KEGG ENZYME: 1.1.1.291

ENZYME: 1.1.1.291

Entry

EC 1.1.1.291                Enzyme

Name

2-hydroxymethylglutarate dehydrogenase;
HgD

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase

Reaction(IUBMB)

(S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+ [RN:R07985]

Reaction(KEGG)

R07985

Substrate

(S)-2-hydroxymethylglutarate;
NAD+ [CPD:C00003]

Product

2-formylglutarate [CPD:C16159];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).

History

EC 1.1.1.291 created 2006

Pathway

ec00760

Nicotinate and nicotinamide metabolism

ec01120

Microbial metabolism in diverse environments

Orthology

K19647

2-hydroxymethylglutarate dehydrogenase

Genes

PPAV:

LOZ86_04730

ADY:	HLG70_00410

CTEZ:

CT3_33160

ACUT:

MRB58_12300

SNAP:

PQ455_08180

STEL:

STAQ_18560(mmsB)

SHUA:

PQ477_20810

FEC:	QNH15_18225

ALKL:

MM271_17440

HYI:	K2M58_02455

EFF:	skT53_09660(mmsB) skT53_13840(garR_1)

CPAT:

CLPA_c02850(hgd)

CPAE:

CPAST_c02850(hgd)

ACOL:

K5I23_11310

DOR:	Desor_0451

TFR:	BR63_08425

ACAE:

HYG86_14495

PROM:

QO263_18055

GEK:	kuro4_03320(mmsB) kuro4_15860(garR) kuro4_16270

TEP:	TepRe1_0398

TAE:	TepiRe1_0442(Hgd)

NTH:	Nther_2161

STED:

SPTER_39160(hgd)

SSPH:

SPSPH_035210(hgd)

SOVA:

SOV_13310(Hgd)

SSID:

SPSIL_018550(hgd)

SLUO:

PS467_35950

KBB:	ccbrp13_22740 ccbrp13_64320

IPO:	Ilyop_0116

NAY:	HYG81_23765

» show all

Reference

1 [PMID:16894175]

Authors

Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.

Title

Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.

Journal

Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103

Sequence

[ag:ABC88394]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.291

IUBMB Enzyme Nomenclature:

1.1.1.291

ExPASy - ENZYME nomenclature database:

1.1.1.291

BRENDA, the Enzyme Database:

1.1.1.291

CAS:	1073478-76-8

LinkDB

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