KEGG   ENZYME: 1.1.1.438
Entry
EC 1.1.1.438                Enzyme                                 
Name
cis-4-hydroxycyclohexanecarboxylate dehydrogenase;
chcB2 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-4-hydroxycyclohexane-1-carboxylate:NAD+ 4-oxidoreductase
Reaction(IUBMB)
cis-4-hydroxycyclohexane-1-carboxylate + NAD+ = 4-oxocyclohexane-1-carboxylate + NADH + H+ [RN:R13283]
Reaction(KEGG)
R13283
Substrate
cis-4-hydroxycyclohexane-1-carboxylate [CPD:C22885];
NAD+ [CPD:C00003]
Product
4-oxocyclohexane-1-carboxylate [CPD:C03767];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Corynebacterium cyclohexanicum is highly specific for the cis-4-hydroxy derivative. cf. EC 1.1.1.226, trans-4-hydroxycyclohexanecarboxylate dehydrogenase.
History
EC 1.1.1.438 created 2024
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K27499  cis-4-hydroxycyclohexanecarboxylate dehydrogenase
Genes
HABD: OM794_22475
BJA: blr3673(blr3673)
BVZ: BRAD3257_5009(fabG)
CGF: CGUA_01550(fabG2)
ARY: ATC04_00405
ACRY: AC20117_12045
ARTP: E5206_11780
ACAO: NF551_15315
PDEL: JCQ34_08350
GPR: JQN66_00275
SATK: SA2016_1178
CCYC: SCMU_09890(chcB2)
SPUE: AB5L97_05090
AMYE: MJQ72_18610
 » show all
Reference
1  [PMID:34583900]
  Authors
Yamamoto T, Hasegawa Y, Lau PCK, Iwaki H
  Title
Identification and characterization of a chc gene cluster responsible for the aromatization pathway of cyclohexanecarboxylate degradation in Sinomonas cyclohexanicum ATCC 51369.
  Journal
J Biosci Bioeng 132:621-629 (2021)
DOI:10.1016/j.jbiosc.2021.08.013
  Sequence
[ccyc:SCMU_09890]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.438
IUBMB Enzyme Nomenclature: 1.1.1.438
ExPASy - ENZYME nomenclature database: 1.1.1.438
BRENDA, the Enzyme Database: 1.1.1.438
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