KEGG ENZYME: 1.1.1.374

ENZYME: 1.1.1.374

Entry

EC 1.1.1.374                Enzyme

Name

UDP-N-acetylglucosamine 3-dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

UDP-N-acetyl-alpha-D-glucosamine:NAD+ 3-oxidoreductase

Reaction(IUBMB)

UDP-N-acetyl-alpha-D-glucosamine + NAD+ = UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+ [RN:R10785]

Reaction(KEGG)

R10785

Substrate

UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
NAD+ [CPD:C00003]

Product

UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose [CPD:C20849];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from the archaeon Methanococcus maripaludis is activated by KCl (200 mM).

History

EC 1.1.1.374 created 2014

Orthology

K18855

UDP-N-acetylglucosamine 3-dehydrogenase

Genes

MHAR:

L1P08_10365

MTAR:

DF168_00473(ligC) DF168_00681(iolG_11)

LLH:	I41_16100(gfo_1)

GCS:	MUN88_08050

GSM:	MUN87_10840

ACTQ:

OG417_13685

DFO:	Dform_01821

CALL:

OZ401_004673

MMP:

MMP0352

MVN:	Mevan_0204

MVO:

Mvol_0228

MTH:

MTH_875

MMG:	MTBMA_c12700

MWO:	MWSIV6_1249

MTEE:

MTTB_05060

METC:

MTCT_0793

METE:

tca_00840(iolX)

METZ:

METMT2_0943

METK:

FVF72_07180

MTHM:

FZP57_05940

METJ:

FZP68_00265

MST:

Msp_1333

METB:

AW729_08855

MEIS:

PXD04_00515

MRU:

mru_1747

MSI:

Msm_0882

MEB:

Abm4_0457

MMIL:

sm9_1833

MEYE:

TL18_08545

MOL:

YLM1_1201

MARO:

MarbSA_18410

METV:

K4897_07085

MEL:	Metbo_2341

MEW:	MSWAN_0318 MSWAN_1278

METH:

MBMB1_0357

MFC:

BRM9_1907

MFI:	DSM1535_0093

MCUB:

MCBB_0333

MSUB:

BK009_11980

METN:

BK008_07620

METT:

CIT01_02215

METO:

CIT02_05040

MEME:

HYG87_03670

MFEG:

GCM10025860_12540

MEER:

NKF70_08195

MRID:

FGU46_03500

MFV:

Mfer_1207

MKA:

MK0248

PFU:

PF0766

PFI:

PFC_02985

PAB:

PAB0775

PYC:	TQ32_02955 TQ32_05360

TGA:	TGAM_0389 TGAM_2151

TSI:

TSIB_2031

TBA:	TERMP_01927

THM:

CL1_0826

TLT:

OCC_01379

THS:	TES1_1882 TES1_2038

TGY:	X802_04125 X802_05770

THV:	ADU37_CDS21840

TCH:	CHITON_0802

TPIE:

A7C91_03605

TCE:	A3L02_07115

TTD:	A3L14_00415

THY:	A3L12_02920

THEI:

K1720_02895 K1720_03050

TAGG:

NF865_02005

MBA:	Mbar_A1138

MBY:	MSBRM_3417

MBW:	MSBRW_3585

MBAR:

MSBR2_3374

MBAK:

MSBR3_3343

MAC:	MA_4448(idh)

MMA:	MM_1122 MM_1153

MMAZ:

MmTuc01_1167 MmTuc01_1203

MMJ:	MSMAS_0150 MSMAS_0181

MMAC:

MSMAC_0156 MSMAC_0186

MVC:	MSVAZ_0134

MEK:	MSKOL_0130

MLS:	MSLAZ_2866

METM:

MSMTP_0134 MSMTP_0214

MEF:	MSWH1_0480 MSWH1_2954

MEQ:	MSWHS_0489 MSWHS_2040

MSJ:	MSSAC_4124 MSSAC_4148

MSZ:	MSSIH_3660 MSSIH_3683

MSW:	MSSIT_3716 MSSIT_3739

MTHR:

MSTHT_1686

MTHE:

MSTHC_1603

MHOR:

MSHOH_0208 MSHOH_0233

MFZ:	AOB57_007590

MHAB:

RSJ42_15000 RSJ42_15120

METW:

AAY43_02320

MBU:	Mbur_0122 Mbur_2030

MMET:

MCMEM_0690

MELO:

J7W08_01555

MPOT:

BKM01_04505

MPY:

Mpsy_0709

MMAV:

RE476_05175

MSEB:

RE474_01465

MHZ:	Metho_1797

MPD:	MCP_0765 MCP_0852 MCP_0895

RCI:	RCIX1923(idhA)

PABI:

PABY_19410

CMA:

Cmaq_0947

» show all

Reference

1 [PMID:18634748]

Authors

Namboori SC, Graham DE

Title

Enzymatic analysis of uridine diphosphate N-acetyl-D-glucosamine.

Journal

Anal Biochem 381:94-100 (2008)
DOI:10.1016/j.ab.2008.06.034

Sequence

[mmp:MMP0352]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.374

IUBMB Enzyme Nomenclature:

1.1.1.374

ExPASy - ENZYME nomenclature database:

1.1.1.374

BRENDA, the Enzyme Database:

1.1.1.374

LinkDB

DBGET integrated database retrieval system