KEGG ENZYME: 1.1.1.419

ENZYME: 1.1.1.419

Entry

EC 1.1.1.419                Enzyme

Name

nepetalactol dehydrogenase;
NEPS1 (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

nepetalactol:NAD+ 1-oxidoreductase

Reaction(IUBMB)

(1) (+)-cis,cis-nepetalactol + NAD+ = (+)-cis,cis-nepetalactone + NADH + H+ [RN:R12483];
(2) (+)-cis,trans-nepetalactol + NAD+ = (+)-cis,trans-nepetalactone + NADH + H+ [RN:R12484]

Reaction(KEGG)

R12483 R12484

Substrate

(+)-cis,cis-nepetalactol [CPD:C22200];
NAD+ [CPD:C00003];
(+)-cis,trans-nepetalactol [CPD:C09804]

Product

(+)-cis,cis-nepetalactone [CPD:C22201];
NADH [CPD:C00004];
H+ [CPD:C00080];
(+)-cis,trans-nepetalactone [CPD:C09791]

Comment

The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. It also catalyses the activity of EC 5.5.1.34, (+)-cis,trans-nepetalactol synthase.

History

EC 1.1.1.419 created 2019

Orthology

K23990

nepetalactol dehydrogenase / (+)-cis,trans-nepetalactol synthase

Reference

1 [PMID:30531909]

Authors

Lichman BR, Kamileen MO, Titchiner GR, Saalbach G, Stevenson CEM, Lawson DM, O'Connor SE

Title

Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.

Journal