KEGG   ENZYME: 1.1.1.302
Entry
EC 1.1.1.302                Enzyme                                 
Name
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase;
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase;
MjaRED;
MJ0671 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+ [RN:R09375 R09376]
Reaction(KEGG)
R09375 R09376
Substrate
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one [CPD:C18910];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC 1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate [1].
History
EC 1.1.1.302 created 2010, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K14654  2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
Genes
QSU112031259 112032646
CMECYME_CMQ053C
CCPCHC_T00006214001
SCEYBR153W(RIB7)
SEUBDI49_1181
SPAOSPAR_B02520
AGOAGOS_AER037C
ERCEcym_5336
KLAKLLA0_F21120g
KMXKLMA_40225(RIB7)
LTHKLTH0G15576g
VPOKpol_1053p40
ZROZYRO0B06028g
CGRCAGL0F05203g
NCSNCAS_0I02380(NCAS0I02380)
NDINDAI_0A06950(NDAI0A06950)
TPFTPHA_0A00760(TPHA0A00760)
TBLTBLA_0F01170(TBLA0F01170)
TDLTDEL_0D05100(TDEL0D05100)
TGBHG536_0G02150
KAFKAFR_0G01390(KAFR0G01390)
KNGKNAG_0K02030(KNAG0K02030)
ZMKHG535_0H03130
PPAPAS_chr3_0156
DHADEHA2G10010g
PICPICST_53707
PGUPGUG_02766
SPAASPAPADRAFT_71929(RIB7)
LELLELG_03576
CALCAALFM_C112810WA(CaO19.6341)
CTPCTRG_03565
COTCORT_0D01370
CDUCD36_11990
CTENCANTEDRAFT_123893
YLIYALI0D06501g
CLUCLUG_04705
CLUSA9F13_11g00902
CAURCJI97_004081
SLBAWJ20_3203(RIB7)
PKZC5L36_0D01230
BBRXBRETT_005247
OPAHPODL_03999
SLUDSCDLUD_005117
NCRNCU08313
NTENEUTE1DRAFT60176(NEUTE1DRAFT_60176)
SMPSMAC_00907
PANPODANSg7218
TTTTHITE_2144327
MTMMYCTH_40367
MGRMGG_12162
PPEIPpBr36_04654
SSCKSPSK_03569
FGRFGSG_05111
FPUFPSE_11283
FVRFVEG_06098
FOXFOXG_08571
NHENECHADRAFT_34089
TRETRIREDRAFT_103563
TRRM419DRAFT_134067
MAJMAA_00162 MAA_06506
CMTCCM_05336
PLJVFPFJ_00973
VALVDBG_01058
VDAVDAG_00672
CFJCFIO01_05397
CHIGCH63R_04717
ELAUCREL1_4492
PFYPFICI_04609
SSLSS1G_14134
BFUBCIN_09g06970(Bcrib7)
MBEMBM_02523
PSCOLY89DRAFT_404441
GLZGLAREA_08672
ANIAN6979.2
AFMAFUA_3G00360 AFUA_4G04730
ACTACLA_053610 ACLA_064060
NFINFIA_000890 NFIA_028600
AORAO090038000135 AO090206000013
ANGANI_1_1020124(An14g00090) ANI_1_2310014(An01g01960)
AFVAFLA_012405 AFLA_013012
ALUCAKAW2_20386S(RIB7_1) AKAW2_40698A(RIB7_2)
ACHEACHE_11425A(RIB7_1) ACHE_31026A(RIB7_2)
APUUAPUU_10865S(RIB7_1) APUU_80640A(RIB7_2)
PCSPc12g01420 Pc13g05670
PDPPDIP_04060 PDIP_14820
TMFPMAA_089800
TRGTRUGW13939_01534
CIMCIMG_08518
CPWCPC735_061800
UREUREG_02583
PBLPAAG_01490
PBNPADG_00292
ABEARB_06025
TVETRV_01178
AJEHCAG_07670
BGHBDBG_09154
PNOSNOG_06577
PTEPTT_14981
BZECOCCADRAFT_87440
BSCCOCSADRAFT_22712
BORCOCMIDRAFT_1994
AALTCC77DRAFT_1062869
ZTRMYCGRDRAFT_32102
PFJMYCFIDRAFT_39238
FFUCLAFUR5_04586
BCOMBAUCODRAFT_30282
TMLGSTUM_00004329001
SPOSPBC21C3.10c
CNECNA06250
CNBCNBA6060
CNGCNAG_00645
CGICGB_A7040W
TMSTREMEDRAFT_29592
TASAA1Q1_03209
PPLPOSPLDRAFT_105579
TVSTRAVEDRAFT_67904
DSQDICSQDRAFT_151510
PCOPHACADRAFT_135222
SHSSTEHIDRAFT_48151
HIRHETIRDRAFT_447382
PSQPUNSTDRAFT_56735
ADLAURDEDRAFT_179567
FMEFOMMEDRAFT_106736
GTRGLOTRDRAFT_67757
LBCLACBIDRAFT_301149
MRRMoror_16011
MOREE1B28_001516
CCICC1G_01877
SCMSCHCODRAFT_71199
ABPAGABI1DRAFT67276(AGABI1DRAFT_67276)
ABVAGABI2DRAFT213834(AGABI2DRAFT_213834)
CPUTCONPUDRAFT_33109
SLASERLADRAFT_476194
WSEWALSEDRAFT_59377
WICJ056_004071
UMAUMAG_06022
MGLMGL_2361
MRTMRET_0151
MSYMMSY001_2063
PGRPGTG_13526
MLRMELLADRAFT_79837
FCYFRACYDRAFT_180826
GTTGUITHDRAFT_114190 GUITHDRAFT_131505
ENFAKI40_0053
PSTPSPTO_0835
PSPPSPPH_3758
PSAVPSA3335_07180
PTREI9H09_07015
PLQAA042_20695
PSILPMA3_16780
PBZGN234_26630
CDIZCEDIAZO_01090
NBLGJV52_09490
RGERGE_09730(ribD)
RBNRBXJA2T_00325
MXAMXAN_4511
SURSTAUR_1765
LLUAKJ09_11143
DHRLGS26_07330
RLGRleg_0777
APOLK9D25_06785
PMAUCP157_01059(ribD_1)
NCBC0V82_24105
BOUI5818_13900
SUZMS7_0065
SAUZSAZ172_2084
SAURSABB_02279
SDTSPSE_1792
PGMPGRAT_22805
PODPODO_30155
PAEFR50345_30305
PSTEPSTEL_17810
PAEHH70357_12225
PAEJH70737_30005
PRIPRIO_4930
PSONJI735_32300
PDHB9T62_31215
PTRIKDC22_32820
SSUSNJAUSS_0664
SUISSUJS14_0689
LRELreu_1915
LRFLAR_1795
LRRN134_10140
LORAYI71_02155
LPONLP475_00835
LALILA20249_09045
CPABG6534_11580
CSRCspa_c21610(ribD2)
FPLAA4U99_18140
RUJE5Z56_10100
BLAUDQQ01_02765
PXVFXF36_05265
EACEAL2_808p00350
IBUIB211_01378c
EBMSG0102_14100
ERBA4V01_01240
ROPROP_02860
ROAPd630_LPD04178
BCVBcav_0207
PEIH9L10_04705
MPHMLP_33080
MICGGJV80_07145
TFABW733_08745
TESBW730_13635
KFLKfla_2502
KQIF1D05_32455
NGNLCN96_40165
SYNPSyn7502_00752
LSCKIK02_18365
DFODform_01517(arfC)
DETHHX448_09060
PSUBPelsub_P2783
LUOHHL09_19405
SOAG3M56_007980
TSUTresu_0724 Tresu_0791
BHCJFL75_05425
LIELIF_A3207(ribD)
LISLIL_13305(ribD2)
LBLLBL_2837
LBILEPBI_I0659
LBFLBF_0637
LSTLSS_10208
LMAYDPV73_04130
LKMEFP84_12375
LWLFHG68_02560
PPNPalpr_2377
ALQC7Y71_009245
ASWUHUW51_15310
AAEaq_436(ribD2)
HYAHY04AAS1_0067
HHOHydHO_0068
HYSHydSN_0071
HTHHTH_1632(ribD2)
HTEHydth_1620
TALThal_0895
TRDTHERU_03020
SULSYO3AOP1_0226
SAFSULAZ_0079
PMXPERMA_0153
TAMTheam_0452
DTEDester_0600
TOPTOPB45_0639
TCMHL41_01570
THETF1847_05870
CTHITHC_0111
ALAMRT761_01843
MJAMJ_0671
MFEMefer_0630
MVUMetvu_1215
MFSMFS40622_1510
MIFMetin_1271
MJHJH146_1228
MESGMLAUSG7_0365(arfC)
MESAMLASG1_1544(arfC)
MIGMetig_0606
MMPMMP1348
MMQMmarC5_0230
MMXMmarC6_1325
MMZMmarC7_0593
MMDGYY_07565
MMAKMMKA1_15710
MMAOMMOS7_14520
MMADMMJJ_14910(ribD2)
MAEMaeo_0660
MVNMevan_0659
MVOMvol_0148
MOKMetok_1394
METFCFE53_04630
MTHMTH_235
MMGMTBMA_c06840(ribD)
MWOMWSIV6_0647
MTEEMTTB_08780
METCMTCT_0197
METEtca_00215(ribD2)
METZMETMT2_0679
METKFVF72_01130
MTHMFZP57_03080
METJFZP68_08115
MSTMsp_1185
METBAW729_09840
MRUmru_1007(ribD)
MSIMsm_0065
MEBAbm4_0661(ribD)
MMILsm9_1007(ribD)
MEYETL18_05380
MOLYLM1_0551
MAROMarbSA_04580
METVK4897_00745
MELMetbo_0239 Metbo_2125
MEWMSWAN_0486 MSWAN_2212
METHMBMB1_0612 MBMB1_1846
MFCBRM9_1623(ribD1) BRM9_2175(ribD2)
MFIDSM1535_1115 DSM1535_2318
MCUBMCBB_0498 MCBB_2139
MSUBBK009_01155 BK009_08405
METNBK008_04065 BK008_08845
METTCIT01_04545 CIT01_09480
METOCIT02_03870 CIT02_08340
MEMEHYG87_09850
MFVMfer_0597
MKAMK0098(ribD)
AFUAF_2007
AFGAFULGI_00022710
APOArcpr_1054
AVEArcve_0930
ASTAsulf_00771
FPLFerp_1264
GACGACE_1041
GAHGAH_01541
MBAMbar_A0489 Mbar_A1048
MBYMSBRM_3060 MSBRM_3306
MBWMSBRW_0514 MSBRW_3673
MBARMSBR2_3018 MSBR2_3261
MBAKMSBR3_3015 MSBR3_3257
MACMA_4092(ribD) MA_4367(ribD)
MMAMM_0826 MM_1058
MMAZMmTuc01_1089
MMJMSMAS_0241 MSMAS_0480
MMACMSMAC_0248 MSMAC_0498
MVCMSVAZ_0230 MSVAZ_3133
MEKMSKOL_0223 MSKOL_3121
MLSMSLAZ_2682 MSLAZ_2978
METMMSMTP_0280 MSMTP_0527
MEFMSWH1_0556 MSWH1_2985
MEQMSWHS_0571 MSWHS_2005
MSJMSSAC_3965 MSSAC_4059
MSZMSSIH_3491 MSSIH_3595
MSWMSSIT_3554 MSSIT_3648
MTHRMSTHT_1446 MSTHT_1760
MTHEMSTHC_1531 MSTHC_1843
MHORMSHOH_0311 MSHOH_0574
MFZAOB57_006315 AOB57_007985
MBUMbur_2352
MMETMCMEM_0497 MCMEM_1294
MELOJ7W08_00505 J7W08_05105
MMHMmah_1489
MHAZBHR79_06285
MEVMetev_0110
MZHMzhil_0187
MPYMpsy_2065
MZIHWN40_12130
MHZMetho_2197
MTPMthe_0604
MCJMCON_0173(ribD) MCON_0968
MHIMhar_0530 Mhar_1003
MHUMhun_0807 Mhun_2575
MRTJKHC33_03740 KHC33_09580
MLAMlab_0643 Mlab_0937
MEMMemar_0446 Memar_1398 Memar_2026
MBGBN140_0241(ribD) BN140_1191
MEMAMMAB1_0301 MMAB1_1511(ribD)
MCHKMchiMG62_05740 MchiMG62_15920(ribD2) MchiMG62_23370
MPIMpet_0779 Mpet_1801 Mpet_2483
MBNMboo_0804 Mboo_0908
MFOMetfor_0570 Metfor_1256 Metfor_2280
MPLMpal_1313 Mpal_2094
MPDMCP_1048 MCP_1651
MEZMtc_1585 Mtc_1959
RCILRC156(ribD) RRC489
HALVNG_1256G(ribG)
HSLOE_2802F(ribG)
HDLHALDL1_09735
HHBHhub_2572(ribG)
HAGSJT689_06455
HABOJRZ79_04905
HNOLT974_09705
HLULT972_05520
HANRLJ422_05145
HJEHacjB3_09430
HALHHTSR_0741(ribD2)
HHSRHSR6_0767(ribG)
HSUHLASF_1655(ribD1)
HSFHLASA_1642(ribD1)
SALRFQU85_11885
HALREFA46_010215
HARAAArcS_1491(ribD)
HAADMW046_00455
HALXM0R89_00075
HAXZM0R88_00085
HMArrnAC1131(ribG)
HHIHAH_1738(ribG)
HHNHISP_08870
HABSG26_16600
HTABVU17_08380
HALJG9465_13710
HSINKDQ40_04760
NPHNP_2672A(arfC)
NMONmlp_2212(ribG)
NHOHWV23_00835
NSALHWV07_01990
HUTHuta_0543
HTIHTIA_2649
HALAHrd1104_07005
HMUHmuk_2416
HALZE5139_15210
HALLLC1Hm_1773(ribG)
HAZPGBQ70_15230
HALIBV210_15800
HSNDV733_15775
HDSHSR122_0701(ribD)
HRRHZS55_18550
HPELHZS54_20950
HLTI7X12_18170
HARCHARCEL1_04465
HDOMUK72_11500
HWAHQ_2510A(arfC)
HWCHqrw_2809(arfC)
HVOHVO_1341(ribG)
HMEHFX_1418(ribG)
HGIABY42_06575
HALEG3A49_09915
HBOHbor_18920
HAQDU484_15805
HAJDU500_15825
HAERDU502_13980
HRAEI982_16385
HLMDV707_07160
HALMFCF25_14180
HLAHlac_0451
HALPDOS48_02425
HALBEKH57_08610
HEZZEO776_03915
HALQHrr1229_003545
HSSJ7656_12960
HSAIHPS36_03305
HAZZKI388_01365
SRUBC2R22_08835
HAEhalTADL_2564
HALNB4589_003750
HALGHUG10_06540
HALUHUG12_10640
HMPK6T50_05340
HREK6T36_05055
HRMK6T25_10900
HACBHbl1158_11180
HDFAArcSl_2345(ribG)
HAHHalar_1451
HTUHtur_5200
HDABB347_16615
HJTDVR14_15370
HSALJMJ58_22280
HLOJ0X27_01730
HAKZJ0X25_20670
NMGNmag_3078(ribG)
HXAHalxa_2802
NATNJ7G_1457
NPENatpe_1235
NVRFEJ81_06720
NPLFGF80_04625
NAYHYG81_04480
HALYHYG82_07005
NGENatgr_2807
HRUHalru_1572
NOUNatoc_3213
SALIL593_07135
SAIMK0C01_03305
HLRHALLA_19995
HLCCHINAEXTREME17660
NAJB1756_02275
NAGAArcMg_1297
NANAArc1_2320
NBGDV706_19555
NASGCU68_20560
SAWLNGM29_11960
MELUMTLP_05680(ribD2) MTLP_12030
MEAMMU439_00250 MU439_04645
PTOPTO0710
FACFACI_IFERC01G0277
FAIFAD_1195
CDIVCPM_0367
TARTALC_00248
MAXMMALV_02330
MERMMINT_16300
MEARMpt1_c11210(arfC)
MEUZKRP56_01265
MARCAR505_1602
ABIAboo_0416
ACFAciM339_0632
APEAPE_1279.1
ACJACAM_0812
SMRSmar_0461
SHCShell_0345
IHOIgni_0956
IISEYM_00140
HBUHbut_0557
PFMPyrfu_0394
PDLPyrde_2005
STOSTK_02850
SOHD1869_00960
SSOSSO2097(ribD)
SOLSsol_2812
SSOASULA_2833
SSOLSULB_2834
SSOFSULC_2831
SSHIJ5U23_02255
SCASSACC_12530
SAISaci_2164(rib7)
SACNSacN8_10530
SACRSacRon12I_10785
SACSSUSAZ_09905
SISLS215_0439
SIAM1425_0481
SIMM1627_0496
SIDM164_0517
SIYYG5714_0399
SINYN1551_2620
SIILD85_0432
SIHSiH_0852
SIRSiRe_0492
SICSiL_0521
SULABFU36_11630
SULEGFS03_06105
SULLEWF20_02425
MSEMsed_0021
MCNMcup_0021
MHKDFR87_07080
MPRUDFR88_06585
MTENGWK48_05080
MJNMjAS7_0608
MEMJMJ1HA_0022
AHOAhos_0760
AMANB6F84_07245
ABRIDFR85_07680
ASULDFR86_06305
AAMBD1866_11615
ACIHHS5_21340
SACDHS1genome_0021
SAZOD1868_01755
CSTYKN1_18470
STEPIC006_1817
SAHSHS7_07080
PAIPAE2985
PISPisl_0385
PCLPcal_1122
PASPars_1352
PYRP186_1547
POGPogu_0862
TNETneu_1742
PYWPYWP30_01861
CMACmaq_1962
TTNTTX_1010(ribD)
TUZTUZN_0676
VDIVdis_2227
VMOVMUT_0666
ASCASAC_1153
ACIASE86_06920
CLGCalag_0376
FFOFFONT_0857
NMRNmar_1612
NIRNSED_08725
NKRNKOR_08775
NIDNPIRD3C_0441(ribD)
NINNADRNF5_0272
NIWNisw_05830
NCLC5F47_08450
NOXC5F49_08335
NUEC5F50_11715
NIPNsoK4_00200
NCTNMSP_1553(arfC)
NICDSQ20_09360
CSYCENSYa_1759
NGANgar_c32620(ribD)
NVNNVIE_021910(ribD)
NEVNTE_03545
TAANMY3_03743(ribD2)
NFNNFRAN_1032(arfC)
NCVNCAV_0047
NBVT478_1325
TAHSU86_005130
NIUDSQ19_00920
NDVNDEV_1966(arfC)
CCAINAS2_0575
LOKILokiarch_12300 Lokiarch_13540
 » show all
Reference
1  [PMID:11889103]
  Authors
Graupner M, Xu H, White RH
  Title
The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin.
  Journal
J Bacteriol 184:1952-7 (2002)
DOI:10.1128/JB.184.7.1952-1957.2002
  Sequence
[mja:MJ_0671]
Reference
2  [PMID:16730025]
  Authors
Chatwell L, Krojer T, Fidler A, Romisch W, Eisenreich W, Bacher A, Huber R, Fischer M
  Title
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.
  Journal
J Mol Biol 359:1334-51 (2006)
DOI:10.1016/j.jmb.2006.04.045
  Sequence
[mja:MJ_0671]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.302
IUBMB Enzyme Nomenclature: 1.1.1.302
ExPASy - ENZYME nomenclature database: 1.1.1.302
BRENDA, the Enzyme Database: 1.1.1.302
LinkDB

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