KEGG   ENZYME: 1.1.1.420
Entry
EC 1.1.1.420                Enzyme                                 
Name
D-apiose dehydrogenase;
apsD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-apiofuranose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-apiofuranose + NAD+ = D-apionolactone + NADH + H+ [RN:R12502]
Reaction(KEGG)
R12502
Substrate
D-apiofuranose [CPD:C21040];
NAD+ [CPD:C00003]
Product
D-apionolactone [CPD:C22218];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose.
History
EC 1.1.1.420 created 2019
Orthology
K23244  D-apiose dehydrogenase
Genes
YAK: ACZ76_03285
YMA: DA391_06270
YHI: D5F51_15710
YEL: LC20_03977
YKI: HRD70_10740
PSMZ: V6L79_15675
COLW: A3Q33_17725
CATE: C2869_05170
AGQ: LQZ07_23980
AGAR: OAG1_41040
GAI: IMCC3135_02045(yhhX_1) IMCC3135_20395(yhhX_2) IMCC3135_21765(yhhX_3)
HAFN: KF947_09250
HADN: NKF27_12800
HAA: A5892_08245
KMA: B9H00_09335
BCAI: K788_0005386
PSPW: BJG93_30030
PTER: C2L65_18735
PGP: CUJ91_23805
PTS: CUJ90_28675
PACP: FAZ97_28280
PEW: KZJ38_24870
PSAA: QEN71_38390
AKA: TKWG_00535
AMIM: MIM_c01400
RHY: RD110_19505
POL: Bpro_3819
VAP: Vapar_6269
VAA: AX767_13030
HYL: LPB072_16415 LPB072_19470
HYC: E5678_14695
BEBA: BWI17_02130
MLO: mll7010
MLN: A9174_13150
MCI: Mesci_5311
MCIC: A4R28_00555
MOP: Mesop_5772
MAM: Mesau_05267
MAMO: A6B35_09525 A6B35_15265
MESW: A9K65_029035
MESM: EJ066_15520
MHUA: MCHK_0234
MJR: EB229_13285
MERD: EB233_28460
MOH: IHQ72_30645
MMEI: LRP31_29975
MESU: LHFGNBLO_001835
NIY: FQ775_04630
NKI: KW403_09355
MESO: BSQ44_08090
PHT: BLM14_21715
ORM: HTY61_08760 HTY61_11910
AMAX: ABWH92_12650
SME: SM_b20353
SMK: Sinme_3825
SMQ: SinmeB_4321
SMX: SM11_pD1260
SMI: BN406_06319
SMEG: C770_GR4pD1249
SMEL: SM2011_b20353
SMER: DU99_31530
SMD: Smed_3766
RHI: NGR_b22030
SFH: SFHH103_05028
SFD: USDA257_c23090
SIX: BSY16_3623
SAME: SAMCFNEI73_pC0431
SINO: SS05631_b62710
ENU: PYH37_000275
SKM: PZL22_001117
EAD: OV14_b0209
ECAA: J3R84_34890
EAW: ACEP9W_27665
RET: RHE_PF00033
REC: RHECIAT_PC0000973
REL: REMIM1_PF00037
RLE: RL4420 pRL120389
RLT: Rleg2_4658
RLG: Rleg_3954 Rleg_4755
RLB: RLEG3_07460 RLEG3_30850
RTR: RTCIAT899_PC04810
RHL: LPU83_pLPU83c0530
RGA: RGR602_PC01948
RHN: AMJ98_PE00036
RPHA: AMC79_PD00980
RHX: AMK02_PD00039
REZ: AMJ99_PD00036
RJG: CCGE525_32375
RHR: CKA34_20650
RGR: FZ934_27690
RAD: CO657_28340
RII: FFM53_014910 FFM53_024655
RBAN: J2J98_22070
RRG: J3P73_22875 J3P73_25320
RLS: HB780_06745
RAW: NE851_31400 NE851_33180
RSUL: N2599_21450
RLW: RlegWSM1455_19965 RlegWSM1455_25725
RRHO: PR018_17250
RTU: PR017_17135
ARA: Arad_9238
RBW: RLCC275e_20295 RLCC275e_25195
RIF: U5G49_004074 U5G49_005405
RHIZ: QMO80_004795
RHIB: I8E17_22840
RHIW: KQ933_24125 KQ933_30300
RFV: RFYW14_03811
SHZ: shn_27380
SZO: K8M09_21790
SOJ: K6301_18790
SSUM: Q9314_21115
KAI: K32_08100 K32_40750
OIN: IAR37_15410
OAN: Oant_3060
OAH: DR92_3443
OPS: A8A54_12325
BPSN: NIK97_14695
BRUC: LJ361_08255
OCR: HGK82_18425
OCL: GTN27_19440
OCC: KMS41_13085
OCH: CES85_5830
BVV: BHK69_03780
BOP: AXW83_04865 AXW83_12440
BOSE: RMR04_14270
XDI: EZH22_15220
STAR: G3545_23065
LNE: FZC33_05825
MET: M446_1313
MMES: MMSR116_11450
MTAD: M6G65_24040
MOC: BB934_35085 BB934_40840
MLD: U0023_31715
CHEL: AL346_05100
DEI: C4375_04970
DNP: N8A98_03290
DAG: PSQ19_05595 PSQ19_10800 PSQ19_12140 PSQ19_12405
DRP: PSQ90_09250
MMED: Mame_04748(afr_4)
AUA: M673_08895
AALA: IGS74_19120
AALM: LUX29_21310
AUZ: Sa4125_32750
RBM: TEF_16860
LAP: ACP90_20155
LABR: CHH27_00105
LABP: FJ695_09720
LABT: FIU93_26710(ydgJ) FIU93_28805(afr4)
LAGG: B0E33_03880 B0E33_28845
RPOP: K1718_20730
LIZ: LGH83_09595
ACUT: MRB58_05620 MRB58_21515
RUA: D1823_13410
RUT: FIU92_00100(afr1)
JAN: Jann_3062
JOV: P8627_01920
RDE: RD1_3788
RLI: RLO149_c006530
RPON: G3256_03960
RFU: ROLI_015600(apsD)
DSH: Dshi_3394
OAR: OA238_c24210
CMAR: IMCC12053_385
MALG: MALG_04066
YPAC: CEW88_19410
TPRO: Ga0080559_TMP299
SULZ: C1J03_17545
SULI: C1J05_01780
SMED: JNX03_08285
SUAL: KDD17_14090
SDUB: R1T39_03375
TOM: BWR18_11220
RPHC: RZ517_13410
RRL: RZS32_013515
AHT: ANTHELSMS3_02504(ligC) ANTHELSMS3_04965(iolX)
THAA: CFI11_01770
OCD: FHY55_04930 FHY55_15985
MALU: KU6B_32170
HAT: RC74_03020 RC74_11925 RC74_11940
PALX: GQA70_00805 GQA70_20180
LSAL: KBK07_12645
ACLD: ACIRQ6_13075
FYT: QF092_01885
PARR: EOJ32_13825
PLIA: E4191_17645
PMAU: CP157_00839(iolG_2)
PSAP: JHX88_15320
DAA: AKL17_3256
TEC: AKL02_017820
YRH: AABB31_21695
GEH: HYN69_13940
LIT: FPZ52_12595
POZ: I0K15_15440
PALW: PSAL_036690(apsD_2)
PPAF: I8N54_14200
CACT: HZ995_04510
HDH: G5B40_16325
FAP: GR316_12720
AALK: LGT41_0010945
AMAQ: GO499_13005 GO499_14460
PBAE: P8S53_15430 P8S53_19850
BOSG: GKR98_16520
FAQ: G5B39_17465
SCAB: LZK98_19770
GOY: GLS_c05880
LCK: HN018_21640
ACR: Acry_1061
AMV: ACMV_08300
SHUM: STHU_22600
SVC: STVA_26220
SKT: IGS68_04965
SMUC: JL100_022755
SROE: JL101_021440
FER: FNB15_20160
HADH: FRZ61_46810
THAR: T8K17_15720 T8K17_18995
SNEA: NBZ79_06410
TRO: trd_0133
FPES: NXS98_03455
RBA: RB3770
RHOI: PSR62_16555
MFF: MFFC18_42680(idhA)
RLC: K227x_46470(iolG_15)
SMAM: Mal15_40850(ycjS_2)
SNEP: Enr13x_29130(ligC_3)
SMAE: TBK1r_20200(ligC_3)
MRI: Mal4_38880(ycjS_5)
CCOS: Pan44_39340(iolG_12)
CCOP: Mal65_01270(iolG_1)
SACI: Sinac_4983
AGV: OJF2_37170(ycjS_3)
TPLA: ElP_26200(ycjS_2)
ABAS: ACPOL_4621
LUB: TBR22_A12690
PMUC: ING2E5A_0782
HHY: Halhy_1306
MSAB: SNE25_30235
CXI: ABWH99_10710
SMON: AWR27_07845
SOQ: LQ777_09285
SENF: GJR95_23830
RHOZ: GXP67_17710
DFQ: NFI81_04970
DPF: ON006_08840
RSI: Runsl_3639
CLIT: OQ292_23185
FBT: D770_14515
RCG: N7E81_17120
PRHO: PZB74_18045
TPEL: P0M28_11635 P0M28_19590
CNQ: PZB72_00920
MARE: EJ994_10370
ZGA: ZOBELLIA_3794
ZLA: Q5W13_08100
FEK: C1H87_18525
FAY: Q4Q34_12295
AQD: D1816_12935
AQE: NBT05_12555
ASAG: FGM00_05285
ALUT: O5O44_05050
NIL: L8T27_020040
BOU: I5818_05095
PJD: Pjdr2_3665
PPY: PPE_03804
PAEQ: R50912_07855
PRI: PRIO_3529
PSWU: SY83_22150
PPSC: EHS13_08910
PALB: EJC50_26040
PRZ: GZH47_24970 GZH47_30105
PLYC: GXP70_27330
PTRI: KDC22_07460
PALO: E6C60_0877 E6C60_1021
PPAB: KET34_26065
ALIC: GI364_18965
MALP: QSU92_07015
NOCD: QJ852_19345
PLAN: A1s21148_06255
TTR: Tter_1997
CCOT: CCAX7_25370
 » show all
Reference
1  [PMID:29867142]
  Authors
Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA
  Title
Functional assignment of multiple catabolic pathways for D-apiose.
  Journal
Nat Chem Biol 14:696-705 (2018)
DOI:10.1038/s41589-018-0067-7
  Sequence
[ara:Arad_9238]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.420
IUBMB Enzyme Nomenclature: 1.1.1.420
ExPASy - ENZYME nomenclature database: 1.1.1.420
BRENDA, the Enzyme Database: 1.1.1.420
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