143988
ACEP: 105625816
PBAR: 105433628
VEM: 105565717
HST: 105186395
DQU: 106745467
CFO: 105253398
FEX: 115241532
LHU: 105669182
PGC: 109858447
OBO: 105283194
PCF: 106784223
NVI: 100118485
CSOL: 105361204
MDL: 103577529
CCIN: 107273475
TCA: 664221
DPA: 109534059
ATD: 109608216
AGB: 108908870
LDC: 111516522
NVL: 108562904
APLN: 108734385
PPYR: 116181766
OTU: 111424643
BMOR: 101745942
BMAN: 114245095
MSEX: 115453125
BANY: 112051544
PMAC: 106718652
PPOT: 106111709
PXU: 106128064
PRAP: 110995965
ZCE: 119837160
HAW: 110379551
TNL: 113494203
PXY: 105388640
API: 100160998
DNX: 107164318
AGS: 114130920
RMD: 113554034
BTAB: 109040041
CLEC: 106672901
HHAL: 106682018
NLU: 111044352
ZNE: 110833268
CSEC: 111866996
FCD: 110841658
PVM: 113818212
HAME: 121857491
HAZT: 108671451
EAF: 111718029
DSV: 119431409
RSAN: 119407146
RMP: 119163556
VDE: 111250517
VJA: 111265922
CSCU: 111620504
PTEP: 107447538
SDM: 118192492
CEL: CELE_C30F8.4(kin-32)
CBR: CBG10801(Cbr-kin-32)
PCAN: 112573819
BGT: 106063815
GAE: 121374936
CRG: 105318395
MYI: 110443300
PMAX: 117326351
OBI: 106874006
LAK: 106150460
NVE: 116603351
EPA: 110246398
ATEN: 116288444
AMIL: 114957984
PDAM: 113681524
SPIS: 111326952
HMG: 100192269(fak)
 » show all
Reference
PMID:8422239
  Authors
Andre E, Becker-Andre M
  Title
Expression of an N-terminally truncated form of human focal adhesion kinase in brain.
  Journal
Biochem Biophys Res Commun 190:140-7 (1993)
DOI:10.1006/bbrc.1993.1022
  Sequence
[hsa:5747]
Reference
  Authors
Schaller MD
  Title
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.
  Journal
J Cell Sci 123:1007-13 (2010)
DOI:10.1242/jcs.045112
  Sequence
[hsa:5747]
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