KEGG ENZYME: 1.1.1.218

ENZYME: 1.1.1.218

Entry

EC 1.1.1.218                Enzyme

Name

morphine 6-dehydrogenase;
naloxone reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

morphine:NAD(P)+ 6-oxidoreductase

Reaction(IUBMB)

morphine + NAD(P)+ = morphinone + NAD(P)H + H+ [RN:R03591 R03592]

Reaction(KEGG)

R03591 R03592

Substrate

morphine [CPD:C01516];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

morphinone [CPD:C01735];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analogue. Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol).

History

EC 1.1.1.218 created 1989, modified 1990

Pathway

ec00950

Isoquinoline alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K03378

morphine 6-dehydrogenase