KEGG   ORTHOLOGY: K05089
Entry
K05089                      KO                                     
Symbol
PDGFRB, CD140B
Name
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04072  Phospholipase D signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map04540  Gap junction
map04630  JAK-STAT signaling pathway
map04810  Regulation of actin cytoskeleton
map05165  Human papillomavirus infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
H01910  Infantile myofibromatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 JAK-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09162 Cancer: specific types
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
Other DBs
GO: 0004992
Genes
HSA: 5159(PDGFRB)
PTR: 462188(PDGFRB)
PPS: 100975853(PDGFRB)
GGO: 101150577(PDGFRB)
PON: 100460001(PDGFRB)
PPYG: 129036804(PDGFRB)
NLE: 100597894(PDGFRB)
HMH: 116471711(PDGFRB)
SSYN: 129486167(PDGFRB)
MCC: 711353(PDGFRB)
MCF: 101867161(PDGFRB)
MTHB: 126956582
MNI: 105466873(PDGFRB)
CSAB: 103244790(PDGFRB)
CATY: 105589876(PDGFRB)
PANU: 101008264(PDGFRB)
TGE: 112626117(PDGFRB)
MLEU: 105543434(PDGFRB)
RRO: 104670408(PDGFRB)
RBB: 108532047(PDGFRB)
TFN: 117065596(PDGFRB)
PTEH: 111552670(PDGFRB)
CANG: 105504227(PDGFRB)
CJC: 100389852(PDGFRB)
SBQ: 101040158(PDGFRB)
CIMI: 108306401(PDGFRB)
ANAN: 105716781(PDGFRB)
CSYR: 103263367(PDGFRB)
MMUR: 105858450(PDGFRB)
LCAT: 123638073(PDGFRB)
PCOQ: 105821582(PDGFRB)
OGA: 100951606(PDGFRB)
MMU: 18596(Pdgfrb)
MCAL: 110284880(Pdgfrb)
MPAH: 110333065(Pdgfrb)
RNO: 24629(Pdgfrb)
MCOC: 116087226(Pdgfrb)
ANU: 117719688(Pdgfrb)
MUN: 110546695(Pdgfrb)
CGE: 100764374(Pdgfrb)
MAUA: 101840188(Pdgfrb)
PROB: 127234263(Pdgfrb)
PLEU: 114707365(Pdgfrb)
MORG: 121440622(Pdgfrb) 121445248
MFOT: 126511093
AAMP: 119815474(Pdgfrb)
NGI: 103747076(Pdgfrb)
HGL: 101721151(Pdgfrb)
CPOC: 100726506(Pdgfrb)
CCAN: 109685664(Pdgfrb)
DORD: 105992616(Pdgfrb)
DSP: 122118168(Pdgfrb)
PLOP: 125339985(Pdgfrb)
NCAR: 124986803
MMMA: 107154281(Pdgfrb)
OCU: 100342872
OPI: 101516431(PDGFRB)
TUP: 102492413(PDGFRB)
GVR: 103585042(PDGFRB)
CFA: 442985(PDGFRB)
CLUD: 112651939(PDGFRB)
VVP: 112927357(PDGFRB)
VLG: 121486777(PDGFRB)
NPO: 129509546(PDGFRB)
AML: 100472005(PDGFRB)
UMR: 103664600(PDGFRB)
UAH: 113263944(PDGFRB)
UAR: 123803639(PDGFRB)
ELK: 111140848
LLV: 125100170
MPUF: 101684361(PDGFRB)
MNP: 132028321(PDGFRB)
MLK: 131831763(PDGFRB)
NVS: 122894113(PDGFRB)
ORO: 101374793(PDGFRB)
EJU: 114211916(PDGFRB)
ZCA: 113929051(PDGFRB)
MLX: 118006692 118006827
NSU: 110586749(PDGFRB)
LWW: 102740115(PDGFRB)
FCA: 101084600(PDGFRB)
PYU: 121045013(PDGFRB)
PCOO: 112860921(PDGFRB)
PBG: 122493456(PDGFRB)
PVIV: 125166177(PDGFRB)
LRUF: 124507266
PTG: 102954207(PDGFRB)
PPAD: 109275948(PDGFRB)
PUC: 125934559
AJU: 106985388
HHV: 120236611(PDGFRB)
BTA: 527165(PDGFRB)
BOM: 102270608(PDGFRB)
BIU: 109562197(PDGFRB)
BBUB: 102392216(PDGFRB)
BBIS: 104996312(PDGFRB)
CHX: 102184426(PDGFRB)
OAS: 101122783(PDGFRB)
BTAX: 128050429(PDGFRB)
ODA: 120863403(PDGFRB)
CCAD: 122439706(PDGFRB)
MBEZ: 129558396(PDGFRB)
SSC: 102166564(PDGFRB)
CFR: 102512951(PDGFRB)
CBAI: 105074292(PDGFRB)
CDK: 105098486(PDGFRB)
VPC: 102545129(PDGFRB)
BACU: 103019883(PDGFRB)
BMUS: 118892250(PDGFRB)
LVE: 103082363(PDGFRB)
OOR: 101272795(PDGFRB)
DLE: 111183086(PDGFRB)
PCAD: 102995915(PDGFRB)
PSIU: 116751332(PDGFRB)
NASI: 112391109(PDGFRB)
ECB: 100071665(PDGFRB)
EPZ: 103549125(PDGFRB)
EAI: 106838493(PDGFRB)
MYB: 102241145(PDGFRB)
MYD: 102764172(PDGFRB)
MMYO: 118658697(PDGFRB)
MLF: 102441579(PDGFRB)
PKL: 118711223(PDGFRB)
EFUS: 103295746(PDGFRB)
MNA: 107535230(PDGFRB)
DRO: 112319577(PDGFRB)
SHON: 118986157(PDGFRB)
AJM: 119061365(PDGFRB)
PDIC: 114509632(PDGFRB)
PHAS: 123807517(PDGFRB)
MMF: 118615300(PDGFRB)
PPAM: 129066549(PDGFRB)
HAI: 109375002(PDGFRB)
RFQ: 117016666(PDGFRB)
PALE: 102887643(PDGFRB)
PGIG: 120581545(PDGFRB)
PVP: 105299436(PDGFRB)
RAY: 107497163(PDGFRB)
MJV: 108385397(PDGFRB)
TOD: 119243270(PDGFRB)
SARA: 101540263(PDGFRB)
SETR: 126006402(PDGFRB)
LAV: 100671240(PDGFRB)
TMU: 101360003
ETF: 101650381(PDGFRB)
DNM: 101411552(PDGFRB)
MDO: 100028943(PDGFRB)
GAS: 123233823(PDGFRB)
SHR: 100917212(PDGFRB)
AFZ: 127550081
PCW: 110192821(PDGFRB)
TVP: 118843247(PDGFRB)
OAA: 100079459(PDGFRB)
GGA: 770488(PDGFRB)
PCOC: 116232153(PDGFRB)
MGP: 100550611(PDGFRB)
CJO: 107320191(PDGFRB)
TPAI: 128081597(PDGFRB)
LMUT: 125700002(PDGFRB)
NMEL: 110405265(PDGFRB)
APLA: 101799587(PDGFRB)
ACYG: 106032823(PDGFRB)
CATA: 118260560(PDGFRB)
AFUL: 116494711(PDGFRB)
TGU: 100223375(PDGFRB)
LSR: 110482721(PDGFRB)
SCAN: 103817301(PDGFRB)
PMOA: 120498517(PDGFRB)
OTC: 121332255(PDGFRB)
PRUF: 121361297(PDGFRB)
GFR: 102045343(PDGFRB)
FAB: 101809926(PDGFRB)
OMA: 130258544(PDGFRB)
PHI: 102111524(PDGFRB)
PMAJ: 107210844(PDGFRB)
CCAE: 111935543(PDGFRB)
CCW: 104689579(PDGFRB)
CBRC: 103611401(PDGFRB)
ETL: 114063193(PDGFRB)
ZAB: 102073695(PDGFRB)
ZLE: 135453548(PDGFRB)
ACHL: 103802359(PDGFRB)
SVG: 106859573(PDGFRB)
MMEA: 130579332(PDGFRB)
HRT: 120759145(PDGFRB)
FPG: 101918438(PDGFRB)
FCH: 102052718(PDGFRB)
CLV: 102096790(PDGFRB)
EGZ: 104123312(PDGFRB)
NNI: 104014196(PDGFRB)
PCRI: 104036032(PDGFRB)
PLET: 104627578(PDGFRB)
EHS: 104517261(PDGFRB)
PCAO: 104049359(PDGFRB)
ACUN: 113485173(PDGFRB)
TALA: 104357574(PDGFRB)
PADL: 103915745(PDGFRB)
AFOR: 103904388(PDGFRB)
ACHC: 115334242(PDGFRB)
HALD: 104324083(PDGFRB)
HLE: 104838898(PDGFRB)
AGEN: 126050952
GCL: 127021839
CCRI: 104163914(PDGFRB)
CSTI: 104563590(PDGFRB)
CMAC: 104479936(PDGFRB)
MUI: 104541100(PDGFRB)
BREG: 104637989(PDGFRB)
FGA: 104074292(PDGFRB)
GSTE: 104258673(PDGFRB)
LDI: 104352678(PDGFRB)
MNB: 103776410(PDGFRB)
OHA: 104326896(PDGFRB)
NNT: 104413057(PDGFRB)
SHAB: 115615917(PDGFRB)
DPUB: 104309991(PDGFRB)
PGUU: 104463785(PDGFRB)
ACAR: 104523710(PDGFRB)
CPEA: 104392712(PDGFRB)
AVIT: 104276794(PDGFRB)
CVF: 104293116(PDGFRB)
RTD: 128916197(PDGFRB)
CUCA: 104059466(PDGFRB)
TEO: 104377141(PDGFRB)
BRHI: 104490081(PDGFRB)
AAM: 106493441(PDGFRB)
AROW: 112964785(PDGFRB)
NPD: 112954304(PDGFRB)
TGT: 104579953(PDGFRB)
DNE: 112996927(PDGFRB)
SCAM: 104142203(PDGFRB)
ASN: 102372962(PDGFRB)
AMJ: 102566175(PDGFRB)
CPOO: 109310161(PDGFRB)
GGN: 109289892(PDGFRB)
PSS: 102460895(PDGFRB)
CMY: 102944650(PDGFRB)
CCAY: 125640811(PDGFRB)
DCC: 119860427(PDGFRB)
CPIC: 101940553(PDGFRB)
CABI: 116819978(PDGFRB)
MRV: 120369946(PDGFRB)
ACS: 100555784(pdgfrb)
ASAO: 132768948(PDGFRB)
PVT: 110086089(PDGFRB)
SUND: 121923103(PDGFRB)
PBI: 103051588(PDGFRB)
PMUR: 107294993
CTIG: 120306869(PDGFRB)
TSR: 106547766(PDGFRB)
PGUT: 117655249(PDGFRB)
APRI: 131190103(PDGFRB)
PTEX: 113433810(PDGFRB)
NSS: 113424511(PDGFRB)
VKO: 123035769(PDGFRB)
PMUA: 114591343(PDGFRB)
PRAF: 128407955(PDGFRB)
ZVI: 118080419(PDGFRB)
HCG: 128348139(PDGFRB)
STOW: 125429083(PDGFRB)
EMC: 129327498(PDGFRB)
XLA: 108712643(pdgfrb.S)
XTR: 100487523(pdgfrb)
NPR: 108785807(PDGFRB)
RTEM: 120932546(PDGFRB)
BBUF: 121008278(PDGFRB)
BGAR: 122928360(PDGFRB)
MUO: 115459682 115475707(PDGFRB)
GSH: 117351655(PDGFRB)
DRE: 559529(pdgfrb)
SRX: 107747104 107754478
SANH: 107690880 107693052
SGH: 107568132 107588322
CCAR: 109046273 109046274
CAUA: 113069557 113113654
CGIB: 127971200 128027781
PTET: 122357618(pdgfrb)
LROH: 127176102(pdgfrb)
OMC: 131553121(pdgfrb)
PPRM: 120473205(pdgfrb)
RKG: 130086544(pdgfrb)
MAMB: 125275641(pdgfrb)
CIDE: 127494775
MASI: 127413383 127418070
TROS: 130549417(pdgfrb)
TDW: 130437873(pdgfrb)
MANU: 129421970(pdgfrb)
IPU: 108274697
IFU: 128618503(pdgfrb)
PHYP: 113529620(pdgfrb)
SMEO: 124392347(pdgfrb)
TFD: 113654892(pdgfrb)
TVC: 132856700(pdgfrb)
TRN: 134307010(pdgfrb)
AMEX: 103036483(pdgfrb)
CMAO: 118811440(pdgfrb)
EEE: 113575581(pdgfrb)
CHAR: 105904594 116220866(pdgfrb)
TRU: 101061130 101074724(pdgfrb)
TFS: 130531302(pdgfrb) 130537161
TNG: GSTEN00014570G001 GSTEN00026578G001
LCO: 104919444 104927056
NCC: 104965701(pdgfrb)
TBEN: 117470913(pdgfrb) 117490686
CGOB: 115014733(pdgfrb) 115019444
PGEO: 117453732(pdgfrb)
GACU: 117556048(pdgfrb)
EMAC: 134859941(pdgfrb) 134872060
ELY: 117260792(pdgfrb) 117270921
EFO: 125894963(pdgfrb) 125898196
PLEP: 121939111 121947843(pdgfrb)
SLUC: 116062368 116064307(pdgfrb)
ECRA: 117951210(pdgfrb)
ESP: 116696884(pdgfrb)
PFLV: 114562615(pdgfrb) 114566403
GAT: 120817382(pdgfrb)
PPUG: 119210567(pdgfrb)
AFB: 129090064(pdgfrb) 129113389
CLUM: 117737933(pdgfrb) 117742953
PSWI: 130209934(pdgfrb)
MSAM: 119888610(pdgfrb) 119895825 119918588
SCHU: 122880357(pdgfrb) 122888272
CUD: 121516062(pdgfrb) 121519179
ALAT: 119008149(pdgfrb) 119031152
MZE: 101466822 101484671(pdgfrb)
ONL: 100695603(pdgfrb) 100709470
OAU: 116329079(pdgfrb) 116329738
OLA: 101155039(pdgfrb) 101156428
OML: 112136844 112153320(pdgfrb)
CSAI: 133446945(pdgfrb) 133460013
XMA: 102229755 102233464(pdgfrb)
XCO: 114139478(pdgfrb) 114153115
XHE: 116713960(pdgfrb) 116728444
PRET: 103459902 103471279(pdgfrb)
PFOR: 103135514 103135517 103141073(pdgfrb)
PLAI: 106939821 106948556(pdgfrb)
PMEI: 106907217(pdgfrb) 106918551
GAF: 122837604(pdgfrb) 122844817
PPRL: 129362573(pdgfrb) 129370750
CVG: 107095000(pdgfrb) 107102292
CTUL: 119777911(pdgfrb) 119785587
GMU: 124860432(pdgfrb) 124876578
NFU: 107375657(pdgfrb)
KMR: 108228837 108240544(pdgfrb)
ALIM: 106517359(pdgfrb) 106532997
NWH: 119408779(pdgfrb)
AOCE: 111569523(pdgfrb) 111575719
MCEP: 125008222(pdgfrb) 125021590
CSEM: 103391002(pdgfrb) 103392104
POV: 109626437(pdgfrb)
SSEN: 122762812 122778422(pdgfrb)
HHIP: 117769118(pdgfrb)
HSP: 118112689(pdgfrb) 118122120
PPLT: 128445395(pdgfrb)
SMAU: 118300833 118319653(pdgfrb)
LCF: 108873646 108899186
SDU: 111226471(pdgfrb) 111239485
SLAL: 111646633(pdgfrb) 111671142
XGL: 120785203(pdgfrb) 120802843
HCQ: 109518748(pdgfrb) 109528881
SSCV: 125981963 125983071
SBIA: 133491365 133509123(pdgfrb)
PEE: 133407552(pdgfrb) 133415885
PTAO: 133467039 133484435(pdgfrb)
BPEC: 110157622 110174958
MALB: 109955104 109973182
BSPL: 114864577(pdgfrb) 114869682
SJO: 128363114(pdgfrb) 128371860
SASA: 100380851(pgfrb) 106604848 106611876
STRU: 115154887 115174164 115205391
OTW: 112220770 112229041 112256098
OMY: 110488623 110504831 110534178
OGO: 123993263 124005726 124011140
ONE: 115129341 115130536 115135457
OKI: 109864648 109873120 109905074
OKE: 118376080(pdgfrb) 118383741 118390546
SALP: 111950745 111965401 111967388
SNH: 120048189 120057342 120062390
CCLU: 121541959 121544573 121579656 121579850
ELS: 105025839 105030015
SFM: 108936824(pdgfrb)
PKI: 111855164(pdgfrb)
AANG: 118223372(pdgfrb) 118234934
LOC: 102697036(pdgfrb)
PSPA: 121297330(pdgfrb) 121324756
ARUT: 117413283(pdgfrb)
PSEX: 120542138(pdgfrb)
LCM: 102361386(PDGFRB)
CMK: 103188232
CPLA: 122556457(pdgfrb)
HOC: 132823488(pdgfrb)
LERI: 129701573(pdgfrb)
NLO: 107218496 107218532
NVG: 124307265
ATEN: 116297063
AQU: 100631815 109593746
 » show all
Reference
PMID:15583853
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]
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