KEGG   ENZYME: 1.1.1.232
Entry
EC 1.1.1.232                Enzyme                                 
Name
15-hydroxyicosatetraenoate dehydrogenase;
15-hydroxyeicosatetraenoate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase
Reaction(IUBMB)
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)+ = 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H + H+ [RN:R04517 R04518]
Reaction(KEGG)
R04517 R04518
Substrate
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate [CPD:C04742];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
15-oxo-5,8,11-cis-13-trans-icosatetraenoate [CPD:C04577];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.232 created 1992
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:3052453]
  Authors
Sok DE, Kang JB, Shin HD.
  Title
15-Hydroxyeicosatetraenoic acid dehydrogenase activity in microsomal fraction of mouse liver homogenate.
  Journal
Biochem Biophys Res Commun 156:524-9 (1988)
DOI:10.1016/S0006-291X(88)80873-8
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.232
IUBMB Enzyme Nomenclature: 1.1.1.232
ExPASy - ENZYME nomenclature database: 1.1.1.232
BRENDA, the Enzyme Database: 1.1.1.232
CAS: 117910-46-0
LinkDB

KEGG   REACTION: R04517
Entry
R04517                      Reaction                               
Name
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD+ 15-oxidoreductase
Definition
(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + NAD+ <=> 15-OxoETE + NADH + H+
Equation
C04742 + C00003 <=> C04577 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00241  C04577_C04742
Enzyme
1.1.1.232
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.232
     R04517  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + NAD+ <=> 15-OxoETE + NADH + H+
Other DBs
RHEA: 23263
LinkDB

KEGG   REACTION: R04518
Entry
R04518                      Reaction                               
Name
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase
Definition
(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + NADP+ <=> 15-OxoETE + NADPH + H+
Equation
C04742 + C00006 <=> C04577 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00241  C04577_C04742
Enzyme
1.1.1.232
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.232
     R04518  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + NADP+ <=> 15-OxoETE + NADPH + H+
Other DBs
RHEA: 23267
LinkDB

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