KEGG   ENZYME: 1.1.1.405
Entry
EC 1.1.1.405                Enzyme                                 
Name
ribitol-5-phosphate 2-dehydrogenase (NADP+);
acs1 (gene name);
bcs1 (gene name);
tarJ (gene name);
ribulose-5-phosphate reductase;
ribulose-5-P reductase;
D-ribulose 5-phosphate reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-ribitol-5-phosphate:NADP+ 2-oxidoreductase
Reaction(IUBMB)
D-ribitol 5-phosphate + NADP+ = D-ribulose 5-phosphate + NADPH + H+ [RN:R01525]
Reaction(KEGG)
R01525
Substrate
D-ribitol 5-phosphate [CPD:C01068];
NADP+ [CPD:C00006]
Product
D-ribulose 5-phosphate [CPD:C00199];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Requires Zn2+. The enzyme, characterized in bacteria, is specific for NADP. It is part of the synthesis pathway of CDP-ribitol. In Haemophilus influenzae it is part of a multifunctional enzyme also catalysing EC 2.7.7.40, D-ribitol-5-phosphate cytidylyltransferase. cf. EC 1.1.1.137, ribitol-5-phosphate 2-dehydrogenase.
History
EC 1.1.1.405 created 2017
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K05352  ribitol-5-phosphate 2-dehydrogenase (NADP+)
K21681  ribitol-5-phosphate 2-dehydrogenase (NADP+) / D-ribitol-5-phosphate cytidylyltransferase
Genes
ECOSEC958_3340
KCOBWI95_19355
HIUHIB_11690(bcs1') HIB_11840(bcs1')
AEUACEE_10835
ALIGNCTC10568_01939(ispD_2)
BTRAF544_4610
PAETNCTC13378_01387
TBVH9L17_00500
PCQPcP3B5_16180(ispD1) PcP3B5_47970(ispD2)
ALJG8D99_14930
ACIUA3K93_11085
SINIGT972_07520
WBOMIS45_03430
CKEB5M06_15305
HYLLPB072_04595
HPSEHPF_20235(ispD2)
HWIA0Z60_06675
CCQN149_1385(ispD)
ABLA7H1H_2199
ATHRATH_1037
NAMNAMH_1606
CPAFC6V80_08920(ispD)
PPRFDPRO_1984(bcs)
PSELGM415_05370(ispD)
SDOSD1155_05535
ZMOZMO0353
ZMNZa10_0885
ZMMZmob_0895
ZMBZZ6_0893
ZMIZCP4_0917
ZMCA265_00908(ispD2)
ZMRA254_00908(ispD2)
ZMPZymop_0844
BSLA7A1_1142
BSYI653_17450
BSUSQ433_19600
BSXC663_3469(tarJ)
BSSBSUW23_17570(tarJ)
BSTGYO_3934(tarJ)
BHTDIC78_13180
BMOJHC660_34680(gutB)
BTEQG4P54_18375
BIQAN935_18030
BITBIS30_07540
BFDNCTC4823_03510(tarJ)
BRYM0696_18135
BJSMY9_3631
BACYQF06_16295
TAIDKS242_14085
VIRX953_16975
FPNABE65_019035
APAKAP3564_02710
PRDF7984_17520
GAJMY490_02515
SAUSA0242 SA0246
SAVSAV0252 SAV0256
SAWSAHV_0251 SAHV_0255
SAHSaurJH1_0243 SaurJH1_0247
SAJSaurJH9_0237 SaurJH9_0241
SAMMW0228 MW0232
SASSAS0228 SAS0233
SARSAR0247 SAR0253
SACSACOL0237 SACOL0241
SAXUSA300HOU_0263 USA300HOU_0267
SAASAUSA300_0246 SAUSA300_0250
SAOSAOUHSC_00221 SAOUHSC_00226
SAENWMN_0186 NWMN_0190
SADSAAV_0220 SAAV_0224
SUUM013TW_0233 M013TW_0237
SUVSAVC_01000 SAVC_01020
SUESAOV_0191 SAOV_0195
SUJSAA6159_00229 SAA6159_00233
SUKSAA6008_00225 SAA6008_00230
SUCECTR2_213 ECTR2_217
SUTSAT0131_00244 SAT0131_00249
SUQHMPREF0772_10246 HMPREF0772_10251
SUZMS7_0240 MS7_0246
SUDST398NM01_0264 ST398NM01_0269
SUXSAEMRSA15_02110 SAEMRSA15_02150
SUWSATW20_02540(tarJ') SATW20_02580(tarJ)
SUGSAPIG0264 SAPIG0269
SUFSARLGA251_02160(tarJ') SARLGA251_02200(tarJ)
SAUASAAG_00733 SAAG_00737
SAUERSAU_000196 RSAU_000200
SAUNSAKOR_00229 SAKOR_00235
SAUSSA40_0210 SA40_0214
SAUUSA957_0225 SA957_0229
SAUGSA268_0222 SA268_0226
SAUZSAZ172_0254 SAZ172_0259
SAUTSAI1T1_2001930 SAI1T1_2001970
SAUJSAI2T2_1001930 SAI2T2_1001970
SAUKSAI3T3_1001930 SAI3T3_1001970
SAUQSAI4T8_1001930 SAI4T8_1001970
SAUVSAI7S6_1001930 SAI7S6_1001970
SAUWSAI5S5_1001920 SAI5S5_1001960
SAUXSAI6T6_1001930 SAI6T6_1001970
SAUYSAI8T7_1001930 SAI8T7_1001970
SAUFX998_0228 X998_0232
SABSAB0195
SUYSA2981_0252 SA2981_0256
SAUBC248_0239 C248_0244
SAUMBN843_2510 BN843_2550
SAUCCA347_259 CA347_263
SAURSABB_01596(tarJ) SABB_01601
SAUIAZ30_01265 AZ30_01285
SAUDCH52_04445 CH52_04465
SAMSNI36_01160 NI36_01180
SUHSAMSHR1132_02200 SAMSHR1132_02240
SERSERP0197
SEPSE_0320
SEPPSEB_00242
SEPSDP17_1630
SSPSSP0355 SSP2179
SWAA284_10560
SPASSTP1_1638
SXYBE24_00380 BE24_10205
SXLSXYLSMQ121_0383 SXYLSMQ121_2179
SXOSXYL_00386 SXYL_02332
SSCHLH95_01795
SEQOSE1039_21960
SCVA4G25_09300
SPETCEP67_06500
SKLC7J89_03590
SCARDWB96_11770
SARLSAP2_04710(tarJ) SAP2_22340(tdh)
SSHNCTC13712_00198(gutB_3) NCTC13712_00202(gutB_4)
SSIMSAMEA4384339_0089(gutB_2) SAMEA4384339_0503
SLLOISP08_02335
SPSDJMB28_02425 JMB28_11805 JMB28_13570
SFFFOB90_06005
SSTESAMEA4384403_1040
LMOlmo1087
LMNLM5578_1170
LMYLM5923_1124
LMTLMRG_00549
LMOCLMOSLCC5850_1093
LMOEBN418_1305
LMOBBN419_1302
LMODLMON_1097
LMOWAX10_14015
LMOQLM6179_1407(tarJ)
LMRLMR479A_1115(tarJ)
LMOMIJ09_04850
LMFLMOf2365_1101
LMCLm4b_01100
LMOGBN389_11140(tarJ)
LMPMUO_05675
LMOLLMOL312_1081
LMOJLM220_05537
LMOZLM1816_14227
LMOXAX24_02825
LMHLMHCC_1546
LMQLMM7_1111
LMLlmo4a_1089
LMGLMKG_01833
LMSLMLG_2570
LMJLMOG_00631
LMWLMOSLCC2755_1085
LMXLMOSLCC2372_1101
LMZLMOSLCC2482_1131
LMONLMOSLCC2376_1052
LMOSLMOSLCC7179_1068
LMOOLMOSLCC2378_1098
LMOYLMOSLCC2479_1101
LMOTLMOSLCC2540_1084
LMOALMOATCC19117_1103
LMOKCQ02_05635
LMVY193_10330
LINlin1072
LWElwe1062
LSGlse_0977
LIVLIV_1028
LIIJL52_05465
LIWAX25_05555
LIAJL58_05685
LIOJL53_06175
LWIUE46_11740
LGZNCTC10812_01810(idnD)
LMARLAX80_005000
ESIExig_0190
EANEab7_0182(tarJ)
EXUESP131_03400
EACEKKI46_01220
GOTAXE85_01085
GMONCTC11323_00090(idnD)
GEQCG018_02855
GSAFOC50_03555
GHANCTC10459_00071 NCTC10459_00103
BCHSJNE38_25530
PNPIJ22_48470
POWIJ21_39000
KURASO14_2501
NTRB0W44_10465
LLDP620_01405
SPNSP_1270
SPDSPD_1126
SPRspr1148
SPWSPCG_1234
SJJSPJ_1184
SNVSPNINV200_11590
SPXSPG_1164
SNTSPT_0958
SNDMYY_0970
SPNNT308_04435
SNESPN23F11640
SPVSPH_1386
SNCHMPREF0837_11231
SNMSP70585_1333
SPPSPP_1308
SNIINV104_10920
SPNGHMPREF1038_01273
SNBSP670_1005
SNPSPAP_1295
SNXSPNOXC11350
SNUSPNA45_00914
SPNESPN034156_02230
SPNUSPN034183_11350
SPNMSPN994038_11240
SPNOSPN994039_11250
SMBsmi_1227(tarJ)
SORSOR_1098(tarJ)
STDSPPN_06310
SIGN596_06770
SIPN597_08675
STVV470_05115
STRNSNAG_1096(yjjN)
SGWD7D53_03565
SAUPNCTC3168_00867
SVFNCTC3166_01881
LCSLCBD_2953
LCELC2W_2927
LCWBN194_28680(tarJ)
LCBLCABL_29250(tdh)
LSLLSL_1953(tdh)
LSIHN6_01675(tdh)
PCEPECL_1839
PIOPI20285_08400
LECLGMK_03550
WCEWS08_0696
WCTWS74_0698
WCIWS105_0758
WCBAO080_09190
WVRIE337_02015
WEIEQG49_03570
EGVEGCR1_00545
EAVEH197_09215
ERAFJ9537_02390
TEYGLW17_02100
ADCFOC79_09370
GADK8O88_07425
CBNCbC4_0710
CBTCLH_2995
CLSCXIVA_02110
CBVU729_1135
RUJE5Z56_01295
EHLEHLA_2452
ACHTbsdcttw_42560
ALKAJ0B03_04325
EUUADJ67_05805
PMICNW74_04235
KPARJL105_07985
EBMSG0102_21260
SGRSGR_4956
SGBWQO_10720
SSXSACTE_2009
SFASfla_4295
SDVBN159_5701
STRPF750_2413
SFISFUL_2153
SCIB446_13640
SXISXIM_15330
STRCAA958_25170
SPRISPRI_4927
SCZABE83_25180
SCXAS200_29490
SRWTUE45_03196(ispD1)
SRNA4G23_01658(ispD2)
STRTA8713_10140
SCLFBB341_19490
SGSAVL59_40270
STSIA4E84_13575
SCADDN051_25530
SLSSLINC_2989
SNWBBN63_23745
SVUB1H20_09990
SLAUSLA_5894
SNZDC008_11175
SGEDWG14_05586(bcs1)
SLKSLUN_13130
SDXC4B68_26825
SGDELQ87_26380
SQZFQU76_09345
SCYAEJ357_15535
STIRDDW44_08240
SGZC0216_08925
SVNCP980_07690
SNKCP967_23320
SHAWCEB94_13980
SFICEIZ62_22315
SGALCP966_11970
SSPODDQ41_06560
SPADDVK44_09025
SFYGFH48_26815
SAQUEJC51_17065
SCAVCVT27_09510
SSUBCP968_08275
SFUGCNQ36_11780
STSUB7R87_09240
SCHACP983_28710
SCOECP976_15105
SBROGQF42_16330
STUIGCM10017668_22430
SATAC5746_13975
SCHFIPT68_12435
SHARHUT13_08350
SCYGS1361_14180(ispD1)
SFEUIM697_08240
SLIAHA039_23505
SVDCP969_14060
SCALI6J39_10210
SFBCP974_09315
SPRACP972_12305
SPEUCGZ69_11785
SGJIAG43_10235
STRYEQG64_09805
SDDD9753_23735
SMAOCAG99_19295
SGOBtest1122_22495
KABB7C62_09600
MOOBWL13_02200(bcs1)
MPRTET475_11965
AARCG127AT_03335
AMAUDSM26151_09170(bcs1)
ASOIMTP13_17175 MTP13_17185
SALAESZ53_05795
ASUFMNQ99_09020
PAEYKUF55_10390
JDEJden_1842
PHWG7075_10580
BLYA2T55_13845
MPHMLP_25850(ispD)
MIKFOE78_14050
MICGGJV80_06215
PSIMKR76_03415
AEZC3E78_05735
AEBC6I20_04370
AEFGEV26_05500
MUZH4N58_06600
THAONI17_015585
TALXFOF52_12610 FOF52_12975
NALB005_2753
NEXNE857_05460 NE857_28875
SAIUJ4H86_12520
SROSros_1351
NCXNocox_05830(ispD2)
NGNLCN96_06510
TBITbis_0719
STPStrop_1684
SAQSare_1679
MAUMicau_2081
MILML5_2188
MICBMicB006_5138
MTUACSH63_14395
MICHFJK98_09765
MTEMGCE86_03895
MCABHXZ27_10760
MSAGGCM10017556_43470
VMAVAB18032_13835
MCRAID554_03250
PLABC6361_28940
PLATC6W10_06500
VERHUT12_09925
CATICS0771_15200
SHIShel_14630
AHATADCFC_17180
DDTAAY81_02970
RTSCE91St31_00270
SNGSNE_A02450(ispD)
RHAWRHABOEDO_000295
RPORRHAB15C_0001222
OTEOter_0455
FPDCTM68_07420
FMOC4N19_12405
BTHBT_1651
BTHOBtheta7330_01408(ispD2_2)
BUNBun01g_05870
BHUMJXR92_013855
BDOEL88_23930
BDHGV66_07440
PCOPI6J50_15570
PDIBDI_1841
MBASALGA_0189
FJOFjoh_2239
FFAFFWV33_09175
FIANA23_00555(ispD)
MRUmru_1057
MSIMsm_0376
MEBAbm4_1002
MMILsm9_0634
MEYETL18_03055
METVK4897_02400
MCUBMCBB_1533(tarJ)
TSITSIB_2019
TPRFA3L09_01820
ABIAboo_0706
 » show all
Reference
1  [PMID:11305920]
  Authors
Zolli M, Kobric DJ, Brown ED
  Title
Reduction precedes cytidylyl transfer without substrate channeling in distinct active sites of the bifunctional CDP-ribitol synthase from Haemophilus influenzae.
  Journal
Biochemistry 40:5041-8 (2001)
DOI:10.1021/bi002745n
  Sequence
[hiu:HIB_11840]
Reference
2  [PMID:15362865]
  Authors
Pereira MP, Brown ED
  Title
Bifunctional catalysis by CDP-ribitol synthase: convergent recruitment of reductase and cytidylyltransferase activities in Haemophilus influenzae and Staphylococcus aureus.
  Journal
Biochemistry 43:11802-12 (2004)
DOI:10.1021/bi048866v
Reference
3  [PMID:18556787]
  Authors
Pereira MP, D'Elia MA, Troczynska J, Brown ED
  Title
Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases.
  Journal
J Bacteriol 190:5642-9 (2008)
DOI:10.1128/JB.00526-08
Reference
4  [PMID:19074383]
  Authors
Baur S, Marles-Wright J, Buckenmaier S, Lewis RJ, Vollmer W
  Title
Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae.
  Journal
J Bacteriol 191:1200-10 (2009)
DOI:10.1128/JB.01120-08
  Sequence
[spr:spr1148]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.405
IUBMB Enzyme Nomenclature: 1.1.1.405
ExPASy - ENZYME nomenclature database: 1.1.1.405
BRENDA, the Enzyme Database: 1.1.1.405
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