KEGG   ENZYME: 1.1.1.218
Entry
EC 1.1.1.218                Enzyme                                 
Name
morphine 6-dehydrogenase;
naloxone reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
morphine:NAD(P)+ 6-oxidoreductase
Reaction(IUBMB)
morphine + NAD(P)+ = morphinone + NAD(P)H + H+ [RN:R03591 R03592]
Reaction(KEGG)
R03591 R03592
Substrate
morphine [CPD:C01516];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
morphinone [CPD:C01735];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analogue. Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol).
History
EC 1.1.1.218 created 1989, modified 1990
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K03378  morphine 6-dehydrogenase
K13374  aldo-keto reductase family 1 member C13
Genes
MMU27384(Akr1c13) 622402(Akr1c12)
MCAL110288103
MPAH110333723
RNO361266(Akr1c13)
CGE100769523
MAUA101839119 101842245 101842874
MORG121432553 121432554 121432601 121432715
MFOT126501682 126501683 126501689
AAMP119816240 119816241 119816242
NGI103725887
CCAN109680003
DORD105980361 105980413 105980416 105980418
DSP122113029
 » show all
Reference
1  [PMID:2580834]
  Authors
Yamano S, Kageura E, Ishida T, Toki S.
  Title
Purification and characterization of guinea pig liver morphine 6-dehydrogenase.
  Journal
J Biol Chem 260:5259-64 (1985)
Reference
2  [PMID:3539118]
  Authors
Yamano S, Nishida F, Toki S.
  Title
Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase.
  Journal
Biochem Pharmacol 35:4321-6 (1986)
DOI:10.1016/0006-2952(86)90712-4
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.218
IUBMB Enzyme Nomenclature: 1.1.1.218
ExPASy - ENZYME nomenclature database: 1.1.1.218
BRENDA, the Enzyme Database: 1.1.1.218
CAS: 97002-71-6
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