Ursus maritimus (polar bear): 103659146 Help Entry 103659146         CDS       T03271                                  Gene name FGFR1 Definition (RefSeq) fibroblast growth factor receptor 1   KO K04362   fibroblast growth factor receptor 1 [EC:2.7.10.1] Organism umr  Ursus maritimus (polar bear) Pathway umr04010   MAPK signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04151   PI3K-Akt signaling pathway umr04520   Adherens junction umr04550   Signaling pathways regulating pluripotency of stem cells umr04714   Thermogenesis umr04810   Regulation of actin cytoskeleton umr04928   Parathyroid hormone synthesis, secretion and action umr05200   Pathways in cancer umr05205   Proteoglycans in cancer umr05215   Prostate cancer umr05218   Melanoma umr05224   Breast cancer umr05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103659146 (FGFR1)    04014 Ras signaling pathway     103659146 (FGFR1)    04015 Rap1 signaling pathway     103659146 (FGFR1)    04020 Calcium signaling pathway     103659146 (FGFR1)    04151 PI3K-Akt signaling pathway     103659146 (FGFR1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     103659146 (FGFR1)    04550 Signaling pathways regulating pluripotency of stem cells     103659146 (FGFR1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     103659146 (FGFR1)  09150 Organismal Systems   09152 Endocrine system    04928 Parathyroid hormone synthesis, secretion and action     103659146 (FGFR1)   09159 Environmental adaptation    04714 Thermogenesis     103659146 (FGFR1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103659146 (FGFR1)    05205 Proteoglycans in cancer     103659146 (FGFR1)    05230 Central carbon metabolism in cancer     103659146 (FGFR1)   09162 Cancer: specific types    05218 Melanoma     103659146 (FGFR1)    05215 Prostate cancer     103659146 (FGFR1)    05224 Breast cancer     103659146 (FGFR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103659146 (FGFR1)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:umr04090]     103659146 (FGFR1)    00536 Glycosaminoglycan binding proteins [BR:umr00536]     103659146 (FGFR1) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      103659146 (FGFR1) Protein kinases [BR:umr01001]  Receptor tyrosine kinases (RTK)   FGFR family [OT]    103659146 (FGFR1) CD molecules [BR:umr04090]  Proteins   103659146 (FGFR1) Glycosaminoglycan binding proteins [BR:umr00536]  Heparan sulfate / Heparin   Growth factors/receptors    103659146 (FGFR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase I-set Ig_3 ig Ig_2 FGFR3_TM V-set Ig_5 C2-set_2 Ig_6 Ig_4 Pkinase_fungal DUF1615 DUF4611 Motif Other DBs NCBI-GeneID:  103659146 NCBI-ProteinID:  XP_008684851 UniProt:  A0A384BQI7 LinkDB All DBs Position Un AA seq 919 aa AA seqDB search MWGWKGLLFWAVLVTATLCTARPAPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD VQSINWLRDGVQLVESNRTRITGEEVEVRDSVPADSGLYACVTSSPSGSDTTYFSVNVSD ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE ALEERPAVMTSPLYLEIVIYCTGAFLISCMVGSVVVYKMKSGTKKSDFHSQMAVHKLAKS IPLRRQVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGK PLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLGAERRVLARGHFVPSHVLDRDPSPAPGA ARGLGGGSGAGRPGELTGPSVSVVSASRKPELRWRGLVLGAAAILAFCSSSCTNSAPSPR KGDKFSECFVFGCLEISFLGHLLVITALNTRIPAPQNLGTESASTLPPAPKAYSLRGYRE IQKKIQFAFISAEQTGLLL NT seq 2760 nt NT seq  +upstreamnt  +downstreamnt atgtggggctggaagggcctcctcttctgggctgtgctggtcacagccacactctgcacc gccaggccggccccaaccttgcctgaacaagcccagccctggggagcccctgtggaagtg gagtccttcctggtccaccctggtgacctgctgcagcttcgctgtcggctgcgggacgat gtccagagcatcaactggctgcgggacggggtgcagctggtggaaagcaaccgtacccgc atcacgggggaggaggtggaggtgcgggattccgtgcctgccgactccggcctctacgct tgtgtgaccagcagcccctcgggcagcgacaccacctacttctccgtcaatgtctcagat gctctcccctcctcggaggacgacgatgatgatgatgactcctcttcagaggagaaagag acagataacaccaaaccaaaccgtatgcccgtggctccgtactggacatccccagaaaag atggaaaagaaattgcacgcagtgccggctgccaagactgtgaagttcaaatgcccttcc agtgggactcccaaccccacgctgcgctggttgaaaaatggcaaagaattcaaacctgac cacaggattggagggtacaaggtccgttacgccacctggagcatcatcatggactccgtg gtgccttcggataagggcaactacacctgcatcgtggagaacgaatatggcagcattaac cacacctaccagctcgacgtcgtggagcggtcccctcaccggcccatcctgcaggcaggg ctgcctgccaacaagaccgtggccctgggcagcaatgtggagttcatgtgtaaggtgtac agtgacccacagccccatatccagtggctgaagcacatcgaggtgaatgggagtaagatt ggtccagacaacctgccttatgtccagatcttgaagactgccggagttaataccaccgac aaagagatggaagtgcttcacttaaggaatgtctcctttgaggacgcgggggagtatacg tgcttggcgggtaactctatcggactctcccatcactctgcatggttgaccgttttggaa gccctggaagagaggccagcagtgatgacctcgcccctgtacctggagatcgtcatctac tgcacgggggccttccttatctcctgcatggtggggtctgtcgtcgtctacaagatgaag agcggcaccaagaagagcgacttccacagccagatggccgtgcacaagctggccaagagc atccctctgcgcagacaggtgtcggctgattctagtgcgtccatgaactctggggttctg ctggttcggccctcacgtctctcctctagtggaacccccatgctggccggggtctctgaa tacgaacttcccgaagaccctcgctgggagctgcctcgagacaggctggttttaggcaaa cccctgggagagggctgctttgggcaggtggtgttggcagaggccattgggctggacaag gacaaacccaaccgtgtgaccaaagtggctgtgaagatgttgaagtcggatgcaacagag aaagacctgtcagacctgatctcagaaatggagatgatgaagatgattgggaagcacaag aacatcatcaacctgctgggggcctgcacgcaggacggtcctttgtacgtcatcgtggag tatgcctccaaaggcaacctgcgggagtacctgcaggcccggcggcctcctgggctggag tactgttacaaccccagccacaacccagaggagcagctctcctccaaggacctggtctcc tgcgcctatcaggtggcccgaggcatggagtatctcgcctccaagaagtgcatacaccga gacctggccgccaggaacgtgctggtgacggaggacaacgtgatgaagatcgcggacttc ggcctcgcgcgggacattcaccacatcgactactataaaaagacaaccaacggccggctg cctgtgaagtggatggcgcccgaggccctgttcgaccggatctacacccaccagagcgac gtctggtcttttggggtgctcctgtgggaaatcttcactctgggaggctccccgtatcct ggcgtgcctgtggaggagcttttcaagctgctgaaggagggtcatcggatggacaagccc agtaactgcaccaatgagctgtacatgatgatgcgggattgctggcatgcggtaccctct cagagacccaccttcaagcagctggtggaagacctgggagcggagaggcgggtacttgct cgtggccacttcgtcccctcccacgtgttggaccgagacccctccccggcacctggcgct gcccgagggctggggggcgggagcggagccggcaggcccggagagctgaccgggccttcg gtgtcggtggtgtccgcctcacgtaagcctgagctccggtggcggggcctcgtcctcggg gctgcagccatcttggctttctgtagttcttcctgtaccaactccgccccatcccccagg aaaggggacaaattctctgaatgtttcgtgttcggctgcttggaaatttcctttctcggc cacctgctggtgatcactgcactcaacacgcgcatccctgctcctcagaacctcggcacc gaatctgctagtactctgccccctgcccctaaagcttactctttgcggggttaccgtgaa atacagaagaaaattcagttcgctttcatttctgcagaacaaacaggattgctgctttaa

Ursus maritimus (polar bear): 103660044 Help Entry 103660044         CDS       T03271                                  Definition (RefSeq) insulin-like growth factor 1 receptor   KO K05087   insulin-like growth factor 1 receptor [EC:2.7.10.1] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr04010   MAPK signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04066   HIF-1 signaling pathway umr04068   FoxO signaling pathway umr04114   Oocyte meiosis umr04140   Autophagy - animal umr04144   Endocytosis umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04152   AMPK signaling pathway umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04510   Focal adhesion umr04520   Adherens junction umr04550   Signaling pathways regulating pluripotency of stem cells umr04730   Long-term depression umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr05200   Pathways in cancer umr05202   Transcriptional misregulation in cancer umr05205   Proteoglycans in cancer umr05214   Glioma umr05215   Prostate cancer umr05218   Melanoma umr05224   Breast cancer umr05225   Hepatocellular carcinoma Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103660044    04014 Ras signaling pathway     103660044    04015 Rap1 signaling pathway     103660044    04066 HIF-1 signaling pathway     103660044    04068 FoxO signaling pathway     103660044    04151 PI3K-Akt signaling pathway     103660044    04152 AMPK signaling pathway     103660044    04150 mTOR signaling pathway     103660044  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     103660044    04140 Autophagy - animal     103660044   09143 Cell growth and death    04114 Oocyte meiosis     103660044   09144 Cellular community - eukaryotes    04510 Focal adhesion     103660044    04520 Adherens junction     103660044    04550 Signaling pathways regulating pluripotency of stem cells     103660044  09150 Organismal Systems   09152 Endocrine system    04913 Ovarian steroidogenesis     103660044    04914 Progesterone-mediated oocyte maturation     103660044   09156 Nervous system    04730 Long-term depression     103660044   09149 Aging    04211 Longevity regulating pathway     103660044    04213 Longevity regulating pathway - multiple species     103660044  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103660044    05202 Transcriptional misregulation in cancer     103660044    05205 Proteoglycans in cancer     103660044   09162 Cancer: specific types    05225 Hepatocellular carcinoma     103660044    05214 Glioma     103660044    05218 Melanoma     103660044    05215 Prostate cancer     103660044    05224 Breast cancer     103660044   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103660044    01522 Endocrine resistance     103660044  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103660044   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:umr04090]     103660044 Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      103660044 Protein kinases [BR:umr01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    103660044 CD molecules [BR:umr04090]  Proteins   103660044 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Recep_L_domain Furin-like fn3 Kinase-like Furin-like_2 DUF4476 Insulin_TMD Motif Other DBs NCBI-GeneID:  103660044 NCBI-ProteinID:  XP_008685869 UniProt:  A0A384BUF8 LinkDB All DBs Position Un AA seq 1149 aa AA seqDB search MKRRVFPPRLNETVTVVYNTVIASLLRAAEPPVTGHYYYAGVCVPTCPPNTYRFEGWRCV DRDFCANIPSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKK TKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALV SLSFLKNLRQILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVS EIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTWKNHIIIRWHRYRPPDY RDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVDPGILLQGLKPWTQY AVYVKAVTLTMVNDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPN GNLSYYIVRWQRQPQDSYLYRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGP CCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVTQITNTTMSSRGRNST VADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSAS NFVFARTMPAEGADDIPGPVTWESRPENSIFLKWPEPENPNGLILMYEIKYGSQIEDQRE CVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKITYENFIHLII ALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREK ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEIENNPVLAPPSLSKMIQMAGE IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP DMLFELMRMCWQYNPKMRPSFLEIISSIKDEMEPGFREVSFYYSEENKPPEPEELDLEPE NMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERA LPLPQSSTC NT seq 3450 nt NT seq  +upstreamnt  +downstreamnt atgaaacgcagggtatttcctccccgccttaatgaaactgtgactgtggtctataatact gtcattgcaagtctgctccgggctgcagagccccctgtcactgggcattactactacgcc ggcgtctgcgtgcccacctgcccgcccaacacctaccgcttcgagggctggcgctgcgtg gaccgcgacttctgcgccaacatccccagcgccgagagcagcgactccgaggggttcgtg atccacgacggcgagtgcatgcaggagtgcccctccgggttcatccggaatggcagtcag agtatgtactgcatcccttgcgaaggtccttgccccaaggtctgtgaggaagagaagaaa acaaagaccattgattctgttacctctgctcaaatgctccaaggatgcaccatcttcaag ggcaatttgctcattaacatccgccgaggcaataacattgcctcggaactggagaacttc atggggctcatcgaggtggtgacaggctacgtgaagattcgccattcccacgccttggtc tccttgtccttcctaaaaaaccttcgccagatcttaggagaggagcagctggaggggaac tactccttctacgtccttgacaaccagaacttgcagcagctgtgggactgggaccaccgc aacctgaccatcaaagctgggaaaatgtactttgctttcaatcccaagttgtgcgtctcc gagatttaccgcatggaggaagtgacagggactaaggggcgccagagcaaaggggacata aacaccaggaacaacggagagcgagcctcctgtgaaagcgacgtcctgcacttcacctct acgaccacatggaagaatcacatcatcataaggtggcaccgttaccggccccccgactac agggacctcatcagcttcactgtctactacaaggaagcaccttttaaaaacgtcacggag tacgatggccaggatgcctgtggctccaacagctggaacatggtggatgtggacctccct cccaacaaggacgtcgatcctggcattttactgcagggactgaagccctggacgcagtat gccgtgtatgtcaaggcggtgaccctcaccatggtgaacgaccacatccgtggggccaag agtgaaatcttgtacattcgtaccaatgcttcagttccttccattcccctggacgttctg tccgcgtccaactcgtcttctcagctcatcgtgaagtggaacccgccgtccctgcccaac gggaacctcagttactacatcgtgaggtggcagcggcagcctcaggacagctacctgtac cggcacaattactgctccaaagacaaaatccccatcaggaagtatgccgacggcaccatc gacgtcgaagaggtgacggagaatcccaagaccgaggtgtgcggcggagagaaggggcct tgctgcgcctgccccaaaaccgaggccgagaagcaggccgagaaggaggaggccgagtac cgcaaagtcttcgagaacttcctgcacaactccatctttgtgcccagaccggaaaggaag cggagagacgtcacacaaatcaccaacaccaccatgtccagccgaggcaggaacagcaca gtggcggacacctataatatcacagacccagaagagctcgagacagaataccctttcttt gagagcagagtagataacaaggagagaactgtcatctctaacctccggccttttactttg taccgcattgacatccacagctgtaaccatgaggctgagaagctgggctgcagcgcctcc aactttgtttttgcaagaaccatgcctgcagaaggagcagatgacattcctgggccggtg acctgggagtcgaggcctgaaaactccatctttctaaagtggccagaacctgagaatccc aatggattgattctaatgtatgaaataaaatacggatcacaaatcgaggatcagcgggaa tgtgtatccagacaggagtacaggaaatatggaggcgccaagcttaaccggctcaacccg gggaactatacagcccggatccaggccacctctctctccgggaatgggtcgtggacggat cctgtgttcttctatgtcccagccaaaataacgtatgaaaacttcatccatctgatcata gctctgcccgttgccgtcctgttgatagtgggagggctggttataatgttgtacgtcttc cacaggaaaagaaataacagcaggctggggaatggagtgctgtacgcgtccgtgaaccca gagtacttcagcgccgccgacgtgtacgtacctgacgagtgggaggttgctcgagagaag atcaccatgagccgagagctgggccagggctcctttgggatggtatacgaaggagtcgcc aaaggcgtggttaaagatgagcccgaaaccagggtggccattaaaacagtgaacgaggct gcgagcatgcgcgaaaggattgaatttctcaatgaggcttcagtgatgaaggagttcaat tgtcaccacgtggtgcggttgctgggcgtggtgtcccagggccagccgacgctggtcatc atggaactgatgacacggggggatctcaaaagctatctcaggtctctgaggccagaaata gagaataatccagtcctagcacctccaagcctgagcaagatgatccagatggctggggag attgcagatggcatggcatacctcaacgccaacaagtttgtccacagagaccttgctgcc cggaactgcatggtggccgaagatttcacggtcaaaatcggagatttcggtatgacaaga gacatctatgagacagactattacaggaaaggaggaaaggggctgctgcctgtgcgctgg atgtcccccgagtctctcaaggatggagtcttcaccactcactctgacgtctggtccttc ggggtcgtgctctgggagattgccacgctggccgaacagccataccagggcttgtccaac gagcaggtccttcgcttcgtgatggagggcggccttctggacaagccggacaactgcccc gacatgctgtttgaactgatgcgcatgtgctggcagtacaaccccaagatgaggccttcc ttcctggagatcatcagcagcatcaaggacgagatggagcccggcttccgggaggtctcc ttctactacagcgaggagaacaagccgcccgagccggaggagctggacctggagcccgag aacatggagagcgtccccctggacccctccgcctcctcgtcctccctgccgctgcccgac agacactcaggacacaaggccgagaacggcccaggccccggcgtgctggtcctccgagcc agcttcgatgagagacagccttacgcgcacatgaacgggggacgcaagaacgagagggcc ttgcctctgccccagtcttcgacctgctga

Ursus maritimus (polar bear): 103664600 Help Entry 103664600         CDS       T03271                                  Gene name PDGFRB Definition (RefSeq) platelet derived growth factor receptor beta   KO K05089   platelet-derived growth factor receptor beta [EC:2.7.10.1] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr04010   MAPK signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04072   Phospholipase D signaling pathway umr04151   PI3K-Akt signaling pathway umr04510   Focal adhesion umr04540   Gap junction umr04630   JAK-STAT signaling pathway umr04810   Regulation of actin cytoskeleton umr05165   Human papillomavirus infection umr05200   Pathways in cancer umr05206   MicroRNAs in cancer umr05214   Glioma umr05215   Prostate cancer umr05218   Melanoma umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103664600 (PDGFRB)    04014 Ras signaling pathway     103664600 (PDGFRB)    04015 Rap1 signaling pathway     103664600 (PDGFRB)    04630 JAK-STAT signaling pathway     103664600 (PDGFRB)    04020 Calcium signaling pathway     103664600 (PDGFRB)    04072 Phospholipase D signaling pathway     103664600 (PDGFRB)    04151 PI3K-Akt signaling pathway     103664600 (PDGFRB)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     103664600 (PDGFRB)    04540 Gap junction     103664600 (PDGFRB)   09142 Cell motility    04810 Regulation of actin cytoskeleton     103664600 (PDGFRB)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103664600 (PDGFRB)    05206 MicroRNAs in cancer     103664600 (PDGFRB)    05230 Central carbon metabolism in cancer     103664600 (PDGFRB)    05231 Choline metabolism in cancer     103664600 (PDGFRB)   09162 Cancer: specific types    05214 Glioma     103664600 (PDGFRB)    05218 Melanoma     103664600 (PDGFRB)    05215 Prostate cancer     103664600 (PDGFRB)   09172 Infectious disease: viral    05165 Human papillomavirus infection     103664600 (PDGFRB)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103664600 (PDGFRB)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103664600 (PDGFRB)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:umr04090]     103664600 (PDGFRB) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      103664600 (PDGFRB) Protein kinases [BR:umr01001]  Receptor tyrosine kinases (RTK)   PDGFR family [OT]    103664600 (PDGFRB) CD molecules [BR:umr04090]  Proteins   103664600 (PDGFRB) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Ig_3 ig I-set Ig_2 V-set C2-set_2 Ig_6 TrmE_N Motif Other DBs NCBI-GeneID:  103664600 NCBI-ProteinID:  XP_008690736 UniProt:  A0A384C771 LinkDB All DBs Position Un AA seq 1099 aa AA seqDB search MQLPSAVPAPVLKGQVLLLPLLLLLGPQASWGLVISPPGPELILNVSSNFVLTCSGPAPV VWERMSQEPLQKMAKTQDGTFSSTLTLTNVSGIDTGEYFCTYKGSHGLEPGERKRLYIFV PDPLMGFLPVDPEELFIFLTEITEITIPCRVTDPRLVVTLHEKKVDIPLPIPYDHQRGFS GTFEDKTYVCKTTIGDKEVDSEAYYVYSLQVSSINVSVNAVQTVVRQGENITIMCIVTGN EVVNFEWTYPRMESGRLVEPVTDFLFNMPSHIRSILHIPSAELGDSGTYICNVSESVNEH RDEKSINVTVVESGYVRLLGELDAIQFAELHRSRTLQVVFEAYPPPTVMWFKDNRTLGDS SAGEISLSTRNVSETRYVSELTLVRVKVAEAGCYTMRAFHEDAEAQLSFQLQVNVPVRVL ELSENHPASGEQTVRCRGRGMPQPHLTWSTCSDLKRCPRELPPTPLGNSSEEESQLETNV TYWPEEQEFEVVSTLRLRRVDQPLSVRCTLHNLLGHDMQEVTVVPHSLPFKVVVISAILA LVVLTIISLIILVMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLDLLARSSEKQALMSELKIMSHLGP HLNVVNLLGACTKGGPIYIXXXXXXXXXXLHRNKHTFLQRCPDKRRPPSAELYSNALPGD LPLPSHVSLPRESDGGYMDMSKDESVDYVPMLAMKGGVKYADIESSSYMAPYDNYVPTAP ERTCRATLINESPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKIC DFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTP YPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLG EGYKKKYQQVDEEFLRSDHPAVLRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYII PLPDPKPEVADEGPLESSPSLASSTLNEVNTSSTISCDSPLEPQEEPEPQPEPQGEPEXA TPLESSCPGPRAETEDSFL NT seq 3300 nt NT seq  +upstreamnt  +downstreamnt atgcagcttccgagcgcagtgccagctcctgtcctcaaaggccaggtgctactgctgccc ctgctgttgctgctgggcccacaggcctcctggggcctggtcatctcacccccggggcca gagcttatcctcaatgtctccagcaactttgtgctgacctgctcaggtccagctccggtg gtgtgggaacggatgtcccaggagcccctgcagaaaatggccaagacccaggatggcacc ttctccagcacactgacactgaccaatgtctctgggatagacacgggagaatacttttgc acctacaaaggctcccatgggctggagcctggggagcggaaacggctctacatctttgtg ccagatcccttgatgggctttctcccggtcgaccccgaggaactattcatcttcctcacg gaaataactgagatcacaattccatgccgagtgacggatccgagactggtggtgacactg cacgagaagaaagtggatatcccgctgcccattccctatgaccaccaacgtggcttctct ggtacctttgaggacaagacctatgtctgcaaaaccaccatcggggacaaggaagtggat tctgaagcctactatgtctacagcctccaggtgtcatccatcaatgtgtcagtgaatgca gtgcagactgtggtccgtcagggtgagaacatcaccatcatgtgcattgtgactggaaat gaggtggtcaacttcgaatggacatacccacgcatggagagcgggcggctggtggagcca gtgactgacttcctcttcaatatgccctcccacatacgctccatcctgcacatccctagt gctgagcttggcgattcagggacctacatctgcaatgtatcggagagcgtgaatgagcat cgagatgaaaagtccatcaatgtcactgtggttgagagtggctacgtgcggctgctggga gagctggacgccatacaattcgcggagctgcaccgcagccggactctgcaggtcgtgttc gaggcctacccgccgcctactgtcatgtggttcaaggacaaccgcacgctaggcgactcc agcgcaggcgagatctccctgtccacacgcaatgtgtctgagacccggtacgtgtcagaa ctgacgttggtgcgggtgaaggtggccgaggcgggctgctacaccatgcgggccttccat gaggacgcggaggcccagctctccttccagctgcaggtcaacgtgcctgtccgtgtgctg gagctgagtgaaaaccaccctgccagcggggagcagacagtccgctgtcgcggcaggggc atgccccagccacacctcacctggtctacctgcagcgacctcaaaagatgtccgcgtgag ctgccgcccacgccgctggggaacagttcggaggaggagagccagctggagactaacgtg acgtactggcccgaggagcaggagttcgaggtggtgagcacactgcgcctgcgccgtgtc gatcagccgctgtcggtgcgctgcactctgcacaacctgctgggacacgacatgcaggag gtcaccgtggtgccgcattctctgcccttcaaggtggtggtgatctcagccatcctggcc ttggtggtcctcacaatcatctccctcatcatcctcgtcatgctctggcagaagaagcca cgttacgagatccgatggaaggtgattgaatccgtgagctccgacggccatgagtacatc tacgtggaccctatgcagctgccctacgactccacctgggagctgccgcgggaccagctt gtgcttggacgcaccctcggttccggggcctttggccaggtggtggaggccacggctcac ggcctgagccattcgcaggccacgatgaaagtggcggttaagatgcttgatttgctggcc cgcagcagcgagaagcaggccctcatgtccgagctgaagatcatgagtcacctcgggccc catctgaacgtggtcaacttgctgggggcctgcaccaaaggaggacccatctacatcann nnnnnnnnnnnnnnnnnnnnnnnnnnnctgcaccgcaacaagcacaccttcctgcagcgc tgccccgacaagcgccgcccgcccagcgccgagctctacagcaacgcgctgcccggcgat ctcccgctgcccagccacgtgtctctgcccagggagagcgacggcggctacatggacatg agcaaggatgagtccgtggactacgtgcccatgctggccatgaaaggaggcgtcaaatac gcagacatcgagtcctccagctacatggccccttacgacaactacgtccccactgctcct gagaggacctgtcgggcaactctgatcaacgagtccccagttcttagctacacggatctc gtgggcttcagctaccaggtggccaacggcatggagttcctggcctccaagaactgtgtc caccgagatctggcagccagaaatgtgctcatctgtgagggcaagctggtcaagatctgt gactttggcctggctcgtgacatcatgcgagactcgaactatatctccaaaggcagcacc ttcctgcctctgaagtggatggctcccgagagcatcttcaacagcctctataccaccctg agcgacgtgtggtccttcgggatcctactctgggagatcttcaccctgggtggcacccct tacccagagctgcccatgaacgaccagttctataacgccatcaagcgagggtaccgcatg gcccagcctgcccacgcctccgacgagatttacgagatcatgcagaagtgctgggaagag aagtttgagatccggcctcctttctcccagctggtgctgcttcttgagaggctgctgggc gagggttacaaaaagaagtaccagcaggtggatgaggagtttctgaggagcgaccaccca gccgtccttcggtcccaagcccgcttgcctggcttccatggcctccgatctcccctggac accagctctgtcctctacactgctgtgcagcccaacgagggtgacaacgactacatcatc cccctgcctgaccccaaacctgaggttgctgatgagggcccactggagagttctcccagc cttgccagctccaccctgaatgaggtcaacacctcctctaccatctcctgcgacagcccc ctggagccccaagaggagcccgagccccagcccgagccccagggggagccggagnccgcc actccactggagtcaagctgccctgggcctcgggccgagacggaggacagcttcctgtag

Ursus maritimus (polar bear): 103672737 Help Entry 103672737         CDS       T03271                                  Gene name PDGFRA Definition (RefSeq) platelet derived growth factor receptor alpha   KO K04363   platelet-derived growth factor receptor alpha [EC:2.7.10.1] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr04010   MAPK signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04072   Phospholipase D signaling pathway umr04144   Endocytosis umr04151   PI3K-Akt signaling pathway umr04510   Focal adhesion umr04540   Gap junction umr04630   JAK-STAT signaling pathway umr04810   Regulation of actin cytoskeleton umr05163   Human cytomegalovirus infection umr05200   Pathways in cancer umr05206   MicroRNAs in cancer umr05214   Glioma umr05215   Prostate cancer umr05218   Melanoma umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103672737 (PDGFRA)    04014 Ras signaling pathway     103672737 (PDGFRA)    04015 Rap1 signaling pathway     103672737 (PDGFRA)    04630 JAK-STAT signaling pathway     103672737 (PDGFRA)    04020 Calcium signaling pathway     103672737 (PDGFRA)    04072 Phospholipase D signaling pathway     103672737 (PDGFRA)    04151 PI3K-Akt signaling pathway     103672737 (PDGFRA)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     103672737 (PDGFRA)   09144 Cellular community - eukaryotes    04510 Focal adhesion     103672737 (PDGFRA)    04540 Gap junction     103672737 (PDGFRA)   09142 Cell motility    04810 Regulation of actin cytoskeleton     103672737 (PDGFRA)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103672737 (PDGFRA)    05206 MicroRNAs in cancer     103672737 (PDGFRA)    05230 Central carbon metabolism in cancer     103672737 (PDGFRA)    05231 Choline metabolism in cancer     103672737 (PDGFRA)   09162 Cancer: specific types    05214 Glioma     103672737 (PDGFRA)    05218 Melanoma     103672737 (PDGFRA)    05215 Prostate cancer     103672737 (PDGFRA)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     103672737 (PDGFRA)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103672737 (PDGFRA)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103672737 (PDGFRA)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:umr04090]     103672737 (PDGFRA) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      103672737 (PDGFRA) Protein kinases [BR:umr01001]  Receptor tyrosine kinases (RTK)   PDGFR family [OT]    103672737 (PDGFRA) CD molecules [BR:umr04090]  Proteins   103672737 (PDGFRA) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Ig_3 I-set ig Ig_2 Herpes_gE V-set Kinase-like Motif Other DBs NCBI-GeneID:  103672737 NCBI-ProteinID:  XP_008699701 UniProt:  A0A384CY35 LinkDB All DBs Position Un AA seq 1098 aa AA seqDB search MACEQFSGTMGTSLLAFLILGSLLTGPSRVFCQLSLPSILPNENEKVVQLNSSFSLRCFG ESEVSWQYPMSEEENPNVEIRNEENNSGLFVAVLEVVSAAAAHTGLYTCYYNHTQTEETD IEGRRIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLRSNDGVVHAS YDSRQGFNGTFSVGPYICEATVRGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETI VVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLRVPEATVKDSGDYECA ARQATKEVKEMKKVTISVHEKGFIEIKPNFSPLEAVDLHEVKHFVVDVQAYPPPRISWLK DNLTLIENLTEITTDIEKIQEIRYRSKLKLIRAKEEDSGHYTIVVQNEDDVKSYTFELLT QVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWAILANNISN IITEVHPRDRSTVEGRVTFTRVEETIAVRCLAKNLLGAESRELKLVAPTLRSELTVAAAV LVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRD GLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHL GPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEKPKKELDIFGLN PADDSTRSYVILSFENNGDYMDMKQADATQYVPMLERKEAAKYSDIQRSLYDRPASSKKK SVLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKI VKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSL GGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWHSEPEKRPSFYHLSEIVE NLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDADNAYIGVTYKNEEDKLKDWEGSLDEQR LSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDID MMDDIGIDSSDLVEDSFL NT seq 3297 nt NT seq  +upstreamnt  +downstreamnt atggcctgcgagcagttttccggaacgatggggacttcccttctggccttcctgatctta ggctctctcctcacagggcccagccgagtcttctgccagctttcattaccctccatcctg ccaaacgaaaatgaaaaggtcgtgcagctgaattcatccttttctctgagatgctttggg gagagtgaagtgagctggcagtaccccatgtctgaagaagagaaccccaatgtggaaatc agaaacgaggagaacaacagcggcctttttgtggccgtgctggaggtggtcagcgcggcg gcggcgcacacgggcttgtacacctgctattacaaccacacccagacggaggagaccgac atcgagggcaggcgtatctacatctacgtgccagacccggatgtagccttcgtgcctctg ggaatgacagattatttagtcatcgtggaggatgatgattctgccatcataccttgtcgc acgactgatcctgagactccggtcaccttgcgcagcaatgacggggtggtgcacgcctcc tatgacagcagacagggcttcaatgggaccttcagcgttgggccctatatctgtgaagcc accgtcaggggaaagaagttccagaccatcccatttaatgtttatgctttaaaagcaacg tcagaacttgatctagaaatggaagctcttaaaactgtgtataagtcaggggagacgatt gtggtcacctgcgccgtctttaacaacgaggtggtcgaccttcagtggacttaccctgga gaagtgaaaggcaaaggcatcaccatgctggaggaaatcaaggtcccgtccatcaaattg gtgtatactctgagggtccccgaggccacggtgaaagatagtggagattatgaatgtgct gcccgccaggccaccaaggaggtcaaagagatgaagaaagtcaccatttctgtccatgag aaagggttcattgaaatcaaacccaacttcagcccgttggaagctgtcgacctgcatgaa gtcaaacatttcgtggtggacgtgcaggcctacccccctcccaggatatcctggctgaag gacaacctgactctgattgaaaatctcacggagatcaccacggacatagaaaagattcag gaaataaggtatcggagcaaattaaagctgatccgtgctaaggaggaagacagtggccat tacacgatcgtcgttcaaaatgaagatgacgtgaagagctatactttcgaactcctaact caagttccctcatctattctggacttggtggacgaccaccacggctccacggggggacag accgtgagatgcaccgccgaagggacgcctcttcctgatatcgagtggatgatttgcaag gatattaagaagtgtaataatgaaacttcatgggcgattttggccaacaatatctcaaac atcatcacggaggtccacccccgagacaggagcactgtggagggccgagtgacgttcacc agagtggaggagaccatcgccgttcgatgtctggccaagaatctccttggggccgagagc cgcgagctcaagctggtggctcccacgctgcgctctgagctcacggtggctgctgccgtc ctcgtgctgctggtgattgtcatcatctccctcatcgtcctggtcgtcatttggaaacag aaaccgaggtatgaaattcgctggagggtcattgaatccatcagcccggatggacatgaa tatatttatgtggacccgatgcagctgccttatgactcgagatgggagtttccaagagat ggactagtgcttggtcgtatcctgggatctggcgcgtttgggaaagtggttgaaggaact gcctatggattaagccgctcccagcctgtcatgaaggtagcagtgaagatgctgaaaccc acagccagatccagtgagaaacaggctcttatgtcggaactgaagataatgactcacctg gggccgcatttaaacattgtgaacttgctgggagcctgtaccaagtcaggccctatttac atcatcactgagtactgcttctatggggatttggtcaactatttgcataagaatagggat agcttcctgagccgccacccggagaagccaaagaaagagctggacatttttggattgaac cctgccgacgacagcacacggagttacgtcattttatcttttgaaaacaacggtgactac atggacatgaagcaagctgacgccacccagtacgtccccatgctggaaaggaaagaggct gccaagtactcagacatccagagatcgctgtatgatcgcccggcctcgtctaagaagaag tctgtgttagactcagaagtcaaaaacctcctttcggatgataactcagaaggccttact ttgttggatttgttgagctttacctatcaagttgcacgaggaatggaatttttggcttcg aaaaattgtgtccaccgggacctggctgctcgaaacgtcctcctggcgcaagggaaaatc gtgaagatctgtgacttcggcctggccagagacatcatgcacgattcgaactacgtgtcg aaaggcagtacctttctccctgtgaagtggatggcccctgagagcatcttcgacaacctc tacaccacactgagtgacgtctggtcttacggcattctgctctgggagatcttttccctc ggcggcacaccctaccccggcatgatggtggattctactttctacaataagattaagagt gggtaccggatggccaagcctgaccacgccaccagtgaagtctacgagatcatggtgaaa tgctggcacagtgagccggagaagagaccctccttctaccacctgagtgagattgtggag aacctgctgcccggacagtataagaagagttacgaaaagattcacctggacttcctgaag agcgaccaccccgccgtggcgcgcatgcgcgtggacgccgacaacgcctacattggcgtc acctacaaaaacgaggaagacaagctgaaggactgggagggcagcctggacgagcagagg ctgagcgcggacagcggctacatcatccccctgcccgacatcgaccctgtccctgaggag gaagacctgggcaagaggaacagacacagctcgcagacctcagaagagagtgctatcgag acaggttcgagcagctccaccttcatcaagagagaggacgagaccatcgaggacatcgac atgatggacgacattggcatagactcctcagacctggtagaggacagcttcctgtga

Ursus maritimus (polar bear): 103674660 Help Entry 103674660         CDS       T03271                                  Gene name EGFR Definition (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr04010   MAPK signaling pathway umr04012   ErbB signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04066   HIF-1 signaling pathway umr04068   FoxO signaling pathway umr04072   Phospholipase D signaling pathway umr04144   Endocytosis umr04151   PI3K-Akt signaling pathway umr04510   Focal adhesion umr04520   Adherens junction umr04540   Gap junction umr04630   JAK-STAT signaling pathway umr04810   Regulation of actin cytoskeleton umr04912   GnRH signaling pathway umr04915   Estrogen signaling pathway umr04921   Oxytocin signaling pathway umr04926   Relaxin signaling pathway umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr05160   Hepatitis C umr05163   Human cytomegalovirus infection umr05165   Human papillomavirus infection umr05171   Coronavirus disease - COVID-19 umr05200   Pathways in cancer umr05205   Proteoglycans in cancer umr05206   MicroRNAs in cancer umr05210   Colorectal cancer umr05212   Pancreatic cancer umr05213   Endometrial cancer umr05214   Glioma umr05215   Prostate cancer umr05218   Melanoma umr05219   Bladder cancer umr05223   Non-small cell lung cancer umr05224   Breast cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103674660 (EGFR)    04012 ErbB signaling pathway     103674660 (EGFR)    04014 Ras signaling pathway     103674660 (EGFR)    04015 Rap1 signaling pathway     103674660 (EGFR)    04630 JAK-STAT signaling pathway     103674660 (EGFR)    04066 HIF-1 signaling pathway     103674660 (EGFR)    04068 FoxO signaling pathway     103674660 (EGFR)    04020 Calcium signaling pathway     103674660 (EGFR)    04072 Phospholipase D signaling pathway     103674660 (EGFR)    04151 PI3K-Akt signaling pathway     103674660 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     103674660 (EGFR)   09144 Cellular community - eukaryotes    04510 Focal adhesion     103674660 (EGFR)    04520 Adherens junction     103674660 (EGFR)    04540 Gap junction     103674660 (EGFR)   09142 Cell motility    04810 Regulation of actin cytoskeleton     103674660 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     103674660 (EGFR)    04915 Estrogen signaling pathway     103674660 (EGFR)    04921 Oxytocin signaling pathway     103674660 (EGFR)    04926 Relaxin signaling pathway     103674660 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     103674660 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103674660 (EGFR)    05206 MicroRNAs in cancer     103674660 (EGFR)    05205 Proteoglycans in cancer     103674660 (EGFR)    05230 Central carbon metabolism in cancer     103674660 (EGFR)    05231 Choline metabolism in cancer     103674660 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103674660 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     103674660 (EGFR)    05212 Pancreatic cancer     103674660 (EGFR)    05225 Hepatocellular carcinoma     103674660 (EGFR)    05226 Gastric cancer     103674660 (EGFR)    05214 Glioma     103674660 (EGFR)    05218 Melanoma     103674660 (EGFR)    05219 Bladder cancer     103674660 (EGFR)    05215 Prostate cancer     103674660 (EGFR)    05213 Endometrial cancer     103674660 (EGFR)    05224 Breast cancer     103674660 (EGFR)    05223 Non-small cell lung cancer     103674660 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103674660 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     103674660 (EGFR)    05171 Coronavirus disease - COVID-19     103674660 (EGFR)    05163 Human cytomegalovirus infection     103674660 (EGFR)    05165 Human papillomavirus infection     103674660 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103674660 (EGFR)    01522 Endocrine resistance     103674660 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103674660 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:umr04147]     103674660 (EGFR) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      103674660 (EGFR) Protein kinases [BR:umr01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    103674660 (EGFR) Exosome [BR:umr04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    103674660 (EGFR)   Exosomal proteins of pancreatic cancer cells    103674660 (EGFR)   Exosomal proteins of bladder cancer cells    103674660 (EGFR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like APH Pkinase_fungal Borrelia_P83 Motif Other DBs NCBI-GeneID:  103674660 NCBI-ProteinID:  XP_008701798 UniProt:  A0A384D413 LinkDB All DBs Position Un AA seq 1212 aa AA seqDB search MHAKGFGNVGPEGSHSRPPTVFSSPVLYCTESICQGTSNRLTQLGTFEDHFLSLQRMFNN CEVVLGNLEITYMQKNYDLSFLKTIQEVAGYVLIALNTVEKIPLENLQVIRGNVLYENTH ALSVLSNYGTNKTGLRELPLRNLHEILQGAVRFSNNPVLCSVETIQWRDIVDGDFVSNMS MDFQNQAGSCQKCDPGCPNGSCWGPGKENCQKLTKVICAQQCSGRCRGRSPSDCRHNQCA AGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPR NYVVTDHGSCVRACSSDSYEVEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIK HFKNCTSISGDLHILPVAFRGDSFTRTLPLDPKELDILKTVKEITGFLLIQAWPENRTDL HAFENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNQKLCYANTINW KKLFGTSSQKTKIINNKDEKGCKAIGHVCHPLCSSEGCWGPEPKDCVSCRNVSRGKECVE KCNVLQGEPREFVENSECIQCHPECLPQAMNVTCTGRGPDSCVKCAHYIDGPHCVKTCPA GIMGENNTLVWKFADANRVCHLCHSNCTYGCAGPGLEGCATNGPKIPSIATGIVGGLLLV VVVALGVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKV LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL LGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYCADWCLQDALPQGMNYLEDRRLVH RDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS DVWSYGVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCWMIDA DSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADE YLIPQQGFFHSPSTSRTPLLSSLSATSNNSAVACIDRNGSCPLKEDSLLQRYSSDPTGTL TEDNIDDTFLPAPEYINQSVPKRPAGSVQNPVYHNQPLNPAPGRDPHYQNPHSNAVGNPE YLNTHPTCVSSVLDGPGLWAQKGNHQISLDNPDYQQDFFPKEAKSNGIFKGPAAENADYL RVAPPSSEFIGA NT seq 3639 nt NT seq  +upstreamnt  +downstreamnt atgcatgccaagggctttgggaatgttggacccgagggctcgcactctcgcccacccact gtcttcagctcacctgttctctattgcacagagtcaatttgccagggcacaagtaaccgg ctcacccagttgggcactttcgaagaccactttctgagccttcagaggatgttcaacaac tgtgaggtggtcctcgggaatttggaaataacctacatgcaaaagaattatgacctttcc ttcttgaagaccatccaggaagtcgccggctatgtactcattgccctcaacacagtggag aagattcctttggaaaaccttcaggtcatccgaggaaacgtgctctatgagaacacccat gccttatccgtcttatccaactacggcacaaataaaaccggactgcgggaacttcccctg agaaacttacacgaaatcctacaaggcgctgtgcgcttcagcaacaaccctgtgctctgc agcgtggaaaccatccagtggcgggatatcgttgacggcgactttgtgagcaatatgtcg atggacttccagaaccaagcgggcagttgccaaaagtgtgatccaggctgtcccaatgga agctgctggggtccgggaaaggagaattgccagaaattgaccaaagtcatctgtgcccag cagtgctcagggcgctgccgcggccggtcccccagcgactgccgccacaaccagtgtgcc gccggctgcacggggccccgcgagagcgactgcctggtctgccgcaagttccgggacgaa gccacgtgcaaggacacctgcccgcccctcatgctgtacaaccccaccacctaccagatg gatgtcaaccccgaggggaagtacagttttggtgccacctgcgtgaagaaatgcccccgt aactacgtggtgacagaccacggttcgtgtgtccgtgcctgcagctccgacagctacgag gtggaggaagacggcgtccgcaaatgtaaaaagtgtgaggggccttgccgcaaagtttgt aatggaataggaattggtgaatttaaagacacactttccattaatgctacaaatattaaa cacttcaaaaattgcacctcaatcagtggagatcttcatatcctgccggtagcatttaga ggtgactccttcacacgtactctacctctggatccaaaggaactggatattctaaaaact gtaaaggaaataacagggtttttgctgattcaggcctggcccgaaaacaggactgacctc catgctttcgagaacctagaaatcatacgtggaagaacaaagcaacatggtcagttttct cttgcggtcgtcggcctggacataacatccttgggattacgctccctcaaggagataagt gatggagacgtgatcatctcaggaaaccaaaaattgtgttatgcaaatacaataaactgg aaaaaactatttgggacttcaagtcagaaaaccaaaatcataaacaacaaagatgaaaaa ggctgcaaggccataggccacgtctgccatccattatgttcatccgagggctgctggggc ccagagccgaaagactgcgtgtcctgccgcaacgtcagccggggcaaggaatgtgtggag aagtgcaatgttctgcagggggagccaagggagtttgtggagaattccgagtgcatacag tgccatccggaatgcctgccccaagccatgaatgtaacctgcacaggacggggaccggac agctgcgtcaagtgtgctcactacatcgatggccctcactgcgtcaagacctgcccggct ggcatcatgggcgagaacaataccctggtctggaagttcgcggatgccaatcgcgtgtgc cacctgtgccattccaactgtacctacggctgtgctgggccaggtcttgaaggctgtgcg acaaacgggcccaagatcccatccattgccaccgggatcgtgggcggcctcctcctggtg gtggtggtggcccttggggtgggcctgttcttgcgccggcggcacatcgtccggaagcgc acgcttcgtagactgctgcaggaaagagagcttgttgagcctcttacacccagcggagaa gctcccaaccaagctctcttgaggatcttaaaggaaacagaattcaaaaagatcaaggtg ctgggctctggagcattcggcacggtgtacaagggactctggatcccagaaggcgagaag gttaaaattcccgtggccatcaaggaattaagagaagccacatctccaaaagccaacaag gaaattcttgatgaagcctacgtgatggccagtgtggacaatcctcacgtgtgccgtctc ctgggcatctgcctgacctccacggtccagctcatcacacagctcatgcccttcggctgc ctcctggactatgtccgcgagcacaaggacaacattggctcccagtactgtgcagattgg tgcctgcaggacgctctcccacagggcatgaactacctggaagaccggcgcttggtgcac cgtgacctggcagccagaaatgtcctggtgaagaccccacagcacgtcaagatcacagat tttgggctggccaaactgcttggtgctgaggagaaagaataccacgcagaaggaggcaaa gtacctatcaagtggatggccttggagtcaattttacaccgaatttatacccaccaaagt gatgtgtggagctatggagtcactgtttgggagttgatgacctttgggtccaagccttat gacggtatccccgcaagtgagatctcaaccatcctggagaaaggagagcgcctcccacag ccgcccatatgcaccatcgatgtctacatgatcatggtcaagtgctggatgatagatgcg gacagtcgcccaaaattccgtgaattgatcattgagttctccaaaatggcccgtgacccc cagcgctaccttgtcatccagggagacgagaggatgcatttgccaagccctacagactcc aacttttaccgcgccctgatggacgaagaggacatggaggacgtcgtggacgccgacgag tacctcatcccccaacagggcttcttccacagtccctccacatcccggacccccctcctg agttccctgagtgccaccagcaacaattccgccgtggcttgcattgacagaaatgggagc tgtcccctcaaagaagacagcctcctgcaacggtacagctcggaccccactggcaccttg accgaggacaacatagatgacaccttcctcccagcacctgaatacataaaccagtccgtt cccaaaaggcctgcgggttctgtccagaaccccgtctatcacaatcagcctctaaatcca gctcctggcagagaccctcactaccagaatccccacagcaacgcagtgggcaaccccgag tatctcaacacacaccctacctgcgtcagcagtgtgctcgacggccccggcctctgggcc cagaaaggcaaccaccagatcagcctggacaacccggactaccagcaggacttctttccc aaggaagccaagtcaaacggcatctttaagggccccgccgctgaaaatgcagactacctg agggtagcgcccccaagcagtgagtttattggagcatga

Ursus maritimus (polar bear): 103676585 Help Entry 103676585         CDS       T03271                                  Gene name MET Definition (RefSeq) MET proto-oncogene, receptor tyrosine kinase   KO K05099   proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr04010   MAPK signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04151   PI3K-Akt signaling pathway umr04360   Axon guidance umr04510   Focal adhesion umr04520   Adherens junction umr05100   Bacterial invasion of epithelial cells umr05144   Malaria umr05200   Pathways in cancer umr05202   Transcriptional misregulation in cancer umr05205   Proteoglycans in cancer umr05206   MicroRNAs in cancer umr05211   Renal cell carcinoma umr05218   Melanoma umr05223   Non-small cell lung cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103676585 (MET)    04014 Ras signaling pathway     103676585 (MET)    04015 Rap1 signaling pathway     103676585 (MET)    04020 Calcium signaling pathway     103676585 (MET)    04151 PI3K-Akt signaling pathway     103676585 (MET)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     103676585 (MET)    04520 Adherens junction     103676585 (MET)  09150 Organismal Systems   09158 Development and regeneration    04360 Axon guidance     103676585 (MET)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103676585 (MET)    05202 Transcriptional misregulation in cancer     103676585 (MET)    05206 MicroRNAs in cancer     103676585 (MET)    05205 Proteoglycans in cancer     103676585 (MET)    05230 Central carbon metabolism in cancer     103676585 (MET)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     103676585 (MET)    05226 Gastric cancer     103676585 (MET)    05218 Melanoma     103676585 (MET)    05211 Renal cell carcinoma     103676585 (MET)    05223 Non-small cell lung cancer     103676585 (MET)   09171 Infectious disease: bacterial    05100 Bacterial invasion of epithelial cells     103676585 (MET)   09174 Infectious disease: parasitic    05144 Malaria     103676585 (MET)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103676585 (MET)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103676585 (MET) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      103676585 (MET) Protein kinases [BR:umr01001]  Receptor tyrosine kinases (RTK)   MET family    103676585 (MET) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Sema Pkinase TIG PSI Pkinase_fungal Kinase-like Linker_histone Ninjurin PepSY_TM Motif Other DBs NCBI-GeneID:  103676585 NCBI-ProteinID:  XP_008704007 UniProt:  A0A384DAD6 LinkDB All DBs Position Un AA seq 1382 aa AA seqDB search MKAPAVIAPGILVLLFTLVQKSYGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHKH HIYLGAVNYIYVLNDKDLQKVAEYKTGPVLEHPDCFPCQDCSHKANLSGGVWEDNINMAL VIDTYYDDQLISCGSVHRGTCQRHVLPPSNTADIQSEVHCMYSPQADEERGQCPDCVVSA LGTKVLISEKDRFINFFVGNTINSSYHPDHLLHSISVRRLKETQDGFKFLTDQSYIDVLP EFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECI LTEKRRKRSTREEVFNILQAAYVSKPGAHLAKQIGANLNDDILYGVFARSKPDSTEPMNR SAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTE FTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGSSTPHVNF RLDSHPVSPEAIVEHPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPPFVQCG WCHDKCVQLEECPTGTWTQEICLPTIYEVSPTSAPLEGGTMLTVCGWDFGFRRNNKFDLK KTKVLLGNDSCTLTLSESTTNMLKCTVGPAVNEHFNISIIIANGRGTAQYSAFSYVDPII TSISPSYGPKTGGTLLTLTGKHLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTPTE FPIKLKIDLANREMNSFSYQEDPIVYAIHPTKSFISGGSTITAVGKNLHSVSVLRMVISV LEARRNFTVACRHRSNSEIICCTTPSLQQLNLELPLKTKAFFMLDGIHSKNFDLIYVHNP VFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCETIYSDSEAVLCKVPND LLRLNNELNIEWKQAVSSTVLGKVIVQPDQNFTGLIVGVISISLILLLLLGLFLWLKRRK QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNG SCRQVQYPLTDLSPMLTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC WHPKAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNIDGEG DT NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt atgaaggcccctgctgtgattgcacctggcatccttgtacttctgtttaccttggtgcag aagagctatggggagtgcaaagaggcactagtaaagtctgagatgaatgtgaacatgaag tatcagcttcccaacttcactgcagaaacacccatccagaatgttgttttacacaagcat catatttacctcggtgcagttaactatatttacgttttaaatgacaaagaccttcagaaa gttgctgagtacaagactgggcccgtgctggaacacccagattgtttcccatgtcaggac tgcagccacaaagccaatttatcaggtggcgtttgggaagataacatcaacatggctcta gttattgacacctactatgatgaccaactcattagctgtggcagtgtccacagagggacc tgccagcgacatgtccttccacccagcaatactgctgatatacagtcggaagttcattgc atgtactctccacaggcagacgaagagcgcggccagtgccctgactgtgtggtgagtgcc ctgggaaccaaagtcctgatatctgaaaaggatcggttcatcaacttcttcgtgggtaac accataaattcctcgtaccatccagatcatttattgcattcgatatcagtgagaaggcta aaggaaacgcaagatggtttcaagtttttgacagaccaatcttatattgatgttctacct gagttcagagattcctaccctattaaatatgtccacgcctttgaaagcaatcattttatt tactttttgacagtccaacgagaaactctagatgctcagacttttcacacaagaataatc aggttctgttctgtagactctggattgcattcctacatggaaatgcctctggagtgtatt ctcacggaaaaaagaagaaagagatccacaagggaggaagtatttaatattctccaagct gcatatgtcagtaagcctggggcccaccttgctaagcaaataggtgccaacctgaatgat gacattctctacggagtgtttgcacgaagcaaaccagattctactgaacccatgaatcgt tctgccgtctgtgcattccctatcaaatatgtcaacgaattcttcaacaagatcgtcaac aaaaacaatgtgagatgtcttcaacatttttatggacccaaccacgaacactgctttaac aggacacttttgagaaattcatcaggctgtgaagtgcgcagtgacgaatatcgaacggag tttaccacagctttgcagcgtgttgacttattcatgggccaattcaaccaagtcctctta acatctatatctaccttcattaaaggagacctcaccattgctaatcttgggacgtcagag ggtcgtttcatgcaggttgtggtttctcgatcaggatcgtcaacccctcatgtgaatttt cgcctggattcccaccctgtgtctccagaagcaattgtggagcacccattaaaccaaaat ggctacacactggtcgtcactgggaagaaaatcaccaagatcccactgaatggcttaggc tgtgaacatttccagtcctgcagtcagtgtctctccgcccctccctttgtgcagtgtggc tggtgccatgacaaatgtgtgcaattggaggaatgccccactggaacatggactcaggag atctgtctgcctacaatctatgaggtttccccaactagtgcacccttggaaggagggaca atgctgaccgtatgtggctgggactttggattcaggaggaataataaatttgatttaaag aaaaccaaagttcttcttggaaatgacagctgcaccttgaccttaagtgagagcacaaca aatatgctgaaatgcacagttggtcctgcagtgaatgagcatttcaatatatccataatt attgcaaatggtcgagggacagcacaatatagtgcattttcctatgtggatcctataata acaagtatttctccaagttatggtcctaagactggcggcaccttgcttactttaactgga aagcacctaaacagtgggaattctagacacatttcaattggtggaaaaacatgtacttta aaaagtgtgtcagatagtattctcgaatgttataccccagctcaaaccactccaactgag ttccctattaaactgaaaattgacttagccaaccgagagatgaacagcttcagttaccag gaagaccccattgtctatgcaattcatccaaccaaatcttttattagtggtgggagcaca ataacagctgttggaaaaaacctgcattcagttagtgtcctgaggatggtaataagtgta ctagaagcaagaaggaactttacagtggcatgtcgacatcgctctaattcagagataatc tgctgtacaactccttcactgcaacagctgaatctggaactccctctgaaaaccaaagcc tttttcatgttagatgggatccattccaaaaactttgatctcatttatgtacataatcct gtgtttaagccttttgaaaagccagtgatgatctcaataggcaatgaaaatgtactggaa attaagggaaatgatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaat aagagctgtgagactatatactcagattctgaagccgttttatgcaaggtccccaatgac ctgctgagattgaacaacgagctaaatatagagtggaagcaagcagtttcttcaaccgtc cttggaaaagtaattgttcaaccagatcagaacttcacaggattgattgttggtgttatc tcaatatcattaatactcttattattactcgggcttttcctgtggctgaaaaggagaaag caaattaaagatctgggcagtgaattagttcgctatgatgcaagagtacacactcctcat ttggataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaa tctgtagactaccgagctacttttccagaagaccagtttcctaactcatctcagaatgga tcatgcagacaagttcagtatcctctgacagacctgtcccccatgcttaccagtggggac tctgatatatccagtccattactgcaaaatactgtccacattgacctcagtgctctaaat ccagagctggtccaggcagtccagcacgtagtgattgggccgagtagcctaattgtgcat ttcaatgaagtcataggaagaggacattttgggtgcgtataccatgggactttgctggac aatgatgacaagaaaattcactgtgctgtgaaatctttgaatcgaatcactgacatagga gaagtttcccagtttctgaccgagggaatcatcatgaaagattttagtcatccaaatgtt ctctcactcttgggaatctgccttcgaagtgaggggtctccgctggtagtcctaccatac atgaaacatggagatcttcgaaatttcattaggaatgagactcataacccaactgtaaaa gatcttattggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaag tttgtccacagagacttggctgcaagaaactgtatgctggatgaaaaattcactgtcaag gttgctgattttggtcttgccagagacatgtatgataaagaatactatagtgtacacaac aaaacaggtgccaagctgcccgtgaagtggatggctttagaaagtctgcaaactcagaag tttaccaccaagtcagatgtgtggtcctttggtgtgctcctctgggaactgatgacaaga ggagcaccaccttatcctgacgtcaacacctttgatataacagtttacttgttgcaaggc agaaggctcctacaacccgaatactgcccagatcccttatatgaagtgatgctcaaatgc tggcaccctaaagctgaactgcgcccatctttttctgaactggtctccaggatatcagca atattctctacttttattggggagcactatgtccatgtgaacgctacttatgtgaatgtc aaatgtgtggctccatacccttctctgctgtcatcacaagataacattgacggcgagggg gacacatga

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