KEGG ENZYME: 1.1.1.385

ENZYME: 1.1.1.385

Entry

EC 1.1.1.385                Enzyme

Name

dihydroanticapsin dehydrogenase;
BacC;
ywfD (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-dihydroanticapsin:NAD+ oxidoreductase

Reaction(IUBMB)

L-dihydroanticapsin + NAD+ = L-anticapsin + NADH + H+ [RN:R10917]

Reaction(KEGG)

R10917

Substrate

L-dihydroanticapsin [CPD:C20940];
NAD+ [CPD:C00003]

Product

L-anticapsin [CPD:C20941];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin.

History

EC 1.1.1.385 created 2015

Pathway

ec00998

Biosynthesis of various antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19548

dihydroanticapsin dehydrogenase

Genes

LPA:	lpa_03406(phaB)

SHAI:

LMH63_18985

KAI:	K32_05950(fabG2)

KOI:	LV478_11255

SKT:	IGS68_30855

AVM:	JQX13_36925

ALAM:

RT761_01341(bacC_5)

BSU:	BSU37720(bacC)

BSR:

I33_3920

BSL:

A7A1_0191

BSH:	BSU6051_37720(bacC)

BSY:	I653_18505

BSUT:

BSUB_04008(bacC)

BSUL:

BSUA_04008(bacC)

BSUS:

Q433_20775

BSO:	BSNT_10430(ywfD)

BSN:	BSn5_09850

BSQ:	B657_37720(bacC)

BSX:	C663_3677(bacC)

BSP:	U712_19010

BSS:	BSUW23_18630(bacC)

BST:

GYO_4158

BIT:	BIS30_08575

BAY:	RBAM_034910(bacC)

BAQ:	BACAU_3520(bacC)

BYA:	BANAU_3673(bacC)

BQY:	MUS_4150(bacC3)

BAMP:

B938_17915(bacC)

BAML:

BAM5036_3421(bacC)

BAMA:

RBAU_3629(bacC)

BAMN:

BASU_3405(bacC)

BAMB:

BAPNAU_3687(bacC)

BAMT:

AJ82_19700

BAMY:

V529_37630(bacC)

BMP:	NG74_03666(gdhIV_2)

BAO:	BAMF_3605(bacC)

BAZ:	BAMTA208_19090(bacC)

BQL:	LL3_03916(bacC)

BXH:	BAXH7_03908(bacC)

BAMI:

KSO_001605

BAMC:

U471_36360

BAMF:

U722_18650

BSIA:

CWD84_01670

BVM:	B9C48_17865

BHT:	DIC78_12115(bacC)

BMOJ:

HC660_36800(bacC)

BTEQ:

G4P54_19450(bacC)

BIQ:	AN935_19105

BSTR:

QI003_22365(bacC)

BPU:

BPUM_3422

BPUM:

BW16_18170

BPUS:

UP12_17615

BALT:

CFN77_18075

BAER:

BAE_05975

BSAF:

BSL056_18715

BCAB:

EFK13_19420(bacC)

BRY:	M0696_19170(bacC)

BJS:

MY9_3863

BACW:

QR42_17170

BACP:

SB24_11240

BACB:

OY17_01120

BACY:

QF06_17300

BACL:

BS34A_40900(bacC)

BALM:

BsLM_3802

BACS:

AUL54_12240

BZH:	NF868_15805

BAEI:

RE735_02175

BAFC:

K3G25_13090(bacC)

BGI:	BGM20_13120

BMUR:

ABE28_019125

PSOP:

KP014_17250

PAUN:

MJA45_08550

MAUU:

NCTC10437_02787(cpnA_3)

MMAG:

MMAD_18390(bacC)

MRF:	MJO55_04500

NIE:	KV110_23495

STRM:

M444_35575

SPHV:

F9278_21500

SDEC:

L3078_20865

SXT:	KPP03845_100609(bacC_1) KPP03845_106164(bacC_4)

SGK:	PET44_33040

SEVR:

LWF01_15475 LWF01_17440

BSUE:

BS3272_08590

JCY:	M6B22_06160

» show all

Reference

1 [PMID:23317005]

Authors

Parker JB, Walsh CT

Title

Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.

Journal

Biochemistry 52:889-901 (2013)
DOI:10.1021/bi3016229

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.385

IUBMB Enzyme Nomenclature:

1.1.1.385

ExPASy - ENZYME nomenclature database:

1.1.1.385

BRENDA, the Enzyme Database:

1.1.1.385

LinkDB

DBGET integrated database retrieval system