Entry Name unspecific peroxygenase;
Class Oxidoreductases;BRITE hierarchy
Sysname substrate:hydrogen-peroxide oxidoreductase (RH-hydroxylating or -epoxidising)
Reaction(IUBMB) RH + H2O2 = ROH + H2O [RN:
R09507 ]
Reaction(KEGG) Substrate Product Comment A heme-thiolate protein (P-450). Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. They catalyse the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. Reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. They have little or no activity toward chloride. Mechanistically, the catalytic cycle of unspecific (mono)-peroxygenases combines elements of the "shunt" pathway of cytochrome P-450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle.
History EC 1.11.2.1 created 2011
Orthology K21820 unspecific peroxygenase
Genes PNO : SNOG_05032 SNOG_07877
TASA : A1Q1_06821 A1Q1_07920
CCAC : CcaHIS019_0600330(CcaverHIS019_0600330)
ADL : AURDEDRAFT_110995(HTP11) AURDEDRAFT_139536(HTP6) AURDEDRAFT_145147(HTP8) AURDEDRAFT_63312(HTP13) AURDEDRAFT_63331(HTP12) AURDEDRAFT_67260(HTP1) AURDEDRAFT_68894(HTP5) AURDEDRAFT_72695(HTP9) AURDEDRAFT_74851(HTP4)
CCI : CC1G_08427 CC1G_08975 CC1G_08981 CC1G_10471 CC1G_10475
ABP : AGABI1DRAFT111702(AGABI1DRAFT_111702) AGABI1DRAFT111721(AGABI1DRAFT_111721) AGABI1DRAFT111729(AGABI1DRAFT_111729) AGABI1DRAFT111734(AGABI1DRAFT_111734) AGABI1DRAFT111735(AGABI1DRAFT_111735) AGABI1DRAFT111738(AGABI1DRAFT_111738) AGABI1DRAFT111742(AGABI1DRAFT_111742) AGABI1DRAFT113735(AGABI1DRAFT_113735) AGABI1DRAFT114754(AGABI1DRAFT_114754) AGABI1DRAFT115045(AGABI1DRAFT_115045) AGABI1DRAFT115049(AGABI1DRAFT_115049) AGABI1DRAFT115479(AGABI1DRAFT_115479) AGABI1DRAFT118546(AGABI1DRAFT_118546) AGABI1DRAFT118596(AGABI1DRAFT_118596) AGABI1DRAFT121696(AGABI1DRAFT_121696) AGABI1DRAFT121894(AGABI1DRAFT_121894) AGABI1DRAFT122208(AGABI1DRAFT_122208) AGABI1DRAFT134005(AGABI1DRAFT_134005) AGABI1DRAFT76879(AGABI1DRAFT_76879) AGABI1DRAFT76887(AGABI1DRAFT_76887) AGABI1DRAFT78772(AGABI1DRAFT_78772) AGABI1DRAFT88344(AGABI1DRAFT_88344)
ABV : AGABI2DRAFT134420(AGABI2DRAFT_134420) AGABI2DRAFT139842(AGABI2DRAFT_139842) AGABI2DRAFT179594(AGABI2DRAFT_179594) AGABI2DRAFT183665(AGABI2DRAFT_183665) AGABI2DRAFT183721(AGABI2DRAFT_183721) AGABI2DRAFT183842(AGABI2DRAFT_183842) AGABI2DRAFT186833(AGABI2DRAFT_186833) AGABI2DRAFT188448(AGABI2DRAFT_188448) AGABI2DRAFT188774(AGABI2DRAFT_188774) AGABI2DRAFT190943(AGABI2DRAFT_190943) AGABI2DRAFT190967(AGABI2DRAFT_190967) AGABI2DRAFT190973(AGABI2DRAFT_190973) AGABI2DRAFT190977(AGABI2DRAFT_190977) AGABI2DRAFT190980(AGABI2DRAFT_190980) AGABI2DRAFT190985(AGABI2DRAFT_190985) AGABI2DRAFT193563(AGABI2DRAFT_193563) AGABI2DRAFT195432(AGABI2DRAFT_195432) AGABI2DRAFT195436(AGABI2DRAFT_195436) AGABI2DRAFT207786(AGABI2DRAFT_207786) AGABI2DRAFT226793(AGABI2DRAFT_226793) AGABI2DRAFT64972(AGABI2DRAFT_64972) AGABI2DRAFT65123(AGABI2DRAFT_65123)
PCUB : JR316_0008266 JR316_0010111 JR316_0012044
SGRA : EX895_002452 EX895_002620 EX895_002801 EX895_005449
» show all Taxonomy Reference Authors Ullrich R, Nuske J, Scheibner K, Spantzel J, Hofrichter M
Title Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes.
Journal Sequence Reference Authors Ullrich R, Hofrichter M
Title The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene.
Journal Sequence Reference Authors Anh DH, Ullrich R, Benndorf D, Svatos A, Muck A, Hofrichter M
Title The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation.
Journal Reference Authors Ullrich R, Dolge C, Kluge M, Hofrichter M
Title Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.
Journal Sequence Reference Authors Aranda E, Kinne M, Kluge M, Ullrich R, Hofrichter M
Title Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases.
Journal Reference Authors Kinne M, Poraj-Kobielska M, Aranda E, Ullrich R, Hammel KE, Scheibner K, Hofrichter M
Title Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with a fungal peroxygenase.
Journal Sequence Reference Authors Kluge M, Ullrich R, Dolge C, Scheibner K, Hofrichter M
Title Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation.
Journal Sequence Reference Authors Kinne M, Poraj-Kobielska M, Ralph SA, Ullrich R, Hofrichter M, Hammel KE
Title Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase.
Journal Reference Authors Pecyna MJ, Ullrich R, Bittner B, Clemens A, Scheibner K, Schubert R, Hofrichter M
Title Molecular characterization of aromatic peroxygenase from Agrocybe aegerita.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 1.11.2.1
ExPASy - ENZYME nomenclature database: 1.11.2.1
LinkDB All DBs
