KEGG   ENZYME: 1.1.1.387
Entry
EC 1.1.1.387                Enzyme                                 
Name
L-serine 3-dehydrogenase (NAD+);
NAD+-dependent L-serine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-serine:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH + H+ (overall reaction) [RN:R10986];
(1a) L-serine + NAD+ = 2-aminomalonate semialdehyde + NADH + H+ [RN:R10985];
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) [RN:R06830]
Reaction(KEGG)
Substrate
L-serine [CPD:C00065];
NAD+ [CPD:C00003];
2-aminomalonate semialdehyde [CPD:C11822]
Product
2-aminoacetaldehyde [CPD:C06735];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080];
2-aminomalonate semialdehyde [CPD:C11822]
Comment
The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC 1.1.1.276, serine 3-dehydrogenase (NADP+)].
History
EC 1.1.1.387 created 2015
Orthology
K19711  L-serine 3-dehydrogenase (NAD+)
Genes
PAEPA0743
PAEVN297_768(mmsB)
PAEIN296_768(mmsB)
PAUPA14_54670
PAPPSPA7_4777(mmsB1)
PAGPLES_46001
PAFPAM18_4296
PNCNCGM2_1469
PAEBNCGM1900_2036
PDKPADK2_21985
PSGG655_21655
PRPM062_03605
PAEPPA1S_22945
PAERPA1R_gp4235
PAEMU769_22455
PAELT223_23470
PAESSCV20265_4784
PAEUBN889_00764
PAEGAI22_11210
PAECM802_765(mmsB)
PAEOM801_767(mmsB)
SECHB18_15310
PMYPmen_1371
PMKMDS_1428
PREPCA10_42930(mmsB)
PPSEBN5_3001(mmsB)
PFUWKF707C_13220
PALCA0T30_07900
PCQPcP3B5_38910(mmsB_2)
PMUIG4G71_26165(mmsB)
PNTG5B91_07900(mmsB)
PPAAB7D75_21565(mmsB)
PDRH681_06605
PKCPKB_4189(mmsb3)
PSETTHL1_4336
PALLUYA_07200
POJPtoMrB4_24440
PLALFXN65_07210(mmsB)
PSEJHNQ25_17590(mmsB)
PKHJLK41_07140(mmsB)
PTYJWV26_17490(mmsB)
PCAMHNE05_11165(mmsB)
PWZJ7655_14815(mmsB)
PTWTUM18999_44190
PCAVD3880_16900(mmsB)
PHFNLY38_18285(mmsB)
PSOAPSm6_05360
PCHEQYM18_14560(mmsB)
PTRLOU419_07020(mmsB)
PDENF1C79_31765(mmsB)
 » show all
Reference
1  [PMID:22128181]
  Authors
Tchigvintsev A, Singer A, Brown G, Flick R, Evdokimova E, Tan K, Gonzalez CF, Savchenko A, Yakunin AF
  Title
Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD+-dependent L-serine dehydrogenase.
  Journal
J Biol Chem 287:1874-83 (2012)
DOI:10.1074/jbc.M111.294561
  Sequence
[pae:PA0743]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.387
IUBMB Enzyme Nomenclature: 1.1.1.387
ExPASy - ENZYME nomenclature database: 1.1.1.387
BRENDA, the Enzyme Database: 1.1.1.387
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