KEGG   ENZYME: 1.1.1.444
Entry
EC 1.1.1.444                Enzyme                                 
Name
sulfofucose 1-dehydrogenase;
sulfofucose dehydrogenase;
SfcH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-deoxy-6-sulfo-D-galactopyranose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
sulfofucose + NAD+ = 6-deoxy-6-sulfo-D-galactono-1,5-lactone + NADH + H+ [RN:R13611]
Reaction(KEGG)
R13611
Substrate
sulfofucose [CPD:C23114];
NAD+ [CPD:C00003]
Product
6-deoxy-6-sulfo-D-galactono-1,5-lactone [CPD:C23115];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme, characterized from the bacterium Paracoccus wurundjeri strain Merri, participates in a sulfofucose degradation pathway. Activity with NADP+ is 28% of that with NAD+. cf. EC 1.1.1.390, sulfoquinovose 1-dehydrogenase.
History
EC 1.1.1.444 created 2025
Pathway
ec00566  Sulfoquinovose metabolism
Orthology
K28731  sulfofucose 1-dehydrogenase
Reference
1  [PMID:40823846]
  Authors
Stewart AWE, Li J, Lee M, Lewis JM, Herisse M, Hofferek V, McConville MJ, Pidot SJ, Scott NE, Williams SJ.
  Title
Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose.
  Journal
mBio 16:e0184025 (2025)
DOI:10.1128/mbio.01840-25
  Sequence
[ag:MDP0926275]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.444
IUBMB Enzyme Nomenclature: 1.1.1.444
ExPASy - ENZYME nomenclature database: 1.1.1.444
BRENDA, the Enzyme Database: 1.1.1.444
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