KEGG   ENZYME: 1.1.1.359
Entry
EC 1.1.1.359                Enzyme                                 
Name
aldose 1-dehydrogenase [NAD(P)+]
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
an aldopyranose:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
an aldopyranose + NAD(P)+ = an aldono-1,5-lactone + NAD(P)H + H+ [RN:R10428 R10429]
Reaction(KEGG)
Substrate
aldopyranose [CPD:C20655];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
aldono-1,5-lactone [CPD:C20616];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.
History
EC 1.1.1.359 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18125  aldose 1-dehydrogenase [NAD(P)+]
Genes
PTOPTO0639
FACFACI_IFERC01G0109
FAIFAD_1034
STOSTK_17040(gdh)
SOHD1869_09575
SSOSSO3003(dhg-1) SSO3042(dhg-2) SSO3204(dhg-3)
SOLSsol_0792 Ssol_0941
SSOASULA_0783 SULA_0820 SULA_0974
SSOLSULB_0785 SULB_0822 SULB_0976
SSOFSULC_0783 SULC_0820 SULC_0975
SSHIJ5U23_00294 J5U23_00444 J5U23_00501
SCASSACC_30460 SACC_31420
SAISaci_1079
SACNSacN8_05250
SACRSacRon12I_05240
SACSSUSAZ_05025
SISLS215_2319 LS215_2487 LS215_2525
SIAM1425_2156 M1425_2315 M1425_2353
SIMM1627_2236 M1627_2394 M1627_2431
SIDM164_2160 M164_2317 M164_2360
SIYYG5714_2283 YG5714_2452 YG5714_2497
SINYN1551_0407 YN1551_0458 YN1551_0633
SIILD85_2423 LD85_2603 LD85_2656
SIHSiH_2102 SiH_2256 SiH_2295
SIRSiRe_2034 SiRe_2200 SiRe_2243
SICSiL_2009 SiL_2165 SiL_2203
SULABFU36_06060 BFU36_07060 BFU36_07270
SULEGFS03_11745 GFS03_12475 GFS03_12660
SULOGFS33_03555 GFS33_04540
SULLEWF20_10710
MSEMsed_1301
MEMJMJ1HA_1509
MCNMcup_0902
MHKDFR87_11970
MPRUDFR88_11815
MTENGWK48_00425
MJNMjAS7_2196 MjAS7_2216 MjAS7_2369
AHOAhos_2067
AMANB6F84_01630 B6F84_05020
ABRIDFR85_11645 DFR85_12080
ASULDFR86_01625 DFR86_04395
AAMBD1866_05350
ACIHHS5_08840
SACDHS1genome_0652 HS1genome_1599
SAZOD1868_03195
CSTYKN1_23070
STEPIC006_0170
SAHSHS7_05220
CMACmaq_1714
VSOVsou_17260
CCAINAS2_0753
 » show all
Reference
1  [PMID:3827812]
  Authors
Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V
  Title
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus.
  Journal
Biochem J 239:517-22 (1986)
DOI:10.1042/bj2390517
Reference
2  [PMID:2803257]
  Authors
Smith LD, Budgen N, Bungard SJ, Danson MJ, Hough DW
  Title
Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum.
  Journal
Biochem J 261:973-7 (1989)
DOI:10.1042/bj2610973
Reference
3  [PMID:12824170]
  Authors
Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ
  Title
Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase.
  Journal
J Biol Chem 278:34066-72 (2003)
DOI:10.1074/jbc.M305818200
  Sequence
[sso:SSO3003]
Reference
4  [PMID:16508107]
  Authors
Theodossis A, Milburn CC, Heyer NI, Lamble HJ, Hough DW, Danson MJ, Taylor GL
  Title
Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:112-5 (2005)
DOI:10.1107/S174430910403101X
Reference
5  [PMID:16556607]
  Authors
Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL
  Title
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.
  Journal
J Biol Chem 281:14796-804 (2006)
DOI:10.1074/jbc.M601334200
  Sequence
[sso:SSO3003]
Reference
6  [PMID:21265750]
  Authors
Haferkamp P, Kutschki S, Treichel J, Hemeda H, Sewczyk K, Hoffmann D, Zaparty M, Siebers B
  Title
An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation?
  Journal
Biochem Soc Trans 39:77-81 (2011)
DOI:10.1042/BST0390077
  Sequence
[sso:SSO3003]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.359
IUBMB Enzyme Nomenclature: 1.1.1.359
ExPASy - ENZYME nomenclature database: 1.1.1.359
BRENDA, the Enzyme Database: 1.1.1.359
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