Ursus arctos (brown bear): 113254577
Help
Entry
113254577 CDS
T05909
Symbol
JAK1
Name
(RefSeq) tyrosine-protein kinase JAK1
KO
K11217
Janus kinase 1 [EC:
2.7.10.2
]
Organism
uah
Ursus arctos (brown bear)
Pathway
uah01521
EGFR tyrosine kinase inhibitor resistance
uah04151
PI3K-Akt signaling pathway
uah04217
Necroptosis
uah04380
Osteoclast differentiation
uah04550
Signaling pathways regulating pluripotency of stem cells
uah04620
Toll-like receptor signaling pathway
uah04621
NOD-like receptor signaling pathway
uah04630
JAK-STAT signaling pathway
uah04658
Th1 and Th2 cell differentiation
uah04659
Th17 cell differentiation
uah05140
Leishmaniasis
uah05145
Toxoplasmosis
uah05152
Tuberculosis
uah05160
Hepatitis C
uah05161
Hepatitis B
uah05162
Measles
uah05163
Human cytomegalovirus infection
uah05164
Influenza A
uah05165
Human papillomavirus infection
uah05166
Human T-cell leukemia virus 1 infection
uah05167
Kaposi sarcoma-associated herpesvirus infection
uah05168
Herpes simplex virus 1 infection
uah05169
Epstein-Barr virus infection
uah05171
Coronavirus disease - COVID-19
uah05200
Pathways in cancer
uah05203
Viral carcinogenesis
uah05212
Pancreatic cancer
uah05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
113254577 (JAK1)
04151 PI3K-Akt signaling pathway
113254577 (JAK1)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
113254577 (JAK1)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
113254577 (JAK1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
113254577 (JAK1)
04621 NOD-like receptor signaling pathway
113254577 (JAK1)
04658 Th1 and Th2 cell differentiation
113254577 (JAK1)
04659 Th17 cell differentiation
113254577 (JAK1)
09158 Development and regeneration
04380 Osteoclast differentiation
113254577 (JAK1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
113254577 (JAK1)
05203 Viral carcinogenesis
113254577 (JAK1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
113254577 (JAK1)
09162 Cancer: specific types
05212 Pancreatic cancer
113254577 (JAK1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
113254577 (JAK1)
05161 Hepatitis B
113254577 (JAK1)
05160 Hepatitis C
113254577 (JAK1)
05171 Coronavirus disease - COVID-19
113254577 (JAK1)
05164 Influenza A
113254577 (JAK1)
05162 Measles
113254577 (JAK1)
05168 Herpes simplex virus 1 infection
113254577 (JAK1)
05163 Human cytomegalovirus infection
113254577 (JAK1)
05167 Kaposi sarcoma-associated herpesvirus infection
113254577 (JAK1)
05169 Epstein-Barr virus infection
113254577 (JAK1)
05165 Human papillomavirus infection
113254577 (JAK1)
09171 Infectious disease: bacterial
05152 Tuberculosis
113254577 (JAK1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
113254577 (JAK1)
05140 Leishmaniasis
113254577 (JAK1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
113254577 (JAK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uah01001
]
113254577 (JAK1)
Enzymes [BR:
uah01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
113254577 (JAK1)
Protein kinases [BR:
uah01001
]
Non-receptor tyrosine kinases
JAK family [OT]
113254577 (JAK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Jak1_Phl
FERM_F2
SH2_1
FERM_F1
ABC1
SH2
RIO1
FERM_C_FAK1
Motif
Other DBs
NCBI-GeneID:
113254577
NCBI-ProteinID:
XP_044239712
LinkDB
All DBs
Position
Unknown
AA seq
1153 aa
AA seq
DB search
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL
CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKHKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT
LVDYKDDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
YSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPLHCPDEVYQLMRKCWEFQPSNRTT
FQNLIEGFEALLK
NT seq
3462 nt
NT seq
+upstream
nt +downstream
nt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagaccgaggtgaatctggaggcccccgagccaggggtggaagtgctcttc
tatctttcggacagggagcccctccggctgggcagcggggagtacacggcagaggagctc
tgcatcagggccgcgcaggaatgttgtatctctcctctgtgtcacaacctctttgctctg
tatgatgagaacaccaagctctggtatgccccgaatcgcaccatcactgttgatgacaag
acatcgctccggctccactaccggatgagattctatttcaccaactggcatgggaccaat
gataatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaaa
aaaaaagtcccagatgcaacccctctccttgacgccagctctctggagtatctgtttgct
cagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagaccgagcag
gatgggcatgatatcgagaatgagtgtctgggaatggcagtcctggccatctcccactac
gctatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata
aataatgttttcaaagatttcttgaaggaatttaacaacaagactatttgtgacagcagt
gtatctactcatgacctgaaggtgaaatacctggccaccttggaaactttgacaaaacat
tatggcgctgaaatatttgagacttccatgttactgatttcatcggaaaatgagatgaat
tggtttcatccaaatgacagtggaaatgttctctactatgaagtgatggtaactggaaat
cttggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaacacaaa
ctgaaacggaaaaagctggaaaataaacacaagaaggatgaggagaaaaacaaaatccgg
gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct
gtggtcagcatcaataagcaggacaacaaaaaaatggaactgaagctctcatcccatgaa
gaggccttgtcctttgtgtccctggtagacggctacttccggctcacagcagatgcccat
cattacctctgcaccgatgtggctcccccgttgatcgtccacaacatacagaatggttgt
catggtccaatctgcacagaatatgccatcaataagttgcggcaagaaggaagcgaggag
gggatgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgactgtcacc
tgctttgaaaaatctgaggtgctgggtggccagaaacagttcaagaactttcagatcgag
gtgcagaaaggccgctacagcctgcacggctcggaccgcagcttccccagcctgggggac
ctgatgagccacctcaagaagcagatcctgcgcacggacaacatcagtttcgtgctgaag
cgctgctgccagcccaagccccgagagatctccaatctgcttgtggctactaagaaagcc
caagagtggcagcctgtctaccccatgagccagctgagttttgaccggatcctcaagaaa
gatattgtgcagggcgagcacctcgggagaggcacacggacacacatctactctggtacc
ctggtggattacaaggatgacgaaggaactgcggaagaaaagagaataaaagtgatcctc
aaagtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg
atgaggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagatgtg
gagaatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcaccgg
aaaagtgatgtcctcaccacaccatggaagttcaaagttgccaagcagctggccagtgcc
ctgagttacttggaggataaagacctggtccacggaaacgtgtgcacgaaaaatcttctc
ctggcccgtgagggcattgacagcgagtgcggcccgttcatcaagctcagtgaccctggc
atccccatcactgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctcca
gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc
acactctgggaaatctgctacaatggcgagatccctctgaaagacaagaccctgattgag
aaagagagattctacgaaagccggtgccggccagtgacaccatcttgtaaggagctggct
gaccttatgacccgctgcatgaactatgaccccaaccagagacctttcttccgagccatc
atgagagacatcaataaactggaagagcagaatccagacattgtttctgaaaaaaagccg
gcaaccgaagtggatcccacgcattttgaaaagcggttcttgaagaggatccgtgacttg
ggagagggccacttcgggaaggtcgagctctgcaggtatgaccctgagggggacaatact
ggggagcaggtggcagtcaaatccctgaagcccgagagtggaggtaaccacatagctgat
ctgaagaaggaaattgaaatcctaaggaacctctatcatgagaacattgtgaagtacaaa
ggcatctgtaccgaagatggaggaaatggtattaagctcatcatggaatttctgccttca
ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagtta
aaatatgccgttcagatttgtaaggggatggactatttgggttctcgtcagtatgttcac
cgggacttggcagcaagaaacgtcctcgttgagagtgagcaccaagtgaaaattggagac
tttggtttgaccaaagccattgaaactgacaaggagtattacacagtcaaggatgatcgg
gacagccctgtgttttggtatgctcccgaatgtttaattcagtgtaaattttatatcgcc
tctgacgtctggtcgtttggagtgactctgcacgagctgcttacttactgtgactccgat
tacagccccatggcgttgttcctgaaaatgataggcccaactcatggccagatgacagtc
acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacttcactgtcca
gatgaggtttatcaacttatgagaaaatgctgggaattccaaccatccaatcggacaact
tttcagaaccttattgaaggatttgaagcacttttaaaataa
Ursus arctos (brown bear): 113256691
Help
Entry
113256691 CDS
T05909
Symbol
JAK3
Name
(RefSeq) tyrosine-protein kinase JAK3 isoform X1
KO
K11218
Janus kinase 3 [EC:
2.7.10.2
]
Organism
uah
Ursus arctos (brown bear)
Pathway
uah04062
Chemokine signaling pathway
uah04151
PI3K-Akt signaling pathway
uah04217
Necroptosis
uah04550
Signaling pathways regulating pluripotency of stem cells
uah04630
JAK-STAT signaling pathway
uah04658
Th1 and Th2 cell differentiation
uah04659
Th17 cell differentiation
uah05161
Hepatitis B
uah05162
Measles
uah05166
Human T-cell leukemia virus 1 infection
uah05169
Epstein-Barr virus infection
uah05200
Pathways in cancer
uah05203
Viral carcinogenesis
uah05223
Non-small cell lung cancer
uah05340
Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
113256691 (JAK3)
04151 PI3K-Akt signaling pathway
113256691 (JAK3)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
113256691 (JAK3)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
113256691 (JAK3)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
113256691 (JAK3)
04659 Th17 cell differentiation
113256691 (JAK3)
04062 Chemokine signaling pathway
113256691 (JAK3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
113256691 (JAK3)
05203 Viral carcinogenesis
113256691 (JAK3)
09162 Cancer: specific types
05223 Non-small cell lung cancer
113256691 (JAK3)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
113256691 (JAK3)
05161 Hepatitis B
113256691 (JAK3)
05162 Measles
113256691 (JAK3)
05169 Epstein-Barr virus infection
113256691 (JAK3)
09163 Immune disease
05340 Primary immunodeficiency
113256691 (JAK3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uah01001
]
113256691 (JAK3)
Enzymes [BR:
uah01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
113256691 (JAK3)
Protein kinases [BR:
uah01001
]
Non-receptor tyrosine kinases
JAK family [OT]
113256691 (JAK3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
SH2_1
Jak1_Phl
ABC1
Kdo
Kinase-like
SH2
FERM_C_FAK1
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
113256691
NCBI-ProteinID:
XP_057167619
LinkDB
All DBs
Position
Unknown
AA seq
1049 aa
AA seq
DB search
MKNGGQRVCAACPRSCSKSVAQPGLCEVSAGSSTPPYPYSRLLPFPNSFYFPNWFGLEKC
HRFGLRKDLASAILDLPVLEHLFAQHRNDLVSGCLPVGLSLKEQGECLSLAVLDLARMAC
EQAQQPEELLKTVSYKVCLPPDLRDLIQGLSFVTRKRIRRTVRRALRRVTACQADRHSLM
AKYIMDLERLDPARAVETFLVSLPGAADGQDAQGLLRVAGDSGIAWCPGGQEALQPFCDF
PEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPAALSFVALVDGYFRLTSDS
RHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDCFLLTV
CVQTPLGPDYKGCLIRCDPTGTFSLAGLGRPHSSLRELLAACWDGGLHVDGVALNLTVCC
TPKPKEKSNLIVVRRGCNPPTSSPVQPQSQCQLSQMTFHKIPPESLEWHENLGHGSFTKI
YRGCRHEVVEGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGD
SIMVQEFVHLGALDTYLLKSGHLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLL
AREGADGNLPFIKLSDPGVSPTVLNREMLTDRIPWVAPECLQEARTLGLEADKWGFGATV
WEVFSGIPMPISTLDPAKKLQFYEEQQQLPAPKWMELATLIQQCMAYESGQRPSFRAIIR
DLNSLITSDYELLSDPTPGALAPRDGLWNGAQLYAYQDPTIFEERHLKYISQLGKGNFGS
VELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFEREIQILKALHSDFIVKYRGVSYGPGR
QSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYASQICKGMEYLGSCRCVHRDLAARNI
LVESETHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGV
VLYELFTYGNKSCSPSAEFLRMMECDRDVPALCRLLELLAEGQRLPAPPACPGEVHELMK
LCWAPSSQDRPTFSALGPQLDALWSASRG
NT seq
3150 nt
NT seq
+upstream
nt +downstream
nt
atgaagaacggaggccagagagtgtgcgctgcttgcccaaggtcatgtagcaagtcggtg
gcacaacctgggctctgtgaggtctcggcagggtcttccacccctccatatccctactcc
aggcttctccccttccccaacagcttttacttccccaactggtttgggctagagaagtgc
caccgctttgggctacgaaaggacttggccagcgccatccttgacctgcccgtcctggag
cacctcttcgcccagcaccgaaatgacctggtgagcggctgcctccccgtgggcctcagt
ctcaaggagcagggtgaatgtctcagcctggcggtgctggacctggcccggatggcctgc
gagcaggctcagcagcctgaggagctgctaaagactgtcagctacaaggtctgcctcccc
cccgacctgcgcgacctgatccaaggcctgagcttcgtgacgcggaagcgcatccggagg
accgtgcgtcgggccctgcgccgcgtgaccgcctgccaggctgacaggcactcgctcatg
gccaagtacattatggacctggagaggctcgacccggccagggcggtcgagaccttcctc
gtgagcctccctggggctgctgatggtcaagatgcgcaggggctgctccgagtggctggt
gacagcggcatcgcatggtgtccaggaggacaagaggccctccagcccttctgcgacttt
ccagaaattgtggacatcagcatcaagcaggctccgcgtgttggcccggccggggagcac
cgcctggtcaccgtcaccaggacagacaaccagatcctggaggccgagttcccggggctg
ccggccgcgttgtccttcgtggcgctcgtcgacggctacttccggctgacctccgactcc
aggcacttcttctgcaaggaggttgctccgccgcggctgctggaggaggtggcagagcag
tgccacggccccatcaccctggattttgccatcaacaagctcaagactgggggttcacgt
ccgggctcctacgttctccgccgcagtccccaggattttgactgcttcctcctcactgtc
tgtgtccagacccccctgggtcctgattacaagggctgcctcatccggtgtgaccccacg
gggaccttctccctggctggcctaggccgtccccacagcagtcttcgagagctcttggca
gcctgctgggacggcgggctgcacgtggatggggttgcgctgaacctcacagtctgctgc
acccccaaacccaaagaaaagtccaacctgattgtggtgcggaggggttgcaaccccccc
acgtcgtcccctgttcagccccaatcccaatgccagctgagtcagatgacgtttcacaag
atccctcctgagagcctggagtggcatgagaacttgggtcacgggtccttcaccaagatt
taccggggttgtcgccatgaggtcgtggagggcgaggcccgggagacggaggtgctgctc
aaagtgatggatgccaagcataaaaactgcatggagtcatttctggaagcagcgagtttg
atgagccaagtgtcataccagcatcttgtgttgctccatggcgtgtgcatggctggagac
agtatcatggtgcaggagtttgtacacctgggagctctggacacgtacctgctcaagtct
ggccacctggtgccagccagctggaagctgcaggtgatcaagcagctggcctacgccctc
aactacctggaagacaaaggcctcccccatggcaatgtctcagcccggaaggtgctcctg
gctcgcgaaggggctgatgggaacctgcccttcatcaagctgagtgaccctggtgtcagc
cccactgtgctaaaccgggagatgctcactgacaggatcccctgggtggcccctgagtgt
ctccaggaggcccggacacttggcttggaagccgacaagtggggttttggtgccacagtc
tgggaggtgttcagcgggatcccgatgcccatcagcaccctggatcctgccaagaagctc
cagttttatgaggaacagcagcagctgcctgcccccaagtggatggagctggccacactg
atccaacagtgcatggcctatgagtcaggccagaggccctccttccgcgccatcatccgt
gacctgaacagcctcatcacttcagattatgagctcctctcagaccccacgcccggtgcc
ttggcgccccgtgacgggctatggaatggcgcccagctctacgcctaccaggaccctacc
atttttgaggagagacacctcaagtacatctcacagctgggcaagggtaacttcggcagc
gtggaactgtgccgctatgacccgctgggtgacaacacgggcgccctagtggcagtgaag
cagctgcagcacagcgggccagaccagcagagggactttgagagggagatccagatcctc
aaagcccttcacagcgacttcatcgtcaagtaccgcggtgtcagctatggcccaggccgt
cagagcttgcggctggtgatggagtacctgcccagcggctgcctgcgcgacttcctgcag
cggcaccgcgcgcgcctcgacgccagccgcctgctcctctacgcctcgcagatctgcaag
ggcatggagtacctgggctcctgccgctgcgtgcaccgcgacctggcagcgcgtaacatc
ctggtggagagcgagacgcacgtcaagatcgccgactttggcctcgccaagctgctgcca
ctcgacaaagactactacgtggtccgcgagcccggccagagccccatcttctggtatgcc
ccagagtccctctctgacaacatcttctcgcgccagtcggatgtctggagcttcggggtc
gtcctgtacgagcttttcacctacggcaacaagagttgcagcccctcagccgagttcctg
cggatgatggaatgtgatcgagatgtccccgccctctgccgcctcctggagctgctggct
gagggccagaggctgcccgcgcctcctgcctgccctggtgaggttcatgagctcatgaag
ctatgctgggcccctagctcgcaagaccggccaacattcagtgccctgggcccccagctg
gatgcgctatggagtgccagccgggggtag
DBGET
integrated database retrieval system
