KEGG ENZYME: 1.1.1.360

ENZYME: 1.1.1.360

Entry

EC 1.1.1.360                Enzyme

Name

glucose/galactose 1-dehydrogenase;
GdhA;
dual-specific glucose/galactose dehydrogenase;
glucose (galactose) dehydrogenase;
glucose/galactose dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glucose/D-galactose 1-dehydrogenase (NADPH)

Reaction(IUBMB)

(1) D-glucopyranose + NADP+ = D-glucono-1,5-lactone + NADPH + H+ [RN:R07147];
(2) D-galactopyranose + NADP+ = D-galactono-1,5-lactone + NADPH + H+ [RN:R01096]

Reaction(KEGG)

R01096 R07147

Substrate

D-glucopyranose [CPD:C00031];
NADP+ [CPD:C00006];
D-galactopyranose [CPD:C00124]

Product

D-glucono-1,5-lactone [CPD:C00198];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-galactono-1,5-lactone [CPD:C02669]

Comment

A zinc protein. The enzyme from the archaeon Picrophilus torridus is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. It shows 20-fold higher activity with NADP+ compared to NAD+. The oxidation of D-glucose and D-galactose is catalysed at a comparable rate (cf. EC 1.1.1.119, glucose 1-dehydrogenase (NADP+) and EC 1.1.1.120, galactose 1-dehydrogenase (NADP+)).

History

EC 1.1.1.360 created 2013

Pathway

ec00030

Pentose phosphate pathway

ec00052

Galactose metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology