KEGG ENZYME: 1.1.1.92

ENZYME: 1.1.1.92

Entry

EC 1.1.1.92                 Enzyme

Name

oxaloglycolate reductase (decarboxylating)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glycerate:NAD(P)+ oxidoreductase (carboxylating)

Reaction(IUBMB)

D-glycerate + NAD(P)+ + CO2 = 2-hydroxy-3-oxosuccinate + NAD(P)H + 2 H+ [RN:R01749 R01750]

Reaction(KEGG)

Substrate

D-glycerate [CPD:C00258];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
CO2 [CPD:C00011]

Product

2-hydroxy-3-oxosuccinate [CPD:C03459];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also reduces hydroxypyruvate to D-glycerate and glyoxylate to glycolate.

History

EC 1.1.1.92 created 1972

Pathway

Glyoxylate and dicarboxylate metabolism

Metabolic pathways

Reference

1 [PMID:4385076]

Authors

Kohn LD, Jakoby WB.

Title

Tartaric acid metabolism. VI. Crystalline oxaloglycolate reductive decarboxylase.

Journal

J Biol Chem 243:2486-93 (1968)

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:	37250-28-5

LinkDB

DBGET integrated database retrieval system