KEGG ENZYME: 1.1.1.132

ENZYME: 1.1.1.132

Entry

EC 1.1.1.132                Enzyme

Name

GDP-mannose 6-dehydrogenase;
guanosine diphosphomannose dehydrogenase;
GDP-mannose dehydrogenase;
guanosine diphosphomannose dehydrogenase;
guanosine diphospho-D-mannose dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

GDP-D-mannose:NAD+ 6-oxidoreductase

Reaction(IUBMB)

GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+ [RN:R00880]

Reaction(KEGG)

R00880

Substrate

GDP-D-mannose [CPD:C00096];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Product

GDP-D-mannuronate [CPD:C00976];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.

History

EC 1.1.1.132 created 1972

Pathway

ec00051

Fructose and mannose metabolism

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

Orthology

K00066

GDP-mannose 6-dehydrogenase

Genes

LARE:

HIV01_005960

PRE:	PCA10_11880(algD) PCA10_38230(algD)

PFUW:

KF707C_11170

POJ:	PtoMrB4_26000(algD) PtoMrB4_46190

PLAL:

FXN65_05555

PAE:	PA3540(algD)

PAEV:

N297_3663(algD)

PAEI:

N296_3663(algD)

PAU:	PA14_18580(algD)

PAG:	PLES_14931(algD)

PAF:	PAM18_1446(algD)

PNC:	NCGM2_4665(algD)

PAEB:

NCGM1900_2744(algD)

PDK:	PADK2_06665

PSG:	G655_07100

PRP:	M062_18755

PAEP:

PA1S_07720

PAER:

PA1R_gp1358

PAEM:

U769_07195

PAEL:

T223_07435

PAES:

SCV20265_1523

PAEU:

BN889_03910(algD)

PAEG:

AI22_26185

PAEC:

M802_3660(algD)

PAEO:

M801_3528(algD)

SECH:

B18_00665

PCQ:	PcP3B5_50680(algD)

PMUI:

G4G71_08975

PNT:	G5B91_26160

PAP:	PSPA7_1605(algD)

PPAA:

B7D75_07435

PPU:	PP_1288(algD)

PPF:

Pput_4437

PPG:	PputGB1_4561

PPW:	PputW619_0889

PPT:

PPS_4403

PPB:	PPUBIRD1_4273

PPI:

YSA_03091

PPX:	T1E_3168(algD)

PPUH:

B479_22150

PPUT:

L483_27235

PPUN:

PP4_08000(algD)

PPUD:

DW66_4794

PFV:	Psefu_3880

PMON:

X969_21685

PMOT:

X970_21320

PPJ:	RK21_00119

PMOL:

CLJ08_08380 CLJ08_22925

PALD:

LU682_024945

PIX:	RIN61_07120

PMOS:

O165_013045 O165_018560

PST:	PSPTO_1243(algD)

PSB:

Psyr_1063

PSYR:

N018_20355

PSP:	PSPPH_1118(algD)

PSAV:

PSA3335_09095

PAMG:

BKM19_008085

PCI:	PCH70_10130

PAVL:

BKM03_07020

PVD:	CFBP1590__4277(algD)

PCAB:

JGS08_19525

PCOF:

POR16_18925

PTRE:

I9H09_05090

PSYI:

MME58_05275

PAST:

N015_05985

PLIJ:

KQP88_04855

PFUV:

NLK61_18730

PFL:	PFL_1024(algD)

PPRC:

PFLCHA0_c10440(algD)

PPRO:

PPC_1062

PFE:	PSF113_4752

PZA:	HU749_024140

PFN:	HZ99_11915

PFO:	Pfl01_0960(algD)

PFS:	PFLU_0990(algD)

PFC:	PflA506_0970(algD)

PPZ:	H045_01690

PFB:

VO64_4071

PMAN:

OU5_2447

PTV:	AA957_09045

PCG:	AXG94_09975

PVR:	PverR02_05230

PAZO:

AYR47_12230

POI:	BOP93_04735

PRX:	HRH33_05805

PMED:

E3Z27_23120

PKR:	AYO71_07540

PMUD:

NCTC8068_04321(algD)

PTOL:

I7845_05045

PMAB:

U0037_04980

PBRE:

QDY63_24165

PFW:	PF1751_v1c09480(algD)

PFF:	PFLUOLIPICF703390

PFX:	A7318_04290

PEN:	PSEEN3453(algD-2) PSEEN4535(algD)

PBA:	PSEBR_a4590

PBC:	CD58_24305

PPUU:

PputUW4_04471(algD)

PDR:	H681_19425

PSV:	PVLB_04235 PVLB_15470

PSK:	U771_06125

PKC:	PKB_0968(algD)

PCH:	EY04_04520

PCZ:	PCL1606_50710

PCP:	JM49_25125

PCHP:

C4K32_1103

PFZ:	AV641_18510

PLQ:	AA042_15150

PALK:

PSAKL28_08740 PSAKL28_31810

PPV:	NJ69_13830

PSES:

PSCI_0721

PSEM:

TO66_05210

PSEC:

CCOS191_0912(algD1) CCOS191_2029(algD2)

PPSY:

AOC04_15730

PSOS:

POS17_1030

PFK:	PFAS1_06330

PANR:

A7J50_0992

PSET:

THL1_1268 THL1_3804

PSIL:

PMA3_24585

PYM:	AK972_0838

PKE:	DLD99_05160

PUM:	HGP31_04975

PGG:	FX982_00687

PGY:	AWU82_19080 AWU82_29005

PSEJ:

HNQ25_10170 HNQ25_19280

PVK:	EPZ47_24330

PEZ:	HWQ56_05050

PBZ:	GN234_24015

PATA:

JWU58_22750

PDW:	BV82_3321 BV82_4690

PZE:	HU754_006270

PMOE:

HV782_005850

PSEP:

C4K39_1041

PPII:

QL104_05175

PVW:	HU752_027430

PTRT:

HU722_0006165

PXA:	KSS93_07790

PSAM:

HU731_021005

PTZ:	HU718_005910

PQI:	KH389_10480 KH389_22245

PSHH:

HU773_022835

PXN:	HU772_004420 HU772_009430

PHV:	HU739_012710

PPRG:

HU725_004085 HU725_014400

PANH:

HU763_020330

PASG:

KSS96_05695

PFAK:

KSS94_04615

PMUY:

KSS95_07475 KSS95_11760

PMAM:

KSS90_04835 KSS90_09905

PAZE:

KSS91_23845

PALV:

KSS97_06295

PCAS:

LOY40_05230

PORY:

EJA05_04800

PWZ:	J7655_04690(algD)

PTK:	EXN22_12380 EXN22_22955

PTW:	TUM18999_50120(algD)

PIE:	HU724_005670

PWY:	HU734_005480

PGF:	J0G10_06075

PCAV:

D3880_05550 D3880_05610

PJU:	L1P09_20850

PIZ:	LAB08_R50410

PPEG:

KUA23_05150

PSII:

NF676_05345

PSIH:

LOY51_04705

PFIT:

KJY40_05935

PASI:

LG197_00315

PKM:	PZ739_23450

PNB:	NK667_22335

PSOA:

PSm6_09920(algD)

PTAI:

ICN73_10950

PKK:	QQ992_23595

PKJ:	Q1W70_05470 Q1W70_21865

PHYG:

JTY93_21615

PHOM:

KJF94_01550 KJF94_13595

PCUC:

PSH97_04640

PTRL:

OU419_22545(algD)

PPAE:

LDL65_16250

PPAO:

K3169_23650

PRHZ:

CRX69_09220

PSJY:

AA098_05025

PSKU:

KUIN1_11040

PSHS:

JJN09_02540

PHEF:

PSH57_05225

PSLP:

BHQ29_07820 BHQ29_17130

PLIS:

NN484_01390

PSNC:

C0058_26885

PFOU:

OZ911_23940

PBEJ:

PSH84_01850

PKV:	QYQ93_05900

PSKP:

KU43P_18940 KU43P_44560

PDEU:

QEP73_14595

PQE:	OSC50_19425

PSDT:

NH234_05830

PCAA:

V6L78_29655

PSIV:

LZ023_33740

PSWO:

SD196_21735(algD)

PMOR:

PMm318_A01820

PTHV:

CE140_22400

PSSX:

DCC84_28260

PAGB:

AWM79_03600

PSNS:

CI807_11825

PSRU:

CCX46_04885

PSNY:

ACPFMA_05065

PSMD:

K5R88_25895

PIM:	OQ460_20600

PBAB:

AAEO81_05605

PSYQ:

HXW90_05545

PMY:	Pmen_1031 Pmen_1678

PMK:

MDS_1082

PALL:

UYA_04885 UYA_15320

PKH:	JLK41_05220(algD)

PTY:	JWV26_01370 JWV26_15965(algD)

PHF:	NLY38_05240(algD) NLY38_16715

PCHE:

QYM18_12805(algD) QYM18_23005(algD)

AVN:	Avin_10970(algD)

AVL:	AvCA_10970(algD)

AVD:	AvCA6_10970(algD)

ACX:	Achr_31180(algD)

EAZ:	JHT90_07865

ENTO:

MTZ49_11930

PDEN:

F1C79_17950

PPHA:

BVH74_05210

PALC:

A0T30_11805

PCAM:

HNE05_07125

MSR:	AU15_13665

MACA:

J2887_18610

GAG:	Glaag_2800

PMES:

FX988_01104

PAT:

Patl_1531

HMI:	soil367_08790

ALKM:

NKI27_00790

CEG:	D0C16_11005

GIL:	NHM04_15470

MNY:	R50073_15990

MEIY:

MIN45_P0136

THIM:

KFB96_07615

TFRI:

Thiofri_03630(algD)

ABO:	ABO_0384(algD)

ALN:	AS19_03970

GSN:	YC6258_00963

OME:	OLMES_2098 OLMES_4477

TAU:

Tola_1407

SVA:

SVA_1550

REV:	HUE57_13005

PLG:	NCTC10937_04283(algD)

RFR:

Rfer_0673

PAQA:

K9V56_012855 K9V56_012880

PAIS:

PFX98_20965

ATER:

MW290_14625

JAG:	GJA_3986(algD)

JAL:	BZG29_08185

JAS:	FJQ89_25120

JLV:	G3257_08340

JRI:	P9875_08610

JAE:	OPV09_08525

MNR:	ACZ75_11680

MASY:

DPH57_12210

MENY:

LSQ66_04000

MASZ:

C9I28_09765

MFLA:

GO485_23875

MPLI:

E1742_23455

TCT:	PX653_13240

PLUE:

EWM63_05620

EHB:	E7V67_006890

MUV:	FIT94_04050

EBA:	ebA4268(algD)

AZO:	azo3269(algD)

AOA:

dqs_3408

ACOM:

CEW83_18780

APP:	CAP2UW1_0858 CAP2UW1_1431

ACOG:

HWD57_11430

AMAX:

ABWH92_04635

ARUI:

G6M88_17210

RHL:	LPU83_pLPU83d0171(algD1) LPU83_pLPU83d1236(algD3)

RGR:	FZ934_26065

RROS:

D4A92_02485 D4A92_22670

RSUL:

N2599_29805

BJA:	blr6296(blr6296)

BRA:

BRADO7047

BRS:

S23_62720

BRC:	BCCGELA001_11045

BIC:	LMTR13_08410

BRK:	CWS35_18850

BRQ:	CIT40_06180

BSYM:

CIT39_05020

BARH:

WN72_18950

BEL:	BE61_69060

BSEP:

HAP48_0031560

BQB:	J4P68_0032835

BAUT:

QA635_27835

BBRA:

QA636_29730

BPAH:

QA639_16165

BRAB:

RX331_09160

TARV:

FIU28_16890

MNO:

Mnod_5882

METI:

DK427_06650

MTEZ:

HPT29_006150

BID:

Bind_3885

MPAR:

F7D14_18240

MAAD:

AZF01_02675

MMED:

Mame_02304(algD)

MLUT:

JET14_03725

JAV:	OXU80_00280

RBM:

TEF_19885

LABR:

CHH27_22980

LABP:

FJ695_16660

RPOP:

K1718_15110

ACUT:

MRB58_00060

RUY:	NOR97_20535

DSH:	Dshi_1896(algD)

MALG:

MALG_02776

CON:	TQ29_00725

YPAC:

CEW88_18640

YAN:	AYJ57_24995

SULZ:

C1J03_23160

TOM:	BWR18_20775

THAA:

CFI11_06320 CFI11_06490

RMH:	LVO79_06000

HAT:	RC74_06375

LSAL:

KBK07_17255

TRY:	QF118_01765

THW:	BMG03_12925

TLB:	RPE78_12915

YPHY:

AABB29_07900

YRH:	AABB31_14955

LIT:	FPZ52_00565

PPRU:

FDP22_22880

POZ:	I0K15_05930

CACT:

HZ995_12210

HDH:	G5B40_09200

AMYL:

QBD29_07855

FAQ:	G5B39_18330

NAR:

Saro_3220

SPHI:

TS85_22025

SSAN:

NX02_04640

ACOB:

P0Y56_12580

EGN:	BMF35_a0516

ERF:	FIU90_00265(algD)

ERYT:

KDC96_15245

PHZ:	CHX26_00290

POT:	E2E27_01460

RAP:	RHOA_PB0089(algD)

HTQ:	FRZ44_03090(algD)

HADH:

FRZ61_03380(algD)

SNEA:

NBZ79_19285

MINW:

ACMVY4_02945

NIS:

NIS_0191

CMED:

FE773_08555

CPAF:

C6V80_01890

DVE:	DESUT3_23450(algD)

DSA:	Desal_3469

DTO:	TOL2_C36540(algD)

BMX:

BMS_2990

STI:

Sthe_1134

SLOM:

PXH66_05790

OLV:	ACMYLB_10770

ROO:	G5S37_25645

FPES:

NXS98_06570

AHEL:

Q31a_57060(algD)

SMAM:

Mal15_36880(algD)

MRI:	Mal4_03640(algD)

SDYN:

Mal52_06430(algD)

SCHL:

QJS52_01950

SSPE:

ACGY09_01855

FTJ:

FTUN_5650

ABA:	Acid345_3792

TRS:	Terro_2830

ADIN:

H7849_05985

SUS:

Acid_0553

LUB:	TBR22_A24300(algD)

BDO:	EL88_09425

NKO:	Niako_7100

CMR:	Cycma_0720

EMAI:

KZP23_20245

SPIB:

G8759_29085

SRHO:

HH216_01470

SENF:

GJR95_15585

SPIO:

WBJ53_24135

DSN:	HWI92_00320

DEND:

ACN9ML_00320

FIB:	A6C57_20705

PKO:	PKOR_16530

CLIT:

OQ292_40240

PRHO:

PZB74_20200

TPEL:

P0M28_17740

CNQ:	PZB72_28250

ZGA:	ZOBELLIA_1984(algD)

MLIL:

QLS71_002625

PPON:

MUN68_016515

CACI:

CLOAM0663

TAM:	Theam_0797

NMV:	NITMOv2_2630(algD)

NNEO:

PQG83_09560

PARH:

I5S86_05480

PHEX:

L0M14_20510

LBP:	V1224_13340

HSG:	HPPSJP_3770(rkpK)

MSM:	MSMEG_5957(algD)

MSG:	MSMEI_5797

MSB:	LJ00_29460

MSN:	LI99_29465

MSH:	LI98_29470

MVA:

Mvan_1699

MSP:	Mspyr1_41390

MNE:	D174_24385

MYN:	MyAD_23925

MTY:	MTOK_31270(algD)

MSAR:

MSAR_24600(algD)

MANY:

MANY_49000(algD)

MPOF:

MPOR_19690

MGO:	AFA91_10990 AFA91_29875

MRF:	MJO55_24360

MDF:	K0O62_25565

MAUS:

JN090_07325

MFRE:

EXE63_09795

MFLU:

HZU40_32750

NHU:	H0264_19875

ROP:	ROP_57960(algD)

RKO:	JWS14_31405

RHOY:

QNA09_05105

TOY:	FO059_04060

SCO:	SCO0382(SCF62.08)

SGRF:

SGFS_035730

SCB:	SCAB_23351

SVL:	Strvi_5599

SHY:

SHJG_7006

SHO:	SHJGH_6766

SRC:	M271_40840

SBH:

SBI_09543

SVE:

SVEN_7199

SLV:	SLIV_36030(algD)

SVT:	SVTN_36100

STRE:

GZL_08291

SLD:

T261_7968

SPRI:

SPRI_2000

STRF:

ASR50_26930

SPAV:

Spa2297_31800

STRT:

A8713_24610

SCLF:

BB341_00345

SGS:	AVL59_31095

SALW:

CP975_03365

SGM:	GCM10017557_19510

SGRS:

V9K83_07275

SLS:	SLINC_8140

SNR:	SNOUR_37270(algD)

SALU:

DC74_1121

SALL:

SAZ_06100

SPLU:

LK06_025850

STRD:

NI25_00640

SSIA:

A7J05_09315

SGV:	B1H19_04475

SALF:

SMD44_08071(algD)

STRO:

STRMOE7_01550

SFK:

KY5_0166c

SGE:	DWG14_01282(algD_2)

SLK:	SLUN_34570

SQZ:	FQU76_01535

SCYA:

EJ357_37150

SKA:	CP970_42095

SVR:	CP971_03305

SFY:	GFH48_34990

SBY:	H7H31_29485

SFUG:

CNQ36_29650

STSU:

B7R87_32065

SCHA:

CP983_11050

SGX:	H4W23_37670

SCOE:

CP976_05755

SSPB:

CP982_01460

SHUN:

DWB77_00748(algD)

SCYG:

S1361_04630(algD)

SFEU:

IM697_33530

SROI:

IAG44_00725

SXN:	IAG42_07115

SGJ:	IAG43_29305

SHK:	J2N69_02610

SINE:

KI385_03390

SLF:	JEQ17_08420

SAOV:

G3H79_06935

SDUR:

M4V62_06475

STAA:

LDH80_04755

SLON:

LGI35_03160

STEE:

F3L20_11870

SYUN:

MOV08_38485

SARG:

HKX69_08010

SJN:	RI060_36395

SCYN:

N8I84_34940

SKG:	KJK29_33180

SFP:	QUY26_02885

STRZ:

OYE22_28860

KBU:	Q4V64_06025

SMIB:

SMIR_07815

SCAJ:

O1G22_01465

STRL:

HEP84_37695

STSD:

HEP87_38640

STRV:

EZV63_33750

SMOD:

POD33_22970

STBR:

ABDE16_00175

SGRO:

UBV09_26080

STAC:

ABII15_36555

SSLI:

R2D22_03205

STYI:

C9F11_00600(algD)

SCIT:

V2W30_37045

SSIR:

WAB15_02205

SOKE:

ACE1N8_27485

STGO:

KBP30_35970

SHUG:

ABVG11_30530

STRK:

R2B38_37105

STHP:

MQE23_11835

KCH:	O1G21_06125

KCM:	ABWK59_01455

HEA:	HL652_13685

ACH:

Achl_2940

TEH:	GKE56_16015

NDK:	I601_0111(algD)

NOF:	MF408_15695

NLB:	P5P86_05690

KSL:	OG809_26460

SRO:

Sros_0655

NOA:	BKM31_42710

NGN:	LCN96_02635

NFS:	OIE67_44765

BSD:	BLASA_0423(algD)

AMD:	AMED_0547(algD)

AMN:

RAM_02805

AMM:	AMES_0545(algD)

AMZ:	B737_0546(algD)

AOI:	AORI_0554(algD)

AJA:	AJAP_36870(algD)

AMQ:	AMETH_0542(ugd)

AMYB:

BKN51_36975

AMYY:

YIM_21485(algD)

AORI:

SD37_38440

AACD:

LWP59_02525

APRT:

MUY14_33840

AROO:

NQK81_20050

ATHM:

L1857_05310

ARHD:

VSH64_40365

AMOG:

QRX60_08495

ACOR:

LCL61_41965

ACAB:

QRX50_04675

ANW:	QP939_09660

AMYD:

K1T34_21425

AMYE:

MJQ72_38830

AMYS:

CVV72_26080

PDX:

Psed_1848

PBRO:

HOP40_15385

PPEL:

H6H00_14920

KUT:	JJ691_61590(algD)

KBR:	Q4V65_17680

PMAD:

BAY61_02365

ACTY:

OG774_25565

HAO:	PCC7418_0427

NPU:	Npun_F5503

NSH:

GXM_00034

CTHE:

Chro_0719

DAH:	DAETH_33720

DMB:	E5F05_17350

SCHV:

BRCON_1950

» show all

Reference

1 [PMID:14245351]

Authors

PREISS J.

Title

SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. II. BIOSYNTHESIS OF GUANOSINE DIPHOSPHOMANNURONATE.

Journal

J Biol Chem 239:3127-32 (1964)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.132

IUBMB Enzyme Nomenclature:

1.1.1.132

ExPASy - ENZYME nomenclature database:

1.1.1.132

BRENDA, the Enzyme Database:

1.1.1.132

CAS:	37250-63-8

LinkDB

DBGET integrated database retrieval system