Ursus arctos horribilis: 113254577 Help Entry 113254577         CDS       T05909                                  Gene name JAK1 Definition (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism uah  Ursus arctos horribilis Pathway uah01521   EGFR tyrosine kinase inhibitor resistance uah04151   PI3K-Akt signaling pathway uah04217   Necroptosis uah04380   Osteoclast differentiation uah04550   Signaling pathways regulating pluripotency of stem cells uah04621   NOD-like receptor signaling pathway uah04630   Jak-STAT signaling pathway uah04658   Th1 and Th2 cell differentiation uah04659   Th17 cell differentiation uah05140   Leishmaniasis uah05145   Toxoplasmosis uah05152   Tuberculosis uah05160   Hepatitis C uah05161   Hepatitis B uah05162   Measles uah05163   Human cytomegalovirus infection uah05164   Influenza A uah05165   Human papillomavirus infection uah05166   Human T-cell leukemia virus 1 infection uah05167   Kaposi sarcoma-associated herpesvirus infection uah05168   Herpes simplex virus 1 infection uah05169   Epstein-Barr virus infection uah05200   Pathways in cancer uah05203   Viral carcinogenesis uah05212   Pancreatic cancer uah05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:uah00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 Jak-STAT signaling pathway     113254577 (JAK1)    04151 PI3K-Akt signaling pathway     113254577 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     113254577 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     113254577 (JAK1)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     113254577 (JAK1)    04658 Th1 and Th2 cell differentiation     113254577 (JAK1)    04659 Th17 cell differentiation     113254577 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     113254577 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     113254577 (JAK1)    05203 Viral carcinogenesis     113254577 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     113254577 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     113254577 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     113254577 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     113254577 (JAK1)    05162 Measles     113254577 (JAK1)    05164 Influenza A     113254577 (JAK1)    05161 Hepatitis B     113254577 (JAK1)    05160 Hepatitis C     113254577 (JAK1)    05168 Herpes simplex virus 1 infection     113254577 (JAK1)    05163 Human cytomegalovirus infection     113254577 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     113254577 (JAK1)    05169 Epstein-Barr virus infection     113254577 (JAK1)    05165 Human papillomavirus infection     113254577 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     113254577 (JAK1)    05140 Leishmaniasis     113254577 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     113254577 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:uah01001]     113254577 (JAK1) Enzymes [BR:uah01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      113254577 (JAK1) Protein kinases [BR:uah01001]  Non-receptor tyrosine kinases   JAK family [OT]    113254577 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 SH2 DUF4079 Motif Other DBs NCBI-GeneID:  113254577 NCBI-ProteinID:  XP_026353695 UniProt:  A0A3Q7VNC1 LinkDB All DBs Position Unknown AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKHKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT LVDYKDDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD YSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPLHCPDEVYQLMRKCWEFQPSNRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagaccgaggtgaatctggaggcccccgagccaggggtggaagtgctcttc tatctttcggacagggagcccctccggctgggcagcggggagtacacggcagaggagctc tgcatcagggccgcgcaggaatgttgtatctctcctctgtgtcacaacctctttgctctg tatgatgagaacaccaagctctggtatgccccgaatcgcaccatcactgttgatgacaag acatcgctccggctccactaccggatgagattctatttcaccaactggcatgggaccaat gataatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaaa aaaaaagtcccagatgcaacccctctccttgacgccagctctctggagtatctgtttgct cagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagaccgagcag gatgggcatgatatcgagaatgagtgtctgggaatggcagtcctggccatctcccactac gctatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaagatttcttgaaggaatttaacaacaagactatttgtgacagcagt gtatctactcatgacctgaaggtgaaatacctggccaccttggaaactttgacaaaacat tatggcgctgaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat tggtttcatccaaatgacagtggaaatgttctctactatgaagtgatggtaactggaaat cttggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaacacaaa ctgaaacggaaaaagctggaaaataaacacaagaaggatgaggagaaaaacaaaatccgg gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct gtggtcagcatcaataagcaggacaacaaaaaaatggaactgaagctctcatcccatgaa gaggccttgtcctttgtgtccctggtagacggctacttccggctcacagcagatgcccat cattacctctgcaccgatgtggctcccccgttgatcgtccacaacatacagaatggttgt catggtccaatctgcacagaatatgccatcaataagttgcggcaagaaggaagcgaggag gggatgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgactgtcacc tgctttgaaaaatctgaggtgctgggtggccagaaacagttcaagaactttcagatcgag gtgcagaaaggccgctacagcctgcacggctcggaccgcagcttccccagcctgggggac ctgatgagccacctcaagaagcagatcctgcgcacggacaacatcagtttcgtgctgaag cgctgctgccagcccaagccccgagagatctccaatctgcttgtggctactaagaaagcc caagagtggcagcctgtctaccccatgagccagctgagttttgaccggatcctcaagaaa gatattgtgcagggcgagcacctcgggagaggcacacggacacacatctactctggtacc ctggtggattacaaggatgacgaaggaactgcggaagaaaagagaataaaagtgatcctc aaagtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagatgtg gagaatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcaccgg aaaagtgatgtcctcaccacaccatggaagttcaaagttgccaagcagctggccagtgcc ctgagttacttggaggataaagacctggtccacggaaacgtgtgcacgaaaaatcttctc ctggcccgtgagggcattgacagcgagtgcggcccgttcatcaagctcagtgaccctggc atccccatcactgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctcca gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc acactctgggaaatctgctacaatggcgagatccctctgaaagacaagaccctgattgag aaagagagattctacgaaagccggtgccggccagtgacaccatcttgtaaggagctggct gaccttatgacccgctgcatgaactatgaccccaaccagagacctttcttccgagccatc atgagagacatcaataaactggaagagcagaatccagacattgtttctgaaaaaaagccg gcaaccgaagtggatcccacgcattttgaaaagcggttcttgaagaggatccgtgacttg ggagagggccacttcgggaaggtcgagctctgcaggtatgaccctgagggggacaatact ggggagcaggtggcagtcaaatccctgaagcccgagagtggaggtaaccacatagctgat ctgaagaaggaaattgaaatcctaaggaacctctatcatgagaacattgtgaagtacaaa ggcatctgtaccgaagatggaggaaatggtattaagctcatcatggaatttctgccttca ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagtta aaatatgccgttcagatttgtaaggggatggactatttgggttctcgtcagtatgttcac cgggacttggcagcaagaaacgtcctcgttgagagtgagcaccaagtgaaaattggagac tttggtttgaccaaagccattgaaactgacaaggagtattacacagtcaaggatgatcgg gacagccctgtgttttggtatgctcccgaatgtttaattcagtgtaaattttatatcgcc tctgacgtctggtcgtttggagtgactctgcacgagctgcttacttactgtgactccgat tacagccccatggcgttgttcctgaaaatgataggcccaactcatggccagatgacagtc acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacttcactgtcca gatgaggtttatcaacttatgagaaaatgctgggaattccaaccatccaatcggacaact tttcagaaccttattgaaggatttgaagcacttttaaaataa

Ursus arctos horribilis: 113256691 Help Entry 113256691         CDS       T05909                                  Gene name JAK3 Definition (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism uah  Ursus arctos horribilis Pathway uah04062   Chemokine signaling pathway uah04151   PI3K-Akt signaling pathway uah04217   Necroptosis uah04550   Signaling pathways regulating pluripotency of stem cells uah04630   Jak-STAT signaling pathway uah04658   Th1 and Th2 cell differentiation uah04659   Th17 cell differentiation uah05161   Hepatitis B uah05162   Measles uah05166   Human T-cell leukemia virus 1 infection uah05169   Epstein-Barr virus infection uah05200   Pathways in cancer uah05203   Viral carcinogenesis uah05223   Non-small cell lung cancer uah05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:uah00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 Jak-STAT signaling pathway     113256691 (JAK3)    04151 PI3K-Akt signaling pathway     113256691 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     113256691 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     113256691 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     113256691 (JAK3)    04659 Th17 cell differentiation     113256691 (JAK3)    04062 Chemokine signaling pathway     113256691 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     113256691 (JAK3)    05203 Viral carcinogenesis     113256691 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     113256691 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     113256691 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     113256691 (JAK3)    05162 Measles     113256691 (JAK3)    05161 Hepatitis B     113256691 (JAK3)    05169 Epstein-Barr virus infection     113256691 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:uah01001]     113256691 (JAK3) Enzymes [BR:uah01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      113256691 (JAK3) Protein kinases [BR:uah01001]  Non-receptor tyrosine kinases   JAK family [OT]    113256691 (JAK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo Kinase-like APH SH2 Motif Other DBs NCBI-GeneID:  113256691 NCBI-ProteinID:  XP_026356281 UniProt:  A0A3Q7V4V1 LinkDB All DBs Position Unknown AA seq 1104 aa AA seqDB search MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDHSAEELCVWAAKA SGILPVYHSLFALATEDLSCWFPPSHIFSVEDSGTQVLVYRLRFYFPNWFGLEKCHRFGL RKDLASAILDLPVLEHLFAQHRNDLVSGRLPVGLSLKEQGECLSLAVLDLARMACEQAQQ PEELLKTVSYKVCLPPDLRDLIQGLSFVTRKRIRRTVRRALRRVTACQADRHSLMAKYIM DLERLDPARAVETFLVSLPGAADGQDAQGLLRVAGDSGIAWCPGGQEALQPFCDFPEIVD ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPAALSFVALVDGYFRLTSDSRHFFC KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDCFLLTVCVQTP LGPDYKGCLIRCDPTGTFSLAGLGRPHSSLRELLAACWDGGLHVDGVALNLTVCCTPKPK EKSNLIVVRRGCNPPTSSPVQPQSQCQLSQMTFHKIPPESLEWHENLGHGSFTKIYRGCR HEVVEGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMVQ EFVHLGALDTYLLKSGHLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLLAREGA DGNLPFIKLSDPGVSPTVLNREMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS GIPMPISTLDPAKKLQFYEEQQQLPAPKWMELATLIQQCMAYESGQRPSFRAIIRDLNSL ITSDYELLSDPTPGALAPRDGLWNGAQLYAYQDPTIFEERHLKYISQLGKGNFGSVELCR YDPLGDNTGALVAVKQLQHSGPDQQRDFEREIQILKALHSDFIVKYRGVSYGPGRQSLRL VMEYLPSGCLRDFLQRHRARLDASRLLLYASQICKGMEYLGSCRCVHRDLAARNILVESE THVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL FTYGNKSCSPSAEFLRMMECDRDVPALCRLLELLAEGQRLPAPPACPGEVHELMKLCWAP SSQDRPTFSALGPQLDALWSASRG NT seq 3315 nt NT seq  +upstreamnt  +downstreamnt atggcacctccaagcgaggagacacccctgatccctcagcgttcctgcagcctctcgtct tcagaggctggtgccctgcatgtgctgctgccccctcggggccctggacccccacagcgc ctatccttctcctttggggaccattcagctgaagagctgtgtgtttgggctgctaaggcc agtggcatcctgcctgtgtaccactccctctttgctctggccacggaggacctgtcctgc tggttccccccgagccacatcttctccgtggaggactcaggcacccaagtcctggtctac aggctccgcttttacttccccaactggtttgggctagagaagtgccaccgctttgggcta cgaaaggacttggccagcgccatccttgacctgcccgtcctggagcacctcttcgcccag caccgaaatgacctggtgagcggccgcctccccgtgggcctcagtctcaaggagcagggt gaatgtctcagcctggcggtgctggacctggcccggatggcctgcgagcaggctcagcag cctgaggagctgctaaagactgtcagctacaaggtctgcctcccccccgacctgcgcgac ctgatccaaggcctgagcttcgtgacgcggaagcgcatccggaggaccgtgcgtcgggcc ctgcgccgcgtgaccgcctgccaggctgacaggcactcgctcatggccaagtacattatg gacctggagaggctcgacccggccagggcggtcgagaccttcctcgtgagcctccctggg gctgctgatggtcaagatgcgcaggggctgctccgagtggctggtgacagcggcatcgca tggtgtccaggaggacaagaggccctccagcccttctgcgactttccagaaattgtggac atcagcatcaagcaggctccgcgtgttggcccggccggggagcaccgcctggtcaccgtc accaggacagacaaccagatcctggaggccgagttcccggggctgccggccgcgttgtcc ttcgtggcgctcgtcgacggctacttccggctgacctccgactccaggcacttcttctgc aaggaggttgctccgccgcggctgctggaggaggtggcagagcagtgccacggccccatc accctggattttgccatcaacaagctcaagactgggggttcacgtccgggctcctacgtt ctccgccgcagtccccaggattttgactgcttcctcctcactgtctgtgtccagaccccc ctgggtcctgattacaagggctgcctcatccggtgtgaccccacggggaccttctccctg gctggcctaggccgtccccacagcagtcttcgagagctcttggcagcctgctgggacggc gggctgcacgtggatggggttgcgctgaacctcacagtctgctgcacccccaaacccaaa gaaaagtccaacctgattgtggtgcggaggggttgcaacccccccacgtcgtcccctgtt cagccccaatcccaatgccagctgagtcagatgacgtttcacaagatccctcctgagagc ctggagtggcatgagaacttgggtcacgggtccttcaccaagatttaccggggttgtcgc catgaggtcgtggagggcgaggcccgggagacggaggtgctgctcaaagtgatggatgcc aagcataaaaactgcatggagtcatttctggaagcagcgagtttgatgagccaagtgtca taccagcatcttgtgttgctccatggcgtgtgcatggctggagacagtatcatggtgcag gagtttgtacacctgggagctctggacacgtacctgctcaagtctggccacctggtgcca gccagctggaagctgcaggtgatcaagcagctggcctacgccctcaactacctggaagac aaaggcctcccccatggcaatgtctcagcccggaaggtgctcctggctcgcgaaggggct gatgggaacctgcccttcatcaagctgagtgaccctggtgtcagccccactgtgctaaac cgggagatgctcactgacaggatcccctgggtggcccctgagtgtctccaggaggcccgg acacttggcttggaagccgacaagtggggttttggtgccacagtctgggaggtgttcagc gggatcccgatgcccatcagcaccctggatcctgccaagaagctccagttttatgaggaa cagcagcagctgcctgcccccaagtggatggagctggccacactgatccaacagtgcatg gcctatgagtcaggccagaggccctccttccgcgccatcatccgtgacctgaacagcctc atcacttcagattatgagctcctctcagaccccacgcccggtgccttggcgccccgtgac gggctatggaatggcgcccagctctacgcctaccaggaccctaccatttttgaggagaga cacctcaagtacatctcacagctgggcaagggtaacttcggcagcgtggaactgtgccgc tatgacccgctgggtgacaacacgggcgccctagtggcagtgaagcagctgcagcacagc gggccagaccagcagagggactttgagagggagatccagatcctcaaagcccttcacagc gacttcatcgtcaagtaccgcggtgtcagctatggcccaggccgtcagagcttgcggctg gtgatggagtacctgcccagcggctgcctgcgcgacttcctgcagcggcaccgcgcgcgc ctcgacgccagccgcctgctcctctacgcctcgcagatctgcaagggcatggagtacctg ggctcctgccgctgcgtgcaccgcgacctggcagcgcgtaacatcctggtggagagcgag acgcacgtcaagatcgccgactttggcctcgccaagctgctgccactcgacaaagactac tacgtggtccgcgagcccggccagagccccatcttctggtatgccccagagtccctctct gacaacatcttctcgcgccagtcggatgtctggagcttcggggtcgtcctgtacgagctt ttcacctacggcaacaagagttgcagcccctcagccgagttcctgcggatgatggaatgt gatcgagatgtccccgccctctgccgcctcctggagctgctggctgagggccagaggctg cccgcgcctcctgcctgccctggtgaggttcatgagctcatgaagctatgctgggcccct agctcgcaagaccggccaacattcagtgccctgggcccccagctggatgcgctatggagt gccagccgggggtag

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